截至2025年12月31日止年度，集团的IVF取卵周期数整体降幅由-5.2%(2024年前三季度至2025年前三季 度期间)进一步收窄至-1.4%(2024年全年至2025年全年期间)。其中集团成都旗舰医院的IVF取卵周期数 改善明显，由2025年前三季度的降幅-1.9%扭转至2025全年同比增长1.3%。同时，大湾区的IVF取卵周 期数由2025前三季度的降幅-13.5%收窄至2025全年的降幅-5.9%。集团美国及老挝海外市场的IVF取卵周 期数也由2025年前三季度的降幅-10.8%收窄至2025全年的降幅-6.9%。 展望2026年及往后，集团将会持续不断地提升临床治疗效果、患者护理质量与服务供给水平，加快核心 生殖医疗技术迭代升级，深化生殖医学领域的科研创新与临床转化，优化就医流程与数字化服务体验， 进一步巩固成都旗舰医院的区域市场地位，加速大湾区新院区搬迁后的产能释放与市场拓展，同时积极 应对海外政策变化，挖掘国际市场增长潜力。依託国家生育支持政策红利与行业发展机遇，公司将持续 夯实竞争力，为广大患者提供更优质的医疗服务，最终实现为股东创造长期稳定的价值回报，助力行业 高质量发展。 锦欣生殖(01 ...

中新网杭州12月28日电(张煜欢)如何引入最先进的试管婴儿技术帮助不孕家庭更好地实现生育梦想？这 是乌鲁木齐当地和周边百姓此前期盼了许久的问题。 2020年9月，伴随着一场为期多年、跨越山河的"组团式"精准医疗援疆行动，生命希望的种子也悄然开 花。浙江大学医学院附属妇产科医院(下称浙大妇院)生殖医学科援疆专家相继扎根新疆维吾尔自治区人 民医院，帮助有生育意愿的家庭在家门口圆梦，让相隔四千多公里的浙江与新疆谱写下一曲"生命之 约"。 院院士黄荷凤在乌鲁木齐实地调研。浙大妇院供图 中国科学 从零开始，试管婴儿呱呱坠地 像大漠胡杨一样扎根，像天山冰雪一样融入。来到新疆维吾尔自治区人民医院后，浙大妇院生殖内分泌 科的四位专家首先优化了既有流程，推动胚胎实验室的筹建，为试管婴儿技术奠定了最初的硬件与理念 基础。她们引入成熟的临床规范、管理流程与标准化文件，手把手培训本地医务人员，推动科室管理走 向规范化、标准化。 五年多时间，她们从基础做起，为当地医院系统性地构建出完整、先进且独立的辅助生殖技术体系，也 为不孕不育家庭点亮了生命希望。 回族姑娘小敏(化名)是其中一名亲历者。多年前，她因为严重输卵管积水而在手术中切除了双 ...

Core Viewpoint - The article discusses the challenges and opportunities in reproductive health, emphasizing the importance of early childbearing and the declining quality of male sperm, while also highlighting the advancements in assisted reproductive technologies [4][5][6]. Group 1: Reproductive Health Challenges - The incidence of infertility in China has increased from 12% in 2007 to 18% in 2020, with male and female factors contributing equally to infertility [9]. - Women over 35 face significant declines in fertility due to reduced egg quantity and quality, while men also experience declining sperm quality with age [8][9]. - The societal trend of late marriage and childbearing is influenced by various factors, including career pressures and educational costs, leading to a rise in high-age pregnancies [9][10]. Group 2: Sperm Quality Decline - Data from the Central South University shows a significant decline in sperm quality, with the acceptance rate for donated sperm dropping from 45.9% in 2006 to around 20% currently [11][12]. - The World Health Organization has revised the normal reference values for sperm parameters, indicating a downward trend in male fertility [11][12]. - Factors such as lifestyle choices, including sleep patterns and stress, significantly impact sperm quality, with younger individuals showing better sperm parameters compared to older students [13][16]. Group 3: Assisted Reproductive Technologies - The Central South University reproductive center has frozen approximately 820,000 embryos, with many serving as a form of "fertility insurance" for couples [28]. - The center emphasizes the importance of sperm donation and the strict regulations surrounding it, including the anonymity of donors and the limitation on the number of births per donor [20][22]. - Advances in reproductive technology are shifting the focus from sperm donation to self-sperm storage and fertility preservation, reflecting a growing trend in the market [23][28].

Core Insights - The academic exchange focused on the role of growth hormone in regulating ovarian function and its clinical applications in reproductive medicine [1][3][5] Group 1: Expert Insights - Professor Xu Chunyang, a leading expert in reproductive medicine, emphasized the importance of growth hormone in directly affecting ovarian cells and indirectly stimulating the liver to secrete IGF-I, which is crucial for follicle development and embryo implantation [3][5] - The challenges of low ovarian response (POR) and decreased fertility in older women were highlighted as common issues in clinical practice [3][5] Group 2: Clinical Applications - Growth hormone usage should follow the principle of "individualized precision treatment," tailoring treatment plans based on patient age, ovarian reserve function, and specific conditions [5] - The application of growth hormone can enhance ovarian sensitivity to ovulation induction drugs, thereby increasing the yield of quality oocytes, but requires careful monitoring of dosage and timing [5][6] Group 3: Collaborative Learning - Active communication among medical staff regarding complex clinical cases was encouraged, with Professor Xu providing solutions to various challenges faced in practice [6][8] - The hospital aims to regularly conduct high-level academic activities to integrate cutting-edge reproductive medicine technologies with clinical practice, enhancing infertility treatment services [8]

Core Viewpoint - The article discusses a groundbreaking study that introduces an AI-based microfluidic sperm detection and recovery system, named STAR, which successfully enabled clinical pregnancy in a male diagnosed with azoospermia, marking a significant advancement in the treatment of male infertility [3][4][8]. Group 1: Technology and Methodology - The STAR system utilizes high-power imaging technology to scan semen samples from azoospermic males, capable of capturing and analyzing millions of images in under an hour [4]. - The system combines high-speed imaging, microfluidic chips, and deep learning algorithms, processing semen at a flow rate of 400μL per hour and capturing images at 300 frames per second [4]. - A time-consistency filter enhances reliability by confirming sperm detection only if at least three out of ten consecutive frames identify sperm [4]. Group 2: Clinical Application and Results - The STAR system was applied to a couple who had been trying to conceive for nearly 20 years, with the male having undergone multiple sperm retrieval attempts with no success [7]. - Initial manual searches of the male's semen sample showed no sperm, but the STAR system identified 7 sperm (2 active) from 2.5 million images scanned [8]. - The two active sperm were successfully injected into two mature eggs, resulting in a positive pregnancy after 19 years of attempts, demonstrating the potential of AI-guided microfluidic technology in overcoming long-standing barriers in male infertility [8]. Group 3: Implications and Future Research - This breakthrough signifies a potential shift from "no hope" to "hope for parenthood" for many couples facing male infertility challenges [8]. - The research team is planning larger clinical studies to evaluate the reproducibility and effectiveness of the STAR system across a broader patient population [8].

Core Insights - The article discusses the significant public health challenge of infertility, affecting 12.6%-17.5% of couples globally, and highlights the role of in vitro fertilization (IVF) as a primary assisted reproductive technology [3] - A recent study published in Nature Medicine introduces the concept of Oocyte and Early Embryo Competence Defects (OECD) and identifies six subtypes based on clinical characteristics, providing new diagnostic standards and genetic mapping for female infertility [4][7] Group 1: OECD Concept and Subtypes - The study systematically proposes the concept of OECD and categorizes it into six subtypes: Empty Follicle, Oocyte Maturation Arrest, Fertilization Failure, Zygote Arrest, Early Embryonic Arrest, and Mixed Phenotype, along with corresponding diagnostic criteria [4][7] - The research involved whole-exome sequencing of 2,140 female OECD infertility patients to explore the genetic landscape and subtype classification [7] Group 2: Genetic Findings and Implications - The research team identified 183 pathogenic or potentially pathogenic mutations across 28 known genes, with varying diagnostic rates among subtypes; for instance, the Empty Follicle subtype had a diagnostic rate of 53% [9] - The study also identified and validated two potential pathogenic genes, MLH3 and CENPH, and suggested nine previously unreported associated genes, providing biological insights into the potential pathogenic mechanisms of ovarian insufficiency [9] - Overall, the genetic findings explain 12.8%-23.1% of OECD cases, offering valuable information for developing diagnostic genetic screening and standardizing subtype classification for OECD patients [9]

Group 1 - The core viewpoint emphasizes the importance of accelerating and improving the reproductive support policy system to promote high-quality population development [1] - Various regions are progressively including suitable assisted reproductive technologies in medical insurance reimbursement as related policies are implemented [1] - A live discussion featuring experts from Peking University Third Hospital will take place on July 30, focusing on assisted reproductive technologies and their impact on patients and clinical practices [1] Group 2 - Dr. Li Rong, a prominent figure in reproductive medicine, serves as the Deputy Director of Peking University Third Hospital and has received the National Outstanding Youth Science Fund [5] - Dr. Liu Ping, a key contributor to the establishment of assisted reproductive technology in mainland China, is currently the Chief Physician at the Reproductive Medicine Center of Peking University Third Hospital [5] - Both experts hold significant positions in various medical associations related to reproductive health and medicine [5] Group 3 - The event can be accessed through the People's Good Doctor App, where users can find health-related content and live discussions [6] - Users are encouraged to follow the People's Health public WeChat account for additional health information and to download the app for viewing [7]

Core Insights - The increasing prevalence of infertility issues among families is attributed to the fast-paced lifestyle and environmental pressures, leading to a growing reliance on assisted reproductive technologies (ART) [1] - Significant advancements in ART, such as multi-gene screening and fertility preservation, have provided hope for many couples wishing to become parents, marking important progress in the field of reproductive health [1] Group 1: Development and Application of ART - Assisted reproductive technology has evolved from initial in vitro fertilization (IVF) to include breakthroughs like multi-gene screening and fertility preservation [1] - The upcoming live discussion on May 9 will feature experts discussing the development and application of ART, highlighting its role in achieving "优生优育" (optimal birth and nurturing) [1] Group 2: Expert Profiles - Huang Guoning, a leading figure in reproductive medicine, holds multiple prestigious positions, including Director of the Reproductive Medicine Center at Chongqing Maternal and Child Health Hospital and Chair of the Reproductive Medicine Branch of the Chinese Medical Association [5] - Lin Ge, another prominent expert, serves as the President of CITIC Xiyuan Reproductive and Genetic Specialty Hospital and has significant roles in various national committees related to reproductive health and stem cell research [5] Group 3: Viewing Information - The live discussion can be accessed through the People's Good Doctor App, which provides health education content [6] - Users can also follow the People's Health public WeChat account for additional health-related interactions and to download the app [7]

Core Insights - The establishment of the Fertility Preservation Alliance for Cancer Patients and the launch of the Early-Onset Breast Cancer Prevention and Fertility Health Project aim to provide comprehensive support for cancer patients' fertility and quality of life [1][3][14] - The initiative addresses the rising incidence of breast cancer among young women in China, with 357,200 new cases reported in 2022, highlighting a significant gap in fertility preservation during cancer treatment [3][5] Group 1: Alliance Formation and Objectives - The Fertility Preservation Alliance is formed by leading experts from various medical fields, including oncology, reproductive medicine, and psychology, to create a collaborative platform for cancer patients [5][7] - The initiative aligns with national health strategies, emphasizing the importance of fertility preservation as a public health issue that impacts population safety and social equity [5][12] Group 2: Challenges and Needs - Young breast cancer patients face a conflict between cancer treatment and fertility preservation, with less than 5% achieving pregnancy despite over 50% expressing a desire for children [3][8] - There is a notable gap between China's treatment standards and international practices, necessitating a systematic approach to address patients' treatment and fertility needs [3][5] Group 3: Multi-Disciplinary Approach - The alliance promotes a multi-disciplinary treatment model to provide personalized care throughout the patient's life cycle, focusing on early intervention and comprehensive management [7][11] - The project aims to enhance public awareness and support for fertility preservation, particularly in the context of early-onset breast cancer, through educational initiatives and community engagement [8][12] Group 4: Future Directions - The initiative plans to establish fertility preservation centers nationwide and develop clinical guidelines to standardize practices [12][14] - A public awareness campaign, including a themed variety show led by cancer patients, aims to reshape societal perceptions of cancer survivorship and fertility [12][14]