医护人员围绕临床实践中的复杂病例展开了积极的沟通交流。大家纷纷提出自己在工作中遇到的难题和困惑，徐春阳教授 一一解答，并与医护人员共同探讨解决方案。现场学术氛围浓厚，思维的火花不断碰撞。 作为拥有30余年妇产科及生殖医学临床经验的权威专家，徐春阳教授在不孕症诊疗、生殖内分泌调控等领域造诣深厚。交 流会上，徐春阳教授以生长激素对卵巢功能的调节及临床应用作为关键切入点，展开了系统且深入的阐述：生长激素是人 体垂体前叶分泌的重要多肽类激素，以脉冲式昼夜节律分泌，不仅能直接作用于卵巢颗粒细胞、卵母细胞，还可通过刺激 肝脏分泌胰岛素样生长因子-I(IGF-I)，间接调节卵泡发育与子宫内膜容受性，为卵母细胞成熟及胚胎着床奠定基础。徐教 授指出，在临床工作中，卵巢低反应(POR)和高龄女性生育力下降是常见且棘手的难题。卵巢低反应意味着卵巢对促排卵 药物的反应不佳，导致获取的优质卵母细胞数量减少；而高龄女性由于身体机能的衰退，生育能力也显著降低。 针对这些问题，徐教授结合一系列典型病例，详细分享了生长激素在临床中的应用经验。徐教授强调，生长激素的使用需 遵循"个体化精准施治"原则。根据患者年龄、卵巢储备功能(AMH、AFC等 ...

Core Viewpoint - The article discusses a groundbreaking study that introduces an AI-based microfluidic sperm detection and recovery system, named STAR, which successfully enabled clinical pregnancy in a male diagnosed with azoospermia, marking a significant advancement in the treatment of male infertility [3][4][8]. Group 1: Technology and Methodology - The STAR system utilizes high-power imaging technology to scan semen samples from azoospermic males, capable of capturing and analyzing millions of images in under an hour [4]. - The system combines high-speed imaging, microfluidic chips, and deep learning algorithms, processing semen at a flow rate of 400μL per hour and capturing images at 300 frames per second [4]. - A time-consistency filter enhances reliability by confirming sperm detection only if at least three out of ten consecutive frames identify sperm [4]. Group 2: Clinical Application and Results - The STAR system was applied to a couple who had been trying to conceive for nearly 20 years, with the male having undergone multiple sperm retrieval attempts with no success [7]. - Initial manual searches of the male's semen sample showed no sperm, but the STAR system identified 7 sperm (2 active) from 2.5 million images scanned [8]. - The two active sperm were successfully injected into two mature eggs, resulting in a positive pregnancy after 19 years of attempts, demonstrating the potential of AI-guided microfluidic technology in overcoming long-standing barriers in male infertility [8]. Group 3: Implications and Future Research - This breakthrough signifies a potential shift from "no hope" to "hope for parenthood" for many couples facing male infertility challenges [8]. - The research team is planning larger clinical studies to evaluate the reproducibility and effectiveness of the STAR system across a broader patient population [8].

Core Insights - The article discusses the significant public health challenge of infertility, affecting 12.6%-17.5% of couples globally, and highlights the role of in vitro fertilization (IVF) as a primary assisted reproductive technology [3] - A recent study published in Nature Medicine introduces the concept of Oocyte and Early Embryo Competence Defects (OECD) and identifies six subtypes based on clinical characteristics, providing new diagnostic standards and genetic mapping for female infertility [4][7] Group 1: OECD Concept and Subtypes - The study systematically proposes the concept of OECD and categorizes it into six subtypes: Empty Follicle, Oocyte Maturation Arrest, Fertilization Failure, Zygote Arrest, Early Embryonic Arrest, and Mixed Phenotype, along with corresponding diagnostic criteria [4][7] - The research involved whole-exome sequencing of 2,140 female OECD infertility patients to explore the genetic landscape and subtype classification [7] Group 2: Genetic Findings and Implications - The research team identified 183 pathogenic or potentially pathogenic mutations across 28 known genes, with varying diagnostic rates among subtypes; for instance, the Empty Follicle subtype had a diagnostic rate of 53% [9] - The study also identified and validated two potential pathogenic genes, MLH3 and CENPH, and suggested nine previously unreported associated genes, providing biological insights into the potential pathogenic mechanisms of ovarian insufficiency [9] - Overall, the genetic findings explain 12.8%-23.1% of OECD cases, offering valuable information for developing diagnostic genetic screening and standardizing subtype classification for OECD patients [9]

Group 1 - The core viewpoint emphasizes the importance of accelerating and improving the reproductive support policy system to promote high-quality population development [1] - Various regions are progressively including suitable assisted reproductive technologies in medical insurance reimbursement as related policies are implemented [1] - A live discussion featuring experts from Peking University Third Hospital will take place on July 30, focusing on assisted reproductive technologies and their impact on patients and clinical practices [1] Group 2 - Dr. Li Rong, a prominent figure in reproductive medicine, serves as the Deputy Director of Peking University Third Hospital and has received the National Outstanding Youth Science Fund [5] - Dr. Liu Ping, a key contributor to the establishment of assisted reproductive technology in mainland China, is currently the Chief Physician at the Reproductive Medicine Center of Peking University Third Hospital [5] - Both experts hold significant positions in various medical associations related to reproductive health and medicine [5] Group 3 - The event can be accessed through the People's Good Doctor App, where users can find health-related content and live discussions [6] - Users are encouraged to follow the People's Health public WeChat account for additional health information and to download the app for viewing [7]

Core Insights - The increasing prevalence of infertility issues among families is attributed to the fast-paced lifestyle and environmental pressures, leading to a growing reliance on assisted reproductive technologies (ART) [1] - Significant advancements in ART, such as multi-gene screening and fertility preservation, have provided hope for many couples wishing to become parents, marking important progress in the field of reproductive health [1] Group 1: Development and Application of ART - Assisted reproductive technology has evolved from initial in vitro fertilization (IVF) to include breakthroughs like multi-gene screening and fertility preservation [1] - The upcoming live discussion on May 9 will feature experts discussing the development and application of ART, highlighting its role in achieving "优生优育" (optimal birth and nurturing) [1] Group 2: Expert Profiles - Huang Guoning, a leading figure in reproductive medicine, holds multiple prestigious positions, including Director of the Reproductive Medicine Center at Chongqing Maternal and Child Health Hospital and Chair of the Reproductive Medicine Branch of the Chinese Medical Association [5] - Lin Ge, another prominent expert, serves as the President of CITIC Xiyuan Reproductive and Genetic Specialty Hospital and has significant roles in various national committees related to reproductive health and stem cell research [5] Group 3: Viewing Information - The live discussion can be accessed through the People's Good Doctor App, which provides health education content [6] - Users can also follow the People's Health public WeChat account for additional health-related interactions and to download the app [7]

Core Insights - The establishment of the Fertility Preservation Alliance for Cancer Patients and the launch of the Early-Onset Breast Cancer Prevention and Fertility Health Project aim to provide comprehensive support for cancer patients' fertility and quality of life [1][3][14] - The initiative addresses the rising incidence of breast cancer among young women in China, with 357,200 new cases reported in 2022, highlighting a significant gap in fertility preservation during cancer treatment [3][5] Group 1: Alliance Formation and Objectives - The Fertility Preservation Alliance is formed by leading experts from various medical fields, including oncology, reproductive medicine, and psychology, to create a collaborative platform for cancer patients [5][7] - The initiative aligns with national health strategies, emphasizing the importance of fertility preservation as a public health issue that impacts population safety and social equity [5][12] Group 2: Challenges and Needs - Young breast cancer patients face a conflict between cancer treatment and fertility preservation, with less than 5% achieving pregnancy despite over 50% expressing a desire for children [3][8] - There is a notable gap between China's treatment standards and international practices, necessitating a systematic approach to address patients' treatment and fertility needs [3][5] Group 3: Multi-Disciplinary Approach - The alliance promotes a multi-disciplinary treatment model to provide personalized care throughout the patient's life cycle, focusing on early intervention and comprehensive management [7][11] - The project aims to enhance public awareness and support for fertility preservation, particularly in the context of early-onset breast cancer, through educational initiatives and community engagement [8][12] Group 4: Future Directions - The initiative plans to establish fertility preservation centers nationwide and develop clinical guidelines to standardize practices [12][14] - A public awareness campaign, including a themed variety show led by cancer patients, aims to reshape societal perceptions of cancer survivorship and fertility [12][14]