核心观点 2025H1 业绩符合预期，中山海济及红岸基元的并表增厚公司业绩，公司表观收入实现稳健增长，内生 业务方面，由于呼吸道发病率相比去年同期处于较低水平，叠加增值税率调整影响，公司内生增长有所 承压。25Q3 呼吸道的发病率仍处于较低水平，预计25Q3 内生收入增长仍有所承压，25Q4 业绩仍需观 测呼吸道疾病发病情况，下半年表观收入同比预计仍有望实现稳定增长。公司作为分子诊断行业龙头， 产品矩阵丰富，行业认可度高，在呼吸道检测领域先发优势明显，居家检测服务的拓展进一步带来业绩 增量，同时看好公司通过并购+自研布局诊疗一体化。 对外投资与并购拓展新增长点，有望打造覆盖全产业链生态的平台型企业公司积极寻找优质标的，通过 设立产业基金，进一步加大对外投资与合作。2025 年初，公司收购中山海济100%股权，布局生长激素 领域，此次收购不仅为公司在儿科领域的长期发展奠定了坚实的基础，更有助于实现打造"诊断+治 疗"一体化健康方案的综合战略布局。此外，公司进一步增资真迈生物，继续深化合作，加速基因测序 国产方案的替代和推动基因技术的国际化突破。上半年，公司测序业务实现营业收入超三千万元，同比 增长三倍。同时进一 ...

特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我们的推送。 第十二届药典委员会执委 中国工程院院士 王军志： 新版药典首次收载了曲妥珠（单抗）、利妥昔（单抗）等8个单抗 抗体的品种 。 这些品种都是我们国家自主研发的，也是在国际上首次纳入药典的品种。 北京大学第三医院药学部主任药师 杨毅恒：最多的就是抗肿瘤药物，共有5个药物，比如说注射用三氧化二砷，是治 疗急性早幼粒细胞白血病，还有一类就是治疗自身免疫性疾病的，比如像阿达木单抗。同时这一次也关注了儿童的用 药，比如说生长激素，专门是治疗儿童早期生长发育缓慢的。 北京大学肿瘤医院乳腺癌预防治疗中心主任医师 范照青：曲妥珠单抗在我们乳腺癌领域是治疗HER2（人表皮生长因 子受体-2）阳性乳腺癌，在晚期乳腺癌（治疗）中有非常广泛的应用。 此外， 中国药典还注重收载国际研发热点，规范、指导相关药物研发，加快我国这类创新药研发上市 。国家药典委员 会秘书长 舒融：2025年版的中国药典填补了19项国内外空白，主要涉及药物研发、质量控制等方面的技术指导原则 和通用技术要求。 2025年版《中国药典》已于2025年 ...

Core Viewpoint - Changchun High-tech aims to enhance its international presence and innovation capabilities by issuing H-shares for listing on the Hong Kong Stock Exchange, with funds primarily allocated for R&D, clinical trials, and international market expansion [1][3]. Fundraising Purpose - The funds raised will be used for two main directions: advancing the innovation pipeline, including clinical trials and regulatory affairs, and establishing a commercial team overseas for global collaboration and market expansion [1][3]. Financial Performance - Since 2022, Changchun High-tech's stock price has experienced significant fluctuations due to rumors surrounding the centralized procurement of growth hormones, culminating in a decline in both revenue and net profit for the first time in nearly two decades in 2024 [3]. Innovation Pipeline - The company has over 40 projects in clinical stages or IND applications, including 11 Class I innovative biological agents and 4 Class I innovative chemical drugs, focusing on endocrine and metabolic diseases, women's health, immune and respiratory systems, and oncology [3][4]. Key Products - GenSci134, a long-acting growth hormone, is currently undergoing Phase I clinical trials for adult growth hormone deficiency and has received IND approval for pediatric growth hormone deficiency and idiopathic short stature [4][5]. - GenSci074, an NK3R antagonist for treating vasomotor symptoms in menopausal women, is in Phase II clinical trials, with competition from other drugs in the same category [7][8]. Oncology Pipeline - The company is developing several innovative drugs targeting prostate, breast, and ovarian cancers, including GenSci139, GenSci140, and GenSci143, which are expected to enter Phase I clinical trials by Q4 2025 [10][11]. - GenSci139 targets low-expressing HER2 tumors and faces a competitive landscape with existing ADC therapies [11][12]. - GenSci140 aims to expand patient coverage for FRα-positive cancers and is the only FRα dual-target ADC in development in China [13][14]. - GenSci143 targets both B7-H3 and PSMA antigens, potentially offering broader patient coverage but is still in early development stages [15]. Other Therapeutic Areas - GenSci098 is a TSHR antagonist for treating thyroid-associated ophthalmopathy, indicating the company's diversification into immune and respiratory diseases [16].

有券商医药行业分析师对21世纪经济报道记者表示，长春高新此次赴港IPO的核心看点，在于其作为国 内生物制药领域"平台型龙头"的稀缺性。对长春高新自身而言，赴港上市不仅是融资渠道的拓宽，更是 国际化战略的关键一步。H股发行将直接带来三重价值：资金支持研发管线加速兑现、提升国际品牌影 响力，和优化股东结构。 记者丨季媛媛 编辑丨张伟贤 刘雪莹 曾经凭借生长激素叱咤资本市场的长春高新，在遭遇业绩滑铁卢后，正加速推进赴港上市计划，试图在 困境中寻找新的出路。 9月29日，据港交所披露，长春高新在港交所递交招股书，拟在香港主板挂牌上市。这标志着这家曾在 A股市场创造"神话"的"生长激素茅"正式开启"A+H"双平台上市征程。 近两年利润大跌超42％ 市值5年缩水1570亿元 2021年5月长春高新市值曾超过2100亿元，截至2025年9月30日，长春高新总市值为人民币530亿元，已 缩水约1570亿元。 招股书显示，2022年至2024年，长春高新收入分别约为126.27亿元、145.66亿元和134.66亿元，2025年 上半年实现66.03亿元。同期公司利润分别为42.15亿元、47.76亿元和27.08亿元，202 ...

Core Viewpoint - Changchun High-Tech Industry (Group) Co., Ltd. is accelerating its plan for a Hong Kong IPO to seek new opportunities amid declining performance, particularly due to over-reliance on its growth hormone business [1][8]. Company Overview - The company submitted its prospectus to the Hong Kong Stock Exchange on September 29, aiming for a listing on the main board [1]. - As of September 29, 2025, the company's total market capitalization was approximately RMB 52.583 billion [1]. Business Challenges - The company has faced significant revenue fluctuations, with projected revenues of approximately RMB 126.27 billion, RMB 145.66 billion, and RMB 134.66 billion from 2022 to 2024, and a net profit decline of 43.01% in 2024 [3][4]. - The primary reason for the revenue decline is the company's heavy dependence on its growth hormone business, which has been affected by price controls from centralized procurement policies [4][5]. Market Dynamics - The growth hormone market in China has seen rapid growth, increasing from RMB 4 billion in 2018 to RMB 11.6 billion in 2023, with a compound annual growth rate (CAGR) of 23.9% [4][5]. - Despite holding a 74% market share, the company faces increasing competition, particularly from long-acting growth hormone products, which are gaining market share at a rate exceeding 50% annually [5]. Vaccine Business Performance - The company's vaccine segment has also struggled, with a reported revenue drop of 39.96% year-on-year in Q1 2025, primarily due to decreased sales of the shingles vaccine [6]. IPO Strategy and Goals - The Hong Kong IPO is seen as a critical step for the company to enhance its international presence, improve financing capabilities, and attract international investors [2][8]. - The company aims to expand its overseas revenue, which was only RMB 1.3 billion in 2024, by diversifying its export product categories and increasing international collaborations [8]. Market Environment and Challenges - The current market sentiment for biotech stocks in Hong Kong is cautious, with a high rate of new stock failures, which could lead to valuation pressures for the company [9]. - The company must navigate uncertainties in drug development and commercialization, as well as the competitive landscape influenced by policy changes and market dynamics [10].

当前，我国创新型产业正处在从高速增长迈向高质量发展的关键阶段。数据显示，2024年国内创新型市 场规模已显著增长，然而，行业也面临产品同质化加剧、部分赛道竞争失序等挑战。越是在转型攻坚 期，企业越应保持战略定力，将资源集中于科技研发、临床验证与产品质量提升上，而非采取短视甚至 违规的竞争手段。 国家监管部门近期连续出台政策，旨在引导行业避免"内卷式竞争"，推动企业转向差异化、高质量的创 新路径。唯有凭借扎实的研发实力和经得起检验的临床价值，企业才能在市场中立于不败之地，这也符 合国家政策导向与行业长远发展利益。 以国内生长激素领域为例，该赛道近年来持续受到市场关注，全年产业规模已达数百亿元。其中，一家 长期专注于生长发育领域的龙头企业，曾凭借其技术和市场优势，在国内占据显著份额，其发展路径在 某种程度上已成为观察行业走向的风向标。此次相关传闻，不论结果如何，都揭示出企业在营销推广环 节中可能存在的合规风险。如果企业将员工捆绑于非常规推广任务，不仅容易扭曲内部文化，更可能侵 蚀可持续发展的根基。 近日，美国食品药品监督管理局(FDA)官网发布公告，提醒消费者警惕某膳食补充剂含有未明示成分伊 布莫仑，引发行业对产 ...

在国内生物医药产业向创新化、多元化升级的浪潮中，长春高新技术产业（集团）股份有限公司（以下 简称"长春高新"）凭借对细分赛道的精准把控，勾勒出生长激素、多元商业化创新产品、新药"出海"授 权"三驾马车"并驾齐驱的全新格局。 今年9月份，长春高新旗下核心子公司长春金赛药业有限责任公司（以下简称"金赛药业"）与丹麦ALK- AbellóA/S公司（以下简称"ALK"）达成变应原特异性免疫治疗（AIT，俗称脱敏治疗）产品合作，将在 中国联合开发并商业化ALK的屋尘螨（HDM）变应原特异性免疫治疗产品，并获得ALK自主开发的3款 产品在中国大陆范围内的独家代理权益。 "脱敏，是我们全力进军免疫与呼吸领域的关键一步，是公司未来重要的业务增长点。未来，金赛药业 力争跻身中国呼吸领域第一梯队。"长春高新总经理，金赛药业创始人、总经理、首席科学家金磊对 《证券日报》记者表示。 在竞争激烈的生物医药领域，如何通过研发创新实现攻势突破、通过多元化与资本运作稳固防线、通过 国际化布局实现护城河延展，是长春高新面临的三道命题。近日，《证券日报》记者走进长春高新，探 寻公司攻与守的博弈之道。 创新为本 筑牢发展基石 创新研发是企业生存 ...

Investment Rating - The investment rating for Changchun High-tech is "Buy" with a target price not specified [5] Core Views - The collaboration with ALK is expected to open a new era in desensitization treatment in China, focusing on allergen-specific immunotherapy products [1][2] - The partnership includes exclusive rights for three products in mainland China, with a collaboration period until December 31, 2039 [2] - The company is projected to have revenue of 135.96 billion, 141.92 billion, and 151.61 billion CNY for the years 2025, 2026, and 2027 respectively, with net profits of 23.89 billion, 25.45 billion, and 28.09 billion CNY for the same years [3] Summary by Sections Collaboration Details - Changchun High-tech has signed a cooperation agreement with ALK to develop and commercialize allergen-specific immunotherapy products in China [1] - The products include subcutaneous allergen extracts and a skin prick test kit, with Changchun High-tech responsible for sales and promotion in the region [2] Market Potential - China has the largest population of dust mite allergy patients globally, yet the market for allergy immunotherapy is underdeveloped, indicating significant unmet clinical needs [3] Financial Projections - Revenue estimates for 2025-2027 are 135.96 billion, 141.92 billion, and 151.61 billion CNY, with net profits projected at 23.89 billion, 25.45 billion, and 28.09 billion CNY [3] - The company anticipates a decline in revenue and profit due to increased market competition, leading to a downward adjustment in previous forecasts [3] Financial Metrics - The company’s financial metrics include an expected revenue growth rate of 0.97% in 2025, followed by 4.38% and 6.83% in 2026 and 2027 respectively [4] - The projected earnings per share (EPS) for 2025 is 5.86 CNY, with a price-to-earnings (P/E) ratio of 20.58 [4]

Core Viewpoint - Changchun High-tech is facing significant challenges due to price reductions from centralized procurement of its core products and a lack of new business development, leading to a dramatic decline in net profit by 42.85% in the first half of 2025, marking a potential fall from grace for this once-prominent stock [1][2]. Financial Performance - In the mid-year report of 2025, the company reported revenue of 6.603 billion yuan, a year-on-year decrease of 0.54%, and a net profit attributable to shareholders of 983 million yuan, down 42.85% year-on-year, indicating a continuous decline in both revenue and profit for the first time in 20 years [2][3]. - The second quarter of 2025 showed revenue of 3.605 billion yuan, a slight increase of 4.16% year-on-year, but net profit fell by 48.83% to 463 million yuan, primarily due to rising sales and R&D expenses [2][3]. - Over the past five years, revenue growth has significantly slowed, with figures of 4.963 billion yuan, 5.831 billion yuan, 6.168 billion yuan, 6.639 billion yuan, and 6.603 billion yuan from 2021 to 2025, while net profit has dropped from 1.923 billion yuan in 2021 to 983 million yuan in 2025 [2][3]. Business Structure and Risks - The decline in net profit is largely attributed to the poor performance of its core subsidiary, Jinsai Pharmaceutical, and losses at Baike Biotechnology, highlighting potential risks in the company's business structure and pipeline layout [3][4]. - The company is overly reliant on a few products, making it vulnerable to market changes, increased competition, or quality issues [3][4]. - The shift in the industry from "generic-driven" to "innovation-driven" poses additional challenges for Changchun High-tech, as it faces high R&D costs and long commercialization cycles [4]. Expense Management - The company's mid-year report for 2025 revealed sales expenses of 2.386 billion yuan, up 23.43% year-on-year, and R&D expenses of 1.155 billion yuan, up 30.22%, together accounting for 53.6% of total revenue, significantly squeezing profit margins [5][6]. - The increase in sales expenses is attributed to the promotion of new products and expansion into new medical departments, while the rise in R&D expenses is due to advancements in technology platforms and clinical trials [6][7]. - The high ratio of total expenses to revenue (46.97%) is above the industry average of 35%, indicating structural inefficiencies within the company [7][8]. Future Outlook - The company faces significant challenges in its transformation journey, and how it navigates these business difficulties will be closely monitored [8].

Core Viewpoint - Changchun High-tech is facing significant challenges due to price reductions from centralized procurement of its core product, growth hormone, and a lack of new business opportunities, leading to a dramatic decline in net profit by 42.85% in the mid-2025 report [2][3]. Financial Performance - In the mid-2025 report, the company reported revenue of 6.603 billion yuan, a year-on-year decrease of 0.54%, and net profit attributable to shareholders of 983 million yuan, down 42.85% [3]. - This marks the first occurrence of simultaneous revenue and net profit decline in nearly 20 years for the company [3]. - The second quarter of 2025 showed revenue of 3.605 billion yuan, a slight increase of 4.16% year-on-year, but net profit fell by 48.83% to 463 million yuan, indicating a "revenue without profit" situation due to rising sales and R&D expenses [3]. Business Structure and Risks - The core reason for the "revenue without profit" phenomenon is the decline in net profit from the core subsidiary, Jinsai Pharmaceutical, and losses at Baike Biotechnology [4]. - The company is overly reliant on a single product, which exposes it to risks from market demand changes and increased competition [4]. - The losses at Baike Biotechnology may stem from an unreasonable pipeline layout and poor market prospects for R&D products [4]. Policy and Industry Context - The significant drop in net profit can be attributed to policy impacts and industry cycles, including the expansion of centralized procurement for growth hormone, which saw price reductions exceeding 50% in some regions [5]. - The company’s core product accounts for over 70% of revenue, highlighting its vulnerability due to reliance on a single product [5]. - The domestic innovative pharmaceutical industry is facing challenges transitioning from a "generic-driven" to an "innovation-driven" model, with high R&D costs and long commercialization cycles putting pressure on cash flow [5]. Expense Management - The company reported a significant increase in expenses, with sales expenses reaching 2.386 billion yuan (up 23.43%) and R&D expenses at 1.155 billion yuan (up 30.22%), together accounting for 53.6% of revenue [7]. - The high sales expenses are attributed to market promotion for new products and expansion into new medical departments [7]. - R&D expenses have surged due to the advancement of new technology platforms and clinical trials, with R&D investment reaching 20.21% of revenue, the highest in five years [7]. Comparative Analysis - The company's expense ratio of 46.97% is significantly higher than the industry average of 35%, indicating structural issues in expense management [8]. - The high sales expenses are driven by increased market competition and the need for extensive promotional activities [8]. - In contrast, other companies like Heng Rui Pharmaceutical have managed to reduce their expense ratios through sales team integration and digital marketing strategies, highlighting potential areas for efficiency improvement for Changchun High-tech [9].