人民财讯8月24日电，安科生物（300009）近日接待机构调研时表示，2025年上半年，公司生长激素新 患入组同比保持增长，生长激素水针的占比持续攀升，目前水针营收占公司整个生长激素系列产品营收 的比例已超40%。由于2024年下半年的新患入组相对不够理想，造成2025年上半年的生长激素营收与去 年同期基本持平。依托上半年的新患入组同比增长，公司将持续推动生长激素的学术推广工作，努力实 现恢复性增长的目标。目前生长激素市场竞争较为激烈，但总体价格体系较为稳定。 ...

问答环节要点生长激素板块：2025年上半年生长激素新患入组同比增长，水针占比超40%，但因2024年 下半年新患入组不佳，2025年上半年营收与去年同期持平。生长激素市场竞争激烈但价格稳定，与维昇 药业合作的长效生长激素"隆培促生长素"预计2025年下半年获批，定位于高端市场。隆培促生长素优 点：安全性好，通过特定技术使生长激素以特定速率缓慢释放，连接结构和载体分子可排出体外；有效 性高，创新技术保持蛋白活性，免疫原性低，IGF - 1应答高于日制剂；稳定性强，优化冷冻干燥工艺， 储存条件更宽松，降低运输和保存负担；便利性与依从性佳，创新自动注射器，隐形针头，每周仅需注 射一次。博生吉公司CAR - T管线布局：包括自体CAR - T，PA3 - 17注射液纳入突破性治疗品种；通用 现货型CAR - T，UTAA09注射液临床试验进展顺利；In vivo CAR - T平台，完成临床前开发进入IIT阶 段；NKCE平台，进展到动物实验阶段。CD7 - CART规划：后续启动II期单臂注册临床并争取附条件上 市，产品获批后计划在一带一路国家直接申报上市，对欧美国家将视情况独立申报或寻找合作。创新药 研发管线：公 ...

安徽安科生物工程（集团）股份有限公司 投资者关系活动记录表 编号：2025-009 证券代码：300009 证券简称：安科生物 | 投资者关系活动 | ☑特定对象调研 □分析师会议 | | --- | --- | | 类别 | □媒体采访 □业绩说明会 | | | □新闻发布会 □路演活动 | | | □现场参观 | | | ☑其他 （电话会议） | | 参与单位名称及 | 华源医药、国盛医药、华福医药、中邮医药、平安证券、华鑫 | | 人员姓名 | 医药、信达医药、华安医药、东吴医药、东方医药、太平资产 | | | 管理、仁桥（北京）资产管理、中信建投基金、优益增投资、 | | | 泰康资产管理、Open Door Investment Management Ltd.、中国国 | | | 际金融、晨岭资本、太朴持信、深圳市尚诚资产管理、高腾国 | | | 际、鸿运私募基金管理、嘉实基金、华泰自营、翼虎投资管理、 | | | 长江养老保险、罗爵资产管理、长城基金管理、昆仑健康、武 | | | 汉证国私募基金、北京金塔股权投资、观合资产、药融圈、杭 | | | 贵投资、北京金百镕投资、上海盟洋投资管理、华宝基金 ...

Group 1 - The stock price of Changchun High-tech is reported at 104.78 yuan, down 0.86% from the previous trading day, with a trading volume of 7.74 billion yuan [1] - The company operates in the biopharmaceutical industry, focusing on the production and sales of biopharmaceuticals and traditional Chinese medicine, with a product line that includes growth hormones and vaccines [1] - Changchun High-tech announced its plan to pursue an IPO in Hong Kong in July, becoming one of 17 A-share companies to announce such plans that month [1] Group 2 - Recent clinical trials for a copy-type Tian Tan smallpox vaccine carrier HIV vaccine by the Chinese Center for Disease Control and Prevention may have a positive impact on the biopharmaceutical vaccine industry [1] - The net inflow of main funds into Changchun High-tech on the day was 471.66 million yuan, with a cumulative net inflow of 1.85 billion yuan over the past five days [1]

Core Viewpoint - Changchun High-tech is facing significant challenges with its financial performance, experiencing its first dual decline in revenue and net profit in nearly a decade, raising concerns about its future growth prospects [1]. Group 1: Financial Performance - In 2024, the company reported revenue of 13.466 billion yuan and a net profit of 2.584 billion yuan, representing year-on-year declines of 7.55% and 43.01% respectively [1]. - The net profit for the first quarter of 2025 further decreased by 44.95% year-on-year, indicating ongoing financial struggles [1]. Group 2: Core Business Challenges - The core business, Jin Sai Pharmaceutical's growth hormone, which contributed over 80% of profits, faced a drastic price drop due to centralized procurement, with prices in the Zhejiang market plummeting from 1,000 yuan to 300 yuan, a 70% decrease, leading to a 40.67% drop in net profit to 2.678 billion yuan [2]. - The entry of competitors like Teva and Novo Nordisk has intensified market competition, undermining the company's previous market dominance [2]. Group 3: Strategic Failures - The vaccine business suffered significantly, with the subsidiary Baike Bio's revenue and net profit both halving in 2024, and the first quarter of 2025 net profit dropping to only 106,000 yuan, a 98% year-on-year decline [3]. - The company's attempt to divest its real estate business for 2.42 billion yuan failed due to unsuccessful convertible bond issuance, which continues to hinder its focus on the pharmaceutical sector [3]. - Despite a 38.8% increase in net profit for Huakang Pharmaceutical, the total profit for the first quarter was only 12 million yuan, insufficient to offset overall losses [3]. Group 4: Operational Discrepancies - In 2024, the sales team increased by 58% to 4,995 personnel, with sales expenses rising to 4.439 billion yuan, contrasting sharply with a reduction of 65 research personnel and a research investment of 2.69 billion yuan [4]. - This shift towards a "sales-heavy" strategy contradicts the company's stated goal of enhancing innovation [4]. Group 5: Future Outlook - In response to its challenges, the company is pursuing a Hong Kong IPO and aims to expand international partnerships, with overseas revenue reported at only 130 million yuan in 2024 [5]. - There are doubts about whether investors in Hong Kong will support this "breakout plan" given the company's declining growth and intense competition in the domestic market [5]. - The situation highlights the risks associated with reliance on a single blockbuster product, suggesting that without restructuring its product matrix and improving innovation efficiency, the company may face severe challenges in the capital market [5].

Summary of Anke Bio's Conference Call Company Overview - Anke Bio focuses on biopharmaceuticals, with a strategic emphasis on traditional Chinese medicine and precision medicine, actively expanding into mRNA, ADC viruses, and cell therapy fields, particularly in the Yangtze River Delta region [2][4][31] Core Products and Development Focus - Main products include growth hormones and interferons for growth development and antiviral applications, with antibody drugs like Trastuzumab approved for market [2][5] - The company is investing heavily in biopharmaceuticals as a key growth driver, with traditional Chinese medicine as a secondary profit source, and focusing on peptides, small molecules, and cell immunotherapy to support performance growth [2][5][31] Research and Development Investment - Over the past seven years, Anke Bio has invested approximately 200 million yuan annually in R&D, accounting for about 10% of revenue, indicating a strong commitment to innovative drug development [7][8] Key R&D Areas - R&D strategy focuses on growth development, reproductive assistance, antiviral and anti-infection fields, and cancer treatment through antibodies, mRNA, CAR-T, and viral therapies [8][9] - Specific projects include in vivo CAR-T technology and mRNA platform development, with clinical trial approvals for HPV, RCV, and COVID-19 [12][13] Clinical Stage Products - Important clinical stage products include HU21 (E9), AK2017 (GHFC), AK1,008, and AK1,012, expected to enter phase III clinical trials by the end of 2025 [3][14][15] - The company plans to utilize all resources to ensure the progress of these products and expedite their market approval [15] Collaborations and Partnerships - Anke Bio is engaged in multiple collaborations, including with Baoyi for the domestic launch of the first long-acting FSH and with Weisen for long-acting growth hormone development [3][31][32] - The company has established partnerships with various academic institutions and companies to enhance its R&D capabilities and product offerings [12][29] Market Potential and Future Plans - The long-acting FSH product is expected to capture a significant market share due to its convenience over short-acting alternatives, with an estimated annual market of 1 million cycles [32] - Anke Bio aims to transition from a focus on generic drugs to innovative drug development, particularly in oncology, autoimmune diseases, cell therapy, and mRNA drugs [34] Additional Insights - The company has a highly qualified R&D team, with 40.64% holding master's degrees or higher, indicating a strong foundation for innovation [11] - Anke Bio's dual-antibody product is currently in phase I clinical trials, with plans to advance to phase II and III based on positive results [24] This summary encapsulates the key points from Anke Bio's conference call, highlighting its strategic focus, product pipeline, R&D investments, and future growth plans.

Group 1 - The article highlights the rising costs and pressures faced by parents regarding their children's health, particularly in managing myopia, dental issues, and height concerns [2][57] - A significant market has emerged around myopia treatment, with the overall myopia rate among children and adolescents in China reaching 52.7%, indicating that one in two children is affected [27][28] - Companies in the myopia treatment sector, such as Opcon Vision and Aier Eye Hospital, are experiencing substantial revenue growth, with Opcon Vision's revenue reaching 1.814 billion and Aier Eye Hospital's revenue at 20.983 billion [30][31] Group 2 - The orthodontics market is also booming, with companies like Times Angel and Invisalign dominating the space, capturing significant market shares and generating substantial revenues [43][44] - The article discusses the high costs associated with dental treatments, with some families spending up to 60,000 on orthodontic solutions, reflecting a growing trend in dental care for children [34][36] - The prevalence of dental issues among children is alarming, with a reported 67.82% incidence of malocclusion, leading to increased demand for orthodontic services [41] Group 3 - Height management is emerging as a new area of concern for parents, with the market for growth hormone treatments and related products projected to reach 8-12 billion, growing at a compound annual growth rate of over 25% [56][57] - Companies like Jinsai Pharmaceutical are leading the growth in the height management sector, with a reported revenue of 10.67 billion, indicating a strong market presence [56] - The societal pressures regarding height are reflected in the increasing willingness of parents to invest heavily in treatments, with some spending tens of thousands on growth hormone therapies [48][49]

Core Viewpoint - Changchun High-tech, once known as "Northeast Medicine King," has faced a significant decline, with its market value evaporating by 160 billion yuan and stock prices plummeting by 84%. However, the approval of a new gout drug, "Jinbeixin," and plans for a Hong Kong IPO have sparked hopes for a turnaround [1][3]. Group 1: R&D and IPO Strategy - Over the past three years, Changchun High-tech has invested more than 6 billion yuan in R&D, with the R&D expense ratio soaring to nearly 20% in 2024. The company has increased its workforce by 2,518 employees, primarily in R&D and self-immune drug promotion [3]. - The company announced the preparation for an H-share listing on July 1, aiming to open up overseas financing channels to alleviate the financial pressure from its 6 billion yuan R&D "black hole" [3]. - Despite the low liquidity in the Hong Kong market, the policy allowing unprofitable innovative drug companies to list provides a lifeline for Changchun High-tech [3]. Group 2: New Drug Approval and Market Challenges - The National Medical Products Administration approved the new drug "Jinbeixin" for acute gouty arthritis, offering new hope for Changchun High-tech. Clinical data shows that it can significantly reduce pain and recurrence risk for patients [6]. - However, the market path for Jinbeixin is fraught with challenges, including competition from domestic rivals and pricing pressures. The expected price of Jinbeixin is 2,000 yuan per injection, which may deter patients if it is not included in medical insurance [7]. Group 3: Diversification Attempts and Lessons Learned - Jinbeixin is not the first attempt at diversification for Changchun High-tech. The company's shingles vaccine, launched in 2022, initially showed promise but saw a revenue drop from 1.82 billion yuan in 2023 to 1.23 billion yuan in 2024, with a 53% decline in net profit [8]. - The decline in the shingles vaccine's market share was attributed to its lower efficacy compared to competitors' products, highlighting the challenges of diversification [8]. Group 4: Decline of Growth Hormone and Future Outlook - The company's growth hormone product, which once held a 75% market share, has seen its revenue significantly impacted by price reductions due to national medical procurement policies, leading to a 43% drop in net profit in 2024 [9]. - Looking ahead, Changchun High-tech has 24 products in clinical stages across various fields, including oncology and reproductive health, indicating potential for future growth if successful in diversifying its product offerings [10].

Core Viewpoint - Changchun High-tech has received approval for its innovative drug Jinbeixin, marking a significant milestone in its transformation efforts after facing declining revenues and profits due to market pressures and reliance on a single product [1][2][3] Group 1: Company Performance - Changchun High-tech's stock price has dropped from a peak of 515.9 yuan per share in 2021 to 98.8 yuan per share currently, resulting in a total market capitalization of 40.3 billion yuan [1] - The company is experiencing its first dual decline in revenue and net profit in nearly 20 years, with significant pressure from the market environment and competition [1] - Revenue from its subsidiary Baike Biotech, which launched a shingles vaccine, peaked at over 1.8 billion yuan in 2023 but fell to 1.23 billion yuan in 2024, with net profit decreasing to 230 million yuan [1] Group 2: Research and Development - Under the leadership of General Manager Jin Lei, Changchun High-tech has increased its R&D investment from 1.66 billion yuan to nearly 2.7 billion yuan over the past three years [3] - The company has developed 23 research pipelines, with 6 classified as Class 1 new drugs, including Jinbeixin, which is seen as a key product for the company's transition [3] - Jinbeixin is the first Class 1 new drug in China for the treatment of acute gouty arthritis, with market potential estimated to reach 1 to 2 billion yuan, although it may not match the performance of its flagship growth hormone product [3]

Core Insights - The article discusses the critical role of sleep in the recovery of the body and brain, highlighting its connection to various health issues such as diabetes, obesity, and cardiovascular diseases [2] - It emphasizes the relationship between sleep and the release of growth hormone (GH), which is essential for muscle and bone growth, and how sleep deprivation disrupts hormonal balance [2][10] Research Findings - A study published in the journal Cell by a team led by Academician Dan Yang reveals the precise regulation of GH release during different sleep stages by two types of neurons in the hypothalamus: GHRH neurons and SST neurons [3][6] - The research identifies that GH release is enhanced during both REM and NREM sleep, regulated by the activity of GHRH and SST neurons [6][9] - The study also uncovers a negative feedback loop where GH enhances the excitability of locus coeruleus (LC) neurons, promoting wakefulness and preventing excessive sleep [10] Mechanisms of GH Regulation - GHRH neurons act like an "accelerator" to promote GH release, while SST neurons function as a "brake" to inhibit it [9] - During NREM sleep, GHRH activity increases moderately while SST activity decreases, facilitating GH release [9] - In REM sleep, both GHRH and SST neurons exhibit explosive activation, ensuring a balanced release of GH [9][10] Implications of Findings - The study provides insights into the neuroendocrine mechanisms behind sleep-dependent GH release, linking metabolic states with sleep tendencies [10] - It highlights the importance of sleep in regulating glucose and lipid metabolism, as well as muscle and bone growth, underscoring the health risks associated with sleep deprivation [10]