Core Viewpoint - Huahao Zhongtian Pharmaceutical-B (02563) announced that its wholly-owned U.S. subsidiary, Biostar Pharma, Inc. (US-Biostar), has completed the first patient dosing in a significant overseas clinical study for UTD1 combined with capecitabine to treat HER2-negative breast cancer brain metastases (BCBM) in a pivotal registration trial in the U.S. (NCT06764940) [1] Group 1 - The study employs a two-stage design, aiming to enroll approximately 120 subjects, with the primary endpoint being the central nervous system objective response rate (CNS-ORR) [2] - Nearly 20 leading research centers across the U.S., including MD Anderson Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, are participating in the study [2] Group 2 - UTD1's unique physicochemical properties and insensitivity to P-glycoprotein-mediated efflux allow it to penetrate the blood-brain barrier (BBB) and combat solid tumor brain metastases, contrasting sharply with taxane drugs [3] - A clinical phase II study presented at the 2025 ASCO conference involving UTD1 combined with bevacizumab and chemotherapy for HER2-negative BCBM included 34 patients, showing a CNS-ORR of 67.6% and a CNS clinical benefit rate (CNS-CBR) of 88.2%, with a median CNS progression-free survival (CNS-PFS) of 15 months [3] - Another phase II study published in the 2025 JAMA Oncology journal included 47 patients, reporting a CNS-ORR of 42.6%, a median CNS-PFS of 10.6 months, and a median overall survival of 15.1 months, with most treatment-related adverse events (TRAEs) being grade 1-2 and manageable [3] Group 3 - Approximately 20-50% of advanced breast cancer patients experience brain metastases, with poor prognosis for HER2-negative BCBM patients, who have a median progression-free survival of only 2-6 months [4] - There is a significant and urgent unmet clinical need for effective drug treatments for HER2-negative BCBM, as no drugs have been approved globally for this condition [4] - UTD1 is expected to change the current treatment landscape and provide new therapeutic options and survival hope for these patients [4]

Core Viewpoint - Huahao Zhongtian Pharmaceutical-B (02563) announced that its wholly-owned U.S. subsidiary, Biostar Pharma, Inc. (US-Biostar), has completed the first patient dosing in a significant overseas clinical study for UTD1 combined with capecitabine to treat HER2-negative breast cancer brain metastases (BCBM) in a key U.S. registration clinical trial (NCT06764940) [1] Group 1 - The study employs a two-stage design, aiming to enroll approximately 120 subjects, with the primary endpoint being the central nervous system objective response rate (CNS-ORR) [2] - Nearly 20 leading research centers across the U.S., including MD Anderson Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, are participating in the study [2] Group 2 - UTD1's unique physicochemical properties and insensitivity to P-glycoprotein-mediated efflux allow it to penetrate the blood-brain barrier (BBB) and combat solid tumor brain metastases, contrasting sharply with taxane drugs [3] - A clinical phase II study presented at the 2025 ASCO conference showed a CNS-ORR of 67.6% and a median CNS-PFS of 15 months for UTD1 combined with bevacizumab and chemotherapy [3] - Another phase II study published in the 2025 JAMA Oncology journal reported a CNS-ORR of 42.6% and a median CNS-PFS of 10.6 months for UTD1 combined with bevacizumab [3] Group 3 - Approximately 20-50% of advanced breast cancer patients experience brain metastases, with HER2-negative BCBM patients having particularly poor prognoses, with a median progression-free survival of only 2-6 months [4] - There is a significant and urgent unmet clinical need for effective treatment options for HER2-negative BCBM, as no drugs have been approved globally for this condition [4] - UTD1 is expected to change the current treatment landscape and provide new therapeutic options and hope for survival for these patients [4]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不 發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失 承擔任何責任。 Beijing Biostar Pharmaceuticals Co., Ltd. 北 京 華 昊 中 天 生 物 醫 藥 股 份 有 限 公 司 於中華人民共和國註冊成立的股份有限公司） （股份代號：2563） 自願性公告 優替德隆治療乳腺癌腦轉移 美國關鍵臨床研究首例患者用藥 本公告由北京華昊中天生物醫藥股份有限公司（「本公司」）自願作出，以使本公司股東及潛 在投資者了解本集團的最新業務發展。 本 公 司 董 事（「 董 事 」）會（「 董 事 會 」）欣 然 宣 佈 ， 本 公 司 全 資 美 國 子 公 司 Biostar Pharma, Inc.（「US -Biostar」）已完成其一項重要海外臨床研究的首例患者給藥：UTD1聯合卡培他濱治 療HER2陰性乳腺癌腦轉移(BCBM)美國關鍵註冊臨床研究(NCT 06764940)。 該研究採用兩階段設計，共擬入組約120例受試者，主要研究終點為中樞 ...

Core Insights - Baiyang Pharmaceutical reported a revenue of 5.627 billion yuan for the first three quarters of 2025, which increases to 6.505 billion yuan when adjusted for the two-invoice system [1] - The net profit attributable to shareholders for the same period was 476 million yuan, with a third-quarter revenue of 1.876 billion yuan and a net profit of 313 million yuan, reflecting a year-on-year growth of 31.43% [1] - The company's core brand business showed strong performance, with brand revenue accounting for 76.54% of total revenue when adjusted for the two-invoice system [1] Financial Performance - For the first three quarters, brand operations generated revenue of 4.101 billion yuan, remaining stable year-on-year, while adjusted revenue reached 4.979 billion yuan, marking an 11.08% increase [1] - The gross profit from brand operations was 1.992 billion yuan, representing a gross profit margin of 94.7%, providing a solid financial foundation for ongoing innovation and transformation [1] Strategic Developments - Baiyang Pharmaceutical is actively transitioning to an innovation-driven enterprise, focusing on strategic investments in fibrosis, oncology, and bone health [2] - The company has expanded its brand matrix in fibrosis treatment through strategic investment in Jikun Pharmaceutical and is also advancing in the oncology sector with innovative products [2] - In the high-end radiotherapy field, Baiyang has established a comprehensive disease coverage and is collaborating with Peking University International Hospital to build a precision radiotherapy center [2] Future Outlook - As the innovative drug and radiotherapy businesses scale up, Baiyang Pharmaceutical is expected to optimize its revenue structure and enhance long-term competitiveness [2] - The company aims to seize new growth opportunities amid the transformation of the pharmaceutical industry, steadily progressing towards becoming an innovative pharmaceutical enterprise [2]

Core Insights - Qingdao Baiyang Pharmaceutical Co., Ltd. reported a revenue of 5.627 billion yuan for the first three quarters of 2025, with a net profit attributable to shareholders of 476 million yuan [1] - In Q3 alone, the company achieved a revenue of 1.876 billion yuan and a net profit of 313 million yuan, marking a year-on-year growth of 31.43% in net profit and 33.33% in basic earnings per share [1] - The core brand business segment showed strong performance, with brand revenue accounting for 76.54% of total revenue when adjusted for the two-invoice system [1] Financial Performance - Total revenue for the first three quarters was 5.627 billion yuan, which increases to 6.505 billion yuan when adjusted for the two-invoice system [1] - Brand operation revenue reached 4.101 billion yuan, remaining stable year-on-year, and 4.979 billion yuan when adjusted, reflecting an 11.08% increase [1] - Gross profit from brand operations was 1.992 billion yuan, with a gross profit margin of 94.7%, providing a solid financial foundation for ongoing innovation [1] Strategic Initiatives - The company is transitioning towards an innovation-driven model, focusing on strategic investments and commercialization in innovative drugs and advanced radiotherapy [2] - In the innovative drug sector, Baiyang Pharmaceutical is expanding its portfolio in fibrosis, oncology, and bone health, including strategic investments in Jikun Pharmaceutical [2] - The company has established a comprehensive disease coverage in high-end radiotherapy and is collaborating with Peking University International Hospital to build a precision radiotherapy center [2] Future Outlook - As the innovative drug and radiotherapy businesses scale up, the company is expected to optimize its revenue structure and enhance long-term competitiveness [2] - Baiyang Pharmaceutical aims to seize new growth opportunities amid the transformation of the pharmaceutical industry, steadily progressing towards becoming an innovative pharmaceutical enterprise [2]

Investment Rating - The report maintains a "Buy" rating for the company with a target price of 30.60 CNY, based on a 20x PE for 2026 [3][6]. Core Views - The company is focusing on optimizing its product structure and accelerating innovation transformation, particularly in the oncology and radiotherapy sectors, which is expected to enhance its clinical advantages and market expansion [11]. - The revenue forecast for 2025-2027 has been adjusted downwards, while gross margin and expense forecasts have been raised, leading to revised earnings per share estimates of 0.91, 1.53, and 1.96 CNY for 2025, 2026, and 2027 respectively [3][11]. Financial Performance Summary - The company reported a revenue of 8,256 million CNY in 2023, with a projected decline to 8,094 million CNY in 2024, followed by a recovery to 8,625 million CNY in 2025, representing a growth of 6.6% [4][13]. - The gross margin is expected to improve from 33.3% in 2023 to 36.3% in 2025, reflecting a strategic shift towards higher-margin products [4][13]. - The net profit attributable to the parent company is forecasted to decrease from 712 million CNY in 2023 to 477 million CNY in 2025, before rebounding to 1,028 million CNY in 2027 [4][13]. - The company’s operating profit is projected to decline significantly in 2025 to 714 million CNY, down from 978 million CNY in 2024, but is expected to recover to 1,171 million CNY in 2026 [4][13]. Business Strategy and Market Position - The company is increasing its investment in innovative drugs and high-value medical devices, with a focus on the oncology and radiotherapy markets, which is anticipated to drive future growth [11]. - The report highlights the successful launch of new products such as the Zap-X Mars Voyager, which has received regulatory approval in 24 countries, indicating a strong international market presence [11]. - The company is also pursuing a dual strategy of "investment incubation + commercialization" to transition into an innovative pharmaceutical enterprise, which includes strategic investments in other biotech firms [11].

Group 1 - Baiyang Pharmaceutical signed a strategic cooperation agreement with Tianjin Jikun Pharmaceutical Technology Co., Ltd. to participate in a 24% equity stake and promote the research and clinical trials of the innovative drug JK1033 for treating idiopathic pulmonary fibrosis (IPF) [1] - Jikun Pharmaceutical is focused on innovative drug development for organ fibrosis and related inflammatory/immune diseases, possessing a comprehensive R&D capability from target discovery to clinical trials [1][2] - The JK1033 project is a small molecule compound derived from traditional Chinese medicine, showing multi-target mechanisms that can intervene in key signaling pathways of pulmonary fibrosis, with clinical trials set to start in January 2025 [2] Group 2 - The cooperation is expected to leverage the strengths of both companies in R&D, manufacturing, commercialization, and capital operations in the field of organ fibrosis, enhancing Baiyang Pharmaceutical's innovative drug portfolio [3] - Baiyang Pharmaceutical reported a revenue of 3.751 billion yuan and a net profit of 163 million yuan in the first half of the year, and is accelerating the introduction of high-value innovative products [3] - The company is transitioning from a commercialization platform to an innovative pharmaceutical enterprise, driven by a dual approach of "investment incubation + commercialization" [3][4]

Core Viewpoint - Baiyang Pharmaceutical reported a strong performance in the first half of 2025, focusing on innovative drugs and devices, with a revenue of 3.751 billion yuan and a net profit of 163 million yuan [1] Group 1: Financial Performance - The company achieved a revenue of 3.751 billion yuan in the first half of the year, with a net profit attributable to shareholders of 163 million yuan [1] - Brand business revenue reached 2.716 billion yuan, showing a year-on-year growth of 1.36%, accounting for 72.41% of total revenue [1] - In Q2, revenue was 1.421 billion yuan, reflecting a quarter-on-quarter growth of 9.75% [1] Group 2: Brand Performance - The main brand, Dical, generated revenue of 905 million yuan, and if adjusted for the two-invoice system, the revenue would be 950 million yuan, maintaining the top position in the domestic imported calcium supplement market for nine consecutive years [1] - The revenue from the brand Fuzheng Huayu reached 371 million yuan, showing a year-on-year increase [1] Group 3: Innovation and Investment - The company is accelerating the introduction of high-value innovative products to create a second growth curve, driven by a dual approach of "investment incubation + commercialization" [1] - Baiyang invested in ZAP Surgical, acquiring commercialization rights for the ZAP-X Mars surgical robot in China, and is working to establish a global production base for radiotherapy equipment domestically [1] - Multiple innovative projects are making substantial progress, including the nationwide promotion of Yutide Long, which has reached over 500 hospitals, and the Phase I clinical study of the new drug NTB-3119M for drug-resistant tuberculosis [1]

Core Viewpoint - Baiyang Pharmaceutical is focusing on innovation and brand operation, showing strong growth in its core business despite market challenges [1][2][4] Financial Performance - In the first half of 2025, the company's revenue reached 3.751 billion yuan, and after adjusting for the two-invoice system, revenue was 4.374 billion yuan [1] - The net profit attributable to shareholders was 163 million yuan, with a net profit of 177 million yuan after excluding non-recurring gains and losses [1] Brand Operation Growth - Brand business revenue was 2.716 billion yuan, a year-on-year increase of 1.36%, accounting for 72.41% of total revenue [2] - In Q2 2025, brand revenue was 1.421 billion yuan, a quarter-on-quarter increase of 9.75% [2] - After adjusting for the two-invoice system, brand revenue was 3.339 billion yuan, a year-on-year increase of 14.91% [2] - The gross profit from brand business reached 1.286 billion yuan, with a gross profit margin of 93.99% [2] Product Innovation and Market Position - The "Calcium Supplement Expert" DQ brand generated 905 million yuan in revenue, maintaining its position as the top imported calcium supplement brand for nine consecutive years [2] - The "Anti-Liver Fibrosis" brand Fuzheng Huayu achieved revenue of 371 million yuan, a year-on-year increase of 37.42% [2] - The NutriSum brand generated 78 million yuan, with a year-on-year growth of 34.83% [2] - The original brand for dry eye treatment, Hailu, achieved revenue of 376 million yuan, a year-on-year increase of 14.86% [2] Strategic Transformation and Investment - Baiyang Pharmaceutical is accelerating its transformation into an innovative pharmaceutical company, driven by national innovation strategies [4] - The company has invested in ZAP Surgical, gaining commercialization rights for the ZAP-X robot in China, and is establishing a global production base for radiation therapy equipment [4] - Strategic investments in Huahao Zhongtian and Beihai Kangcheng have secured commercialization rights for new cancer treatment drugs in mainland China [4] - The strategic transformation aims to address industry changes and leverage the company's strengths for long-term growth [4]

Core Insights - Baiyang Pharmaceutical (301015.SZ) reported a revenue of 3.751 billion yuan for the first half of 2025, which increases to 4.374 billion yuan when adjusted for the two-invoice system [1] - The net profit attributable to shareholders was 163 million yuan, with a net profit of 177 million yuan after excluding non-recurring gains and losses [1] Business Segments - The company operates mainly in three segments: brand operation, wholesale distribution, and retail. In the first half of the year, it focused on brand operation, achieving a revenue of 2.716 billion yuan, a year-on-year increase of 1.36%, and accounting for 72.41% of total revenue [1] - When adjusted for the two-invoice system, brand business revenue reached 3.339 billion yuan, reflecting a year-on-year growth of 14.91% [1] - The gross profit from brand operations was 1.286 billion yuan, with a gross profit margin of 93.99%, making it the primary source of profit for the company [1] Innovation and Strategic Investments - Baiyang Pharmaceutical is accelerating the introduction of new products and investing in innovative resources to create a second growth curve [1] - The company has strategically invested in global leaders in radiation therapy, such as ZAP Surgical, and innovative pharmaceutical companies like Huahao Zhongtian and Beihai Kangcheng, acquiring commercialization rights for products including the ZAP-X Mars surgical robot and a new generation of microtubule inhibitor chemotherapy drug [1] - Several innovative projects have made substantial progress, including the anti-drug-resistant tuberculosis new drug NTB-3119M entering Phase I clinical trials, and the cooperative product 99mTc-3PRGD2 being included in priority review [2] - The cooperative product RAB001 for treating osteonecrosis is currently undergoing Phase II clinical trials [2]