Core Viewpoint - Lijun Group's research indicates significant advancements in its biopharmaceutical platform, focusing on autoimmune, reproductive, and vaccine sectors, with key products nearing approval and promising clinical results [1][4][5] Group 1: Autoimmune Sector - Lijun Biopharmaceutical's core product, Lakanqita monoclonal antibody, shows a PASI100 response rate of 49.5% in severe psoriasis, outperforming the control group at 40.2%, and is expected to receive approval by the end of this year [1][6][7] - The company has completed Phase III clinical trials for ankylosing spondylitis, with approval anticipated next year, and significant sales growth for another product, tocilizumab, is expected in 2025 [1][4] Group 2: Reproductive Sector - The recombinant human follicle-stimulating hormone injection is expected to be approved within this year, reinforcing the company's leading position in the assisted reproductive field [1][4] Group 3: Vaccine Sector - The quadrivalent influenza recombinant protein vaccine, the first of its kind with an adjuvant, has completed Phase I safety trials and is expected to enter Phase II clinical trials in March [5] Group 4: Overseas Expansion Strategy - The company adopts a "dual-track" strategy for international expansion, focusing on licensing its innovative pipeline to mature markets and exporting formulations to emerging markets [2][9] - In Southeast Asia, the company is building a localized platform through the acquisition of IMP in Vietnam, while in South America, it is prioritizing registration and channel development in Brazil [9] Group 5: Cardiovascular Pipeline - H001, an oral direct thrombin inhibitor, is the fastest progressing project in its category in China, showing comparable efficacy to enoxaparin with a lower bleeding risk, and is preparing for Phase III trials [3][10] Group 6: GnRH Pipeline - The GnRH pipeline covers all indications and various formulations, with key products like the three-month formulation of leuprolide expected to be approved this year [11][12] Group 7: Chemical Preparation Sector - The chemical preparation sector generated 47.2 billion yuan in revenue from January to September 2025, accounting for 51.8% of the company's total revenue, serving as a core revenue support [13][14] - Future growth will be driven by product upgrades, innovative product launches, and deepening market penetration in core therapeutic areas [14][15][16]

Business Overview - Lizhu Biopharmaceuticals operates three main business segments: autoimmune, reproductive, and vaccine fields [2][3] - The core product in the autoimmune field, Lakanqita monoclonal antibody, has shown superior efficacy in clinical trials compared to competitors [4][5] Autoimmune Field - Lakanqita monoclonal antibody targets IL-17A/F dual sites, with a PASI100 response rate of 49.5% in clinical trials, outperforming the control group at 40.2% [4] - The product is expected to receive approval by the end of 2026, with significant market potential due to its unique characteristics [5] Reproductive Field - The recombinant human follicle-stimulating hormone (r-FSH) injection is anticipated to be approved within the year, reinforcing the company's leadership in assisted reproduction [3] Vaccine Field - The quadrivalent recombinant protein influenza vaccine is the first of its kind with an adjuvant, having completed Phase I trials and expected to enter Phase II in March [3] International Expansion Strategy - The company adopts a dual-track strategy for international expansion, focusing on licensing out innovative pipelines and direct exports to emerging markets [5][6] - Key markets include Southeast Asia and South America, with Vietnam and Brazil as strategic hubs for regulatory advantages and market growth [6] Cardiovascular Pipeline - H001, an oral direct thrombin inhibitor, is the fastest progressing project in its category, aimed at preventing venous thromboembolism (VTE) post-orthopedic surgeries [7] - The product has shown comparable efficacy to standard therapies and is preparing for Phase III trials [8] GnRH Pipeline - The GnRH pipeline covers all related indications and various formulations, making it the most comprehensive in China [9] - Key products include leuprolide with multiple formulations expected to launch soon, enhancing market presence [9] Chemical Preparation Segment - The chemical preparation segment generated revenue of 4.72 billion CNY, accounting for 51.8% of the company's total revenue in the first nine months of 2025 [10][11] - Growth drivers include product upgrades, innovation, and a focus on core therapeutic areas [11][12]

Core Insights - The company focuses on sustainable development through R&D innovation and internationalization, enhancing its presence in "strong advantages" and "high potential chronic disease" sectors, particularly in digestion, mental health, cardiovascular, metabolism, and autoimmune fields [1] Investment Highlights - The company maintains a "buy" rating and raises the target price to CNY 49.13 per share from CNY 43.96. Projected revenues for 2025-2027 are CNY 120.36 billion, CNY 123.95 billion, and CNY 130.29 billion, with growth rates of 1.9%, 3.0%, and 5.1% respectively. Net profits are forecasted at CNY 22.21 billion, CNY 22.95 billion, and CNY 23.91 billion, with growth rates of 7.7%, 3.4%, and 4.2%. EPS is expected to be CNY 2.46, CNY 2.54, and CNY 2.64 [2] R&D Pipeline Progress - The company reports significant advancements in its R&D pipeline. In the digestion sector, the P-CAB product JP-1366 tablet has been submitted for market approval, and the injection form has completed the first patient enrollment in Phase II. In the autoimmune sector, the IL-17A/F psoriasis and ankylosing spondylitis indications have completed Phase III trials, with psoriasis expected to be submitted for approval this year. In the mental health sector, the NS-041 tablet for epilepsy has completed Phase II enrollment, and the IND application for depression has been accepted. The new indication for Triptorelin microspheres for central precocious puberty has completed Phase III enrollment. Additionally, a new oral GnRH antagonist project for assisted reproduction is preparing for Phase II trials, and a quadrivalent influenza recombinant protein vaccine has completed Phase I enrollment. The semaglutide diabetes indication is expected to be approved this year, with the weight loss indication in late Phase III trials [3] International Expansion - The company is enhancing its overseas business layout, particularly in Vietnam, where a company acquisition is under approval. The target company, Imexpharm, has shown stable performance with over 20% growth in revenue, profit, and EBITDA. Imexpharm has the largest EU-GMP product line in Vietnam, and both companies are planning product and process transfers to leverage Imexpharm's established market channels and EU-GMP certification for expanding innovative drug products into overseas markets [3] Catalysts - Key catalysts include the ramp-up of new product volumes, clinical data from innovative drug pipelines, and external collaborations for licensing innovative drug pipelines [4]

Macro Research - The growth rate of national general public budget revenue increased by 0.8% year-on-year from January to October 2025, with a marginal recovery in October to 3.2% compared to 2.6% in September, primarily driven by tax revenue [3][4] - The decline in non-tax revenue has expanded, reflecting a reduced reliance on non-tax income by the government [4] - National general public budget expenditure grew by 2% year-on-year from January to October 2025, with a significant drop in October to -9.8% compared to 3.1% in September, indicating a need for continued fiscal support to stabilize the economy [4][5] Fixed Income Research - The global monetary and fiscal system has undergone significant changes since 2008, which may provide more relevant insights for predicting domestic economic and fixed income asset trends than historical experiences from the 1990s [7][8] - The government’s increasing leverage has not led to a corresponding rise in household and corporate leverage, resulting in a rapid increase in interest rates independent of the recovery in these sectors [8] Transportation Research - The short-term profitability of the company is under pressure due to maintenance impacts, but the high-quality route network is expected to reveal significant profit elasticity, with a projected increase in profitability driven by rising ticket prices and fleet turnover recovery in the next two years [10][11] - The company’s net profit for the first three quarters of 2025 was 1.09 billion yuan, a year-on-year decrease of 14%, primarily due to maintenance impacts [10][11] Communication Research - The company maintained its profit forecast but lowered its target price while keeping a buy rating, as the Q4 performance is expected to rebound despite short-term fluctuations [13][14] - The company achieved a revenue of 16.5 billion yuan in the first three quarters of 2025, a year-on-year increase of 221.7%, with a net profit of 6.33 billion yuan, reflecting strong growth despite a slight decline in Q3 [14]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不 發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的任何損 失承擔任何責任。 自願性公告 簽署專利及技術轉讓協議 一、協議簽署概況 近日，麗珠醫藥集團股份有限公司 Livzon Pharmaceutical Group Inc.* Inc.*（「本公司」） 控股子公司珠海市麗珠單抗生物技術有限公司（「麗珠單抗」）與廣東華南疫苗股份有限 公司（「華南疫苗」）簽署了《流感重組蛋白疫苗項目專利及技術轉讓協議》（「協議」）。 根據協議約定，華南疫苗擬將基於項目技術開發的最終銷售形態的三價流感重組蛋白疫苗 及/或四價流感重組蛋白疫苗的項目權利轉讓給麗珠單抗，麗珠單抗需向華南疫苗支付相應 的專利及技術轉讓費（包括首付款、開發里程碑款及銷售里程碑款）及銷售提成。 目標產品為流感重組蛋白疫苗，已經獲得國家藥品監督管理局的批准開展預防流行性感冒 的臨床試驗。 本次交易已經本公司經營管理層審議批准，根據相關規定，無需提交本公司董事會及股東 大會審議。本次交易不構成關聯交易。 1 二、交易對方的基本信 ...