Core Viewpoint - The Chinese vaccine industry is transitioning from scale expansion to value creation, driven by national immunization strategies and WHO vaccine prioritization policies, with local companies leveraging technological innovation to enhance multi-valent vaccines and lifecycle protection strategies [1] Group 1: Product Development and Innovation - CanSino Biologics' 13-valent pneumonia vaccine PCV13i has been approved for market launch, representing a significant step in the globalization of domestic vaccines [2] - The core value of PCV13i is based on three pillars: technological breakthroughs, clinical validation, and application optimization [2] - The vaccine employs a unique dual carrier technology using a non-toxic mutant of diphtheria toxin (CRM197) and tetanus toxin (TT), enhancing immunogenicity and reducing interference with other vaccines [3] Group 2: Clinical Data and Efficacy - Clinical data shows that PCV13i significantly outperforms control groups in inducing high levels of specific antibodies against key serotypes that are prevalent in China, confirming its regional adaptability [4] - The safety profile of PCV13i is comparable to that of control vaccines, with adverse reactions primarily being mild, facilitating its commercial application [4] Group 3: Market Demand and Commercialization - The urgency for pneumonia vaccines is underscored by the high mortality rates associated with pneumonia in children under five, particularly in China, where vaccination rates are below 18% [6][8] - The global market for pneumonia vaccines is robust, with the 13-valent pneumonia vaccine consistently ranking among the top-selling vaccines, indicating significant market potential [9] Group 4: Strategic Market Positioning - PCV13i is positioned to leverage existing distribution networks and cold chain logistics established by CanSino's previous vaccine, enhancing market penetration efficiency [10] - The vaccine's production process meets EU GMP standards and is suitable for halal certification, providing a competitive edge in Southeast Asian markets [10] Group 5: Long-term Value Creation - CanSino's vaccine matrix, including products for polio and DTP, is establishing a comprehensive defense against bacterial diseases in children, aligning with international quality standards [11] - The launch of PCV13i is expected to catalyze short-term performance while the ongoing innovation in the product matrix builds long-term value, suggesting potential for re-evaluation in market valuation [12]

21世纪经济报道记者闫硕 北京报道 2024年，受行业政策调整、民众接种意愿下降、市场需求变化等多重因素影响，我国多家疫苗上市企业 业绩均呈现大幅度下滑，行业承压前行。 随着2024年年报陆续披露，在Wind疫苗指数中，2024年营业收入的均值（算数平均）为71.31亿元，而 这一数值在2023年为90.99亿元，同比降低21.63%；2024年净利润均值（算数平均）为7.87亿元，2023 年则为12.22亿元，同比降低35.60%。 财报显示，智飞生物、万泰生物、华兰疫苗等企业营业收入降幅均超50%，沃森生物、百克生物、金迪 克等企业降幅也在30%以上。不过，康希诺在其四价流脑结合疫苗曼海欣®的驱动下，同时其经营受全 球公共卫生事件的影响已经基本消除，去年营收大幅增长130%以上。 | | | | 疫苗企业2024年业绩一栏表(节选; | | 单位:亿元) | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 代理 | 简称 | 2024年曹业收入 | 2023年营业收入 | 同比变动 | 2024年归母净利演 | 2023年归母净利润 | 同 ...