流动性方面，生物疫苗ETF盘中换手1.9%，成交489.22万元。拉长时间看，截至7月10日，生物疫苗ETF近1周日均成交1087.57万元。 规模方面，生物疫苗ETF近2周规模增长878.44万元，实现显著增长，新增规模位居可比基金第一。 截至7月10日，生物疫苗ETF近1年净值上涨22.89%。从收益能力看，截至2025年7月10日，生物疫苗ETF自成立以来，最高单月回报为26.27%，最长连涨月 数为3个月，最长连涨涨幅为14.87%，上涨月份平均收益率为6.41%。 截至2025年7月11日午间收盘，中证疫苗与生物技术指数强势上涨1.35%，成分股康华生物上涨12.02%，特宝生物上涨7.96%，康辰药业上涨7.69%，康弘药 业、诺诚健华等个股跟涨。生物疫苗ETF(562860)上涨1.32%。 值得注意的是，该基金跟踪的中证疫苗与生物技术指数估值处于历史低位，最新市净率PB为2.6倍，低于指数近3年88.03%以上的时间，估值性价比突出。 生物疫苗ETF紧密跟踪中证疫苗与生物技术指数，中证疫苗与生物技术指数选取不超过50家业务涉及疫苗研发、疫苗生产、疫苗耗材、疫苗生产设备以及其 他生物科技领域上市 ...

Core Viewpoint - WanTai Biologics has officially launched its nine-valent HPV vaccine "Xinkening®9" at a price of 499 yuan per dose, significantly undercutting the imported vaccine price and marking the end of the "high-price era" for HPV vaccines in China [1][6]. Pricing and Market Impact - The imported nine-valent HPV vaccine "Gardasil 9" is priced at approximately 1318 yuan per dose, with a total cost of nearly 4000 yuan for three doses, while "Xinkening®9" costs about 1497 yuan for three doses [1]. - "Xinkening®9" is the only HPV vaccine approved for a two-dose regimen for ages 9-17, reducing the cost for this age group to 998 yuan, thereby enhancing accessibility and compliance [1]. Historical Context and Market Dynamics - Prior to the launch of "Xinkening®9", the nine-valent HPV vaccine market in China was monopolized by Merck's "Gardasil 9," which faced a dramatic shift from high demand and scarcity to excess inventory [2]. - In 2023, the batch issuance of "Gardasil 9" reached 36.55 million doses, a year-on-year increase of 136.16%, making Merck the highest-grossing multinational pharmaceutical company in China that year [2]. Sales Performance and Challenges - Merck's global sales of the HPV vaccine in 2024 were $8.583 billion, a 3% decline year-on-year, primarily due to weak performance in the Chinese market [3]. - To address high inventory levels, Merck announced a suspension of supply to China starting in early 2025, expected to last until at least mid-2025 [3]. Financial Performance of WanTai Biologics - WanTai Biologics reported a 59.25% year-on-year decline in revenue for 2024, totaling 2.245 billion yuan, with a net profit drop of 91.49% to 106 million yuan [3]. - The company faced significant challenges due to a price collapse in its two-valent vaccine, leading to a drastic reduction in government procurement prices [3]. Market Potential and Future Outlook - The potential market for HPV vaccines in China is substantial, with 70%-80% of the 300 million women aged 9-45 yet to be vaccinated [4]. - National Investment Securities predicts that WanTai's nine-valent HPV vaccine could reach a sales peak of 22.8 billion yuan, with projected revenues of 3.17 billion yuan, 11.4 billion yuan, and 28.63 billion yuan for 2025-2027 [4]. Competitive Landscape - Several domestic pharmaceutical companies are in the late clinical stages of developing their own nine-valent HPV vaccines, creating a competitive environment for WanTai [5]. - WanTai has initiated a Phase III clinical trial for a male indication, but competitors like Kanglaite have already started their trials earlier [5]. International Expansion - WanTai aims to become a leading global vaccine supplier by 2030, with plans to have 3 to 5 WHO pre-qualified products [5]. - Competitors are also pursuing international markets, with Kanglaite planning to submit for approval in Indonesia and Ruike Biologics exploring the Middle East [5]. Industry Trends - The World Health Organization has warned that global HPV vaccine supply may exceed demand from 2025 to 2030, potentially leading to a price war and industry reshuffling [5]. - The WHO's recommendation for a single-dose HPV vaccination regimen could further intensify market competition [5].

21世纪经济报道记者闫硕 北京报道 2024年，受行业政策调整、民众接种意愿下降、市场需求变化等多重因素影响，我国多家疫苗上市企业 业绩均呈现大幅度下滑，行业承压前行。 随着2024年年报陆续披露，在Wind疫苗指数中，2024年营业收入的均值（算数平均）为71.31亿元，而 这一数值在2023年为90.99亿元，同比降低21.63%；2024年净利润均值（算数平均）为7.87亿元，2023 年则为12.22亿元，同比降低35.60%。 财报显示，智飞生物、万泰生物、华兰疫苗等企业营业收入降幅均超50%，沃森生物、百克生物、金迪 克等企业降幅也在30%以上。不过，康希诺在其四价流脑结合疫苗曼海欣®的驱动下，同时其经营受全 球公共卫生事件的影响已经基本消除，去年营收大幅增长130%以上。 | | | | 疫苗企业2024年业绩一栏表(节选; | | 单位:亿元) | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 代理 | 简称 | 2024年曹业收入 | 2023年营业收入 | 同比变动 | 2024年归母净利演 | 2023年归母净利润 | 同 ...