公司点评 | 神州细胞 产品销售阶段承压，临床管线值得期待 神州细胞（688520.SH）2025 年中报点评 财务摘要：25H1 公司实现营收 9.72 亿元（-25.50%），低于预期目标，主要 原因是受地区及地区联盟集采降价、医保控费等影响，重组凝血八因子的整 体市场收缩，公司核心产品安佳因®的销售收入出现了一定程度的下滑；归 母净利润-0.34 亿元，扣非后归母净利润-0.36 亿元。拆分到季度来看 25Q1/Q2 收入 5.20/4.52 亿元，归母净利润 0.64/-0.98 亿元，扣非后归母净 利润 0.24/-0.60 亿元。25H1 公司毛利率 94.79%，销售/管理/研发/财务费用 率分别为 43.4%/8.8%/39.0%/4.5%。 核心产品销售承压，新品种放量可期。25 年上半年受政策因素影响产品销 售承压，公司借助精准的市场策略，确保重点省份的集采中标和价格调整幅 度优于行业平均。公司继续加大下沉市场的渠道拓展，努力争取更多入院机 会和覆盖更多患者，目标是尽快实现安佳因®销售的企稳回升。抗体药物瑞 帕妥单抗（安平希®）、生物类似药阿达木单抗（安佳润®）和贝伐珠单抗（安 贝珠®）等 ...

Core Viewpoint - The company reported a revenue of 972 million yuan for the first half of 2025 and is actively optimizing its capital structure through a private placement to raise up to 900 million yuan for R&D funding, reflecting confidence in its future prospects and commitment to investor interests [2][5]. Group 1: Financial Performance - The company's revenue for the reporting period was 972 million yuan, influenced by price reductions in its core product Anjain® due to regional alliance procurement and medical insurance cost control [3]. - The company is implementing a private placement plan to raise no more than 900 million yuan, which will enhance its capital structure and support R&D efforts [2][5]. Group 2: R&D and Innovation - The company is focusing on expanding its market presence and ensuring competitive pricing for its products, with new products gradually contributing to revenue growth [3]. - The self-developed antibody drugs Anpingxi®, Anjairun®, and Anbeizhu® have been included in the national medical insurance, covering various indications in autoimmune diseases, hematological malignancies, and solid tumors [3]. - The company has 13 products in clinical stages, targeting multiple disease areas, and is accelerating the transition of more candidates from preclinical to clinical research [4]. Group 3: Operational Efficiency - R&D investment remains around 390 million yuan, supporting 14 major products in clinical stages and optimizing clinical project priorities based on various factors [4]. - The company is enhancing its operational efficiency by controlling costs across various dimensions, including financial management, R&D project management, production processes, and operational management [6]. - A project management computer system has been trialed to improve R&D speed, quality stability, and cost-effectiveness [6].

Core Insights - Shenzhou Cell reported a significant decline in revenue and profit for the first half of 2025, with revenue at 972 million yuan, down 25.50% year-on-year, and a net loss of 34 million yuan, reversing from profit to loss [1][3][4] Financial Performance - Revenue for the first half of 2025 was 972 million yuan, a decrease from 1.304 billion yuan in the same period last year, reflecting a 25.50% decline [3] - Total profit was -33.86 million yuan, compared to a profit of 126 million yuan in the previous year, marking a 126.86% decrease [3] - Net profit attributable to shareholders was -33.77 million yuan, down 126.87% from 125.71 million yuan year-on-year [3] - The company’s cash flow from operating activities was -206 million yuan, a significant drop from 131 million yuan in the previous year, indicating a 257.03% decline [6] Business Overview - Shenzhou Cell focuses on the research and commercialization of biopharmaceutical products, including treatments for cancer, autoimmune diseases, infectious diseases, and genetic disorders [4] - The main product, Anjain®, faced sales declines due to regional price reductions and healthcare cost controls, leading to a contraction in the overall market for recombinant factor VIII [4][5] Market Strategy - To counteract declining sales, Shenzhou Cell plans to implement targeted market strategies to secure procurement contracts in key provinces and improve pricing adjustments [4] - The company is also expanding its market presence internationally, having received approvals for Anjain® in Pakistan and Indonesia, and submitted applications in Vietnam [4] Legal and Compliance Issues - Shenzhou Cell is facing challenges related to a healthcare fraud case involving its subsidiary, which has raised concerns in the market [5] - The company maintains that the actions of a few individuals do not reflect its overall operational strategy and compliance standards [5] Capital and Funding - In June 2025, Shenzhou Cell announced a plan to issue A-shares to raise up to 900 million yuan, aimed at enhancing its core competitiveness and risk management capabilities [8] Market Performance - As of August 28, 2025, Shenzhou Cell's stock price was 64.28 yuan per share, down 1.85%, with a total market capitalization of 28.626 billion yuan [9]

Group 1 - Shanghai ChaoSilicon Semiconductor Co., Ltd. has had its IPO application accepted by the Shanghai Stock Exchange, despite being in a loss position until the end of 2024, exemplifying the trend of unprofitable tech companies being listed on the Sci-Tech Innovation Board [1] - The implementation of the "Eight Measures for Deepening the Reform of the Sci-Tech Innovation Board" has led to a significant increase in the overall technological innovation capability and market activity of listed companies on the Sci-Tech Innovation Board [1][2] - The capital market is increasingly embracing hard technology companies, as evidenced by the acceptance of multiple IPO applications from unprofitable firms in the semiconductor and biomedicine sectors [2][3] Group 2 - The global consensus is shifting from "profit worship" to "innovation value," emphasizing the importance of reinvesting profits into research and development rather than focusing solely on financial statements [3] - The successful listing of unprofitable tech companies is expected to create a strong demonstration effect and attract more innovative resources to the hard technology sector, aiding in the advancement of strategic emerging industries [3][4] - Since the establishment of the Sci-Tech Innovation Board, 54 companies have gone public while unprofitable, primarily in the new generation information technology and biomedicine sectors, with a total market value of approximately 1.43 trillion yuan [5] Group 3 - Companies like Beijing Shenzhou Cell Biology Technology Group and Shanghai MicroPort EP MedTech have successfully turned profitable after significant R&D investments, showcasing the potential for growth in the hard technology sector [6] - Regulatory bodies in China are enhancing the inclusivity of the capital market to better support tech companies, with plans to improve listing and investment systems [7] - The capital market's recognition of the "innovation time difference" allows for a system that values long-term innovation, which is crucial for driving high-quality economic development in China [7]

Core Viewpoint - The article discusses the acceptance of Shanghai Super Silicon Semiconductor Co., Ltd.'s IPO application on the Sci-Tech Innovation Board, highlighting the trend of unprofitable companies being welcomed into the capital market under the "Eight Measures for the Sci-Tech Innovation Board" policy [1][3][4]. Group 1: Company Overview - Shanghai Super Silicon is one of the earliest companies in China engaged in large-size silicon wafers for integrated circuits and is recognized as a national high-tech enterprise [5]. - The company plans to raise 4.965 billion yuan for projects related to the production of 300mm thin silicon epitaxial wafers and high-end semiconductor silicon material research and development [6]. Group 2: Market Context - Since the introduction of the "Eight Measures," three unprofitable companies have had their IPO applications accepted, indicating a shift in the capital market's approach to supporting hard technology enterprises [7]. - The article notes that the acceptance of Shanghai Super Silicon's IPO reflects the capital market's commitment to embracing hard technology companies that represent new productive forces [7]. Group 3: Policy and Market Trends - The "Eight Measures" aim to improve the identification mechanism for technology companies and support high-quality unprofitable tech firms in listing on the Sci-Tech Innovation Board [3][9]. - The article emphasizes that the global consensus is shifting from a focus on profitability to valuing innovation, as seen in the performance of major tech companies in the U.S. [10]. - As of now, 54 companies listed on the Sci-Tech Innovation Board were unprofitable at the time of their IPO, with a total fundraising of 202.731 billion yuan and a combined market value of 1.43 trillion yuan as of May 2025 [11][12]. Group 4: Future Outlook - The article suggests that the reforms in the capital market, particularly the Sci-Tech Innovation Board, will continue to evolve, providing a more inclusive environment for technology innovation and industry development [16].

Core Viewpoint - The acceptance of Shanghai Super Silicon's IPO application on the Sci-Tech Innovation Board marks a significant step in embracing unprofitable technology companies, reflecting the capital market's commitment to supporting hard technology enterprises and new productive forces [1][2]. Group 1: Company Overview - Shanghai Super Silicon is one of the earliest companies in China engaged in large-size silicon wafers for integrated circuits and is recognized as a national high-tech enterprise [2]. - The company plans to raise 4.965 billion yuan for projects related to the production of 300mm thin silicon epitaxial wafers and high-end semiconductor silicon material research and development [2]. - As of the end of 2024, Shanghai Super Silicon is still in a loss-making state [2]. Group 2: Industry Context - Since the introduction of the "Sci-Tech Innovation Board Eight Measures," three unprofitable companies have had their IPO applications accepted by the Shanghai Stock Exchange [2]. - The acceptance of Shanghai Super Silicon's IPO application indicates a broader trend of the capital market welcoming hard technology enterprises, with ten other unprofitable companies currently undergoing IPO reviews [2][8]. - The Sci-Tech Innovation Board has seen a total of 54 companies go public while unprofitable, primarily in the new generation information technology and biopharmaceutical sectors [5][6]. Group 3: Policy Support - The "Sci-Tech Innovation Board Eight Measures" aims to enhance the identification mechanism for technology companies and support high-quality unprofitable tech firms in going public [1][8]. - Recent policies have been implemented to provide a more inclusive environment for unprofitable companies, signaling a commitment to fostering innovation and technological advancement [8][9]. - The China Securities Regulatory Commission emphasizes the need for effective market mechanisms combined with proactive government support to facilitate the listing of quality unprofitable tech companies [9][10].