Core Viewpoint - The Chinese beauty industry is undergoing a deep upgrade driven by technology and consumer demand, with pharmaceutical companies emerging as key players due to their strong R&D capabilities and quality systems [3][4]. Industry Overview - Over 400 pharmaceutical companies in China are venturing into the cosmetics sector, aiming to transform pharmaceutical technology into effective skincare and health aesthetic products [3]. - The market for cosmetics in China reached approximately 1,073.82 billion yuan in 2024, continuing to exceed the trillion yuan mark for two consecutive years [8]. Company Profile: Zhejiang Haizheng Pharmaceutical Co., Ltd. - Established in 1956, Haizheng Pharmaceutical has a long history in chemical and pharmaceutical production, with a diversified business matrix focusing on various therapeutic areas [5][6]. - The company reported a revenue of 9.787 billion yuan and a net profit of 600 million yuan in 2024, with R&D investment reaching 420 million yuan [6]. Strategic Moves - Haizheng Pharmaceutical is actively engaging in the "pharmaceutical + aesthetics" trend, leveraging its industrial strength and R&D foundation to innovate in synthetic biology and health aesthetic products [4][9]. - The establishment of Haizheng Weilan and Luan Sheng Synthetic Biology marks the company's strategic entry into health aesthetics and synthetic biology, respectively [9][13]. Product Development and Innovation - Luan Sheng Synthetic Biology has developed over 30 raw material varieties, focusing on high-tech and high-value products to avoid low-level price competition [13][14]. - The company plans to create a product pyramid structure, including "road lamp products" for quick commercialization and "lighthouse products" for mid-term development [14]. Market Strategy - Haizheng Weilan aims to build a comprehensive health aesthetic platform, integrating pharmaceutical e-commerce and innovative business models [15][16]. - The company is focusing on nutrition, functional skincare, and medical beauty, utilizing its raw material advantages to develop products that address joint health and liver protection [18]. Future Outlook - The ultimate goal for Haizheng Pharmaceutical is to establish a complete value chain from synthetic biology raw material innovation to health aesthetic brand products, ensuring each link maintains pharmaceutical-grade quality [21][22]. - The company emphasizes a long-term approach to development, prioritizing solid R&D and reliable quality over quick market gains [22].

Core Viewpoint - Zhejiang Haizheng Pharmaceutical Co., Ltd. held its sixth meeting of the tenth board of directors on August 22, 2025, where several key resolutions were passed, including asset impairment provisions, correction of prior accounting errors, and governance structure adjustments [1][2][3]. Group 1: Financial Decisions - The board approved the proposal for asset impairment provisions with unanimous support [1]. - A resolution was passed to correct prior accounting errors, also receiving unanimous approval [2]. - The half-year report for 2025 was reviewed and approved by the board [2]. Group 2: Governance Changes - The company decided to abolish the supervisory board and amend its articles of association to enhance governance structure, with the audit committee taking over relevant responsibilities [2][3]. - The proposal to establish, amend, and abolish certain corporate governance systems was approved, aimed at improving operational standards [4]. Group 3: Strategic Initiatives - The company plans to publicly transfer 100% equity of its wholly-owned subsidiary, Zhejiang Pharmaceutical Industry Co., Ltd., with an estimated value of 392.23 million yuan and a proposed minimum transfer price of 430 million yuan [4][5]. - A resolution was passed to establish a wholly-owned subsidiary in Brazil, with an investment of 5 million Brazilian Reais, to support international expansion [5][6]. Group 4: Social Responsibility - The company and its subsidiaries will donate medicines valued at approximately 2.14 million yuan to the Xinjiang Red Cross Foundation, reflecting its commitment to social responsibility [6]. Group 5: Upcoming Events - The company has scheduled its first extraordinary general meeting of 2025 for September 10, 2025, to discuss the resolutions passed [7].

Core Viewpoint - After parting ways with Pfizer, Zhejiang Haizheng Pharmaceutical Co., Ltd. is facing significant challenges in its development despite recent approval for its active pharmaceutical ingredient, fumarate bedaquiline [2] Group 1: Company Background - Haizheng Pharmaceutical, founded in 1956 and listed in 2000, is a state-controlled comprehensive pharmaceutical group with a diverse portfolio including chemical drugs, biological drugs, and veterinary drugs [3] - The company’s core products include the self-developed first-class new drug Haibomab, a cholesterol absorption inhibitor, and other medications for liver bile accumulation treatment [3] Group 2: Partnership with Pfizer - The partnership with Pfizer began in September 2012, creating Haizheng Pfizer Pharmaceutical Co., Ltd. with a total investment of $295 million, where Haizheng held a 51% stake [3][4] - Initially, the collaboration was beneficial, significantly boosting Haizheng's revenue through the exclusive production of off-patent antibiotics [4] - However, production issues at Pfizer's overseas factories led to a significant revenue drop, and by 2017, Pfizer completely exited the partnership [4] Group 3: Financial Performance - Haizheng Pharmaceutical has experienced a continuous decline in revenue from 2022 to 2024, with year-on-year decreases of 0.82%, 13.82%, and 5.65% respectively [5][6] - In Q1 2025, the company reported revenue of 2.632 billion yuan, a 3.48% decrease year-on-year, and a net profit of 194 million yuan, down 21.85% [5] Group 4: Market Challenges - The company’s performance has been adversely affected by centralized procurement policies, leading to a significant reduction in market share for key products [6] - In 2023, the revenue from self-operated pharmaceutical preparations decreased by 10.41 billion yuan, indicating a substantial impact from procurement policies [6] Group 5: Innovation and R&D - Haizheng's self-developed drug Haibomab has shown promising sales growth, reaching over 400 million yuan in 2023, with potential peak sales estimated at 1.954 billion yuan [7] - The company has recently received approval for HS387, targeting advanced ovarian cancer and non-small cell lung cancer, but faces intense competition in these markets [8] - R&D investment has fluctuated, with 2024's R&D expenditure at 416 million yuan, representing 4.25% of revenue, indicating a focus on innovation despite financial pressures [10] Group 6: Future Prospects - The approval of fumarate bedaquiline is a positive development, but the company faces challenges in scaling production and market entry [9] - The overall effectiveness of Haizheng's R&D platforms and the impact of past collaborations with Pfizer on current innovation efforts remain uncertain [10]

Summary of Key Points from the Conference Call Company and Industry Overview - **Company**: 海正药业 (Haizheng Pharmaceutical) and 博瑞生物 (Borui Biopharmaceutical) - **Industry**: Pharmaceutical and Biotechnology Core Insights and Arguments Haizheng Pharmaceutical 1. **Transformation and Innovation**: Haizheng is actively transforming by enhancing its innovative drug pipeline through internal R&D and external collaborations, focusing on products like HS387 and Haibo Maibu tablets, which saw a 100% annual sales growth after entering the medical insurance system [2][3] 2. **Leadership Changes**: The new leadership under CEO Xiao has brought significant changes, improving operational efficiency and achieving record high net profits [8][9] 3. **Product Strategy**: The company is implementing a "big product" strategy, aiming for substantial sales from key products, including Haibo Maibu, projected to reach sales of 800 to 1,000 million [9] Borui Biopharmaceutical 1. **Growth Since Spin-off**: Since its spin-off in 2019, Borui has expanded its commercial product line from 1 to 7.5 products, with revenue increasing from 200 million to 1.63 billion, reflecting a compound annual growth rate of approximately 35% [2][5] 2. **Innovative Drug Development**: Borui has made significant strides in innovative drugs, including the launch of Anruixin (Zebetomab), the first Class 1 innovative drug in China, and is focusing on autoimmune and tumor immunity fields [6][7] 3. **ADC Platform**: Borui's unique approach in the ADC (Antibody-Drug Conjugate) platform, utilizing dual payload toxins and stable linker technology, enhances efficacy and reduces toxicity, positioning it competitively in the market [12][13] Additional Important Insights 1. **Market Expansion**: Borui is exploring the pet economy and has established a leading position in veterinary medicine, while also expanding into medical aesthetics and e-commerce channels [10][9] 2. **Future Revenue Goals**: Borui aims to achieve over 7.5 billion in revenue by 2029-2030, with expectations of significant contributions from various product lines [27][28] 3. **IPO Plans**: Borui is actively pursuing an IPO on the Sci-Tech Innovation Board, with a pre-IPO valuation of 13 billion as of late 2022, and is expected to meet listing conditions by June 2023 [29][22] This summary encapsulates the key developments and strategic directions of Haizheng Pharmaceutical and Borui Biopharmaceutical, highlighting their growth trajectories, innovative strategies, and market positioning within the pharmaceutical industry.

Core Viewpoint - The core strategy of Haizheng Pharmaceutical is to return to the top tier of the domestic market by focusing on human medicine while developing animal medicine and health products as complementary wings [1] Group 1: Business Strategy and Development - Haizheng Pharmaceutical aims to establish a diversified development pattern with a focus on human medicine and two wings: animal medicine and health products [1] - The company has transformed its original raw material plant into a biopharmaceutical industrial park covering over 1,500 acres, encompassing high-end biopharmaceuticals, injectable and oral formulations, and export raw materials [1][3] - The company has been exporting raw materials to over 70 countries and regions since 1992, with more than 400 overseas clients, including major global pharmaceutical companies [3] Group 2: Production and Quality Control - Haizheng Pharmaceutical emphasizes the importance of high-quality raw materials, with production bases in Taizhou, Fuyang, and Nantong, featuring a complete production line with fermentation capacity of 17,000 cubic meters and synthesis capacity of 2,300 cubic meters [6] - The Fuyang base has established an international standard QEHS system and has successfully undertaken CMO orders from international giants like Merck and Codexis [6][12] - The company has passed inspections from various global regulatory bodies, including WHO, FDA, and EMA, demonstrating its commitment to quality [12] Group 3: Innovation and Product Development - The company has accelerated its transition from raw materials to formulation business, with its subsidiary Hanhui Pharmaceutical achieving significant sales growth [8][10] - Haizheng Pharmaceutical has developed its first-class innovative drug, Haibomab, which has enriched its product line [10] - The company has successfully completed technology transfers for several original products, filling gaps in domestic technology transfer for original products [10] Group 4: Animal Health Sector - The animal health sector is a key focus for Haizheng Pharmaceutical, leveraging its expertise in human medicine standards to create high-quality veterinary products [14] - The company has established a comprehensive product matrix covering pets, pigs, and ruminants, with a commitment to rigorous quality standards [15] - Haizheng Animal Health has achieved significant milestones, including the first domestic deworming drug with sales exceeding 100 million and successful market entries in countries like Vietnam [15]