以岭药业专利中药全球注册情况 "走出去"：理论先行，科技破局，让中医药惠及世界 11月22日，来自越南、泰国、中国、加拿大等国家和地区的专家学者齐聚一堂，围绕络病理论的最新科 研进展展开深入交流，共商中医药现代化与国际化发展路径。 第二十一届国际络病学大会海外论坛在越南举行 "走出去"是中医药国际化的关键起点。以岭药业深知，中医药要走向世界，理论必须先行。33年来，企 业以"科技创新，成果转化，产业发展"为核心发展战略，系统构建了络病理论体系。该体系被国医大师 路志正评价为"中医络病学发展史上的第四个里程碑"。 以岭医药研究院中医药分院副院长、络病研究部主任李红蓉博士在采访时介绍称，以岭药业从"络病证 治"到"脉络学说"再到"气络学说"，搭建完成了络病研究三大理论框架，相关专著如《络病学》《脉络 论》《气络论》已出版发行，为中医络病学学科发展奠定了坚实的理论基础，《络病学》英文版教材在 弗吉尼亚整合医学大学、加拿大安大略中医学院、新加坡中医学院等海外教育机构开课，助力国际中医 药人才培养。以岭药业在该理论指导下继承创新，创立了"理论+临床+新药+实验+循证"一体化的中医 学术创新与转化新模式。 基于坚实的络病 ...

以岭药业总部 "络病理论是中医药学独特的组成部分，也是以岭药业研发体系的核心灵魂。"吴瑞告诉记者，在络病理论指导下，以岭药 业建立起"理论—临床—科研—产业—教学"五位一体运营模式，形成了"理论+临床+新药+实验+循证"一体化的中医药创新 转化路径。 截至目前，以岭药业成功研发17个专利中药，覆盖心脑血管、呼吸、糖尿病、肿瘤、神经、泌尿、妇科、抗衰老等八大疾 病领域，其中11个品种进入国家医保目录、5个进入国家基药目录，成为中医药创新转化的典范。 "研发不是成本，而是我们最核心的增长动力。"吴瑞告诉记者，以岭的每一根增长曲线，都源自研发的持续投入与突破。 今年前三季度，公司实现归母净利润10亿元，同比增长80.33%。其中，第三季度，公司实现归母净利润3.32亿元，单季盈 利创历史新高。公司前三季度研发费用支出达5.44亿元，占营收比例9.27%，持续位居中药行业前列。 ◎记者 刘立 闫刘梦 从一本《络病学》教材到在海内外建立130余家络病专业委员会，从一味院内制剂到17款专利新药，从一家河北药企到国 际化医药集团……这就是国内中医药产业领军企业以岭药业的成长轨迹。 "以岭将科技创新作为立企之本，以络病理论为 ...

Group 1 - The core viewpoint of the article highlights the strategic developments and growth trajectories of various companies in Hebei, including their market performance and innovative initiatives [11][19][20]. - Hebei's listed companies have implemented market value management plans, with 74 companies executing annual and mid-term dividends totaling over 28 billion yuan [11]. - Yiling Pharmaceutical has increased its market share in the cardiovascular oral traditional Chinese medicine market from 13.64% in 2015 to 18.13% in 2024, serving as a stable growth driver for the company [11][28]. Group 2 - Wireless Media is expanding its business from traditional IPTV services to smart home and enterprise digitalization, aiming to redefine the value of large screens through technology [12][13]. - The company has a user base of nearly 15 million IPTV subscribers, and it is actively developing a smart media cloud platform to create a new ecosystem combining AI and new media [13][15]. - Financial support for local enterprises has been significant, with Financial Securities issuing 8 rounds of science and technology bonds totaling 8.2 billion yuan to support R&D investments [20][23]. Group 3 - Colin Electric aims to become a world-class comprehensive energy service provider by integrating smart grids, renewable energy, and comprehensive energy services [32][34]. - The company has seen significant growth in its renewable energy sector, focusing on photovoltaic and energy storage solutions, and is transitioning from equipment supplier to integrated solution provider [33][36]. - In the third quarter, Colin Electric reported a revenue of 3.216 billion yuan, a year-on-year increase of 23.63%, and a net profit of 217 million yuan, marking a 45.9% increase [36]. Group 4 - Yiling Pharmaceutical has established a comprehensive R&D system guided by the theory of "Luo Disease," leading to the successful development of 17 patented traditional Chinese medicines [26][28]. - The company emphasizes the importance of R&D as a core growth driver, with R&D expenses accounting for 9.27% of revenue, positioning it among the leaders in the traditional Chinese medicine industry [28][29]. - Yiling's products have gained international recognition, with significant studies published in top medical journals demonstrating their efficacy in treating cardiovascular conditions [29][30].

Core Viewpoint - Yiling Pharmaceutical (002603.SZ) has demonstrated strong performance in Q3 2025, with revenue of 1.827 billion yuan, a year-on-year increase of 3.78%, and a significant growth in net profit, indicating robust business fundamentals and potential for future growth [3][4]. Business Foundation - The company has a solid foundation in traditional Chinese medicine, with 17 patented products, 11 of which are included in the national medical insurance directory, ensuring stable growth [4][5]. - Key products such as Tongxinluo Capsule and Qiyuqiangxin Capsule have maintained top positions in the cardiovascular market, supported by clinical guidelines [5]. Growth Potential - The biopharmaceutical segment is advancing with a strategy that includes both generic and innovative drug development, leading to a second growth phase [6][7]. - The health segment targets specific consumer needs, tapping into a trillion-level health consumption market, which provides new growth opportunities [6][7]. R&D Investment - Yiling Pharmaceutical invested 544 million yuan in R&D in the first three quarters of 2025, leading the domestic traditional Chinese medicine sector, with cumulative R&D investment exceeding 5 billion yuan from 2019 to 2024 [6][7]. - The company has established a robust pipeline with multiple products in various stages of development, ensuring sustainable growth [7][8]. International Expansion - The company has expanded its international presence, with products like Tongxinluo Capsule and Qiyuqiangxin Capsule entering over 50 countries, enhancing its global market reach [10][11]. Shareholder Returns - The company has shown commitment to shareholder returns, with earnings per share reaching 0.5988 yuan, a year-on-year increase of 80.31%, and a dividend payout of 5.01 billion yuan, representing 77% of the profit [11].

Investment Rating - The report assigns a "Buy-A" investment rating to the company, with an upward adjustment in rating [4]. Core Views - The company has shown a significant recovery in profit, with a 80.33% year-on-year increase in net profit for the first three quarters of 2025, despite a 7.82% decline in revenue [1]. - The company is focusing on innovation and has made substantial progress in both research guidelines and new drug development [3]. - The financial metrics indicate improved profitability, with a net profit margin increase of 8.36 percentage points to 16.99% due to enhanced gross margin and optimized expense ratios [2]. Financial Performance Summary - For the first three quarters of 2025, the company achieved revenue of 5.868 billion yuan, a decrease of 7.82% year-on-year, while net profit reached 1 billion yuan, an increase of 80.33% [1]. - The gross margin for the first three quarters was 60.53%, up 7.14 percentage points year-on-year, and the expense ratio decreased to 39.08%, down 2.78 percentage points [2]. - The company expects revenues of 8.262 billion yuan, 9.116 billion yuan, and 10.004 billion yuan for 2025, 2026, and 2027 respectively, with net profits projected at 1.254 billion yuan, 1.451 billion yuan, and 1.670 billion yuan [7][8]. Innovation and Development Summary - The company has made significant advancements in its traditional Chinese medicine sector, with key products recommended in major clinical guidelines [3]. - New drug approvals and registrations are progressing, with multiple products at various stages of clinical trials and regulatory approval [4][7]. - The company is also increasing its efforts in innovative drug development, with several new drugs in clinical stages and plans for international market registrations [4][7].

Core Viewpoint - Yiling Pharmaceutical, a leading enterprise in traditional Chinese medicine, has shown significant performance recovery and growth in 2025, with a notable increase in revenue and profit margins [1] Financial Performance - In the first three quarters of 2025, the company achieved operating revenue of 5.868 billion yuan and a net profit attributable to shareholders of 1 billion yuan, representing a year-on-year increase of 80.33% [1] - The company's non-recurring net profit reached 966 million yuan, up 90.53% year-on-year [1] - The sales gross margin and net margin have been continuously rising, indicating enhanced profitability and resilience [1] R&D and Innovation - Yiling Pharmaceutical places a strong emphasis on R&D, maintaining high investment levels with R&D expenses of 544 million yuan, accounting for 9.27% of revenue, ranking among the top in the traditional Chinese medicine industry [1] - The company is leveraging modern medical recognition to enhance the international acceptance of its products, particularly through evidence-based studies [2][3] Internationalization Efforts - The core product, Qiliqiangxin Capsule, has shown significant benefits for heart failure patients, with a 22% reduction in major adverse cardiovascular events when used alongside standard treatments [2] - The Baizi Bujin Capsule has been successfully launched in Canada and is gaining traction in the European and American markets, being recognized as a benchmark for the internationalization of traditional Chinese medicine anti-aging products [2] - Yiling Pharmaceutical's internationalization aligns with national policies promoting the global expansion of traditional Chinese medicine [3] Standardization and Quality Control - The company has established 60 standardized Chinese medicinal herb cultivation bases across 20 provinces, ensuring quality and supporting rural revitalization [4] - Recent inspections have confirmed the quality of core raw materials, with several bases passing GAP (Good Agricultural Practices) checks [4] Systematic Approach to Modernization - Yiling Pharmaceutical is systematically constructing a model for the internationalization of traditional Chinese medicine through R&D innovation, international registration, evidence-based research, and source control [4] - The dual drivers of policy support and global health demand are facilitating the modernization of traditional Chinese medicine, providing a replicable industrial path for greater global health governance [4]

Core Viewpoint - Yiling Pharmaceutical has demonstrated significant growth in its third-quarter financial results, showcasing a remarkable increase in net profit and cash flow, indicating a strong operational quality and strategic focus on R&D [1][2][3]. Financial Performance - In the third quarter, the company achieved a net profit of 332 million yuan, a staggering year-on-year increase of 1264.61%, marking a record high for quarterly profit [1][3]. - For the first three quarters, the cumulative net profit reached 1 billion yuan, reflecting an 80.33% year-on-year growth, while the non-recurring net profit grew by 90.53% to 966 million yuan [5]. - The operating revenue for the third quarter was 1.827 billion yuan, up 3.78% year-on-year [4]. Cash Flow and Operational Quality - The net cash flow from operating activities for the first three quarters surged to 1.278 billion yuan, a remarkable increase of 296.19%, exceeding the net profit for the same period [8][9]. - Improved cash flow is attributed to enhanced efficiency in accounts receivable management, optimized inventory control, and effective cost management, with selling expenses decreasing by 19.03% [9][10]. R&D Investment - Yiling Pharmaceutical invested 544 million yuan in R&D during the first three quarters, with a research intensity of 9.27%, indicating a commitment to innovation [11][12]. - The company has maintained a high level of R&D investment over the past six years, totaling nearly 5 billion yuan, reflecting its focus on long-term growth through innovation [12][14]. - The company has made significant progress in clinical research, with multiple studies published in prestigious medical journals, enhancing the credibility and market acceptance of its products [14][15]. Product Development and Market Position - The company has a diverse product pipeline, with ongoing development in various therapeutic areas, including cardiovascular, respiratory, and metabolic diseases [15][16]. - Yiling Pharmaceutical's core products have shown steady growth, supported by strong clinical data and market reputation, contributing to a balanced performance across its product lines [5][6]. Strategic Outlook - The combination of high profit growth, robust cash flow, and increased R&D investment positions Yiling Pharmaceutical favorably for sustainable development in the evolving pharmaceutical industry [10][16].

Core Insights - The QUEST study, which evaluates the efficacy of traditional Chinese medicine Qiliqiangxin capsules in treating chronic heart failure, has been recognized as one of the top ten research advancements in cardiovascular disease for 2024 [1][4]. Group 1: Study Overview - The QUEST study is the first hard endpoint study in China focusing on traditional Chinese medicine for chronic heart failure, demonstrating a 22% reduction in the risk of major composite endpoint events compared to the control group [4]. - The study also reported a 24% reduction in the risk of heart failure exacerbation leading to rehospitalization and a 17% reduction in cardiovascular mortality, indicating the treatment's safety and good tolerability [4]. Group 2: Subgroup Analyses - Subgroup analyses revealed that Qiliqiangxin capsules have minimal impact on blood pressure and provide clinical benefits for heart failure with reduced ejection fraction (HFrEF) patients, regardless of baseline systolic blood pressure [5]. - The analysis of NT-ProBNP levels showed that Qiliqiangxin significantly lowers plasma NT-proBNP levels in HFrEF patients, demonstrating consistent tolerability across different baseline NT-proBNP levels [5]. - The analysis regarding left ventricular ejection fraction (LVEF) indicated that the benefits of Qiliqiangxin in reducing cardiovascular events are consistent across various LVEF levels, with more significant absolute benefits observed in patients with low LVEF [6]. Group 3: Implications for Traditional Chinese Medicine - The inclusion of the QUEST study in the top ten advancements highlights the scientific value of traditional Chinese medicine in modern medical research and offers new treatment options for patients with reduced ejection fraction heart failure [6]. - The ongoing promotion and application of the study's findings may lead to significant advancements in cardiovascular disease management in China, showcasing the potential of integrating traditional and modern medicine [6].

Core Viewpoint - Yiling Pharmaceutical has demonstrated strong core profitability indicators in its 2025 mid-term report, with a revenue of 4.04 billion yuan and a net profit of 669 million yuan, reflecting a year-on-year increase of 26.03% [1] Group 1: Financial Performance - The company has proposed a cash dividend of 3 yuan per 10 shares (including tax) as a way to reward shareholders [1] - Yiling's average annual R&D investment over the past three years has remained stable at 900 million yuan, ranking among the top three in the industry [1] - In 2024, R&D expenses are expected to account for 13.94% of revenue, significantly higher than the industry average [1] Group 2: Innovation and R&D - Yiling has maintained a stable innovation rhythm, with 1-2 new Class 1 traditional Chinese medicine (TCM) applications submitted for approval each year [2] - The company has successfully approved five Class 1 new drugs in the past five years, with four entering the medical insurance directory [2] - The recent approval of Qifang Nasal Congestion Tablets is expected to participate in national medical insurance negotiations by the end of the year, laying a foundation for future revenue growth [2] Group 3: International Expansion - Yiling's core theory of "Luo Disease" is transitioning from a "Chinese theory" to a "global topic," with clinical trials published in top international journals [3] - The company has registered and launched over ten TCM products in more than 50 countries and regions, translating international expansion into tangible sales [3] Group 4: Market Valuation - Despite Yiling's dual advantages of being an "innovative drug" and "international expansion" company, the market still values it using traditional TCM PE frameworks, failing to recognize its extensive R&D pipeline [4] - The estimated reasonable market value of Yiling is around 30 billion yuan, indicating a 20%-30% valuation discrepancy compared to current market consensus [4] - The ongoing policy support for TCM innovation and accelerated drug review processes present unprecedented development opportunities for Yiling [4]

Core Viewpoint - The release of the first expert consensus on the cardiovascular event chain provides a Chinese characteristic clinical drug treatment plan that integrates traditional Chinese medicine and Western medicine, aiming to systematically intervene in cardiovascular diseases [1][2][3] Group 1: Expert Consensus Overview - The expert consensus titled "Expert Consensus on Systematic Intervention of Cardiovascular Event Chain with Tongluo Drugs" was published during the 12th Chinese Association of Integrative Medicine Vascular Disease Conference [1] - The consensus addresses the need for new intervention methods for the cardiovascular event chain, which is characterized by a series of events leading to severe outcomes such as myocardial infarction and heart failure [1] Group 2: Mechanisms and Clinical Evidence - The consensus includes a series of Tongluo drugs (e.g., Jinlida granules, Tongxinluo capsules) and their mechanisms and clinical evidence for intervening in diseases related to the cardiovascular event chain, such as diabetes, stroke, coronary heart disease, arrhythmia, and heart failure [2] - Significant clinical evidence from national key research projects supports the breakthroughs in traditional Chinese medicine, including the prevention of type 2 diabetes and improvements in coronary plaque stability [2] Group 3: Impact and Future Prospects - The consensus is expected to enhance the prevention and treatment of cardiovascular diseases, significantly reducing their incidence and mortality rates [3] - The release of the consensus is anticipated to attract global attention to traditional Chinese medicine and stimulate further research in the integration of traditional and modern medical practices [3]