Core Viewpoint - Recently, Shijiazhuang Four Drug Group announced the approval of its generic version of Benidipine Hydrochloride Tablets, which is considered equivalent to the original product. According to MoSheng Pharmaceutical data, over 20 pharmaceutical companies have received approval for this product so far [1][10]. Group 1: Product Overview - Benidipine Hydrochloride Tablets are calcium channel blockers that selectively inhibit calcium ion influx across vascular smooth muscle cell membranes, thereby reducing peripheral vascular resistance, which helps in lowering blood pressure and alleviating angina [4]. - The total sales of Benidipine Hydrochloride Tablets in the full terminal hospital market are expected to exceed 2 billion yuan in 2024, making it one of the top 10 cardiovascular system drugs in terms of sales [4][5]. Group 2: Market Competition - In the 2024 full terminal hospital market, Benidipine Hydrochloride Tablets exhibit a three-way competitive landscape. Yangtze River Pharmaceutical holds the leading market share at 27.61%, followed by North China Pharmaceutical with 25.24%, and Nanchang Hongyi Pharmaceutical at 16.31% [6]. Group 3: Industry Participation - Currently, 22 companies, including Shijiazhuang Four Drug, North China Pharmaceutical, and Yangtze River Pharmaceutical Group, have received approval for Benidipine Hydrochloride Tablets, with 4 companies participating in the eighth batch of centralized procurement [10]. - In terms of generic drug development, over 30 companies, including Jiangsu Wango Pharmaceutical and Hunan Jiudian Pharmaceutical, are in the process of applying for the generic version under category 4 [10][13].

Core Viewpoint - The company has obtained the drug production registration approval from the National Medical Products Administration of China for Amlodipine Besylate Tablets (5mg and 2.5mg), classified as a Category 4 chemical drug, indicating it has passed the consistency evaluation [1] Group 1 - Amlodipine Besylate Tablets are primarily used for the treatment of hypertension, chronic stable angina, and vasospastic angina, and can be used alone or in combination with other medications [1]

苯磺酸左氨氯地平片主要用于高血压、慢性稳定性心绞痛及血管痉挛性心绞痛的治疗，可单独应用或与 其他药物联合应用。 智通财经APP讯，石四药集团(02005)发布公告，本集团已取得中国国家药品监督管理局有关苯磺酸左氨 氯地平片(5mg 及2.5mg)的药品生产注册批件，均属于化学药品第4类，视同通过一致性评价。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不會就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致之任何損失承擔任何責任。 苯磺酸左氨氯地平片主要用於高血壓、慢性穩定性心絞痛及血管痙攣性心絞痛的治療，可單獨 應用或與其他藥物聯合應用。 本公告為本公司自願發佈，目的是使股東及潛在投資者瞭解本集團最新業務發展情況。 承董事局命 執行董事兼公司秘書 周興揚 香港，二零二五年十月十七日 自願公告 產品開發的最新進展 石四藥集團有限公司（「本公司」，連同其附屬公司，「本集團」）董事局（「董事局」）欣然公告， 本集團已取得中國國家藥品監督管理局有關苯磺酸左氨氯地平片(5mg 及2.5mg)的藥品生產註 冊批件，均屬於化學藥品第4類，視同通過一致性評價。 於本公告日期，董事局成員包括執行董事曲繼廣先生、蘇學軍先生、孟國先生、周興揚先生及 曲婉蓉女士，非執行董事劉文軍先生，以及獨立非執行董事王亦兵先生、周國偉先生及姜廣策 先生。 ...

Core Viewpoint - The company, Anglikang, has announced a share buyback plan, indicating confidence in its business and future growth potential, while also focusing on enhancing employee incentives through stock ownership [1][2] Group 1: Share Buyback and Financials - Anglikang has repurchased a total of 3,599,700 shares, accounting for approximately 1.78% of its total share capital, with a total transaction amount of 50,001,275.28 yuan [1] - The buyback price range was between 12.17 yuan and 17.00 yuan per share, with a planned total expenditure of no less than 50 million yuan and no more than 70 million yuan [1] - The company aims to use the repurchased shares for future employee stock ownership plans or equity incentives [1] Group 2: Business Operations and Market Position - Anglikang primarily engages in the production and manufacturing of pharmaceuticals, including chemical raw materials, formulations, and specialized intermediates [1] - The company has established a comprehensive industrial chain in the production of oral cephalosporins and other pharmaceutical products, enhancing its market competitiveness [1] - The customer structure is clear, with domestic sales accounting for 75.85% and international sales for 24.15%, focusing on large pharmaceutical and chemical companies [2] Group 3: Research and Development - In the first half of 2025, the company's R&D investment reached 85.6 million yuan, representing 11.82% of its operating revenue, resulting in the acquisition of 4 invention patents and 5 utility model patents [3] - The product line includes core products with high market share and new formulations that have won centralized procurement bids, aiding market expansion [3] - The company is developing innovative drugs, with several candidates entering clinical trials, establishing a complete product pipeline from generics to innovative drugs [3] Group 4: Strategic Growth and Future Prospects - The acquisition of Keri Bio has strengthened Anglikang's cash flow and market position, with Keri Bio expected to achieve a net profit margin of 40% in 2024 [4] - The company is focusing on the pet medicine sector, with ambitious sales targets and numerous projects in the pipeline, which are anticipated to become new growth drivers [4] - Anglikang has implemented environmentally friendly production techniques and established a comprehensive quality management system, aligning with industry standards [3]

Core Viewpoint - The company, Anglikang, reported a revenue of 724 million yuan in the first half of 2025, with significant contributions from its formulation, API, and specialty intermediates businesses, indicating a positive growth trajectory despite market fluctuations [1][2]. Financial Performance - In H1 2025, the company achieved revenues of 315 million yuan from formulations, 288 million yuan from APIs, and 90.12 million yuan from specialty intermediates, with gross margins of 46.67%, 21.94%, and 70.20% respectively [1]. - The company's R&D investment reached 85.6 million yuan, accounting for 11.82% of its revenue, highlighting its commitment to innovation [1][4]. Business Structure and Market Strategy - The company maintains a diversified business structure, with domestic sales accounting for 75.85% and international sales for 24.15%, focusing on large pharmaceutical and feed enterprises [2]. - Through a combination of direct sales and deep distribution, the company has established a stable market foundation in the chemical API and formulation sectors [2]. R&D and Innovation - The company is advancing its innovation strategy, with multiple new drug projects entering clinical stages, including ALK-M001/BM2216 and ALK-N001/QHL-1618 [1][4]. - In H1 2025, the company secured four invention patents and five utility model patents, reflecting its strong focus on R&D [4]. Strategic Collaborations - The company signed a licensing agreement with Yafei Biopharmaceutical and Qinhuli Biopharmaceutical to develop the innovative drug ALK-N002/IMD-1005, which targets CD47 for cancer treatment [5][6]. - This collaboration aims to enhance the company's product portfolio in the oncology sector, leveraging unique drug design for improved therapeutic outcomes [6][7]. Market Expansion in Emerging Sectors - The company is actively expanding into the pet medicine and nutrition market, which is projected to grow significantly, with the pet medicine market expected to increase from 9.39 billion yuan in 2020 to 20.95 billion yuan by 2024, reflecting a compound annual growth rate of 22.2% [8]. - The company has made progress in its pet medicine R&D projects, completing several product registrations and enhancing market recognition through initiatives like the "Angmai Cup" veterinary anesthesia case competition [8]. Future Outlook - Anglikang aims to continue its growth trajectory by integrating resources to optimize product layout and transitioning from a focus on generic drugs to a model that includes specialty generics, modified new drugs, and innovative drugs [9]. - The company is committed to sustainable development and enhancing its brand recognition in the modern pharmaceutical industry [9].

Financial Performance - In the first half of 2025, the company achieved a total revenue of 72,435.50 million RMB and a net profit attributable to shareholders of 6,592.51 million RMB, with a non-recurring net profit of 4,369.69 million RMB [3] - The company experienced growth due to increased sales from products entering centralized procurement, stabilizing the previously declining formulation business [3] Business Segments API and Specialty Intermediates - The API business faced fluctuations primarily due to a sluggish antibiotic market and reduced demand from downstream formulations [3] - The specialty intermediates segment saw a decline in revenue, particularly in the 25-hydroxyvitamin D3 series, influenced by customer demand fluctuations and global policy changes [3] Innovative and Improved Drugs - The company is focusing on innovative drugs, with ALK-N001/QHL-1618 currently in Phase I clinical trials, and plans to explore various solid tumor types [4][11] - The company aims to increase investment in innovative drug development, with a projected total investment of around 300 million RMB for 2024, covering two innovative drug pipelines [6] R&D and Team Development - The R&D team is being optimized to support innovative drug development, with plans to recruit clinical and medical teams [6] - The company is currently prioritizing the introduction of external innovative drug pipelines while maintaining an open collaboration approach [6] Capital Expenditure and Future Projects - The largest anticipated capital expenditure is for the construction of an 8,000-ton amoxicillin and 2,000-ton ampicillin production project, with a total investment of approximately 336 million RMB [7] - The company plans to gradually advance existing projects while considering new R&D pipeline introductions based on operational conditions [7] Market Outlook - The orders for 25-hydroxyvitamin D3 are expected to be lower than initial projections due to demand fluctuations and global policy impacts [8] - The sales of formulation products like benazepril and ketone acid tablets are showing stabilization, with significant growth from selected products due to centralized procurement [8] Future Strategies - The company is committed to enhancing its innovative drug pipeline and commercializing products based on clinical research outcomes [13] - The pet medicine sector is progressing as planned, with multiple new veterinary drug products being registered, although overall sales remain modest [13]

Core Insights - The establishment of a "drug unavailability" service window in Qingpu District addresses the issue of residents, particularly the elderly and chronic disease patients, facing difficulties in obtaining necessary medications at local health clinics [1][2] - The initiative has successfully resolved nearly a hundred cases of drug shortages, with over 90% of these related to chronic disease medications, achieving a 100% satisfaction rate among residents [1][2] Summary by Sections - **Service Implementation**: Since April, Qingpu District has introduced a dedicated service window for residents to report difficulties in obtaining medications, allowing for a more efficient drug delivery system [1][2] - **Challenges Addressed**: The service aims to tackle the limited drug availability in rural areas, exacerbated by an increasing number of chronic disease patients and the elderly population [2] - **Resource Optimization**: The initiative is designed to prevent resource waste by ensuring that community health service centers maintain a variety of medications without overstocking in individual village clinics that may serve only a small number of residents [2] - **Drug Availability Statistics**: Currently, over 80% of medications available in tertiary hospitals can be found in community health service centers, with plans to further enhance this ratio through improved coordination within the medical service network [3]

Core Points - The company achieved an operating income of 9.87 billion yuan in 2024, with a total profit of 310 million yuan, reflecting a stable performance amidst challenges [2][24] - The company plans to achieve an operating income of 10 billion yuan and a profit of 400 million yuan in 2025, focusing on quality and efficiency [11][24] - The company has implemented significant governance reforms, including the establishment of a "4+1" committee system to enhance decision-making and independence [5][12] Group 1: Annual Meeting and Governance - The annual shareholders' meeting is scheduled for June 11, 2025, combining on-site and online voting [3][4] - The board of directors has held eight meetings and approved 37 proposals during the reporting period, ensuring compliance with regulations [6][12] - The company has established a specialized meeting mechanism for independent directors to enhance governance [5][12] Group 2: Financial Performance - In 2024, the company reported a revenue decrease of 2.48%, with pharmaceutical chemical revenue increasing by 0.48% [24][25] - The total assets reached 21.47 billion yuan, with a net profit attributable to the parent company of 127 million yuan, an increase of 1.22 million yuan year-on-year [24][25] - The company plans to maintain a debt limit of 12 billion yuan for 2025, with total investments of 1.705 billion yuan [24][27] Group 3: Market and Product Development - The company has optimized its business layout, successfully participating in national procurement, with significant sales growth in key products [8][9] - The company aims to enhance its market share in chemical preparations and expand its biological drug portfolio [11][13] - The company has reported a 26.8% increase in revenue from potential products, indicating strong market performance [8][9] Group 4: Research and Innovation - The company has invested in R&D, achieving several new drug registrations and advancing clinical trials for key products [9][14] - The company has applied for 52 patents in 2024, with 22 patents granted, showcasing its commitment to innovation [9][14] - Collaborations with universities and research institutions have been established to enhance technological advancements [9][14] Group 5: Social Responsibility and Investor Relations - The company has actively engaged in investor protection activities and improved communication channels with shareholders [7][12] - The company has undertaken social responsibility initiatives, including rural revitalization projects [7][12] - The company emphasizes transparency and compliance in its investor relations management [6][12]

Core Viewpoint - The company has received the drug registration certificate for Amlodipine Besylate Tablets from the National Medical Products Administration, which is expected to enhance its market competitiveness [1] Group 1: Drug Registration and Market Impact - The drug Amlodipine Besylate Tablets is a calcium channel blocker with antihypertensive effects [1] - The estimated domestic sales for the drug in 2024 are approximately 4.671 billion yuan [1] - The company invested around 8.2991 million yuan in the research and development of this drug [1]