Core Viewpoint - Breast cancer is the most common malignant tumor among women globally, with an increasing incidence rate, approximately 2.3 million new cases reported annually according to the World Health Organization [1] Group 1: Incidence and Demographics - The incidence of breast cancer is rising both globally and in China, with a notable increase in younger patients [3] - Breast cancer typically occurs more frequently in women around the ages of 55 to 60, with a secondary peak in women around 40 years old [3] - Younger breast cancer patients tend to experience faster disease progression and a higher likelihood of lymph node metastasis [3] Group 2: Symptoms and Self-Examination - The primary symptom of breast cancer is a breast lump, with about 80% of patients presenting with this symptom at diagnosis [5] - Most early-stage breast cancer patients do not exhibit obvious symptoms, making regular self-examination crucial [5] - Recommended self-examination frequency is once every one to two months, including visual checks for skin changes and nipple discharge [7] Group 3: Screening and Diagnosis - Due to the uncertainty of self-examinations, regular hospital screenings are essential, including ultrasound, mammography, MRI, and ductoscopy [9] - Early-stage breast cancer often presents with calcifications that are difficult to detect via ultrasound, necessitating mammography for accurate diagnosis [9] - It is advised that women over 40 undergo mammography screenings every one to two years, especially if abnormalities are detected on X-rays [11]

Core Insights - The five-year survival rate for breast cancer patients can reach nearly 90% if detected early, while the rate drops to less than 30% for late-stage patients [8] Group 1: Breast Cancer Statistics and Trends - The five-year survival rate for breast cancer in China has gradually increased, exceeding 60% recently, but the early diagnosis rate still lags behind developed countries due to insufficient screening precision [2][3] - The incidence of breast cancer among women in China is rising, particularly in the age groups of 30 and below, and 35 to 45 years old [3][4] - Over 20% of breast cancer patients are diagnosed at late stages (III-IV) [4] Group 2: Screening and Diagnosis - The "Two Cancers" screening program (breast and cervical cancer) is included in basic public health services for women aged 35-64, but awareness and participation in screening among younger women are still low [2][5] - Current screening methods, including breast ultrasound and mammography, have shown high detection rates, with early detection rates in underdeveloped regions reaching 71% [4] - The precision of screening needs improvement, especially for younger women who may not prioritize regular check-ups [5] Group 3: Technological Innovations - Advances in imaging technology and the integration of AI in diagnostic processes are enhancing the accuracy of early breast cancer screenings [6][7] - Genetic testing and AI risk assessment technologies are becoming crucial for high-risk populations, particularly those with mutations in BRCA1 and BRCA2 genes [7] Group 4: Clinical Benefits of Early Detection - Early detection of breast cancer significantly improves clinical outcomes and societal benefits, with a stark contrast in survival rates between early and late-stage diagnoses [8]

Core Viewpoint - Breast cancer is a significant health threat to women in China, with a rising incidence rate, necessitating earlier screening for high-risk individuals [1][2][3] Group 1: Breast Cancer Statistics and Risk Factors - In 2022, there were 357,200 new breast cancer cases in China, accounting for 15.6% of all new cancer cases [1] - Family history, particularly if a direct relative was diagnosed with breast cancer before the age of 50, significantly increases individual risk and warrants earlier screening [1][2] Group 2: Screening Recommendations - For women under 40, especially those with high-risk factors (e.g., family history, breast hyperplasia), ultrasound is recommended due to its safety and accessibility [2] - Women over 40 should consider a combined screening approach using mammography and ultrasound to improve detection rates, particularly for microcalcifications [2] - High-risk individuals should undergo personalized management based on specific risk factors, including reproductive history and lifestyle choices [2] Group 3: Importance of Early Detection - Early detection can lead to a nearly 90% five-year survival rate for breast cancer, compared to less than 30% for late-stage diagnoses [3] - Young women should not ignore symptoms such as breast lumps or unusual skin changes, as early intervention is crucial regardless of age [3]

Core Insights - Different age groups require tailored health check-up items to effectively monitor health risks and conditions [1] Group 1: Health Check-up Recommendations by Age - For individuals aged 30-40, the focus should be on monitoring blood pressure, blood sugar, and blood lipids due to lifestyle factors leading to obesity [3][4] - Women in this age group should prioritize gynecological and breast examinations, while men should start prostate checks after age 35 [6][7] - For those aged 40-50, cardiovascular diseases and cancer risks increase, necessitating heart-related tests and cancer screenings [6][7] - Individuals over 50 should begin screening for bone density and metabolic levels, as well as gastrointestinal diseases and cardiovascular conditions [9][11] Group 2: Common Misconceptions about Health Check-ups - It is a misconception that more expensive tests yield better results; the focus should be on tests that are appropriate for individual health needs [13][15] - Waiting until experiencing discomfort before getting a check-up is incorrect; regular check-ups are essential for early disease detection [15][17] - Post-check-up, it is crucial to thoroughly review the report and seek further medical advice for any significant findings [17][19]

Group 1 - The core focus of health check-ups varies by age group, with specific tests recommended for different age ranges [1][5][9] - For individuals aged 30-40, monitoring blood pressure, blood sugar, and blood lipids is crucial, with recommendations for semi-annual checks [2][3] - Women in this age group should prioritize gynecological and breast examinations, while men should begin prostate checks after 35 [4][6] Group 2 - For the 40-50 age group, cardiovascular health and cancer screenings become critical, as this period is identified as a "high-risk" health phase [5][6] - Recommended tests include cardiac ultrasounds, ECGs, and lung CT scans to screen for lung cancer, alongside breast and cervical cancer screenings for women [6][7] - Individuals with a family history of tumors should undergo early screenings [8] Group 3 - For those aged 50 and above, bone density and vascular health are emphasized, with a focus on osteoporosis and gastrointestinal diseases [9][10] - Regular screenings for bone density and gastrointestinal issues, including gastroscopy, are advised, along with cardiovascular health checks [10] - Eye examinations are also recommended for this age group [10] Group 4 - Common misconceptions about health check-ups include the belief that more expensive tests yield better results, which is not necessarily true [11][12][13] - It is incorrect to wait until feeling unwell to seek check-ups, as early detection is key to effective intervention [13] - Post-examination, individuals should carefully review their reports and seek further medical advice for any significant findings [13]

Core Viewpoint - Breast cancer is a significant health threat to women in China, but advancements in medical treatment have improved the 5-year survival rate to 83.2% [1] Group 1: Current Situation and Statistics - Approximately 72% of breast cancer patients in China are diagnosed at an early stage, yet 30% of high-risk patients may experience recurrence within the first few years [1] - The 5-year survival rate for late-stage breast cancer is only 20%, with a median survival time of 2-3 years [1] Group 2: Genetic Factors and Risk Assessment - 5%-10% of breast cancer patients have hereditary breast cancer due to genetic mutations, with BRCA1/2 being the most critical susceptibility genes [2] - 5%-20% of breast cancer patients in China carry BRCA mutations, which are more common in HER2-negative breast cancer, particularly in triple-negative breast cancer (TNBC) [2] Group 3: Importance of Genetic Testing - Genetic testing for BRCA1/2 is recommended for patients with a family history of breast cancer and those diagnosed with invasive TNBC, especially with lymph node involvement [3] - Accurate diagnosis through genetic testing is essential for developing personalized treatment plans and improving treatment efficacy [3] Group 4: Treatment and Prevention Strategies - New treatment options based on genetic mutations require clear identification of the mutation-carrying population for effective outcomes [4] - Regular breast cancer screenings are advised for women aged 35 to 70, along with self-examinations to facilitate early detection and treatment [4]