（来源：南京晨报） 转自：南京晨报 近日，南京市妇幼保健院妇科内分泌科副主任医师孙艳丽在门诊接诊了一位特殊患者。该患者口服黄体 酮胶囊第一盒时无任何不适，服用第二盒期间却突然出现头晕、昏倒症状。经详细问诊，医生发现关键 诱因——患者服药期间食用了柚子。西柚，这一常见水果，为何会与妇科内分泌药物产生如此强烈的反 应？ 孙艳丽介绍，西柚中含有呋喃香豆素类化合物，这类物质会抑制人体内的药物代谢酶CYP3A4的活性。 血液中需要该酶代谢的药物浓度便会异常升高，相当于间接"加量"服药，进而引发一系列不良反应。 在妇科内分泌领域，以下几类常用药物，需与西柚保持明确的"安全距离"： 1.孕激素类药物 如黄体酮、地屈孕酮等，常用于调节月经周期、保胎治疗。与西柚同服时，血药浓度升高易引发头晕、 嗜睡、恶心，严重时可能出现昏厥、心悸，就像上述案例中的患者一样。 2.雌激素类药物 包括雌二醇、戊酸雌二醇等，多用于激素替代治疗、改善围绝经期症状。西柚会增强此类药物的药效， 可能导致体内雌激素水平过高，增加乳房胀痛、不规则阴道出血等风险。 3.短效口服避孕药 西柚与部分短效口服避孕药同服，可干扰药物代谢，加重恶心、头晕、头痛、乳房胀等 ...

Financial Performance - Cumulative revenue for the first three quarters of 2025 is 2.826 billion, a decrease of 12.71% compared to the same period last year [2] - Single-quarter revenue for Q3 2025 is 956 million, down 13% year-on-year from 1.099 billion [3] - Cumulative net profit after deducting non-recurring items is 363 million, a decline of 30.3% from 521 million in the previous year [3] - Single-quarter net profit for Q3 2025 is 96 million, down approximately 21% from 123 million in Q2 2025 [3] - Gross margin for the first three quarters is approximately 62.3%, up from 54.6% in the same period last year [3] Asset and Liability Overview - Total assets as of the end of Q3 2025 are 7.263 billion, with net assets of 6.025 billion [3] - Asset-liability ratio is approximately 17.04% [3] Sales and Profit Decline Analysis - Sales revenue decline is attributed to factors such as centralized procurement, price fluctuations in raw materials, and intensified market competition [3] - Prices of raw materials have shown a downward trend, affecting both revenue and profit margins [3] - The company aims to enhance production efficiency and innovate to adapt to the changing market landscape [3] Sales Expense Increase - Increase in sales expenses is primarily due to the market introduction phase of several new products [4] - The company is preparing a professional sales team to support the commercialization of new products [4] R&D Strategy - The company has completed the consistency evaluation of existing products and is actively exploring new targets based on clinical needs [5] - Focus on innovative development, including steroid-based innovations and exploring new attractive products beyond steroid limitations [5] Export Situation - The company's export of formulation products is in its early stages, with limited sales primarily in the U.S. market [6] - The company is strategically planning its export products based on various factors including market demand and entry barriers [6] Market Performance by Product Category - Gynecological products generated 310 million in sales, down from 340 million last year, with a notable decrease in sales of progesterone capsules [7] - Respiratory products achieved 600 million in sales, a 15% increase year-on-year, while sales of tiotropium bromide inhalation powder declined by 32% [8] Company Collaboration - Italian Newchem company reported stable revenue of approximately 434 million in the first quarter, maintaining collaboration with Xianju [9] - The company is enhancing production processes and exploring new markets to support future growth [9] Product Approval Status - The company submitted a New Drug Application for Omecamtiv Mecarbil injection in September 2024, currently in the review process [10]

Core Viewpoint - In 2024, the company achieved revenue of 4 billion yuan, a slight year-on-year decline, while net profit attributable to shareholders was significantly impacted by a fine related to sodium dexamethasone sales, with a stable growth in non-recurring net profit [1][2][3] - The impact of centralized procurement on the formulation segment has been largely digested, and new products are continuously being introduced, with expectations for accelerated growth in 2025 [1][4] - Revenue from the raw materials segment declined due to inventory destocking by overseas clients and price decreases, but sales volume remains stable, with a positive outlook for gradual recovery [1][5] Financial Performance - In 2024, the company reported operating revenue of 4.001 billion yuan, a year-on-year decrease of 2.98%, and a net profit attributable to shareholders of 397 million yuan, down 29.46% [2][3] - The non-recurring net profit for 2024 was 549 million yuan, reflecting a year-on-year increase of 2.15% [2][3] - For Q1 2025, the company achieved operating revenue of 1.01 billion yuan, a year-on-year decline of 2.9%, with a net profit of 140 million yuan, down 4.7% [2][3] Formulation Segment - In 2024, the formulation sales revenue reached 2.276 billion yuan, an increase of 8% year-on-year [4] - Key therapeutic areas showed varied performance, with gynecology and family planning sales at 450 million yuan, stable year-on-year; anesthetic muscle relaxants at 160 million yuan, up 55%; respiratory products at 880 million yuan, up 31%; and dermatology products at 230 million yuan, up 19% [4] - The company’s new products are expected to accelerate growth, with significant sales increases in new offerings such as sodium glucosamine injection [4][6] Raw Materials Segment - In 2024, revenue from raw materials and intermediates was 1.55 billion yuan, a year-on-year decline of 13% [5] - The decline was attributed to inventory destocking in the international market and increased competition leading to price drops [5][6] - The company is expected to see a recovery in the raw materials segment as prices stabilize and market share increases [5][6] Expense Analysis - In 2024, the company's sales, management, and R&D expense ratios were 25.84%, 7.74%, and 6.63%, respectively, with slight increases year-on-year [7] - The gross margin improved to 57.49%, up 4.61 percentage points, attributed to the clearing of centralized procurement impacts and operational efficiency [7] - The net profit margin was 10%, significantly impacted by a fine provision of 195 million yuan [7] Future Outlook - The company is expected to achieve stable growth in revenue and profit in 2025, with non-centralized procurement products anticipated to grow steadily [8] - Revenue projections for 2025-2027 are 4.35 billion, 4.81 billion, and 5.48 billion yuan, with year-on-year growth rates of 8.6%, 10.7%, and 13.8% respectively [8]