Group 1 - The core viewpoint of the article is that He Yuan Bio has established a commercial partnership with China National Pharmaceutical Group (Sinopharm) and other distributors to enhance its market presence and product promotion [1] - He Yuan Bio has signed distribution agreements with multiple pharmaceutical distributors, including Sinopharm and Betta Pharmaceuticals, completing a sales network layout across over 30 provinces and cities in China [1] - Sinopharm acts as a commercial partner for He Yuan Bio in specific regions, focusing on academic promotion, market expansion, and channel development to jointly enhance product market coverage and clinical application [1]

Group 1 - The core viewpoint of the article highlights the collaboration between He Yuan Bio and China National Pharmaceutical Group (Sinopharm) as a commercial partner in specific regions, focusing on product promotion and market expansion [1] - He Yuan Bio has established a sales network across more than 30 provinces and cities in China through agreements with multiple distributors, including Sinopharm and Betta Pharmaceuticals [1] - The company is actively engaged in academic promotion, market development, and channel construction with Sinopharm to enhance product market coverage and clinical application [1]

Core Points - The Shenzhen-Hong Kong Stock Connect Medical Index (HKD) closed at 4433.77 points, down 0.69%, with a trading volume of 6.716 billion HKD and a turnover rate of 0.73% [1] - Among the index constituents, 18 stocks rose while 39 stocks fell, with Global Medical leading the gainers at 3.66% and Health Road leading the decliners at 6.35% [1] Index Constituents Summary - The top ten constituents of the Shenzhen-Hong Kong Stock Connect Medical Index include: - Mindray Medical (14.56% weight, latest price 200.62, market cap 243.24 billion) [1] - Yier Eye Hospital (11.62% weight, latest price 11.50, market cap 107.24 billion) [1] - Lejin Medical (4.85% weight, latest price 15.74, market cap 29.01 billion) [1] - Aimeike (4.80% weight, latest price 145.06, market cap 43.89 billion) [1] - Yuyue Medical (4.66% weight, latest price 35.82, market cap 35.91 billion) [1] - Yingke Medical (3.64% weight, latest price 42.40, market cap 27.78 billion) [1] - Furuide (3.59% weight, latest price 67.36, market cap 17.85 billion) [1] - Meinian Health (3.58% weight, latest price 5.21, market cap 20.39 billion) [1] - Sinopharm (3.35% weight, latest price 18.63, market cap 58.14 billion) [1] - Ping An Good Doctor (2.63% weight, latest price 13.39, market cap 28.93 billion) [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled 83.77 million HKD, while retail investors saw a net inflow of 61.08 million HKD [1] - Specific stock capital flows include: - Mindray Medical: main fund net inflow of 37.11 million, retail net outflow of 4.23 million [2] - Yuyue Medical: main fund net inflow of 3.70 million, retail net inflow of 4.71 million [2] - Over the past 10 days, one stock was newly added to the index [2]

Personnel Changes - Yunnan Baiyao announced the election of Zhang Wenxue as chairman and Dong Ming as vice chairman during the first meeting of the 11th board of directors on November 10, 2025 [2] - China National Pharmaceutical Group (Sinopharm) reported the resignation of Zhao Bingxiang from multiple positions, including non-executive director and chairman, with Jin Bin proposed as the new chairman [3] - Huatai Medical announced a board restructuring, nominating several candidates for its third board of directors, including current executives from Mindray Medical [4] - Hanyu Pharmaceutical reported the retirement of its executive director Pinxiang Yu and appointed two new executive directors, Shen Yaping and Tang Yangming [5] - GSK China appointed Sheng Feng as vice president, responsible for market access and commercial operations, effective December 1, 2025 [12] Executive Appointments - Medtronic appointed Larry Xu as vice president for orthopedic and neurosurgery business in China, effective November 10, 2025 [9] - Pfizer China announced the appointment of Su Tianyu as head of the broad market division, effective immediately [10][11] - Eli Lilly appointed Carole Ho as president of the neuroscience division, while Adrienne Brown was promoted to president of the immunology division [15] - Restore Medical appointed Chris Cleary, former senior vice president at Medtronic, as chairman of the board [18] Resignations - Johnson & Johnson announced the departure of Alex He, vice president and head of the PINS division, effective December 31, 2025 [8] - Several executives across various companies, including Chen Changbing from Sinopharm United and Wang Junbo from Guangyu Yuan, submitted their resignations due to work adjustments [3][5]

Core Points - Zhao Bingxiang has resigned from his position as Chairman of Sinopharm Holdings after 14 months due to work arrangement reasons [2][3] - Jin Bin, a veteran from the Sinopharm system, will succeed Zhao as Chairman, with Li Ying also proposed as a non-executive director [3] - Sinopharm Holdings is a subsidiary of China National Pharmaceutical Group and a leading player in China's pharmaceutical distribution industry [3] Financial Performance - In the first half of 2024, Sinopharm Holdings reported total revenue of 294.73 billion yuan, a year-on-year decrease of 2.07% [4] - The medical device distribution and retail businesses experienced revenue declines of 7.08% and 6.43%, respectively, while the pharmaceutical distribution business saw a slight revenue increase of 0.47% [4] - The company's net profit attributable to shareholders fell by 9.76% to 3.704 billion yuan due to declining revenue and lower gross margins [4] Strategic Initiatives - Zhao emphasized the importance of innovation and service transformation in the company's annual report, aiming to enhance profitability and value [4] - The company is focusing on strengthening its service-oriented business models, including marketing services, third-party logistics, and private label manufacturing [4] - In the first half of 2025, the company continued to face revenue and profit declines, with a reported revenue of 286 billion yuan, down 2.95% year-on-year [5]

Core Points - The Shenzhen-Hong Kong Medical Index (983035) closed at 4554.17 points, up 0.2%, with a trading volume of 7.409 billion yuan and a turnover rate of 0.81% [1] - Among the index constituents, 38 stocks rose while 17 fell, with Yidu Technology leading the gainers at 3.5% and Mylab leading the decliners at 4.98% [1] Index Constituents Summary - The top ten constituents of the Shenzhen-Hong Kong Medical Index include: - Mindray Medical (sz300760) with a weight of 14.56% and a latest price of 201.62, down 1.17% [1] - Aier Eye Hospital (sz300015) with a weight of 11.62% and a latest price of 11.57, up 0.61% [1] - Lepu Medical (sz300003) with a weight of 4.85% and a latest price of 16.00, up 0.38% [1] - Aimeike (sz300896) with a weight of 4.80% and a latest price of 146.00, up 0.43% [1] - Yuyue Medical (sz002223) with a weight of 4.66% and a latest price of 36.25, up 1.54% [1] - Yingke Medical (sz300677) with a weight of 3.64% and a latest price of 43.48, up 0.95% [1] - Furuide (sz300049) with a weight of 3.59% and a latest price of 69.38, up 2.53% [1] - Meinian Health (sz002044) with a weight of 3.58% and a latest price of 5.27, down 1.50% [1] - Sinopharm (hk01099) with a weight of 3.35% and a latest price of 18.58, up 2.00% [1] - Ping An Good Doctor (hk01833) with a weight of 2.63% and a latest price of 13.53, up 1.22% [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled 172 million yuan, while retail funds saw a net inflow of approximately 84.92 million yuan [3] - Notable capital flows include: - Sanbo Brain Science (301293) with a main fund net inflow of 26.77 million yuan [3] - Ruimait (301367) with a main fund net inflow of 16.21 million yuan [3] - Chutian Technology (300358) with a main fund net inflow of 11.20 million yuan [3] - The index constituents underwent an adjustment with one new stock added in the last ten days [3]

Policy Developments - The National Healthcare Security Administration exposed a healthcare fraud industry chain in Shanghai, leading to the prosecution of an individual for fraud, resulting in significant losses to the national healthcare fund [1] - The crackdown on healthcare fraud has become more systematic and normalized in recent years, highlighting the importance of protecting the healthcare fund [1] Drug and Device Approvals - Anglicon received a drug registration certificate for Ertugliflozin Metformin Extended-Release Tablets, aimed at improving blood sugar control in adults with type 2 diabetes [2] - Betta Pharmaceuticals announced that its application for the marketing authorization of Ensartinib Capsules for treating ALK-positive non-small cell lung cancer has been accepted by the European Medicines Agency [3] - Innovent Biologics received approval for its IL-23p19 monoclonal antibody for the treatment of moderate to severe plaque psoriasis in adults [4] - Warner Pharmaceuticals obtained a drug registration certificate for Formoterol Fumarate Inhalation Solution, intended for the maintenance treatment of COPD [5] - Shanghai Pharmaceuticals announced that its Tramadol Hydrochloride Injection passed the consistency evaluation for generic drugs, which may enhance its market competitiveness [6] Major Industry Events - Biontech received a milestone payment of $250 million from Bristol-Myers Squibb related to the Iza-bren project, with potential for additional payments based on future milestones [7] - Jining Pharmaceutical plans to invest 893 million yuan in a hospital expansion project to meet the growing health demands in the region [8] - Maiwei Biotech completed Phase IIa clinical trials for its innovative drug 9MW1911 in COPD patients, showing significant reductions in acute exacerbation rates [9] Shareholder Actions - Sanofi Biotech announced plans for shareholders to reduce their holdings by a total of 0.0240% of shares due to personal financial needs [10] Management Changes - Sinopharm Holdings announced management changes, including the resignation of several executives and the appointment of new leadership, which will take effect upon shareholder approval [11]

Core Viewpoint - China National Pharmaceutical Group (国药控股) announced the resignation of key board members and the appointment of new directors, indicating a significant leadership change within the company [1] Group 1: Resignations - Mr. Zhao Bingxiang has resigned from multiple positions including non-executive director, chairman of the board, and various committee roles effective from the date of appointment of his successors at the shareholders' meeting [1] - Ms. Feng Rongli has also resigned from her roles as non-executive director and committee member, with her resignation effective upon the appointment of her successor [1] Group 2: Appointments - The board has proposed the appointment of Mr. Jin Bin and Ms. Li Ying as non-executive directors [1] - Mr. Jin has been elected as chairman and authorized representative, pending shareholder approval for his non-executive director appointment [1] - Mr. Jin will also serve as the chairman of the nomination committee, strategic and investment committee, and as a member of the legal compliance and environmental, social, and governance committee, subject to shareholder approval [1]

Core Viewpoint - China National Pharmaceutical Group (国药控股) announced the resignation of key board members and the appointment of new directors, indicating a significant leadership change within the company [1] Group 1: Resignations - Mr. Zhao Bingxiang has resigned from multiple positions including non-executive director, chairman of the board, and various committee roles effective from November 28, 2025 [1] - Ms. Feng Rongli has also resigned from her roles as non-executive director and committee member effective from the same date [1] Group 2: Appointments - The board has proposed the appointment of Mr. Jin Bin and Ms. Li Ying as non-executive directors [1] - Mr. Jin Bin is set to be elected as chairman and authorized representative of the board, pending shareholder approval at the upcoming general meeting [1] - Mr. Jin will also take on roles as chairman of the nomination committee, strategic and investment committee, and member of the legal compliance and environmental, social, and governance committee, subject to shareholder approval [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致之任何損失承擔任何責任。 公告 （1） 建議更换非執行董事、董事長及授權代表； （2） 董事委員會組成變更；及 （3） 暫停辦理股份過戶登記 （1）建議更換非執行董事、董事長及授權代表 非執行董事、董事長及授權代表辭任 國藥控股股份有限公司（「本公司」）董事（「董事」）會（「董事會」）謹此宣佈，由 於工作安排原因，於 2025 年 11 月 28 日，趙炳祥先生（「趙先生」）已向董事會提出辭任 非執行董事、董事會董事長（「董事長」）、董事會提名委員會（「提名委員會」）主席、 董事會戰略與投資委員會（「戰略與投資委員會」）主席、董事會法律合規與環境、社會 及治理委員會（「法律合規與環境、社會及治理委員會」）委員及本公司授權代表（根據 香港聯合交易所有限公司證券上市規則（「上市規則」）第 3.05 條規定）（「授權代表」） 職務；馮蓉麗女士（「馮女士」）已向董事會提出辭任非執行董事、董事會薪酬委員會委 員及提名委員會委員職務，上述辭 ...