Core Points - The Shenzhen-Hong Kong Medical Index (983035) closed at 4554.17 points, up 0.2%, with a trading volume of 7.409 billion yuan and a turnover rate of 0.81% [1] - Among the index constituents, 38 stocks rose while 17 fell, with Yidu Technology leading the gainers at 3.5% and Mylab leading the decliners at 4.98% [1] Index Constituents Summary - The top ten constituents of the Shenzhen-Hong Kong Medical Index include: - Mindray Medical (sz300760) with a weight of 14.56% and a latest price of 201.62, down 1.17% [1] - Aier Eye Hospital (sz300015) with a weight of 11.62% and a latest price of 11.57, up 0.61% [1] - Lepu Medical (sz300003) with a weight of 4.85% and a latest price of 16.00, up 0.38% [1] - Aimeike (sz300896) with a weight of 4.80% and a latest price of 146.00, up 0.43% [1] - Yuyue Medical (sz002223) with a weight of 4.66% and a latest price of 36.25, up 1.54% [1] - Yingke Medical (sz300677) with a weight of 3.64% and a latest price of 43.48, up 0.95% [1] - Furuide (sz300049) with a weight of 3.59% and a latest price of 69.38, up 2.53% [1] - Meinian Health (sz002044) with a weight of 3.58% and a latest price of 5.27, down 1.50% [1] - Sinopharm (hk01099) with a weight of 3.35% and a latest price of 18.58, up 2.00% [1] - Ping An Good Doctor (hk01833) with a weight of 2.63% and a latest price of 13.53, up 1.22% [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled 172 million yuan, while retail funds saw a net inflow of approximately 84.92 million yuan [3] - Notable capital flows include: - Sanbo Brain Science (301293) with a main fund net inflow of 26.77 million yuan [3] - Ruimait (301367) with a main fund net inflow of 16.21 million yuan [3] - Chutian Technology (300358) with a main fund net inflow of 11.20 million yuan [3] - The index constituents underwent an adjustment with one new stock added in the last ten days [3]

Policy Developments - The National Healthcare Security Administration exposed a healthcare fraud industry chain in Shanghai, leading to the prosecution of an individual for fraud, resulting in significant losses to the national healthcare fund [1] - The crackdown on healthcare fraud has become more systematic and normalized in recent years, highlighting the importance of protecting the healthcare fund [1] Drug and Device Approvals - Anglicon received a drug registration certificate for Ertugliflozin Metformin Extended-Release Tablets, aimed at improving blood sugar control in adults with type 2 diabetes [2] - Betta Pharmaceuticals announced that its application for the marketing authorization of Ensartinib Capsules for treating ALK-positive non-small cell lung cancer has been accepted by the European Medicines Agency [3] - Innovent Biologics received approval for its IL-23p19 monoclonal antibody for the treatment of moderate to severe plaque psoriasis in adults [4] - Warner Pharmaceuticals obtained a drug registration certificate for Formoterol Fumarate Inhalation Solution, intended for the maintenance treatment of COPD [5] - Shanghai Pharmaceuticals announced that its Tramadol Hydrochloride Injection passed the consistency evaluation for generic drugs, which may enhance its market competitiveness [6] Major Industry Events - Biontech received a milestone payment of $250 million from Bristol-Myers Squibb related to the Iza-bren project, with potential for additional payments based on future milestones [7] - Jining Pharmaceutical plans to invest 893 million yuan in a hospital expansion project to meet the growing health demands in the region [8] - Maiwei Biotech completed Phase IIa clinical trials for its innovative drug 9MW1911 in COPD patients, showing significant reductions in acute exacerbation rates [9] Shareholder Actions - Sanofi Biotech announced plans for shareholders to reduce their holdings by a total of 0.0240% of shares due to personal financial needs [10] Management Changes - Sinopharm Holdings announced management changes, including the resignation of several executives and the appointment of new leadership, which will take effect upon shareholder approval [11]

Core Viewpoint - China National Pharmaceutical Group (国药控股) announced the resignation of key board members and the appointment of new directors, indicating a significant leadership change within the company [1] Group 1: Resignations - Mr. Zhao Bingxiang has resigned from multiple positions including non-executive director, chairman of the board, and various committee roles effective from the date of appointment of his successors at the shareholders' meeting [1] - Ms. Feng Rongli has also resigned from her roles as non-executive director and committee member, with her resignation effective upon the appointment of her successor [1] Group 2: Appointments - The board has proposed the appointment of Mr. Jin Bin and Ms. Li Ying as non-executive directors [1] - Mr. Jin has been elected as chairman and authorized representative, pending shareholder approval for his non-executive director appointment [1] - Mr. Jin will also serve as the chairman of the nomination committee, strategic and investment committee, and as a member of the legal compliance and environmental, social, and governance committee, subject to shareholder approval [1]

Core Viewpoint - China National Pharmaceutical Group (国药控股) announced the resignation of key board members and the appointment of new directors, indicating a significant leadership change within the company [1] Group 1: Resignations - Mr. Zhao Bingxiang has resigned from multiple positions including non-executive director, chairman of the board, and various committee roles effective from November 28, 2025 [1] - Ms. Feng Rongli has also resigned from her roles as non-executive director and committee member effective from the same date [1] Group 2: Appointments - The board has proposed the appointment of Mr. Jin Bin and Ms. Li Ying as non-executive directors [1] - Mr. Jin Bin is set to be elected as chairman and authorized representative of the board, pending shareholder approval at the upcoming general meeting [1] - Mr. Jin will also take on roles as chairman of the nomination committee, strategic and investment committee, and member of the legal compliance and environmental, social, and governance committee, subject to shareholder approval [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致之任何損失承擔任何責任。 公告 （1） 建議更换非執行董事、董事長及授權代表； （2） 董事委員會組成變更；及 （3） 暫停辦理股份過戶登記 （1）建議更換非執行董事、董事長及授權代表 非執行董事、董事長及授權代表辭任 國藥控股股份有限公司（「本公司」）董事（「董事」）會（「董事會」）謹此宣佈，由 於工作安排原因，於 2025 年 11 月 28 日，趙炳祥先生（「趙先生」）已向董事會提出辭任 非執行董事、董事會董事長（「董事長」）、董事會提名委員會（「提名委員會」）主席、 董事會戰略與投資委員會（「戰略與投資委員會」）主席、董事會法律合規與環境、社會 及治理委員會（「法律合規與環境、社會及治理委員會」）委員及本公司授權代表（根據 香港聯合交易所有限公司證券上市規則（「上市規則」）第 3.05 條規定）（「授權代表」） 職務；馮蓉麗女士（「馮女士」）已向董事會提出辭任非執行董事、董事會薪酬委員會委 員及提名委員會委員職務，上述辭 ...

Core Points - The Shenzhen-Hong Kong Medical Index (983035) closed at 4494.42 points, up 0.15%, with a trading volume of 7.52 billion yuan and a turnover rate of 0.75% [1] - Among the index constituents, 32 stocks rose while 24 fell, with Medical Pulse leading the gainers at 3.65% and Health Road leading the decliners at 3.41% [1] Index Constituents Summary - The top ten constituents of the Shenzhen-Hong Kong Medical Index include: - Mindray Medical (14.56% weight, latest price 196.30 yuan, market cap 238 billion yuan, up 1.50%) [1] - Yier Eye Hospital (11.62% weight, latest price 11.40 yuan, market cap 106.31 billion yuan, down 0.26%) [1] - Lejin Medical (4.85% weight, latest price 15.87 yuan, market cap 29.26 billion yuan, up 0.13%) [1] - Aimeike (4.80% weight, latest price 146.26 yuan, market cap 44.26 billion yuan, up 0.83%) [1] - Yuyue Medical (4.66% weight, latest price 35.70 yuan, market cap 35.79 billion yuan, down 0.67%) [1] - Yingke Medical (3.64% weight, latest price 41.53 yuan, market cap 27.21 billion yuan, up 1.94%) [1] - Furuide (3.59% weight, latest price 67.08 yuan, market cap 17.78 billion yuan, up 1.36%) [1] - Meinian Health (3.58% weight, latest price 5.28 yuan, market cap 20.67 billion yuan, down 1.68%) [1] - Sinopharm (3.35% weight, latest price 18.42 yuan, market cap 57.48 billion yuan, down 0.69%) [1] - Ping An Good Doctor (2.63% weight, latest price 13.66 yuan, market cap 29.52 billion yuan, down 1.83%) [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled 58.83 million yuan, while retail investors saw a net inflow of 78.07 million yuan [1] - Specific stock capital flows include: - Aimeike: Main fund net inflow of 46.99 million yuan, retail net outflow of 30.07 million yuan [2] - Mindray Medical: Main fund net inflow of 33.08 million yuan, retail net outflow of 17.11 million yuan [2] - Furuide: Main fund net inflow of 13.68 million yuan, retail net outflow of 19.08 million yuan [2] Recent Adjustments - The Shenzhen-Hong Kong Medical Index has undergone adjustments in the last 10 days, with one new stock added [2]

Core Insights - The Shenzhen-Hong Kong Stock Connect Medical Index (983036) closed at 4391.58 points, up 0.14%, with a trading volume of HKD 8.259 billion and a turnover rate of 0.75% [1] - Among the index constituents, 32 stocks rose while 24 fell, with Mai Rui Medical leading the gainers at 3.65% and Jian Kang Zhi Lu leading the decliners at 3.41% [1] Index Constituents Summary - The top ten constituents of the Shenzhen-Hong Kong Stock Connect Medical Index are as follows: - Mai Rui Medical (sz300760) holds a weight of 14.56%, latest price at HKD 196.30, with a market cap of HKD 238 billion and a gain of 1.50% [1] - Yan Er Eye Hospital (sz300015) has a weight of 11.62%, latest price at HKD 11.40, with a market cap of HKD 106.31 billion and a decline of 0.26% [1] - Le Jin Medical (sz300003) has a weight of 4.85%, latest price at HKD 15.87, with a market cap of HKD 2.93 billion and a slight gain of 0.13% [1] - Ai Mei Ke (sz300896) has a weight of 4.80%, latest price at HKD 146.26, with a market cap of HKD 44.26 billion and a gain of 0.83% [1] - Yu Yue Medical (sz002223) has a weight of 4.66%, latest price at HKD 35.70, with a market cap of HKD 35.79 billion and a decline of 0.67% [1] - Ying Ke Medical (sz300677) has a weight of 3.64%, latest price at HKD 41.53, with a market cap of HKD 27.21 billion and a gain of 1.94% [1] - Fu Rui Co., Ltd. (sz300049) has a weight of 3.59%, latest price at HKD 67.08, with a market cap of HKD 17.78 billion and a gain of 1.36% [1] - Mei Nian Health (sz002044) has a weight of 3.58%, latest price at HKD 5.28, with a market cap of HKD 20.67 billion and a decline of 1.68% [1] - China National Pharmaceutical (hk01099) has a weight of 3.35%, latest price at HKD 18.42, with a market cap of HKD 57.48 billion and a decline of 0.69% [1] - Ping An Good Doctor (hk01833) has a weight of 2.63%, latest price at HKD 13.66, with a market cap of HKD 29.52 billion and a decline of 1.83% [1] Capital Flow Analysis - The net outflow of main funds from the index constituents totaled HKD 58.83 million, while retail investors saw a net inflow of HKD 78.07 million [1] - The detailed capital flow for the top stocks shows: - Ai Mei Ke (300896) had a main fund net inflow of HKD 46.99 million but a retail net outflow of HKD 30.07 million [2] - Mai Rui Medical (300760) experienced a main fund net inflow of HKD 33.08 million with retail outflows [2] - Other stocks like Fu Rui Co., Ltd. (300049) and Li Bang Instruments (300206) also showed mixed capital flows with net inflows from main funds but outflows from retail investors [2] Recent Adjustments - In the past 10 days, there has been an adjustment in the Shenzhen-Hong Kong Stock Connect Medical Index, with one new stock added [2]

Core Insights - JPMorgan Chase & Co. increased its stake in China National Pharmaceutical Group Corporation (国药控股) by acquiring 2,104,841 shares at an average price of HKD 20.1147 per share, totaling approximately HKD 42.34 million [1] - Following this acquisition, JPMorgan's total holdings in the company rose to 67,182,181 shares, representing an increase in ownership from 4.84% to 5.00% [1] Summary by Categories Shareholding Changes - JPMorgan Chase & Co. acquired an additional 2,104,841 shares of China National Pharmaceutical Group [1] - The average purchase price was HKD 20.1147 per share, amounting to a total investment of about HKD 42.34 million [1] - The new total shareholding of JPMorgan in the company is 67,182,181 shares, increasing its ownership percentage to 5.00% [1]

Group 1 - Morgan Stanley increased its stake in China National Pharmaceutical Group (01099) by 2,104,841 shares at a price of HKD 20.1147 per share, totaling approximately HKD 42.3382 million [1] - After the increase, the total number of shares held by Morgan Stanley is approximately 67,182,200, representing a holding percentage of 5% [1]

Group 1 - Morgan Stanley increased its stake in China National Pharmaceutical Group (01099) by 2,104,841 shares at a price of HKD 20.1147 per share, totaling approximately HKD 42.34 million [1] - After the increase, Morgan Stanley's total shareholding in China National Pharmaceutical Group is approximately 67,182,200 shares, representing a 5% ownership stake [1]