Core Viewpoint - The innovative drug sector in A-shares has experienced significant value reassessment in 2023, with the innovative drug index rising over 70% year-to-date, driven by favorable policies and major transactions in the industry [3][4]. Group 1: Market Performance - On July 28, 2023, Heng Rui Medicine announced a potential deal worth $12 billion (approximately 86 billion RMB) with GlaxoSmithKline, leading to a surge in its stock price, which hit a four-year high with a market cap of 411.8 billion RMB [3]. - The innovative drug sector saw a collective increase of over 3% on the same day, reflecting strong investor sentiment [3]. Group 2: Policy Support - The National Healthcare Security Administration and the National Health Commission released measures on July 1, 2023, to support the high-quality development of innovative drugs, including the establishment of a diversified payment system and improving accessibility [3]. - A press conference on July 24, 2023, indicated a shift in drug procurement policies, moving away from a simple lowest price reference to promote healthier industry development [3]. Group 3: Fund Performance - All 265 innovative drug-themed funds reported positive returns in 2023, with 152 funds achieving returns over 30%, and the highest return exceeding 80% [4]. - The top-performing fund in the 1 million to 10 million RMB category is the Hua Bao Health Mixed A fund, with a return of 82.55% year-to-date [5][6]. - In the 1 billion to 5 billion RMB category, the Chang Cheng Health Mixed A fund led with a return of 74.64% [7]. - The Peng Hua Medical Technology Stock A fund topped the 5 billion to 20 billion RMB category with a return of 81.85% [8][9]. - The top fund in the 20 billion RMB and above category is the Zhong Ou Medical Innovation Stock A fund, achieving a return of 58.65% [10][11].

Summary of Key Points from the Conference Call Industry Overview - The Chinese innovative pharmaceutical industry is experiencing a significant enhancement in strength, with its share of global first-in-class drugs increasing to 19% [7] - Multinational corporations (MNCs) are facing a severe patent cliff, with major companies like Merck, AbbVie, and BMS having over 60%, 58%, and 69% of their 2024 revenues coming from drugs facing patent expiration within the next five years [8][9] - MNCs are actively seeking business development (BD) transactions to address these challenges, with strong cash reserves available for such activities [10] Business Development Trends - The trend of Chinese innovative drugs going global is robust, driven by the strengthening capabilities of Chinese companies and the impending patent cliffs faced by MNCs [2] - MNCs are expected to engage in more BD transactions, particularly in the second half of 2025 and into 2026, as they seek to replenish their pipelines [2] Oncology Sector Insights - The oncology field is shifting from PD-1 combined with chemotherapy to next-generation immuno-oncology (IO) and antibody-drug conjugates (ADC) [3] - Potential MNC buyers in this space include AstraZeneca, Pfizer, and Merck, all of which are looking to enhance their portfolios with next-generation IO and ADC assets [3] Metabolic Disease Developments - The metabolic field is evolving from merely focusing on weight loss to comprehensive metabolic management, including fat reduction and muscle preservation [4][5] - Companies like Novo Nordisk and AstraZeneca are exploring oral medications and multi-target approaches in this area [4] Immune and Inflammatory Disease Innovations - New directions in the immune and inflammation sector include novel targets and engineering innovations, with significant investments from companies like AbbVie and Sanofi [6] - Emerging targets such as TL1a are attracting substantial investments, indicating a strong interest in this area [20] Market Position of Chinese Innovative Drugs - Chinese innovative drug companies have made significant strides in global markets, with improved clinical data quality and increased academic recognition [7] - The presence of Chinese companies in the oncology sector is growing, with several projects in advanced stages of development [14] MNC Strategies for BD Transactions - MNCs are focusing on four main strategies for BD transactions: consolidating core areas, entering new fields, exploring opportunities, and investigating new technologies [11] - The willingness of MNCs to invest in promising assets at the preclinical stage is evident, particularly in high-potential areas like TL1a [20] ADC and TCE Technology Developments - The ADC field is characterized by a tiered approach, with MNCs diversifying their portfolios across various targets [15] - T-cell engagers (TCE) are being developed for blood cancers and autoimmune diseases, with ongoing clinical trials showing promising results [16] Conclusion - The ongoing trends in the Chinese pharmaceutical industry, coupled with the challenges faced by MNCs, are creating a fertile ground for increased collaboration and investment opportunities in the global market [29]

Core Viewpoint - Southbound capital has significantly increased its investment in the Hong Kong stock market this year, leading to a historical net inflow of over 840 billion HKD, surpassing previous records and contributing to a strong performance in the market [1][2]. Group 1: Southbound Capital Inflows - As of July 29, 2023, southbound capital has recorded a cumulative net inflow of 8420.02 billion HKD, marking a historical high for the year and more than double the inflow of the same period in 2024 [1][2]. - The daily net inflow peaked on April 9, 2023, with 355.86 billion HKD, setting a record for single-day inflows [1]. - In 135 trading days this year, there were net inflow days on 114 occasions, accounting for over 80% of the trading days [1]. Group 2: Market Performance - The Hang Seng Index has risen over 27% year-to-date, while the Hang Seng Technology Index has increased by over 26% [1][3]. - Major stocks with market capitalizations exceeding 1 trillion HKD have all seen gains, with Xiaomi Group-W up over 60% and Tencent Holdings up over 34% [1][4]. - The Hong Kong stock market has outperformed major global markets, with the Hang Seng Index, Hang Seng China Enterprises Index, and Hang Seng Technology Index showing respective increases of 27.24%, 25.46%, and 26.33% [3]. Group 3: Sector and Stock Performance - Southbound capital has heavily invested in the financial, information technology, and consumer discretionary sectors, with holdings valued at 14517.43 billion HKD, 11115.84 billion HKD, and 7175.67 billion HKD respectively [2][3]. - Notable individual stock holdings include Tencent Holdings at over 5400 billion HKD, and other significant investments in China Mobile, Xiaomi Group-W, and Alibaba-W, each exceeding 2000 billion HKD [2][3]. Group 4: Valuation and Future Outlook - The rolling P/E ratio of the Hang Seng Index has increased to 10.49 times, up from 8.96 times at the beginning of the year, indicating a rise in market valuation [5][6]. - Analysts predict that southbound capital inflows could exceed 1 trillion HKD for the year, although the pace may slow in the second half [6][7]. - The overall market sentiment remains positive, with expectations of continued upward movement supported by improved fundamentals and ongoing capital inflows [6][7].

Group 1 - The core viewpoint of the news highlights the strong performance of the Hong Kong innovative drug sector, with specific stocks like China Biologic Products leading the gains [1][5] - China Biologic Products' subsidiary, Lixin Pharmaceutical, received FDA approval for its innovative drug LM-350 "CDH17ADC," indicating significant potential for future growth [2][3] - The Hong Kong Stock Connect Innovative Drug ETF (520880) has shown a year-to-date increase of 58.95%, outperforming other indices significantly [5][6] Group 2 - Analysts from Zhongyin International expect China Biologic Products to have 1 to 2 licensing deals become more visible, reflecting the company's growth potential in the global market [3] - Huachuang Securities noted that China Biologic Products is innovating across four major fields: oncology, respiratory diseases, liver diseases, and surgical/pain management, which could lead to a second growth curve starting in 2025 [3] - The Hong Kong Stock Connect Innovative Drug ETF passively tracks the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which focuses on the innovative drug industry chain, with the top ten constituent stocks accounting for 75.85% of the index weight [3][4]

Core Viewpoint - The Hang Seng Healthcare Index (HSHCI) has shown positive performance, with significant increases in constituent stocks, indicating a favorable market environment for healthcare investments [3][4]. Group 1: Market Performance - As of July 28, 2025, the HSHCI rose by 0.64%, with notable gains from stocks such as MicroPort Medical (up 9.51%) and Eddy Health Holdings (up 3.93%) [3]. - The Hang Seng Healthcare ETF (513060) opened higher, increasing by 1.22% to a latest price of 0.66 yuan, and has accumulated a 0.92% rise over the past week [3]. - The ETF recorded a turnover of 0.79% during the trading session, with a transaction volume of 61.18 million yuan, and an average daily trading volume of 2.815 billion yuan over the past week, ranking first among comparable funds [3]. Group 2: Policy and Industry Outlook - The national procurement policy is expected to expand from pharmaceuticals to medical devices, potentially leading to performance reversals in high-value consumables and in vitro diagnostics sectors [4]. - The medical device sector is anticipated to benefit from a recovery in procurement activities this year, with expectations of an earnings turning point in the third quarter [4]. Group 3: ETF Performance Metrics - The latest size of the Hang Seng Healthcare ETF is 7.656 billion yuan, placing it in the top third among comparable funds [4]. - The ETF has seen a net value increase of 29.88% over the past two years, with a maximum monthly return of 28.34% since inception [4]. - The ETF's Sharpe ratio for the past year is 2.30, indicating strong risk-adjusted returns [4]. Group 4: Valuation and Tracking Accuracy - The HSHCI's latest price-to-earnings ratio (PE-TTM) is 31.72, which is below 84.29% of the historical data over the past three years, suggesting a low valuation [6]. - The ETF has the highest tracking accuracy among comparable funds, with a tracking error of 0.060% over the past year [6]. - The top ten weighted stocks in the HSHCI account for 60.54% of the index, including companies like BeiGene and WuXi Biologics [6].

Investment Rating - The report maintains a "Positive" outlook for the pharmaceutical and biotechnology industry in China [6]. Core Insights - Small nucleic acid drugs are expected to become the third major class of drugs after small molecules and antibodies, with unique advantages such as broad targets, strong specificity, high development efficiency, and long dosing intervals [9][38]. - The commercialization of rare diseases is maturing, and the long-term advantages for chronic diseases are becoming evident, with significant sales growth for products like Spinraza and Leqivo [9][60]. - There is a notable increase in business development (BD) activities, highlighting the potential of early-stage chronic disease pipelines [9]. Summary by Sections 1. Small Nucleic Acids: Potential as a New Drug Class - Small nucleic acid drugs, including ASO, siRNA, and Aptamer, interact with mRNA to regulate gene expression, offering a new technological pathway for drug development [13]. - The global market for small nucleic acid drugs has grown from $1.04 billion in 2017 to $5.09 billion in 2024, with a CAGR of 25.5% [60]. 2. Milestones in Overseas and Domestic Markets - In the overseas market, significant developments are expected in the TTR field and cardiovascular diseases, with drugs like Vutrisiran and Pelacarsen showing promise [9]. - In China, new therapies for chronic hepatitis B and competitive advancements in cardiovascular drugs are emerging, with several companies making progress in their pipelines [9][60]. 3. Investment Recommendations and Targets - The report suggests focusing on high-quality domestic companies involved in the development of small nucleic acid drugs targeting chronic hepatitis B and cardiovascular diseases, such as HengRui Medicine, China National Pharmaceutical Group, and others [9].

Core Viewpoint - China National Pharmaceutical Group is a leading innovative research and R&D-driven pharmaceutical group in China, with a focus on both generic and innovative drug development [1][2][3] Group 1: Financial Performance - Revenue is projected to grow from 23.647 billion yuan in 2020 to 28.866 billion yuan in 2024, while net profit remains stable due to increased investment in innovative drug R&D [1] - The revenue from chemical generics is expected to recover to 16.81 billion yuan in 2024, reflecting a growth of 3.1%, with the tenth batch of centralized procurement products accounting for only 1% of total revenue [1] Group 2: Innovation and Product Pipeline - The company has significantly increased its R&D pipeline, with the number of innovative products launched rising from 3 to 18 since 2022, including 9 innovative drugs [2] - The proportion of revenue from innovative products has increased from 12% in 2018 to 41.8% in 2024, with expectations to exceed 50% in 2025 and reach 60% by 2027 [2] Group 3: Strategic Goals and Market Position - The company aims to establish a strong global competitive position in oncology, respiratory, liver disease, and surgical/pain management, with plans for business development transactions to become a regular source of income starting in 2025 [3] - The projected revenues for 2025, 2026, and 2027 are 34.062 billion yuan, 36.602 billion yuan, and 39.674 billion yuan, respectively, with corresponding net profits of 3.932 billion yuan, 4.288 billion yuan, and 4.743 billion yuan [3]

Investment Rating - The report assigns a "Buy" rating for China Biopharmaceutical (01177.HK) with a target price of HKD 9.35, compared to the current price of HKD 6.71 [3][11]. Core Views - The company is expected to see a continuous increase in the proportion of innovative drugs, leading to a potential revaluation of its value [6][11]. - The company has a robust pipeline with over 90 innovative molecules in development, indicating significant growth potential [40][46]. - The transition from generic to innovative products is anticipated to enhance the company's revenue structure, with innovative product revenue expected to exceed 50% by 2025 and 60% by 2027 [9][11]. Financial Summary - Total revenue projections for 2024A, 2025E, 2026E, and 2027E are HKD 28,866 million, HKD 34,062 million, HKD 36,602 million, and HKD 39,674 million respectively, with year-on-year growth rates of 50.1%, 12.3%, 9.1%, and 10.6% [2]. - Net profit attributable to shareholders is projected to be HKD 3,500 million, HKD 3,932 million, HKD 4,288 million, and HKD 4,743 million for the same years, with corresponding growth rates of 50.1%, 12.3%, 9.1%, and 10.6% [2]. - The company’s earnings per share (EPS) is expected to increase from HKD 0.19 in 2024 to HKD 0.25 in 2027 [2]. Company Overview - China Biopharmaceutical is a leading innovative research and development-driven pharmaceutical group in China, with a history of being recognized among the top 50 global pharmaceutical companies [6][15]. - The company has successfully transitioned to a focus on innovation since 2018, increasing its number of innovative products from 3 to 18, including 9 innovative drugs [23][40]. - The company’s revenue from innovative products has significantly increased, from 12% in 2018 to 41.8% in 2024, with plans to further increase this proportion in the coming years [9][25]. Pipeline and Product Development - The company has a rich pipeline with over 90 innovative molecules, with plans to launch an average of 5 innovative products annually over the next three years [40][41]. - The company’s innovative products are expected to have global competitiveness, with a focus on areas such as oncology, respiratory diseases, liver diseases, and pain management [10][40]. - The company aims to establish out-licensing as a key strategic goal starting in 2025, which is expected to become a recurring source of income and profit [10][46].

Core Viewpoint - The company has received FDA approval for clinical trials of its self-developed anti-tumor drug LM-350 "CDH17ADC," which targets the mechanism of CDH17 in tumors, aiming to provide more effective treatment options for patients [1] Group 1 - The drug LM-350 "CDH17ADC" is designed to address the role of CDH17 in tumors [1] - The FDA's IND approval marks a significant milestone for the company's research and development efforts [1] - The new drug aims to enhance treatment efficacy for patients suffering from cancer [1]

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed with a gain of 1.95% on July 24, with a trading volume of 2.504 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of July 23, 2024, the fund's shares totaled 2.166 billion, with a total size of 3.863 billion yuan, reflecting a year-to-date increase of 447.94% in shares and 922.49% in size [1] Fund Performance - The current fund manager, Ma Jun, has managed the fund since its inception, achieving a return of 78.32% during the management period [2] - The fund's recent trading activity shows a cumulative trading amount of 41.889 billion yuan over the last 20 trading days, with an average daily trading amount of 2.094 billion yuan [1] - Year-to-date, the cumulative trading amount is 125.021 billion yuan, with an average daily trading amount of 0.926 billion yuan [1] Holdings Overview - Major holdings in the fund include: - Innovent Biologics (9.52% holding, 26 million yuan market value) - WuXi Biologics (9.47% holding, 25.8 million yuan market value) - BeiGene (8.73% holding, 23.8 million yuan market value) - CanSino Biologics (7.62% holding, 20.8 million yuan market value) - China National Pharmaceutical Group (7.17% holding, 19.6 million yuan market value) [2] - Other significant holdings include CSPC Pharmaceutical Group (6.34% holding) and Ascletis Pharma (2.86% holding) [2]