Group 1 - The core viewpoint of the reports indicates a recovery in domestic innovative drug research and development due to the resurgence of capital market financing and an increase in overseas transactions for innovative drugs [1] - The price of experimental monkeys, essential for innovative drug research, has risen from approximately 85,000 yuan in mid-2024 to about 90,000 yuan [1] - The CXO industry is expected to see performance recovery in the second half of 2025, driven by the continuous upward momentum of innovative drugs primarily from overseas partners pushing clinical pipelines [1] Group 2 - The report highlights a shift in global early-stage drug innovation research from Europe and the US to China, with multinational pharmaceutical companies increasingly sourcing innovative pipelines from Chinese biotech firms [1] - The proposed administrative order by the Trump administration to restrict the import of experimental treatments from China has sparked intense lobbying from two opposing groups: US biotech investors facing competition from Chinese innovations and large pharmaceutical companies benefiting from low-cost Chinese drugs [1] - The report emphasizes that the income and profit scale of large US pharmaceutical companies far exceed that of US biotech firms, suggesting they may have greater lobbying influence [1] Group 3 - The announcement of a 100% tariff on patented drugs unless pharmaceutical companies build factories in the US is expected to have a limited impact on the CXO sector, as many multinational companies already have plans to establish facilities in the US [2] - Significant investment plans have been announced by several multinational pharmaceutical companies for building factories and R&D facilities in the US, including Eli Lilly's $27 billion and Roche's $50 billion investments over the next five years [2] - The report notes that the construction of factories in the US typically takes over five years, and the progress may be affected by political and market uncertainties [2]

Group 1 - Tencent Holdings (00700) leads the net inflow with 2.642 billion, representing a 22.29% increase in share price [1][2] - Sunac China Holdings (00412) follows with a net inflow of 889 million, but its share price decreased by 6.00% [1][2] - SMIC (00981) has a net inflow of 684 million, with a share price increase of 5.72% [1][2] Group 2 - Hong Kong Exchanges and Clearing (00388) experiences the highest net outflow at -351 million, with a slight share price increase of 0.18% [1][2] - ZTE Corporation (00763) has a net outflow of -299 million, with a share price decrease of 0.18% [1][2] - China Biologic Products Holdings (01177) sees a net outflow of -210 million, with a share price decline of 1.72% [1][2] Group 3 - Weilu Group (01196) has the highest net inflow ratio at 68.77% [1][3] - Jiangsu Nanjing Highway (00177) follows with a net inflow ratio of 62.76% [1][3] - Air China (00753) ranks third with a net inflow ratio of 54.19% [1][3] Group 4 - Guangzhou-Shenzhen Railway (00525) has the highest net outflow ratio at -50.24% [1][3] - China Unicom (00762) follows with a net outflow ratio of -41.90% [1][3] - China Telecom (00728) ranks third with a net outflow ratio of -35.91% [1][3]

(Incorporated in the Cayman Islands with limited liability) （於開曼群島註冊成立之有限公司） （Stock Code 股份代號：1177） NOTIFICATION LETTER 通知信函 Dear Non-Registered Shareholders, Sino Biopharmaceutical Limited (the "Company") – Notice of publication of 2025 Interim Report (the "Current Corporate Communication") The English and Chinese versions of the Company's Current Corporate Communication are now available on the Company's website at www.sinobiopharm.com and the website of The Stock Exchange of Hong Kong Limited (the "Stock ...

(Incorporated in the Cayman Islands with limited liability) （於開曼群島註冊成立之有限公司） （Stock Code 股份代號：1177） NOTIFICATION LETTER 通知信函 Dear Registered Shareholders, 26 September 2025 Sino Biopharmaceutical Limited (the "Company") – Notice of publication of 2025 Interim Report (the "Current Corporate Communication") The English and Chinese versions of the Company's Current Corporate Communication are now available on the Company's website at www.sinobiopharm.com and the website of The Stock Exchange of Hong Kong Limit ...

SINO BIOPHARMACEUTICAL LIMITED ( 於開曼群島註冊成立之有限公司) (股票編號：1177) 中期報告 2025 Interim Report 2025 中期報告 公司資料 公司法定名稱 中國生物製藥有限公司 股票代號 1177 公司網址 www.sinobiopharm.com 公司註冊地點 開曼群島 主板上市日期 二零零三年十二月八日 創業板上市日期 二零零零年九月二十九日 董事 執行董事 謝其潤女士 （主席） 謝炳先生 （資深副主席） 鄭翔玲女士 （副主席） 謝承潤先生 （首席執行長） 謝炘先生 田舟山先生 獨立非執行董事 陸正飛先生 李大魁先生 魯紅女士 張魯夫先生 李國棟醫生 執行董事委員會 謝其潤女士 （主席） 謝炳先生 鄭翔玲女士 謝承潤先生 謝炘先生 審核委員會 陸正飛先生 （主席） 李大魁先生 魯紅女士 李國棟醫生 薪酬委員會 張魯夫先生 （主席） 陸正飛先生 魯紅女士 提名委員會 謝其潤女士 （主席） 謝炳先生 陸正飛先生 魯紅女士 張魯夫先生 李國棟醫生 環境、社會及管治委員會 鄭翔玲女士 （主席） 謝其潤女士 李國棟醫生 公司秘書 陳凱年先生 授權代表 謝炳 ...

Major Events - China Railway (00390) recently won bids for 11 major projects, with a total contract value of approximately 50.215 billion yuan [1] - China Communications Technology (03969) secured four important projects in the railway market from July to August [1] - Chow Tai Fook (00659) plans to issue convertible bonds worth 2.218 billion HKD, converting approximately 10% of shares in First Journey Holdings (00697) [1] - Shanghai Pharmaceuticals (02607) transferred 40% equity of Shanghai Pharmaceuticals Group to Shanghai Shansi for about 6.7215 billion yuan [1] - Tianjin Port Development (03382) plans to invest 95.403 million yuan to acquire 5% equity in Eurasia International [1] - Tianjin Port Development (03382) intends to acquire 40% equity in Alliance International for 723 million yuan, increasing its stake to 100% [1] - First Journey Holdings (00697) received investment from Beijing Robotics Fund in Quan Zhi Bo, continuing to increase investment in the robotics industry [1] - Boleton (01333) signed a strategic cooperation agreement with Mingyang Mining to promote the electrification and intelligence of mining transportation [1] - China Biopharmaceutical (01177) completed the first patient enrollment in the Phase I clinical trial of LM-350 "CDH17 ADC" in Australia [1] - Xinjiang Xinmin Mining (03833) proposed to issue A-shares [1] - Jihong Co., Ltd. (02603) expects a year-on-year increase of 55%-65% in net profit attributable to shareholders for the first three quarters [1] Buybacks and Shareholding Changes - Tencent Holdings (00700) repurchased 844,000 shares for 550 million HKD on September 25 [1] - Midea Group (00300) repurchased 2.0 billion yuan worth of 2.7455 million A-shares on September 25 [1] - Anta Sports (02020) repurchased 99.819 million HKD worth of 106,500 shares on September 25 [1] - Guoquan (02517) plans to use up to 100 million HKD for further repurchase of H-shares [1] - Juzi Holding increased its stake by acquiring 1.15 million shares in Giant Bio (02367) [1] - Harmony Health, a shareholder of Goldwind Technology (02208), reduced its holdings by approximately 57.14185 million shares [1]

中国生物制药(01177)发布公告，公司全资附属公司礼新医药科技(上海)有限公司("礼新医药")自主研发 的国家1类创新药LM-350"CDH17抗体偶联药物(ADC)"在澳洲开展的I期临床试验已顺利完成首例患者入 组，标志着这一创新疗法正式进入临床开发阶段。 LM-350是基于礼新医药新一代ADC技术平台LM-ADCTM开发的一款靶向CDH17的ADC，能够高度选 择性地结合CDH17，具有很强的内化能力。LM-350采用IgG1野生型构型，同时具备抗体依赖细胞介导 的细胞毒性作用(ADCC)活性。临床前研究显示，LM-350在多个异种移植模型中表现出显著的抗肿瘤活 性，尤其在对MMAE耐药或伊立替康耐药的结直肠癌细胞中效果突出。 CDH17在多种肿瘤侵袭转移中发挥重要作用，并在约99%的结肠癌、86%的胃腺癌、79%的食管腺癌、 50%的胰腺导管腺癌中高表达。消化道肿瘤(包括结直肠癌、胃癌、胰腺癌、食管癌等)是全球发病率和 死亡率最高的癌症种类之一，2022年全球新发患者数量超过400万人，存在巨大的尚未被满足的临床需 求。 本次临床研究为一项LM-350在晚期实体肿瘤患者中的安全性、耐受性、药代动力学特 ...

LM-350是基于礼新医药新一代ADC技术平台LM-ADC开发的一款靶向CDH17的ADC，能够高度选择性 地结合CDH17，具有很强的内化能力。LM-350采用IgG1野生型构型，同时具备抗体依赖细胞介导的细 胞毒性作用(ADCC)活性。临床前研究显示，LM-350在多个异种移植模型中表现出显著的抗肿瘤活性， 尤其在对MMAE耐药或伊立替康耐药的结直肠癌细胞中效果突出。 CDH17在多种肿瘤侵袭转移中发挥重要作用，并在约99%的结肠癌、86%的胃腺癌、79%的食管腺癌、 50%的胰腺导管腺癌中高表达。消化道肿瘤(包括结直肠癌、胃癌、胰腺癌、食管癌等)是全球发病率和 死亡率最高的癌症种类之一，2022年全球新发患者数量超过400万人，存在巨大的尚未被满足的临床需 求。 格隆汇9月25日丨中国生物制药(01177.HK)公告，公司全资附属公司礼新医药科技(上海)有限公司("礼新 医药")自主研发的国家1类创新药LM-350"CDH17抗体偶联药物(ADC)"在澳洲开展的I期临床试验已顺利 完成首例患者入组，标志着这一创新疗法正式进入临床开发阶段。 ...

智通财经APP讯，中国生物制药(01177)发布公告，公司全资附属公司礼新医药科技(上海)有限公司("礼 新医药")自主研发的国家1类创新药LM-350"CDH17抗体偶联药物(ADC)"在澳洲开展的I期临床试验已顺 利完成首例患者入组，标志着这一创新疗法正式进入临床开发阶段。 LM-350是基于礼新医药新一代ADC技术平台LM-ADCTM开发的一款靶向CDH17的ADC，能够高度选 择性地结合CDH17，具有很强的内化能力。LM-350采用IgG1野生型构型，同时具备抗体依赖细胞介导 的细胞毒性作用(ADCC)活性。临床前研究显示，LM-350在多个异种移植模型中表现出显著的抗肿瘤活 性，尤其在对MMAE耐药或伊立替康耐药的结直肠癌细胞中效果突出。 CDH17在多种肿瘤侵袭转移中发挥重要作用，并在约99%的结肠癌、86%的胃腺癌、79%的食管腺癌、 50%的胰腺导管腺癌中高表达。消化道肿瘤(包括结直肠癌、胃癌、胰腺癌、食管癌等)是全球发病率和 死亡率最高的癌症种类之一，2022年全球新发患者数量超过400万人，存在巨大的尚未被满足的临床需 求。 本次临床研究为一项LM-350在晚期实体肿瘤患者中的安全性、耐 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完 整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內 容而引致的任何損失承擔任何責任。 自願公告 LM-350「CDH17 ADC」完成澳洲I期臨床首例患者入組 中國生物製藥有限公司（「本公司」，連同其附屬公司統稱「本集團」）董事會（「董事會」）宣佈，本公司全 資附屬公司禮新醫藥科技（上海）有限公司（「禮新醫藥」）自主研發的國家1類創新藥LM-350「CDH17抗 體偶聯藥物(ADC)」在澳洲開展的I期臨床試驗已順利完成首例患者入組，標誌著這一創新療法正式進 入臨床開發階段。 LM-350是基於禮新醫藥新一代ADC技術平台LM-ADCTM開發的一款靶向CDH17的ADC，能夠高度選 擇性地結合CDH17，具有很強的內化能力。LM-350採用IgG1野生型構型，同時具備抗體依賴細胞介 導的細胞毒性作用(ADCC)活性。臨床前研究顯示，LM-350在多個異種移植模型中表現出顯著的抗 腫瘤活性，尤其在對MMAE耐藥或伊立替康耐藥的結直腸癌細胞中效果突出。 CDH17在多種腫瘤侵襲轉移中發揮重要作 ...