Summary of Key Points Core Viewpoint - On July 7, 34 Hong Kong-listed companies conducted share buybacks, totaling 30.99 million shares and an aggregate amount of HKD 921 million [1][2]. Group 1: Buyback Details - Tencent Holdings repurchased 1.002 million shares for HKD 501 million, with a highest price of HKD 502.000 and a lowest price of HKD 494.400, bringing its total buyback amount for the year to HKD 38.542 billion [1][2]. - AIA Group repurchased 5.5 million shares for HKD 377 million, with a highest price of HKD 69.150 and a lowest price of HKD 68.050, totaling HKD 16.352 billion in buybacks for the year [1][2]. - Founder Holdings repurchased 10.386 million shares for HKD 1.174 million, with a highest price of HKD 1.150 and a lowest price of HKD 1.110, accumulating HKD 3.541 million in buybacks for the year [1][2]. Group 2: Buyback Rankings - The highest buyback amount on July 7 was from Tencent Holdings at HKD 501 million, followed by AIA Group at HKD 377 million [1][2]. - In terms of share quantity, Founder Holdings had the most significant buyback with 10.386 million shares, followed by AIA Group with 5.5 million shares and China Electric Power Technology with 2.26 million shares [1][2].

翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 和鉑醫藥控股有限公司 FF305 呈交日期： 2025年7月7日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括庫 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：02142） 授出購股權 本公告乃根據香港聯合交易所有限公司（「聯交所」）證券上市規則（「上市規則」） 第17.06A條刊發。 和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱為「本集團」）董事會 （「董事會」）謹此宣佈，於2025年6月30日，根據本公司股東（「股東」）於2020年 11月23日採納的購股權計劃（「購股權計劃」），本公司向合資格參與者授出購股權 （「購股權」），惟須待承授人接納後生效。 授出購股權 授出購股權（「授出購股權」）的詳情如下： 授出日期： 2025年6月30日 所授出購股權數目： 3,465,000份 1 承授人數目： 三名本集團非關連僱員（不包括高級管理層）（「購股 權承授人」） 所授出購股權行權價格： 每股本公司股份（「股份」）8.604港元。行權價格為以 ...

Core Viewpoint - The article discusses a patent dispute between two leading Chinese biopharmaceutical companies, Heptares Therapeutics and Baiaosaitu, focusing on their antibody technology platforms, which are crucial for their revenue and cash flow [2][5]. Company Overview - Heptares Therapeutics, known as "China's BD King," provides drug development and antibody technology to global pharmaceutical companies [4]. - Baiaosaitu, referred to as "China's Mouse King," initially focused on providing transgenic mice for drug testing and has developed its own antibody technology platform [4][13]. Patent Dispute Details - The core of the patent dispute involves a technology for producing antibody drugs, which is essential for both companies' operations [5]. - Heptares' technology was acquired from a Dutch company in 2016 and received patent authorization in China in 2022 after a lengthy legal battle [6][18]. - Baiaosaitu's technology was developed internally over ten years, with claims that it could reach Heptares' level in just three months [7]. - Heptares filed a lawsuit against Baiaosaitu in September 2024, alleging patent infringement, while Baiaosaitu countered by challenging the jurisdiction and claiming Heptares' patent is invalid [7][8]. Financial Performance - Heptares has secured significant contracts, including a deal worth up to $620 million, and has generated $185 million in revenue from licensing its technology from 2020 to 2024 [11]. - Baiaosaitu's antibody business revenue reached 318 million yuan in 2024, with a year-on-year growth of over 80% [14]. Technology Comparison - The article highlights the differences in technology between the two companies, with Baiaosaitu's platform utilizing a more comprehensive gene replacement method compared to Heptares' approach [22][25]. - The dispute centers on whether the methods of producing heavy-chain antibodies are equivalent, with differing opinions on the implications of gene usage [25]. Market Impact - The ongoing patent dispute has affected the market valuations of both companies, with Heptares' stock experiencing significant fluctuations in response to developments in the case [23].

Core Viewpoint - A patent dispute between two leading Chinese biopharmaceutical companies, Heptares Therapeutics-B and Baiaosaitu-B, has emerged, impacting their market valuations and highlighting the significance of their antibody technology platforms [2][4]. Company Overview - Heptares Therapeutics, based in Shanghai, is known as the "King of BD" in China, providing drug development and antibody technology to global pharmaceutical companies [2]. - Baiaosaitu, located in Beijing, is referred to as the "Mouse King" and specializes in providing transgenic mice for drug testing [2]. Patent Dispute Details - The core of the dispute revolves around a technology for producing antibody drugs, which is crucial for the revenue and cash flow of both companies [2]. - Heptares acquired its technology from a Dutch company in 2016, receiving patent authorization in 2022 after a lengthy legal battle with the Chinese National Intellectual Property Administration [3][10]. - Baiaosaitu developed its technology internally over a decade, claiming it could reach Heptares' level in just three months [3]. Legal Proceedings - Heptares filed a lawsuit against Baiaosaitu in September 2024, alleging patent infringement, while Baiaosaitu challenged the jurisdiction and sought to invalidate Heptares' patent [3][4]. - In mid-2025, Baiaosaitu's counteractions were unsuccessful, with the Supreme Court affirming the jurisdiction of the Shanghai Intellectual Property Court and the validity of Heptares' patent [4]. Financial Performance - Heptares secured a significant contract worth up to $620 million, with $47 million in upfront payments, and has generated $185 million in revenue from licensing its technology from 2020 to 2024 [5][6]. - Baiaosaitu's antibody business revenue reached 318 million yuan in 2024, marking an over 80% year-on-year growth, with partnerships established with seven of the top ten global pharmaceutical companies [8]. Technology Comparison - The dispute has sparked discussions among investors regarding the superiority of the two companies' platforms, with some favoring Baiaosaitu's technology as more advanced [7][14]. - Baiaosaitu's platform utilizes a method that incorporates over 120 human V genes, while Heptares' platform only integrates nine, leading to claims of a technological edge [13][14]. Market Impact - Following the public disclosure of the patent dispute, Heptares' stock price fell by 15.47% as investors reacted to the perceived advantages of Baiaosaitu's technology [14].

和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：2142） 提名委員會的職權範圍 3. 會議 1 2.1 委員會成員由董事會不時委任，其中大多數成員須為符合香港聯合交易所有 限公司證券上市規則（「上市規則」，經不時修訂）不時規定之獨立性要求的獨 立非執行董事，並須至少有一名不同性別的董事。 2.2 董事會須委任一名委員會成員擔任主席（「主席」），而該名成員必須為董事會 主席或獨立非執行董事。 3.1 除本文另有指明者外，本公司組織章程細則（「細則」，經不時修訂）所載規管 董事會議及議事程序的條文須應用於委員會會議及議事程序。 3.2 委員會成員可親身或透過其他電子通訊方式或由成員可能協定的其他方式出 席委員會會議。 3.3 委員會每年須最少舉行一次會議，需要時可增開會議。 2 3.4 委員會成員委任的替任人可於委員會會議上代表該成員。 3.5 主席須負責領導委員會，包括安排會議、編製會議議程及向董事會提供定期 報告。 3.6 委員會會議可由其任何成員召開。 3.7 法定人數須為兩名委員會成員。 3.8 除非委員會全體成員另行協定，否則委員會例會須至 ...

Core Viewpoint - A patent dispute between two biopharmaceutical companies, HAPO (和铂医药-B) and Baiaosaitu (百奥赛图-B), has sparked significant discussion in the industry and impacted their market valuations. HAPO recently secured a major contract worth up to $620 million based on its antibody technology, while the patent dispute centers around HAPO's claims of patent infringement by Baiaosaitu regarding antibody technology [1][2]. Company Overview - HAPO, founded in 2016, acquired a Dutch biotechnology company to obtain its fully human antibody transgenic mouse platform, HarbourMice, which is now a core asset. The ongoing patent case involves the only heavy chain antibody (HCAb) technology from this platform [2][4]. - Baiaosaitu, established in 2009, initially focused on gene-edited mice and has developed a reputation for its PD-1 humanized mice, which are used in antibody development. The company has transitioned to antibody discovery and has seen significant revenue growth [3][4]. Patent Dispute Details - The patent dispute began in September 2024 when HAPO accused Baiaosaitu of infringing on its "combining molecule" patent related to the production of fully human heavy chain antibodies [4][6]. - The global market for antibody drugs has surpassed $200 billion, with the technology in question being considered a "chip-level" technology in biomedicine [1][5]. Market Position and Financials - HAPO has not yet launched any drugs but has achieved profitability through business development partnerships, with potential transaction values exceeding $5.5 billion since 2022 [2][3]. - Baiaosaitu's antibody business revenue reached 318 million yuan in 2024, reflecting over 80% year-on-year growth, with seven of the top ten global pharmaceutical companies as clients [3][6]. Technical Aspects of the Dispute - The dispute centers on the methods of producing heavy chain antibodies, with HAPO using a method that knocks out the light chain, while Baiaosaitu employs a silencing technique. The core issue is whether these methods are equivalent [9][10]. - There are only six companies globally with fully human heavy chain antibody mouse platforms, highlighting the competitive landscape [6]. Legal Proceedings - Following the lawsuit, Baiaosaitu has taken steps to challenge the jurisdiction of the Shanghai Intellectual Property Court and has sought to invalidate HAPO's patent [10][11]. - The Chinese biopharmaceutical sector is experiencing a surge in patent applications, indicating a potential increase in related legal disputes in the future [11].

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 和鉑醫藥控股有限公司 呈交日期： 2025年6月27日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | | 是 | | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括 ...

Group 1 - Xiansheng Pharmaceutical announced that its insomnia treatment drug Daridorexant (brand name: Kewiko®) has been approved for marketing in China, enhancing patient access and supporting long-term use [1] - HAP Pharmaceutical entered a global strategic collaboration with Otsuka Pharmaceutical to develop a BCMAxCD3 bispecific T-cell engager, receiving an upfront payment of $47 million and potential additional payments up to $623 million based on future milestones [1] - Baotai announced a licensing agreement with Stein for the commercialization rights of BAT2406 (Dupilumab) in Latin America, with total upfront and milestone payments potentially reaching $10 million [1] Group 2 - David Medical received a medical device registration certificate for its electric stretcher, which offers significant advantages over traditional manual devices, improving operational efficiency and reducing the burden on healthcare personnel [2] - Hanyu Pharmaceutical's subsidiary received approval for the listing of its active pharmaceutical ingredient Acetate Degarelix, which is used to treat advanced prostate cancer [3] - China Traditional Chinese Medicine reported that its innovative TCM drug Yushudapin's registration application has been accepted, showing significant efficacy in improving early symptoms of depressive disorders [4]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 和鉑醫藥控股有限公司 呈交日期： 2025年6月25日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括 ...