Core Insights - Heptares Therapeutics has entered into an evaluation and licensing agreement with Umoja Biopharma to combine their respective platforms for the development of in vivo CAR-T cell products, marking a deepening of their strategic partnership established in September 2024 [1][2] Company Overview - Umoja Biopharma is a clinical-stage biotechnology company focused on developing more accessible and effective in vivo CAR-T cell therapies for oncology and autoimmune diseases [2] - The company's VivoVec gene delivery technology enhances the patient's immune system's ability to combat diseases, supported by an advanced manufacturing facility located in Louisville, Colorado [2] - Umoja Biopharma aims to improve the accessibility and effectiveness of immunotherapies, helping more patients lead better and fuller lives [2]

Group 1 - The core viewpoint of the news is that Nona Bio, a wholly-owned subsidiary of Harbour BioMed, has entered into an evaluation and licensing agreement with Umoja Biopharma to advance the development of multiple in vivo CAR-T cell products [1] - The agreement signifies a deepening of the strategic partnership established between the two companies in September 2024 [1] - Under the terms of the agreement, Nona Bio will receive an upfront payment, potential option payments, and milestone payments related to the discovery and development of collaborative projects [1] Group 2 - Umoja Biopharma is a clinical-stage biotechnology company focused on developing more accessible and effective in vivo CAR-T cell therapies for oncology and autoimmune diseases [2] - The VivoVec in vivo gene delivery technology from Umoja Biopharma enhances the patient's immune system's ability to combat diseases [2] - The company operates an advanced slow virus vector development and manufacturing facility located in Louisville, Colorado, which supports its core technology [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） （股份代號：02142） 自願公告 與UMOJA BIOPHARMA訂立評估與授權協議 本公告由和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱「本集團」）自願 作出，以告知本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，本公司全資子公司諾納生物（蘇州）有限公司 （「諾納生物」）已與Umoja Biopharma, Inc.（「Umoja Biopharma」）訂立評估與授權 協議（「協議」），旨在將諾納生物的HCAb Harbour Mice®平台和NonaCarFxTM平台 與Umoja Biopharma的VivoVecTM平台相結合，共同推進多款體內CAR-T細胞產品 研發。協議標誌著兩家公司於2024年9月建立的戰略合作夥伴關係進一步深化拓 展。 根據協議 ...

Summary of Key Points Core Viewpoint - On November 4, 38 Hong Kong-listed companies conducted share buybacks, totaling 62.68 million shares and an aggregate amount of HKD 294 million [1][2]. Group 1: Buyback Details - China Feihe repurchased 18 million shares for HKD 76.11 million, with a highest price of HKD 4.260 and a lowest price of HKD 4.210, bringing its total buyback amount for the year to HKD 233 million [1][2]. - COSCO Shipping Holdings repurchased 4.5 million shares for HKD 61.70 million, with a highest price of HKD 13.960 and a lowest price of HKD 13.600, accumulating a total buyback amount of HKD 45.30 billion for the year [1][2]. - Pacific Shipping repurchased 10 million shares for HKD 26.09 million, with a highest price of HKD 2.640 and a lowest price of HKD 2.580, totaling HKD 22.91 million in buybacks for the year [1][2]. Group 2: Notable Companies - The largest buyback amount on November 4 was by China Feihe at HKD 76.11 million, followed by COSCO Shipping Holdings at HKD 61.70 million [1][2]. - In terms of share quantity, China Feihe led with 18 million shares repurchased, followed by Pacific Shipping with 10 million shares and Sinopec with 5.15 million shares [1][2]. - Noteworthy is that companies like Fenbi and Taimei Medical Technology conducted their first buybacks of the year on this date [2].

Core Viewpoint - The company, Heptagon Pharmaceuticals-B (02142), announced a share buyback plan, indicating confidence in its financial position and future prospects [1] Group 1 - The company will repurchase 200,000 shares [1] - The total expenditure for the buyback is HKD 2.5849 million [1] - The buyback is scheduled for November 4, 2025 [1]

Core Viewpoint - Heptagon Pharmaceuticals-B (02142.HK) announced a share buyback of 200,000 shares at a cost of HKD 2.58 million on November 4 [1] Group 1 - The company executed a buyback program, indicating a commitment to returning value to shareholders [1] - The total expenditure for the buyback was HKD 2.58 million, reflecting the company's financial strategy [1] - The number of shares repurchased was 200,000, which may influence the stock's market performance [1]

智通财经APP讯，和铂医药-B(02142)发布公告，于2025年11月4日斥资258.49万港元回购20万股。 ...

如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | | 是 | | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括庫存股份）數 目 | | 佔有關事件前的現有已發 行股份（不包括庫存股 份）數目百分比 (註3) | 庫存股份數目 | | 每股發行/出售價 (註4) | 已發行股份總數 | | 於下列日期開始時的結存(註1) ...

Core Insights - The traditional pharmaceutical industry faces significant challenges with lengthy R&D processes and high costs, while AI is emerging as a transformative force to enhance efficiency and capabilities [1][5] - Hu-mAtrIx™ AI platform by Heptares Therapeutics has been launched, marking a significant advancement in AI-driven drug development [1] - The establishment of the AI + Biopharmaceutical Ecosystem Alliance aims to foster collaboration across the industry, enhancing data sharing and innovation [1][5] AI's Impact on Drug Development - AI is revolutionizing drug development by optimizing antibody affinity, specificity, and stability, leading to improved efficacy and reduced side effects [1] - AI applications span from target discovery to clinical trials, significantly reducing costs and time in the drug development process [2] - AI can design complex proteins that traditional methods struggle to create, showcasing its potential to unlock new therapeutic avenues [2] Clinical Trial Enhancements - AI has achieved over 80% accuracy in patient profiling and clinical protocol matching, approaching human expert levels [3] - The integration of AI in clinical trial recruitment can save approximately 40% of the time required for patient enrollment [3] Collaborative Efforts and Industry Transformation - Heptares Therapeutics has initiated partnerships with various companies to enhance AI applications in drug discovery, emphasizing the need for a holistic approach rather than isolated advancements [4] - The AI alliance aims to address the critical challenge of translational prediction in drug development, which has historically been a major risk factor [4][5] - The alliance's focus on data interoperability among pharmaceutical companies, hospitals, and research institutions is crucial for maximizing AI's potential in drug development [5]

Core Insights - A total of 30 companies conducted share buybacks on October 30, 2025, with China Feihe (06186) leading in both the number of shares repurchased and the total amount spent [1][2] - The total buyback amount for China Feihe was 50.23 million yuan, with 12 million shares repurchased, representing a significant investment in its own stock [1][2] Summary by Company - **China Feihe (06186)**: Repurchased 12 million shares for 50.23 million yuan; cumulative buybacks for the year reached 30.95 million shares, accounting for 0.341% of total share capital [2] - **China Petroleum & Chemical Corporation (00386)**: Repurchased 4.78 million shares for 19.72 million yuan; cumulative buybacks for the year reached 102 million shares, accounting for 0.080% of total share capital [2] - **Stone Four Pharmaceutical Group (02005)**: Repurchased 5 million shares for 15.41 million yuan; cumulative buybacks for the year reached 44.20 million shares, accounting for 1.498% of total share capital [2] - **Lianlian Digital (02598)**: Repurchased 1.38 million shares for 11.31 million yuan; cumulative buybacks for the year reached 4.45 million shares, accounting for 1.065% of total share capital [2] - **Gushengtang (02273)**: Repurchased 290,100 shares for 8.33 million yuan; cumulative buybacks for the year reached 5.88 million shares, accounting for 2.482% of total share capital [2] - **Lianyi Technology-W (09959)**: Repurchased 2.3 million shares for 7.42 million yuan; cumulative buybacks for the year reached 80.04 million shares, accounting for 3.746% of total share capital [2] - **Mongolian Dairy (02319)**: Repurchased 400,000 shares for 5.70 million yuan; cumulative buybacks for the year reached 22.42 million shares, accounting for 0.573% of total share capital [2] - **Kangchen Pharmaceutical (01681)**: Repurchased 280,000 shares for 4.21 million yuan; cumulative buybacks for the year reached 7.84 million shares, accounting for 9.216% of total share capital [2] - **Other Companies**: Various other companies also participated in buybacks, with amounts ranging from 4.51 million yuan to 6 million yuan, and share counts varying significantly [2]