Investment Rating - The report maintains a strong confidence in the pharmaceutical sector's potential for a reversal in 2025, particularly focusing on innovative drugs and the recovery of left-side sectors as the biggest investment opportunities for the year [5][14]. Core Insights - The innovative drug sector is expected to continue its upward trend, with BD (business development) activities anticipated to catalyze market movements. The upcoming ESMO conference (October 17-21) is highlighted as a key event for clinical data disclosures from domestic innovative drug companies [2][13]. - The report emphasizes the importance of recent Nobel Prize discoveries related to peripheral immune tolerance, which are relevant to the development of new therapies in oncology and autoimmune diseases. This underscores the significance of innovation in these fields [40][50]. - The report notes that the CXO industry in China is entering a recovery phase, with improvements expected in industry orders, capacity utilization, and performance metrics due to enhanced domestic investment and financing data [2][5]. Summary by Sections Innovative Drugs - The innovative drug sector has seen a recent pullback, but the long-term upward trend remains intact. The report suggests that the market is awaiting further BD catalysts and highlights the importance of upcoming clinical data from the ESMO conference [2][13]. - The report indicates that the overall sentiment in the innovative drug sector is still positive, with a focus on potential breakthroughs in cancer and autoimmune therapies following the recent Nobel Prize discoveries [40][50]. Biologics - Novo Nordisk announced an agreement to acquire Akero for $4.7 billion, with Akero's FGF21 analog EFX showing promise as a leading therapy for metabolic dysfunction-related fatty liver disease (MASH) [3][51]. - The report suggests that EFX is the only drug in Phase 2 trials demonstrating significant fibrosis regression in F4 patients, highlighting the need for continued attention to developments in this area [51][57]. Medical Devices - The commercialization of innovative products is accelerating, with domestic replacements making significant progress. For instance, MicroPort's Tumi laparoscopic surgical robot has surpassed 100 global orders and is leading the domestic market share [4][58]. - The report notes that the Tumi robot has received market access in over 60 countries and regions, with a strong presence in high-end markets such as Europe [60][62]. Traditional Chinese Medicine - There has been a continuous increase in new drug IND and NDA applications for traditional Chinese medicine, with 92 new IND applications and 42 NDA applications reported in the first nine months of 2025 [3][64]. - The report highlights ongoing policy support for traditional Chinese medicine, which is expected to drive further innovation and development in this sector [64][65].

【深圳商报讯】（记者 陈燕青）港股药明合联再次遭到股东药明康德的减持。药明康德10月9日晚称已 减持药明合联3030万股，套现逾23亿港元。截至10日收盘，药明康德和药明合联均下跌逾7%。 药明康德公告，公司于10月8日通过大宗交易方式，出售了其间接控股子公司所持有的药明合联3030万 股，约占其总股本的2.47%。此次交易成交金额达到约23.46亿港元（不含交易费用）。 本次减持对药明康德的财报将产生立竿见影的效果。公司称，出售的药明合联股票在账面上列为"长期 股权投资"。经公司财务部门初步测算，本次出售药明合联的投资净收益对公司2025年度税后净利润的 影响约为16.79亿元，占公司2024年归属净利润的比例超过10%。 记者注意到，最近一年药明康德已多次减持药明合联。2024年11月、2025年1月药明康德分别减持药明 合联3600万股和5000万股，累计成交金额约24.26亿港元；2025年4月，公司继续减持药明合联5080万 股，成交金额约21.78亿港元。如果加上本次减持，最近一年药明康德累计减持药明合联69.5亿港元。 ...

0:00 10月9日，药明康德公告， 公司10月8日通过大宗交易继续出售所持有的药明合联3030万股股票，约占 药明合联当前总股本的2.47%，成交金额约23.46亿港元（不包含手续费等交易费用），占公司最近一期 （2024年度）经审计归属母公司股东净资产的3.67%。 ...

格隆汇10月8日丨微创机器人-B(02252.HK)公告，根据集团内部初步统计数据，截至本公告日期，集团 旗下腔镜、骨科、血管介入核心产品的综合订单量累计突破170台，其中，核心产品图迈腔镜手术机器 人("图迈")于全球范围内累计商业化订单超过百台，图迈全球已装机近80台，稳居国产品牌首位，商业 化进程已进入全面加速的阶段。 作为首个进入海外市场的国产腔镜手术机器人，图迈海外订单已突破60台，装机覆盖亚洲、欧洲、非 洲、大洋洲、南美洲等近40个国家和地区，并在意大利、比利时、印度、巴西、阿根廷、阿联酋等数十 个国家的主流医院体系开展规模化临床手术。近日，集团在全球高端医疗市场的商业化布局又一次迎来 里程碑式突破，图迈于一家全球排名前二的顶尖医学机构先后完成单孔和多孔系列的商业化部署，成功 实现组合式智能手术全解方案的落地执行。 基于集团结合机器人和远程技术构建的突破性创新生态体系，图迈正在加速满足全球市场多层级临床需 求，截至本公告日期，图迈全球人体临床手术量已累计突破15,000例。 ...

基于集团结合机器人和远程技术构建的突破性创新生态体系，图迈正在加速满足全球市场多层级临床需 求，截至本公告日期，图迈全球人体临床手术量已累计突破15,000例。 智通财经APP讯，微创机器人-B(02252)发布公告，根据集团内部初步统计数据，截至本公告日期，集团 旗下腔镜、骨科、血管介入核心产品的综合订单量累计突破170台，其中，核心产品图迈腔镜手术机器 人(图迈)于全球范围内累计商业化订单超过百台，图迈全球已装机近80台，稳居国产品牌首位，商业化 进程已进入全面加速的阶段。 作为首个进入海外市场的国产腔镜手术机器人，图迈海外订单已突破60台，装机覆盖亚洲、欧洲、非 洲、大洋洲、南美洲等近40个国家和地区，并在意大利、比利时、印度、巴西、阿根廷、阿联酋等数十 个国家的主流医院体系开展规模化临床手术。近日，集团在全球高端医疗市场的商业化布局又一次迎来 里程碑式突破，图迈于一家全球排名前二的顶尖医学机构先后完成单孔和多孔系列的商业化部署，成功 实现组合式智能手术全解方案的落地执行。 ...

自願性公告 — 圖邁全球訂單逾百台 本公告由上海微創醫療機器人（集團）股份有限公司（「本公司」，連同其附屬公 司統稱為「本集團」）自願作出，以向本公司股東（「股東」）及潛在投資者提供有 關本集團的最新業務進展情況。 根據本集團內部初步統計數據，截至本公告日期，本集團旗下腔鏡、骨科、血 管介入核心產品的綜合訂單量累計突破170台，其中，核心產品圖邁腔鏡手術 機器人（「圖邁」）於全球範圍內累計商業化訂單超過百台，圖邁全球已裝機近 80台，穩居國產品牌首位，商業化進程已進入全面加速的階段。 基於本集團結合機器人和遠程技術構建的突破性創新生態體系，圖邁正在加 速滿足全球市場多層級臨床需求，截至本公告日期，圖邁全球人體臨床手術量 已累計突破15,000例。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 Shanghai MicroPort MedBot (Group) Co., Ltd. 上海微創醫療機器人（ 集 團 ）股份有限公司 （於中華人民共和國註冊成 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年9月30日 狀態: 新提交 致：香港交易及結算所有限公司 FF301 公司名稱: 上海微创医疗机器人（集团）股份有限公司 呈交日期: 2025年10月8日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | | 其他類別 (請註明) | | 於香港聯交所上市 (註1) | | 否 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | N/A | 說明 | 內資股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 6,599,543 | RMB | | 1 | RMB | | 6,599,543 | | 增加 / 減少 (-) | | | | | | | RMB | | | | 本月底結存 | | | 6,599,543 | RMB | | 1 | RMB | | 6,599,543 | | ...

Core Viewpoint - The MSCI China Healthcare Index has increased by 74.0% year-to-date, outperforming the MSCI China Index by 37.3% [1] Group 1: Market Trends - The recovery in capital market financing and the increase in overseas trading scale for innovative drugs have led to a rebound in domestic innovative drug research and development demand [1] - The CXO industry is expected to see performance recovery in the second half of the year due to the impact of U.S. interest rate cuts [1] Group 2: Regulatory Impact - The anticipated increase in tariffs on innovative drugs by the U.S. is expected to have a limited impact on the CXO sector [1] - Many multinational pharmaceutical companies already have plans to establish factories in the U.S., which may mitigate potential negative effects [1] Group 3: Future Outlook - The ongoing upward momentum for innovative drugs is expected to primarily come from overseas partners driving clinical progress for authorized pipelines [1] - There is optimism regarding valuation recovery opportunities in consumer healthcare, with recommendations to buy stocks in companies such as 3SBio, Junshi Biosciences, WuXi AppTec, Genscript Biotech, China National Pharmaceutical Group, and Innovent Biologics [1]

Core Viewpoint - The article highlights the collective rise of the MicroPort group stocks following the announcement of MicroPort Medical's restructuring of its cardiac rhythm management business, which aims to alleviate pressure related to meeting listing standards [1] Group 1: Stock Performance - MicroPort Medical (00853) increased by 8.47%, reaching HKD 14.21 [1] - HeartLink Medical-B (02160) rose by 4.55%, reaching HKD 1.38 [1] - MicroPort Robotics-B (02252) saw a 4.28% increase, reaching HKD 28.26 [1] - MicroPort Neuroscience (02172) grew by 2.88%, reaching HKD 12.52 [1] Group 2: Business Restructuring - MicroPort Medical announced the restructuring of its cardiac rhythm management business, with its subsidiary MicroPort HeartLink planning to merge with CRM Cayman [1] - Upon completion of the merger, CRM Cayman will become a wholly-owned subsidiary of MicroPort HeartLink, focusing on arrhythmia management solutions [1] - The pre-transaction equity value of CRM Cayman is reported to be USD 680 million [1] Group 3: Ownership and Investment - MicroPort Medical currently holds a 46.12% stake in HeartLink Medical and a 50.13% stake in CRM Cayman [1] - In July 2021, Hillhouse Capital, along with CPE and Springhill, invested USD 300 million in MicroPort's cardiac rhythm management subsidiary, acquiring a 26.3% stake [1] - There is an agreement that if CRM Cayman does not achieve a qualified listing and a market value of at least USD 1.5 billion by July 17, 2025, MicroPort must repurchase all shares at an annualized return of 8% [1]

Core Viewpoint - The stocks of the MicroPort group have collectively risen, driven by the announcement of a restructuring in the cardiac rhythm management business, which aims to alleviate pressure related to meeting listing standards [1] Group 1: Stock Performance - MicroPort Medical (00853) increased by 8.47%, reaching HKD 14.21 [1] - HeartLink Medical-B (02160) rose by 4.55%, reaching HKD 1.38 [1] - MicroPort Robotics-B (02252) saw a 4.28% increase, reaching HKD 28.26 [1] - MicroPort Neuroscience (02172) grew by 2.88%, reaching HKD 12.52 [1] Group 2: Business Restructuring - MicroPort Medical announced the restructuring of its cardiac rhythm management business, with a subsidiary, MicroPort HeartLink, planning to merge with CRM Cayman [1] - Post-merger, CRM Cayman will become a wholly-owned subsidiary of MicroPort HeartLink, focusing on solutions for arrhythmia management, with a pre-transaction equity value of USD 680 million [1] - MicroPort Medical currently holds a 46.12% stake in HeartLink Medical and a 50.13% stake in CRM Cayman [1] Group 3: Strategic Intent - The restructuring is seen as a strategy to mitigate the pressure of meeting the "qualified listing" requirements for the cardiac rhythm management business [1] - In July 2021, Hillhouse Capital, along with CPE and Springhill, invested USD 300 million in MicroPort's cardiac rhythm management subsidiary, acquiring a 26.3% stake [1] - An agreement was made that if CRM does not achieve a qualified listing and a market value of at least USD 1.5 billion by July 17, 2025, MicroPort must repurchase all shares at an annualized return of 8% [1]