Core Viewpoint - Chuangsheng Group-B (06628) experienced a significant stock price increase following positive clinical trial results for its partner Inhibrx Biosciences, Inc.'s (INBX.US) DR5-targeting antibody, ozekibart, in treating advanced or metastatic, unresectable sarcoma patients [1] Company Summary - Chuangsheng Group's stock rose nearly 10% during trading, closing up 4.75% at HKD 3.09, with a trading volume of HKD 4.006 million [1] - The company holds exclusive development and commercialization rights for ozekibart in China, Hong Kong, Macau, and Taiwan [1] Industry Summary - Inhibrx Biosciences announced positive primary results from a registrational clinical study evaluating the efficacy of ozekibart compared to placebo in patients with advanced or metastatic, unresectable soft tissue sarcoma [1] - Inhibrx plans to submit a marketing application for ozekibart for soft tissue sarcoma indications to U.S. regulatory authorities by the end of June 2026 [1]

消息面上，创胜集团公布，合作伙伴Inhibrx Biosciences, Inc. (INBX.US)近日公布四价死亡受体5(DR5)激 动型抗体ozekibart注册性临床研究积极主要结果，该研究评估ozekibart单药相较安慰剂在晚期或转移 性、不可切除的软骨肉瘤患者中的疗效。 基于该结果，Inhibrx计划于2026年6月底前向美国监管机构递交该产品的软骨肉瘤适应症上市许可申 请。创胜集团目前拥有ozekibart在中国、香港、澳门及台湾的独家开发和商业化权益。 智通财经APP获悉，创胜集团-B(06628)盘中一度涨近10%，截至发稿，涨4.75%，报3.09港元，成交额 400.6万港元。 ...

Core Viewpoint - Chuangsheng Group-B (06628) experienced a significant intraday increase of nearly 10%, currently up 4.75% at HKD 3.09, with a trading volume of HKD 4.006 million [1] Group 1: Company Developments - Chuangsheng Group announced that its partner Inhibrx Biosciences, Inc. (INBX.US) reported positive primary results from the registration clinical study of the DR5 agonistic antibody ozekibart [1] - The study evaluated the efficacy of ozekibart as a monotherapy compared to a placebo in patients with advanced or metastatic, unresectable chondrosarcoma [1] - Based on these results, Inhibrx plans to submit a marketing application for the chondrosarcoma indication to U.S. regulatory authorities by the end of June 2026 [1] Group 2: Market Position - Chuangsheng Group holds exclusive development and commercialization rights for ozekibart in China, Hong Kong, Macau, and Taiwan [1]

Ozekibart是首个在随机对照试验中显着改善软骨肉瘤患者PFS的在研药物，目前该疾病尚无任何获批的 系统性治疗方案。令人鼓舞的临床数据进一步证实了该产品对于全球患者以及公司拥有独家授权地区的 价值。 格隆汇10月31日丨创胜集团-B(06628.HK)发布公告，合作伙伴Inhibrx Biosciences, Inc.("Inhibrx"，纳斯 达克代码：INBX)公布了注册性临床研究ChonDRAgon(n=206)的积极主要结果。该研究评估了 ozekibart(INBRX-109)单药相较安慰剂在晚期或转移性、不可切除的软骨肉瘤患者中的疗效。基于该结 果，Inhibrx计划于2026年6月底前向美国监管机构递交ozekibart软骨肉瘤适应症的上市许可申请。根据 公司通过其全资子公司杭州奕安济世生物药业有限公司(HJB)所签署的许可协议，公司拥有 ozekibart(INBRX-109)在中国大陆、中国香港、中国澳门及中国台湾的独家开发和商业化权益。 来源：格隆汇APP ...

Core Viewpoint - Inhibrx Biosciences, Inc. announced positive primary results from the ChonDRAgon clinical study evaluating ozekibart (INBRX-109) for advanced or metastatic, unresectable chondrosarcoma patients, leading to plans for a U.S. regulatory submission by June 2026 [1] Group 1: Clinical Study Results - The ChonDRAgon study involved 206 participants and demonstrated significant improvement in progression-free survival (PFS) for chondrosarcoma patients treated with ozekibart compared to placebo [1] - Ozekibart is the first investigational drug to show a significant improvement in PFS in a randomized controlled trial for this patient population [1] Group 2: Regulatory and Commercial Plans - Inhibrx plans to submit a marketing application for ozekibart for chondrosarcoma to U.S. regulatory authorities by the end of June 2026 [1] - The company holds exclusive development and commercialization rights for ozekibart in mainland China, Hong Kong, Macau, and Taiwan through a licensing agreement with its wholly-owned subsidiary, HJB [1] Group 3: Market Implications - The encouraging clinical data reinforces the value of ozekibart for global patients and in regions where the company has exclusive rights [1] - Currently, there are no approved systemic treatment options for chondrosarcoma, highlighting the potential market opportunity for ozekibart [1]

来源：智通财经网 创胜集团-B(06628)公布，合作伙伴Inhibrx Biosciences, Inc. (Inhibrx，纳斯达克代码：INBX)公布了註册 性临床研究ChonDRAgon (n=206)的积极主要结果。该研究评估了ozekibart(INBRX-109)单药相较安慰剂 在晚期或转移性、不可切除的软骨肉瘤患者中的疗效。基于该结果，Inhibrx计划于 2026年6月底前向美 国监管机构递交ozekibart软骨肉瘤适应症的上市许可申请。根据公司通过其全资子公司杭州奕安济世生 物药业有限公司(HJB)所签署的许可协议，公司拥有ozekibart(INBRX-109)在中国大陆、中国香港特别行 政区、中国澳门特别行政区及中国台湾地区的独家开发和商业化权益。 据悉，Ozekibart是首个在随机对照试验中显著改善软骨肉瘤患者PFS的在研药物，目前该疾病尚无任何 获批的系统性治疗方案。令人鼓舞的临床数据进一步证实了该产品对于全球患者以及公司拥有独家授权 地区的价值。 除注册性临床试验外，Inhibrx还在推进ozekibart的扩展队列，评估其与基于伊立替康(irinotecan)的方案 联合用 ...

除注册性临床试验外，Inhibrx还在推进ozekibart的扩展队列，评估其与基于伊立替康(irinotecan)的方案 联合用于尤文肉瘤及结直肠癌的治疗。早期结果显示出令人鼓舞的信号，支持进一步探索ozekibart在这 些医疗需求远未得到满足的难治性肿瘤中的潜力。 创胜集团-B(06628)公布，合作伙伴Inhibrx Biosciences,Inc.(Inhibrx，纳斯达克代码：INBX)公布了註册性 临床研究ChonDRAgon(n=206)的积极主要结果。该研究评估了ozekibart(INBRX-109)单药相较安慰剂在 晚期或转移性、不可切除的软骨肉瘤患者中的疗效。基于该结果，Inhibrx计划于2026年6月底前向美国 监管机构递交ozekibart软骨肉瘤适应症的上市许可申请。根据公司通过其全资子公司杭州奕安济世生物 药业有限公司(HJB)所签署的许可协议，公司拥有ozekibart(INBRX-109)在中国大陆、中国香港特别行政 区、中国澳门特别行政区及中国台湾地区的独家开发和商业化权益。 据悉，Ozekibart是首个在随机对照试验中显著改善软骨肉瘤患者PFS的在研药物，目前该疾病 ...

据悉，Ozekibart是首个在随机对照试验中显著改善软骨肉瘤患者PFS的在研药物，目前该疾病尚无任何 获批的系统性治疗方案。令人鼓舞的临床数据进一步证实了该产品对于全球患者以及公司拥有独家授权 地区的价值。 除注册性临床试验外，Inhibrx还在推进ozekibart的扩展队列，评估其与基于伊立替康(irinotecan)的方案 联合用于尤文肉瘤及结直肠癌的治疗。早期结果显示出令人鼓舞的信号，支持进一步探索ozekibart在这 些医疗需求远未得到满足的难治性肿瘤中的潜力。 智通财经APP讯，创胜集团-B(06628)公布，合作伙伴Inhibrx Biosciences, Inc. (Inhibrx，纳斯达克代码： INBX)公布了註册性临床研究ChonDRAgon (n=206)的积极主要结果。该研究评估了ozekibart(INBRX- 109)单药相较安慰剂在晚期或转移性、不可切除的软骨肉瘤患者中的疗效。基于该结果，Inhibrx计划于 2026年6月底前向美国监管机构递交ozekibart软骨肉瘤适应症的上市许可申请。根据公司通过其全资子 公司杭州奕安济世生物药业有限公司(HJB)所签署的许可协议， ...

本公告由創勝集團醫藥有限公司（「本公司」）自願作出，旨在告知本公司股東及潛 在投資者有關最新業務進展。本公告所用但並無另行界定的詞彙應與本公司日期 為2021年9月14日的招股章程中所賦予該等詞彙的涵義相同。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 Transcenta Holding Limited 創勝集團醫藥有限公司 （以存續方式於開曼群島註冊的有限公司） （股份代號：6628） 自願公告 有關創勝集團合作夥伴Inhibrx公佈ozekibart治療軟骨肉瘤的 II期臨床試驗積極結果，計劃於2026年遞交BLA的業績進展 創勝集團醫藥有限公司 本公司董事會（「董事會」）欣然公佈，合作夥伴Inhibrx Biosciences, Inc. （「Inhibrx」，納斯達克代碼：INBX）公佈了註冊性臨床研究ChonDRAgon （n=206）的積極主要結果。該研究評估了ozekibart(INBRX-109)單藥相較安慰劑在 晚期或轉移性、 ...

Investment Rating - The report maintains an investment rating of "Outperform" with a rating of A [5] Core Insights - The report highlights the significant performance of domestic new drugs showcased at the ESMO 2025 conference, with several companies presenting excellent clinical data [3][21] - The report emphasizes the importance of academic conferences as key catalysts for the innovative drug sector, particularly mentioning ESMO, ASCO, and WCLC as critical events for Chinese pharmaceutical companies [20] Weekly New Drug Market Review - From October 20 to October 26, 2025, the top five gainers in the new drug sector were: - 欧康维视 (+8.87%) - 君圣泰 (+8.21%) - 诺思兰德 (+7.07%) - 友芝友 (+4.42%) - 海创药业 (+3.73%) - The top five losers were: - 康宁杰瑞 (-17.72%) - 北海康成 (-14.42%) - 创胜集团 (-14.29%) - 宜明昂科 (-13.40%) - 来凯医药 (-12.40%) [16][17] Recommended Focus Stocks - The report suggests focusing on several stocks with potential catalysts, including: 1. Products with high overseas volume certainty after MNC certification: - PD-1 upgraded product: 三生制药 - GLP-1 asset: 联邦制药 - ADC assets: 科伦博泰, 百利天恒 2. Potential heavyweights for overseas MNC authorization: - PD-1 upgraded products: 康方生物, 信达生物 - Breakthroughs in autoimmune fields: 益方生物, 中国抗体 - Innovative target ADC: 复宏汉霖, 石药集团 3. Stocks likely to benefit from medical insurance negotiations and commercial insurance innovative drug directories: - Beneficiaries of medical insurance directory: 恒瑞医药, 康诺亚, 迈威生物, 智翔金泰, 海创药业 - Beneficiaries of commercial insurance innovative drug directory: 药明巨诺, 科济药业 [2][20] New Drug Approval and Acceptance - This week, four new drug or new indication applications were approved, and five new drug or new indication applications were accepted in the domestic market [9] - A total of 46 new drug clinical applications were approved, and 31 new drug clinical applications were accepted [10] Key Domestic Market Events - 信达生物 announced a global strategic partnership with Takeda to accelerate the development of new generation tumor immunotherapy and antibody-drug conjugate therapies [11] - 康宁杰瑞 and 石药集团 announced that their HER2 bispecific antibody-drug conjugate JSKN003 received breakthrough therapy designation from the CDE [11] - 和黄医药 presented clinical data for HMPL-A251 at the AACR-NCI-EORTC conference [11] Key Overseas Market Events - 罗氏 received FDA approval for Gazyva/Gazyvaro for the treatment of active lupus nephritis in adult patients [12] - Electra Therapeutics announced that its therapy ELA026 received breakthrough therapy designation from the FDA and PRIME qualification from the EMA [12] - 安斯泰来 announced that the FDA accepted its supplemental biologics license application for the antibody-drug conjugate Padcev in combination with Keytruda [12]