Group 1 - The legal opinion letter confirms the legality of the convening and holding procedures of Changchun Baike Biotechnology Co., Ltd.'s 2024 annual shareholders' meeting [1][2][4] - The meeting was convened by the company's sixth board of directors and held on May 13, 2025, with a combination of on-site and online voting [3][4] - A total of 96 shareholders (or their proxies) attended the meeting, representing 290,916,681 shares, which is 70.3278% of the total voting shares [4][5] Group 2 - The voting results for the agenda items were as follows: - For the 2024 Board of Directors Work Report, 99.8660% voted in favor [5] - For the 2024 Supervisory Board Work Report, 99.8660% voted in favor [6] - For the 2024 Profit Distribution Plan, 99.9287% voted in favor [6] - For the 2024 Annual Report, 99.8340% voted in favor [7] - For the Director Compensation Plan, 99.3688% voted in favor, with related shareholders abstaining [8] - For the Supervisor Compensation Plan, 99.6008% voted in favor, with related shareholders abstaining [9] - For the appointment of the 2025 financial audit and internal control audit institutions, 99.8390% voted in favor [10] Group 3 - The legal opinion concludes that the convening, holding procedures, qualifications of the convenor and attendees, as well as the voting procedures and results of the meeting are all in compliance with relevant laws, regulations, and the company's articles of association [2][10]

证券代码：688276 证券简称：百克生物 公告编号：2025-020 长春百克生物科技股份公司 2024年年度股东会决议公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 本次会议是否有被否决议案：无 一、会议召开和出席情况 | 1、出席会议的股东和代理人人数 | 96 | | --- | --- | | 普通股股东人数 | 96 | | 2、出席会议的股东所持有的表决权数量 | 290,916,681 | | 普通股股东所持有表决权数量 | 290,916,681 | | 3、出席会议的股东所持有表决权数量占公司表决权数量的比 | 70.3278 | | 例（%） | | | 普通股股东所持有表决权数量占公司表决权数量的比例（%） | 70.3278 | （四）表决方式是否符合《公司法》及公司章程的规定，会议主持情况等。 （一）股东会召开的时间：2025 年 5 月 13 日 （二）股东会召开的地点：长春百克生物科技股份公司 5 楼会议室（吉林省长春 市卓越大街 138 号） （三）出席会议的普通股股东 ...

北京植德律师事务所 关于长春百克生物科技股份公司 2024 年年度股东会的 法律意见书 植德京（会）字[2025]0048号 二〇二五年五月 北京市东城区东直门南大街 1 号来福士中心办公楼 12 层 邮编：100007 12th Floor, Raffles City Beijing Offices Tower, No.1 Dongzhimen South Street,Dongcheng District, Beijing 100007 P.R.C. 电话（Tel）: 010-56500900 传真（Fax）: 010-56500999 www.meritsandtree.com 北京植德律师事务所 关于长春百克生物科技股份公司 2024 年年度股东会的 法律意见书 植德京（会）字[2025]0048 号 致：长春百克生物科技股份公司（贵公司） 北京植德律师事务所（以下简称"本所"）接受贵公司的委托，指派律师出席 并见证贵公司 2024 年年度股东会（以下简称"本次会议"）。 2．本所律师无法对网络投票过程进行见证，参与本次会议网络投票的股东资格、 1 网络投票结果均由上海证券交易所交易系统和互联网投票系 ...

- The report predicts adjustments to the sample stocks of seven major broad-based indices in the Chinese market, including CSI 300, CSI 500, SSE 50, STAR 50, STAR 100, ChiNext Index, and ChiNext 50, based on the index compilation rules and data as of April 30, 2025 [1][7] - The CSI 300 Index selects stocks from the Shanghai and Shenzhen markets that meet criteria such as good operational status, no significant financial issues, and no abnormal price fluctuations. The selection process involves ranking stocks by daily average trading volume and market capitalization over the past year, applying buffer rules, and excluding stocks with significant losses or long-term suspensions. Adjustments are limited to 10% of the constituent stocks per review [8] - The CSI 500 Index excludes CSI 300 constituents and follows a similar methodology, focusing on stocks with good operational status, no financial irregularities, and stable price movements. Stocks are ranked by daily average trading volume and market capitalization, with buffer rules applied, and adjustments are capped at 10% of the constituent stocks [10] - The SSE 50 Index is derived from the SSE 180 Index, selecting stocks based on daily average market capitalization and trading volume over the past year. The accuracy of SSE 50 predictions depends on the SSE 180 Index's accuracy. Adjustments are limited to 10% of the constituent stocks [13] - The STAR 50 Index represents the top 50 securities on the STAR Market by market capitalization and liquidity. Stocks are ranked by daily average market capitalization, with buffer rules applied, and adjustments are capped at 10% of the constituent stocks [15] - The STAR 100 Index includes 100 mid-sized securities from the STAR Market, reflecting the performance of mid-cap companies. The selection process is similar to STAR 50, with adjustments limited to 10% of the constituent stocks [17] - The ChiNext Index selects stocks from the ChiNext Board based on the top-ranked daily average market capitalization over the past six months. Buffer rules are applied, and stocks with significant losses or long-term suspensions are excluded. Adjustments are capped at 10% of the constituent stocks [20] - The ChiNext 50 Index selects the most liquid stocks from the ChiNext Index's 100 constituents, considering industry coverage and applying buffer rules. Adjustments are limited to 10% of the constituent stocks [24]

Investment Rating - The report does not explicitly state an investment rating for the vaccine industry Core Insights - The overall trend in the vaccine industry shows a decline in batch approvals for most vaccine types in Q1 2025, with some exceptions showing recovery or growth in demand [7][29][46] Summary by Category Multi-Component Vaccines - In Q1 2025, multi-component vaccines saw a total of 17 batch approvals, a decrease of 26% compared to the previous year [11][15] - The five-component vaccine maintained its batch approval at 17, while the four-component vaccine had no approvals [15][12] Pneumonia Vaccines - Total batch approvals for pneumonia vaccines in Q1 2025 were 23, down 30% year-on-year [19][21] - The 13-valent pneumonia vaccine had 19 approvals, remaining stable, while the 23-valent vaccine saw a significant drop to 4 approvals, down 71% [24][19] HPV Vaccines - HPV vaccine approvals increased to 57 batches in Q1 2025, a growth of 63% [29][27] - The two-valent HPV vaccine saw a remarkable increase of 367%, with all approvals coming from Wantai Biological Pharmacy [29][32] Influenza Vaccines - Influenza vaccine approvals totaled 29 batches, a significant increase of 263% year-on-year [34][38] - The three-valent influenza vaccine had 28 approvals, while the four-valent vaccine had only 1 approval, down 67% [38][41] Rabies Vaccines - Batch approvals for rabies vaccines increased to 223 in Q1 2025, a growth of 37% [46][48] - The freeze-dried rabies vaccine accounted for the majority of approvals, with Chengda Biological achieving 105 approvals, a 110% increase [48][46] Varicella Vaccines - Varicella vaccine approvals slightly decreased to 83 batches, down 2% [53][54] - The largest contributor was Baike Biological, with 33 approvals, marking a 38% increase [54][53] Hib Vaccines - Hib vaccine approvals fell to 7 batches, a decrease of 50% [59][58] EV71 Vaccines - EV71 vaccine approvals continued to decline, with only 4 batches approved, down 69% [64][63] Rotavirus Vaccines - Rotavirus vaccine approvals totaled 21 batches, a decrease of 46% [68][67] DTP Vaccines - DTP vaccine approvals increased to 18 batches, a growth of 167% [72][73] Meningitis Vaccines - Meningitis vaccine approvals totaled 85 batches, down 34% [78][79] - The AC polysaccharide vaccine accounted for 55 approvals, a decrease of 47% [84][79] Hepatitis B Vaccines - Hepatitis B vaccine approvals increased to 87 batches, a growth of 28% [91][90] IPV Vaccines - IPV vaccine approvals totaled 22 batches, a decrease of 33% [93][92]

Core Viewpoint - The financial report of Changchun High-tech shows a significant decline in both revenue and net profit, marking the end of an 18-year growth trend, leading to a sharp drop in stock price [2][4][24]. Group 1: Financial Performance - In 2024, the company's operating revenue was 13.47 billion yuan, a decrease of 7.55% compared to 2023, which was 14.57 billion yuan [3]. - The net profit attributable to shareholders was 2.58 billion yuan, down 43.01% from 4.53 billion yuan in 2023 [3]. - Basic earnings per share fell to 6.42 yuan, a decline of 42.73% from 11.21 yuan in the previous year [3]. - The total assets at the end of 2024 were 31.05 billion yuan, a slight increase of 1% from 30.74 billion yuan in 2023 [3]. Group 2: Market Dynamics - The decline in performance is attributed to the impact of centralized procurement policies, which led to significant price reductions for key products, particularly the long-acting growth hormone [12][14]. - The revenue from Jin Sai Pharmaceutical, a subsidiary, was 10.67 billion yuan, down 3.73%, with net profit dropping 40.67% to 2.68 billion yuan [12]. - The competitive landscape has intensified, with new entrants offering lower-priced alternatives, threatening Changchun High-tech's market position [19]. Group 3: Cost and Investment - The company faced increased costs, with R&D expenses rising by 25.75% to 2.17 billion yuan, driven by accelerated new product development [13]. - Sales expenses increased by 11.81% to 4.44 billion yuan due to a rise in sales personnel to cope with market competition [13]. - Management expenses also grew by 25.59% to 1.20 billion yuan, further squeezing profit margins [13]. Group 4: Future Outlook - Despite the current downturn, the company is focusing on innovation and international expansion, with 24 key products in clinical stages [20]. - The approval of new products, such as the recombinant follicle-stimulating hormone injection, is expected to contribute over 500 million yuan in revenue by 2025 [20]. - However, uncertainties remain regarding the sustainability of growth and the impact of ongoing competitive pressures and market conditions [24].

Core Insights - The market for shingles vaccines in China has experienced rapid growth due to an aging population and increased public health awareness, with the market size expected to reach 5.6 billion yuan by 2024 after a recovery from a significant drop in 2021 [1][13] - The incidence of shingles is notably high among individuals aged 50 and above, driving sustained demand for vaccines [1][13] - The public's awareness of shingles and its prevention is gradually increasing, further propelling the market's growth [1][13] Industry Overview - Shingles vaccines are designed to prevent shingles, a disease caused by the reactivation of the Varicella-Zoster Virus, which initially causes chickenpox [2][4] - The industry chain includes upstream raw material suppliers, midstream vaccine developers and manufacturers, and downstream logistics and healthcare providers [4] Development History - The shingles vaccine industry in China has evolved from non-existence to local innovation, with the first imported vaccine, GSK's Shingrix, approved in 2019 [6][9] - The launch of the first domestic live attenuated shingles vaccine by Baike Biological in January 2023 marked a significant milestone, expanding the eligible age group for vaccination [6][9] - The market is now characterized by competition between imported and domestic vaccines, with expectations for a surge in domestic vaccine approvals in the coming years [6][9] Market Dynamics - The number of vaccine approvals has increased significantly, with Baike Biological's vaccine receiving 22 approvals in the first three quarters of 2023, indicating strong market performance [9] - The domestic vaccine market is expected to grow rapidly, driven by aging demographics and improved public health policies [9][11] Key Companies - Baike Biological has established itself as a leader in the shingles vaccine market, with a revenue of 883 million yuan in 2023, although it is projected to decline to 251 million yuan in 2024 [17] - Wantai Biological, another key player, reported a revenue of 5.511 billion yuan in 2023, down 50.73% from the previous year, and is expected to generate 2.245 billion yuan in 2024 [19] Future Trends - Domestic vaccines are anticipated to dominate the market due to their competitive pricing and alignment with local needs [21] - The improvement of health insurance policies is expected to enhance vaccine accessibility and increase public willingness to get vaccinated [22] - The development of multivalent and combination vaccines is becoming a significant trend, aiming to provide broader protection and improve vaccination efficiency [23]

Group 1: Company Performance - Baike Bio reported a revenue of approximately 1.229 billion RMB for 2024, a year-on-year decline of 32.64% [1] - The net profit attributable to shareholders was around 232 million RMB, down 53.67% year-on-year [1] - The decline in performance is primarily attributed to reduced sales of the shingles vaccine [1] Group 2: Green Bamboo Bio's Situation - Green Bamboo Bio's stock price fell by 9.09% on May 2, leading to significant sell-offs, with a trading volume of 1.8036 million shares, the highest since 2024 [2] - The company has experienced a drastic decline in liquidity, with 10 months in the past 17 months having a monthly trading volume of less than 200,000 shares [2] - Green Bamboo Bio's market capitalization is currently around 4.1 billion HKD, below the 7 billion HKD threshold required for inclusion in the Hang Seng Index [4] Group 3: Financials of Green Bamboo Bio - Green Bamboo Bio reported a net loss of 168 million RMB for the year, a reduction of 32.5% compared to the previous year's loss of 249 million RMB [4] - The company has not yet commercialized any products, with total revenue remaining at zero [4] - Research and development expenses decreased by 21.7% to 135 million RMB [4] Group 4: Product Development - Green Bamboo Bio's core product, the recombinant shingles vaccine LZ901, has completed Phase III clinical enrollment and submitted a Biologics License Application (BLA) [6] - LZ901 is expected to be the first shingles vaccine with a tetrameric molecular structure, targeting adults aged 50 and above [6] - The vaccine is positioned to compete with GSK's Shingrix, which has seen significant sales growth, reaching 3.446 billion GBP in 2023 [8] Group 5: Market Dynamics - The domestic vaccine industry is facing structural adjustment pressures, with a decline in consumer willingness to receive vaccinations and a significant drop in demand for self-paid vaccines [10] - The competition in the vaccine market is intense, with over 10 manufacturers competing in areas like rabies and influenza vaccines [10] - The market for shingles vaccines is currently less competitive, with only Baike Bio's Ganwei and GSK's Shingrix available, providing an opportunity for LZ901 if it commercializes as expected [10] Group 6: Challenges Ahead - Despite the potential of LZ901, the company may struggle to significantly improve its financial structure and fundamentals due to market education challenges and profit margin pressures [11] - The current vaccination rate for shingles in China is only 0.1%, significantly lower than in developed countries, indicating a need for market education [10]

证券代码：688276 证券简称：百克生物 长春百克生物科技股份公司 2024 年年度股东会会议资料 二零二五年五月 四、股东及股东代理人要求在股东会现场会议上发言的，应于股东会召开前 一天向会议会务组进行登记。会议主持人根据会务组提供的名单和顺序安排发 言。现场要求提问的股东及股东代理人，应当按照会议的议程举手示意，经会议 主持人许可后方可提问。有多名股东及股东代理人同时要求提问时，先举手者先 提问；不能确定先后时，由主持人指定提问者。 会议进行中只接受股东及股东代理人发言或提问。发言或提问应围绕本次会 议议题进行，简明扼要，时间不超过 5 分钟。发言或提问时需说明股东名称及所 持股份总数。每位股东及股东代理人发言或提问次数不超过 2 次。 五、股东及股东代理人要求发言时，不得打断会议报告人的报告或其他股东 及股东代理人的发言。在股东会进行表决时，股东及股东代理人不再进行发言。 股东及股东代理人违反上述规定，会议主持人有权加以拒绝或制止。 百克生物 2024 年年度股东会会议资料 2024 年年度股东会会议须知 为了维护全体股东的合法权益，确保股东会的正常秩序和议事效率，保证会 议的顺利进行，根据《中华人民 ...

中信证券股份有限公司关于 长春百克生物科技股份公司 2024年持续督导工作现场检查报告 根据《证券发行上市保荐业务管理办法》《上海证券交易所科创板股票上市 规则》和《上海证券交易所上市公司持续督导工作指引》等有关法律、法规的规 定,中信证券股份有限公司(以下简称"中信证券"、"保荐人")作为正在对长春 百克生物科技股份公司(以下简称"百克生物"、"上市公司"、"公司")进行持续 督导工作的保荐人,对公司2024年度持续督导期间(以下简称"本持续督导期") 的规范运行情况进行了现场检查,现就现场检查的有关情况报告如下: 一、本次现场检查的基本情况 (一)保荐人 中信证券股份有限公司 (二) 保荐代表人 王晨晨、朱绍辉 (三)现场检查时间 2025年4月9日至2025年4月28日 (四) 现场检查人员 王晨晨、朱绍辉、杜博闻 现场检查人员查阅了上市公司最新章程、三会议事规则及会议材料,财务管 理、内部审计、募集资金管理、对外担保管理制度、关联交易制度等相关内控制 度,查阅了公司 2024年度内部控制自我评价报告、2024年度内部控制审计报告 等文件,对高级管理人员进行访谈。 经查阅前述文件,保荐人认为: 本持续督 ...