长春百克生物科技股份公司 关于 2025 年前三季度计提资产减值准备的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 长春百克生物科技股份公司（以下简称"公司"）于2025年10月29日召开第 六届董事会第十次会议，审议通过了《关于2025年前三季度计提资产减值准备的 议案》，该议案无需提交股东会审议。现将相关情况公告如下： 一、本次计提减值准备情况概述 为真实、准确地反映公司截至2025年9月30日的财务状况，根据《企业会计 准则》及公司会计政策、会计估计的相关规定，本着谨慎性原则，对截至2025 年9月30日公司及子公司的存货、长期资产等相关资产进行了减值测试，对可能 发生资产减值损失的相关资产计提减值准备。 证券代码：688276 证券简称：百克生物 公告编号：2025-042 经测试，计提资产减值准备共计4,861.43万元，影响合并报表损益-4,861.43 万元，具体如下： | 序号 | | 项目 | 2025 | 年 | 月 9 | 30 | 日计提金额（万元） | | | --- | --- | -- ...

Financial Performance - The company's operating revenue for Q3 2025 was ¥189,546,595.31, a decrease of 53.50% compared to the same period last year[3]. - The total profit for the period was -¥104,969,647.34, reflecting a decline of 187.09% year-over-year[3]. - The net profit attributable to shareholders was -¥84,677,091.89, down 179.31% from the previous year[3]. - The basic earnings per share for the period was -¥0.20, a decline of 176.92% compared to the same period last year[3]. - The net profit for the first three quarters of 2025 was -158,250,519.93 RMB, compared to a net profit of 244,369,819.42 RMB in the same period of 2024, representing a significant decline[32]. - Operating profit for the current period was -226,720,962.84 RMB, a decrease from 283,707,576.25 RMB in the previous year[32]. - Total comprehensive income for the first three quarters of 2025 was -167,252,623.54 RMB, compared to 223,606,855.63 RMB in the same period of 2024[33]. - The company's total revenue for the first three quarters of 2025 was ¥474,411,792.53, a decrease of 53.8% compared to ¥1,026,012,316.58 in the same period of 2024[42]. - Operating profit for the first three quarters of 2025 was a loss of ¥500,145,675.71, compared to a profit of ¥286,862,678.73 in the first three quarters of 2024[42]. - Net profit for the first three quarters of 2025 was a loss of ¥388,894,096.21, while the net profit for the same period in 2024 was ¥247,493,581.24[42]. Revenue and Sales - The company's revenue decreased due to returns of the shingles vaccine and a reduction in sales of the varicella vaccine, with a total revenue impact of approximately 14,386.23 million RMB from the shingles vaccine[13]. - The sales volume of the shingles vaccine for the period was 65,400 doses, leading to a revenue decrease of 14,386.23 million RMB, with estimated returns impacting revenue by 30,879.8 million RMB[14][15]. - The varicella vaccine sales volume decreased by 1,339,700 doses, resulting in a revenue decline of 14,037.30 million RMB, attributed to increased competition and changes in local immunization policies[16]. Research and Development - Research and development expenses amounted to ¥79,697,327.78, representing 42.05% of operating revenue, an increase of 34.45 percentage points[4]. - Research and development expenses increased to 138,541,423.72 RMB in 2025 from 116,503,270.72 RMB in 2024, indicating a focus on innovation[32]. - The company is focusing on developing a combined DTPa-Hib vaccine, which, if approved, will enhance its vaccine product pipeline and provide new growth opportunities[22][24]. - The company received approval for the liquid nasal influenza vaccine, which is expected to enhance the company's product structure and core competitiveness[18][19]. - The liquid nasal influenza vaccine is designed for individuals aged 3 to 17 years and aims to provide a more convenient vaccination option[18]. - The company also obtained approval for the clinical trial of the acellular pertussis-diphtheria-tetanus combined vaccine, which addresses public health needs and aims to improve vaccination coverage[20]. - The company is conducting clinical research to expand the eligible population for the liquid nasal influenza vaccine, enhancing its vaccine pipeline[19]. Financial Position - The total assets at the end of the reporting period were ¥5,210,196,644.05, a slight increase of 0.10% from the end of the previous year[4]. - The company's total assets as of September 30, 2025, were ¥5,278,313,448.12, compared to ¥5,503,880,417.19 as of December 31, 2024[39]. - The company's total liabilities rose to CNY 1,252,597,411.50 as of September 30, 2025, compared to CNY 987,120,567.56 at the end of 2024, indicating an increase of approximately 27%[29]. - Total liabilities as of September 30, 2025, were ¥1,250,110,065.86, an increase from ¥984,884,421.21 as of December 31, 2024[39]. - The company's long-term equity investments increased significantly to CNY 359,471,539.14 as of September 30, 2025, from CNY 33,482,864.39 at the end of 2024[27]. - The total equity of the company as of September 30, 2025, was ¥4,028,203,382.26, compared to ¥4,518,995,995.98 as of December 31, 2024[40]. Cash Flow and Investments - The net cash flow from operating activities was -¥14,809,350.60, a decrease of 106.46% year-to-date[3]. - Cash flow from operating activities for the first three quarters of 2025 was -14,809,350.60 RMB, down from 229,104,857.16 RMB in 2024[36]. - The company’s cash and cash equivalents decreased to CNY 157,439,788.29 as of September 30, 2025, from CNY 344,869,136.24 at the end of 2024, representing a decline of approximately 54.4%[27]. - The ending cash and cash equivalents balance for the first three quarters of 2025 was $157.33 million, down 42.1% from $272.23 million in 2024[46]. - Cash outflow from investment activities in the first three quarters of 2025 was $286.79 million, a decrease of 26.9% from $392.33 million in 2024[46]. - Cash inflow from borrowings in the first three quarters of 2025 was $269.08 million, slightly up from $256.08 million in 2024[46]. - Cash outflow for repaying debts in the first three quarters of 2025 was $75.83 million, a decrease of 64.7% from $213.97 million in 2024[46]. Shareholder Information - The company reported a total of 10,824 common shareholders at the end of the reporting period[10]. - The largest shareholder, Changchun High-tech Industry (Group) Co., Ltd., holds 41.46% of the shares[10]. Strategic Outlook - The company warns investors about the uncertainties associated with the clinical trials of its new vaccines, emphasizing the potential risks involved[22][24]. - The overall performance reflects challenges in vaccine sales but also highlights strategic advancements in product development and regulatory approvals[12][13]. - The company aims to mitigate investment risks associated with the uncertain timeline for the market launch of the liquid nasal influenza vaccine[19]. - The company plans to implement new accounting standards starting in 2025, which may affect financial reporting[47]. - The board of directors announced the financial results on October 29, 2025[48].

Core Viewpoint - The domestic vaccine industry is experiencing significant pressure due to economic downturns, declining birth rates, reduced vaccination willingness, and intensified market competition, leading to frequent executive changes among companies [1][3]. Group 1: Executive Changes - Sun Wanfeng has resigned from his position as employee representative director and vice president of Baike Bio, but will continue as assistant to the chairman [1]. - There are rumors of changes in the management of Kangtai Bio, but the company has confirmed that Vice President Yu Bing remains in his position [1]. - Frequent executive turnover is noted in the domestic vaccine industry, with several companies undergoing leadership changes since late 2024 [3]. Group 2: Financial Performance - In the first half of 2025, only 5 out of 10 listed vaccine companies in A-shares reported revenue growth, with only 3 achieving positive net profit growth [3]. - Baike Bio reported a revenue of 284.9 million yuan with a net loss of 73.57 million yuan, marking a year-on-year revenue decline of 53.93% and a net profit decline of 153.47% [4]. - Kangtai Bio's revenue was 1.392 billion yuan with a net profit of 37.53 million yuan, showing a revenue growth of 15.81% but a significant net profit decline of 77.30% [4]. Group 3: Market Competition - The HPV vaccine market is experiencing aggressive price competition, with prices for the bivalent HPV vaccine dropping below 100 yuan, and the lowest price recorded at 27.5 yuan per dose [5]. - The flu vaccine market is also seeing price reductions, with prices for quadrivalent flu vaccines dropping from 128 yuan to 88 yuan per dose [6]. - The pneumococcal vaccine market is highly competitive, with Pfizer withdrawing from the market due to intense competition from domestic products [6]. Group 4: Growth Opportunities - Despite the challenges, there are structural growth opportunities in the vaccine market, exemplified by Olin Bio's adsorbed tetanus vaccine, which achieved a revenue growth of 35.17% in the first half of 2025 [7].

Core Viewpoint - The upcoming flu season in 2025 is expected to be significant, with a different strain circulating compared to last year, leading to lower immunity among the public. Vaccination remains the most effective preventive measure, and there is a noticeable increase in vaccine demand across various regions [1][4][5]. Vaccine Supply and Demand - There is a surge in flu vaccine demand, particularly among parents for their children, leading to situations where appointments are available but vaccines are not [6][8]. - The government procurement price for trivalent vaccines has dropped to a historical low of 5.5 yuan per dose, while the price of quadrivalent vaccines has remained stable [2][12]. - Sanofi, a major overseas player, has resumed supply to the Chinese market after a 10-month hiatus, but this has not significantly impacted the market dynamics as domestic manufacturers continue to dominate [10][11]. Flu Activity and Trends - The flu season may start earlier than in previous years, with reports indicating an increase in flu cases, particularly in southern provinces [3][4]. - The predominant strain this year is H3N2, which poses a higher risk due to lower public immunity compared to last year's H1N1 strain [4][5]. Pricing Dynamics - The price of trivalent vaccines has decreased significantly, while quadrivalent vaccines have stabilized after a previous price war [12][13]. - The procurement prices for government-subsidized vaccines have varied, but the overall trend indicates a potential for future price adjustments due to market conditions [13][14]. Market Competition - The return of Sanofi to the Chinese market raises questions about competitive dynamics, but domestic manufacturers like Sinopharm, Beijing Kexing, and Hualan Biological remain the primary suppliers [10][11]. - The flu vaccine market is characterized as an incremental market with substantial demand, and companies do not view each other strictly as competitors [11]. Recommendations for Public Health - Health authorities continue to recommend annual flu vaccinations as the best preventive measure, alongside personal hygiene practices [5][6]. - Increased public awareness and education about the importance of flu vaccination are essential for improving vaccination rates [13].

Core Viewpoint - Changchun Baike Biological Technology Co., Ltd. plans to deposit a maximum of RMB 150 million of temporarily idle raised funds in fixed-term deposits to enhance fund utilization efficiency and increase returns for the company and its shareholders [1][3][4]. Fundraising Basic Situation - The company raised a total of RMB 1,500,675,944.50 through the public offering of 41,284,070 shares at a price of RMB 36.35 per share, with a net amount of RMB 1,395,794,418.15 after deducting various fees [1][2]. Purpose of Fund Deposit - The purpose of depositing the idle funds is to improve the efficiency of fund usage while ensuring that it does not affect the implementation of investment projects and the safety of the raised funds [3][4]. Deposit Details - The maximum amount to be deposited is RMB 150 million, with a usage period from October 24, 2025, to April 23, 2026, allowing for rolling use within this timeframe [4][6]. Implementation and Management - The board of directors has authorized the chairman or designated personnel to sign relevant legal documents, with the finance department responsible for organizing the implementation [6][9]. Information Disclosure - The company will comply with relevant regulations and timely fulfill information disclosure obligations, ensuring that the purpose of the raised funds remains unchanged [7][8]. Impact on Daily Operations - The plan to deposit idle funds will not affect the normal operation of the company's daily funds or the implementation of investment projects, ensuring no harm to the interests of the company and its shareholders [9][10]. Decision-Making Process - The board of directors approved the proposal during the ninth meeting of the sixth board on October 23, 2025, without needing to submit it to the shareholders' meeting [11][12].

Core Points - Baike Bio announced the resignation of Sun Wanfeng from his position as employee representative director and vice president due to work adjustments [2] - After his resignation, Sun Wanfeng will continue to serve as the assistant to the chairman [2]

Group 1 - The core point of the article is that Baike Biotechnology announced the resignation of Sun Wanfeng from his position as employee representative director and vice president, while he will continue to serve as assistant to the chairman [1] - Baike Biotechnology's revenue composition for the year 2024 is entirely from biopharmaceuticals, accounting for 100.0% [1] - As of the report, Baike Biotechnology has a market capitalization of 9.2 billion yuan [1]

中信证券股份有限公司 关于长春百克生物科技股份公司 将部分暂时闲置募集资金以定期存款方式存放的核查意见 根据《证券发行上市保荐业务管理办法》《上市公司募集资金监管规则》《上海 证券交易所科创板上市公司自律监管指引第1号——规范运作》《上海证券交易所科创 板股票上市规则》《科创板上市公司持续监管办法（试行）》等有关规定，作为长春 百克生物科技股份公司（以下简称"百克生物"或"公司"）首次公开发行股票并上市的 保荐机构，中信证券股份有限公司（以下简称"中信证券"）对百克生物将部分暂时闲 置募集资金以定期存款方式存放的事项进行了核查，具体如下： 一、募集资金基本情况 经中国证券监督管理委员会《关于同意长春百克生物科技股份公司首次公开发行 股票注册的批复》（证监许可[2021]1594号）的同意，公司采用向社会公开发行方式 发行人民币普通股（A股）41,284,070股，发行价格为每股36.35元，募集资金总额 1,500,675,944.50元，扣除承销费、保荐费、审计费、律师费、信息披露等发行费用 104,881,526.35元后，实际募集资金净额为1,395,794,418.15元。上述资金到位情况经大 信会计 ...

证券代码：688276 证券简称：百克生物 公告编号：2025-040 公司董事会于近日收到孙晚丰先生提交的辞职报告。孙晚丰先生因工作调整 申请辞去公司第六届董事会职工代表董事、副总经理职务。离任后，孙晚丰先生 仍在公司担任董事长助理职务。 关于公司职工代表董事、高级管理人员离任的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 长春百克生物科技股份公司（以下简称"公司"）董事会于近日收到孙晚 丰先生提交的辞职报告。孙晚丰先生因工作调整申请辞去公司第六届董事会职工 代表董事、副总经理职务。离任后，孙晚丰先生仍在公司担任董事长助理职务。 孙晚丰先生的离任不会导致公司董事会人数低于法定最低人数，不会影 响公司董事会的正常运作，也不会影响公司正常的经营发展。 一、董事、高级管理人员离任情况 （一）提前离任的基本情况 长春百克生物科技股份公司 | | | | | | | | 是否继续 在上市公 | | 是否存 在未履 | | --- | --- | --- | --- | --- | --- | --- | --- ...

长春百克生物科技股份公司 关于将部分暂时闲置募集资金以定期存款方式存放的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 长春百克生物科技股份公司（以下简称"百克生物"或"公司"）于2025 年10月23日召开第六届董事会第九次会议，审议通过了《关于将部分暂时闲置募 集资金以定期存款方式存放的议案》，同意将最高额度不超过人民币1.5亿元（含 本数）的暂时闲置募集资金以定期存款方式存放，使用期限自前次闲置募集资金 现金管理的授权到期之日起6个月内有效，即2025年10月24日至2026年4月23日。 在前述额度及期限范围内，公司可以循环滚动使用该部分闲置募集资金。公司董 事会对上述事项发表了明确同意的意见，保荐机构中信证券股份有限公司（以下 简称"保荐机构"）出具了明确同意的核查意见。上述事项在董事会审批权限范 围内，无需提交股东会审议。现将相关情况公告如下： 一、募集资金基本情况 经中国证券监督管理委员会《关于同意长春百克生物科技股份公司首次公开 发行股票注册的批复》（证监许可[2021]1594号）的同意，公司采用向 ...