Core Viewpoint - Merck reported strong fourth-quarter earnings driven by demand for its cancer immunotherapy Keytruda, but provided a modest 2026 outlook that fell short of Wall Street expectations due to upcoming patent expirations and generic competition [1][2]. Financial Performance - For the fourth quarter, Merck posted net income of $2.96 billion, or $1.19 per share, compared to $3.74 billion, or $1.48 per share, in the same period last year [4]. - Adjusted earnings for the fourth quarter were $2.04 per share, slightly above the expected $2.01 per share [6]. - Revenue for the quarter was $16.4 billion, a 5% increase from the previous year, and exceeded expectations of $16.19 billion [5][6]. 2026 Outlook - Merck anticipates 2026 revenue between $65.5 billion and $67 billion, lower than analysts' expectations of $67.6 billion [2]. - The company expects adjusted earnings per share to be between $5 and $5.15, compared to the analyst estimate of $5.36 [2]. Acquisition and Charges - The 2026 guidance includes a one-time charge of approximately $9 billion, or around $3.65 per share, related to the acquisition of Cidara, which is developing a flu prevention drug [3]. Cost Management - Merck is implementing a cost-cutting plan aimed at reducing expenses by $3 billion by the end of 2027 to offset revenue losses from the upcoming patent expiration of Keytruda in 2028 [5]. Drug Pricing Deal - Under a "most favored nation" deal, Merck will sell existing treatments to Medicaid patients at the lowest price offered in other developed nations and will receive a three-year reprieve from tariffs [4].

In this article7974.T-JPTOPSHOT - A Super Mario character is pictured at a Nintendo display ahead of the launch of the company's Switch 2 console, an electronics store in the city of Nagoya, Aichi prefecture on June 2, 2025.Richard A. Brooks | Afp | Getty ImagesThe Switch has become Nintendo's best-selling console of all time, nearly nine years after its release. The device's importance to the Japanese gaming giant cannot be understated. Ahead of the Switch's release in March 2017, Nintendo was coming off t ...

Vancouver, British Columbia - February 3, 2026 ‑ TheNewswire – Harvest Gold Corporation (TSXV: HVG) (“Harvest Gold” or the “Company”) announces that it has met the required exploration expenditure obligation of $1,250,000 through its 2025 exploration program in the Northern and Central portion of the Mosseau property, its flagship property in the Urban Barry Belt in Quebec’s Abitibi region.Harvest Gold President and CEO, Rick Mark, states: “We have come a long way in the last 18 months and are now in an exc ...

Core Insights - Merck & Co., Inc. reported financial results for Q4 and full year 2025, highlighting a 5% increase in Q4 sales to $16.4 billion and a 1% increase in full-year sales to $65.0 billion, driven by strong demand for its innovative portfolio, particularly KEYTRUDA and new product launches [3][11][14] Financial Performance - Q4 2025 sales reached $16.4 billion, up from $15.6 billion in Q4 2024, marking a 5% increase [3] - Full-year sales for 2025 were $65.0 billion, compared to $64.2 billion in 2024, reflecting a 1% growth [11] - Non-GAAP EPS for Q4 2025 was $2.04, a 19% increase from $1.72 in Q4 2024, while full-year non-GAAP EPS was $8.98, up 17% from $7.65 in 2024 [30][11] Product Performance - KEYTRUDA sales in Q4 2025 were $8.4 billion, a 7% increase from $7.8 billion in Q4 2024, driven by strong global uptake in oncology [7] - GARDASIL sales declined by 34% in Q4 2025 to $1.0 billion, primarily due to lower demand in China and Japan [7] - Animal Health sales grew by 8% in 2025 to $6.4 billion, supported by higher demand for livestock products [16] Strategic Developments - The company completed the acquisition of Cidara Therapeutics for approximately $9.2 billion, enhancing its portfolio [37] - Merck announced positive late-stage trial results from 18 Phase 3 trials and initiated 21 new Phase 3 studies across various therapeutic areas [33] Regulatory and Pipeline Updates - The FDA approved KEYTRUDA and KEYTRUDA QLEX for the perioperative treatment of muscle-invasive bladder cancer [33] - The company is advancing its pipeline with significant regulatory milestones and ongoing studies in oncology, infectious diseases, and cardiometabolic areas [33][36] Future Outlook - For full-year 2026, Merck anticipates sales between $65.5 billion and $67.0 billion, with a non-GAAP effective tax rate expected between 23.5% and 24.5% [41][45] - Non-GAAP EPS for 2026 is projected to be between $5.00 and $5.15, including a one-time charge related to the acquisition of Cidara [46]

Core Insights - The Travel Vaccines Market is projected to grow from USD 5.22 billion in 2025 to USD 10.69 billion by 2033, with a CAGR of 9.37% from 2026 to 2033, driven by international tourism, business travel, and increased awareness of vaccine-preventable diseases [1][6]. Market Size and Forecast - The U.S. Travel Vaccines Market is expected to grow from USD 1.42 billion in 2025 to USD 2.49 billion by 2033, at a CAGR of 7.32%, supported by outbound travel to emerging economies and increased vaccination services [4]. - The overall Travel Vaccines Market is anticipated to expand significantly, with a base year of 2025 and a forecast period from 2026 to 2033 [6]. Government Initiatives and Immunization Programs - Public health agencies globally are promoting vaccination to prevent diseases like yellow fever and hepatitis among travelers, enhancing vaccine uptake through national immunization policies and partnerships with travel agencies [5]. Market Segmentation Analysis - By Disease Type: Influenza dominates the market with a 38.50% share in 2025, expected to rise to 41.50% by 2033, while the "others" category is the fastest-growing segment, increasing from 10.38% to 12.63% [9]. - By Booking Channel: Online booking leads with a 59.75% market share in 2025, projected to grow to 70.25% by 2033, reflecting the trend towards digital healthcare solutions [10]. - By Tourist Type: Domestic travelers hold 61.13% of the market in 2025, but their share is expected to decrease to 55.88% by 2033, while international travelers will grow from 38.88% to 44.13% [11]. Regional Insights - North America holds the largest share of the Travel Vaccines Market at 41.13% in 2025, driven by strong healthcare systems and vaccination programs [15]. - The Asia Pacific region is the fastest-growing market, with a CAGR of 2.57%, fueled by increased travel and improved healthcare infrastructure [16]. Competitive Landscape - Major companies in the Travel Vaccines Market include GlaxoSmithKline, Merck & Co., Sanofi, and Pfizer, among others, indicating a competitive environment with significant R&D investments [13].

好的，各位投资人，晚上好，然后欢迎参加我们的医药每周谈第 236 期，关于 GP MOOC 2026 的海外公司的一个进展。然后我是中银建投医药分析师徐颖翔。然后就是关于整个 Gilead 海外公司的一个情况吧。我们可以看得出来，在整个基于摩根这个期间的话，海外 的药企主要就是在一个专利悬崖的一个压力下面，是加速转型与和与技术兑现。大部分跨 国药企的话，是通过一个大规模的 BD 和并购来平滑自己重磅产品专利的到期的一个销售 冲击。包括默沙东规划 700 亿美元的一个新的产品组合，BMS 的话这几年也完成了 300 亿美元的一个并购交易，阿斯利康的话也是目标在 2030 年能够实现一个 800 亿美元的一 个营收。 因此这几年的话，整个受并购与 BD 还是各家跨国药企最重要的一个战略布局的一个方向， 主要也就是为了应对专利悬崖，同时聚焦高确定性的资产，以及技术平台的一个补强。另 一方面的话，也是整个 AI，从工具也上升到了一个制药的一个核心生产力。成为整个制药 行业的一个核心的驱动，驱动力之一。多家跨国药企，包括礼来、阿斯利康、赛诺菲，都 在 GD Morgan 期间。通过与英伟达以及各种其他的 AI 公司达成 ...

Group 1 - The "Brain-Computer Interface Developers Conference" in Tianjin is a key event to watch for the day [1] - The Reserve Bank of Australia will announce its policy interest rate at 11:30 AM [1] - RBA Governor Philip Lowe will hold a monetary policy press conference at 12:30 PM [1] Group 2 - The preliminary Consumer Price Index (CPI) for January in France will be released at 3:45 PM [1] - Major U.S. companies including Merck, Pfizer, and PayPal are set to report their earnings before the market opens [1] - Richmond Fed President Barkin will discuss the U.S. economy at 9:00 PM [1] Group 3 - The Wall Street Journal's Invest Live event will feature Federal Reserve officials, timing to be determined [1] - Federal Reserve Governor Bowman is scheduled to speak at 10:40 PM [1] - After market close, AMD and other companies like Advanced Micro Devices, Chipotle Mexican Grill, Electronic Arts, and Take-Two Interactive Software will release their earnings reports [1]

Merck & Co. reports Q4 2025 earnings on Tuesday, Feb. 3, 2026, before market open. Wall Street expects earnings of $2.01 per share on revenue of $16.12 billion, representing 3.1% year-over-year growth. Shares have gained 13% over the past year, outperforming the healthcare sector's broader returns. Here's what investors should watch for. This infographic outlines Wall Street's expectations for MRK's Q4 2025 earnings report on February 3, 2026, alongside analyst price targets and historical beat rates. The N ...

Last week we saw a plethora of important earnings results and increased market volatility. This wee should be another busy one with a lot of important companies due to report. This week we have Amazon (AMZN), Palantir (PLTR), Advanced Micro Devices (AMD), Alphabet (GOOGL), PayPal (PYPL), Pfizer (PFE), Uber Technologies (UBER), Disney (DIS) and Merck (MRK) all reporting in what shapes as a busy and pivotal week for stocks. Before a company reports earnings, implied volatility is usually high because the m ...

报告导读： Moderna 个体化 mRNA 癌症疫苗 V940 在高危黑色素瘤中的 5 年随访结果 支持疫苗机制能提供持久免疫应答，为后续 III 期与注册推进提供了更充分的临床依据。 事件。 2026 年 1 月 21 日， Moderna 与默沙东联合披露个体化 mRNA 癌症疫苗 V940 （ mRNA-4157 ）联合 Keytruda 用于高危黑色素瘤辅助治疗的 IIb 期 5 年随访结果。该联合治疗方案在较长时间内维持了既往观察到的疗效水平，支持其能够诱导并维持相对持久的免疫应答。 核心读出数据支持疫苗机制能提供持久免疫应答。 KEYNOTE-942 研究结果显示 V940 联合 Keytruda 降低 49% 高危黑色素瘤患者复发或死亡风险，疗效 从 2 年随访时的 44% 提升至 3 年的 49% 并在 5 年随访时仍维持在 49% 。同时未发现新的安全性信号。 V940 的整体推进节奏在同类项目中较为靠前。 mRNA-4157 目前已开展 8 项 II/III 期临床研究，适应症覆盖黑色素瘤、非小细胞肺癌、膀胱癌及肾细胞癌 等多种实体瘤。其中黑色素瘤 III 期临床试验已完成入组，预计将于 ...