（责任编辑：徐自立） 药明康德10月10日起股价大幅下挫，6个交易日中4个交易日股价下跌。 中国经济网北京10月17日讯 药明康德(603259.SH)今日收报96.60元，跌幅4.41%。 湘财证券股份有限公司研究员蒋栋10月10日发布研报《药明康德(603259)：R端开源引流 D&M潜 力不断释放》称，维持药明康德"买入"评级。 ...

Core Viewpoint - The recent stock price fluctuations of WuXi AppTec are attributed to significant share reductions, with the company selling a substantial portion of its holdings in WuXi AppLink, leading to notable market reactions [2][3]. Group 1: Stock Performance and Financial Impact - WuXi AppTec announced the sale of 30.3 million shares of WuXi AppLink, representing 2.47% of the total shares, for approximately HKD 23.46 billion, which is 3.67% of the company's net assets for 2024 [2]. - Following the announcement, WuXi AppTec's A-share price dropped from HKD 112.85 to HKD 95.92, a decline of over 15%, before recovering slightly to HKD 101.06, resulting in a net decrease of 10.45% [2]. - WuXi AppLink's stock also experienced significant declines, with three consecutive days of drops of 7.29%, 3.97%, and 5.51%, before a partial recovery, leading to an overall decrease of 9.87% compared to pre-announcement levels [2]. Group 2: Share Reduction History and Utilization of Funds - Over the past year, WuXi AppTec has conducted four rounds of share reductions, totaling 167 million shares or 13.87% of its stake in WuXi AppLink, raising over HKD 69 billion [3]. - The proceeds from these share reductions have been primarily allocated to global capacity expansion, talent acquisition, and strengthening the company's unique CRDMO business model [3]. - In 2025, WuXi AppTec reported revenues of HKD 20.8 billion and a net profit of HKD 8.561 billion, reflecting a year-on-year growth of 101.92%, with a cumulative stock price increase of over 85% since the beginning of the year [3]. Group 3: ESG Ratings and Environmental Goals - WuXi AppTec achieved an AAA rating in the latest MSCI ESG rating adjustments, maintaining a leading position in the global biopharmaceutical industry [4]. - The company has set ambitious greenhouse gas reduction targets, aiming for a 42% reduction in operational emissions by 2030, based on 2024 levels, and a 25% reduction in specific categories of emissions [5][6]. - Compared to its peers, WuXi AppTec faces a more challenging path to meet its reduction targets, as its baseline emissions are significantly higher than those of competitors like IQVIA and Parexel [6]. Group 4: Operational Emissions and Challenges - WuXi AppTec's operational emissions have been on the rise, with a 4.28% increase in 2023 and an expected 11.35% increase in 2024, complicating the achievement of its 2030 reduction goals [8]. - The company has shifted from a "intensity reduction" approach to a more stringent "absolute reduction" target, requiring a reduction of total emissions from 597,600 tons to below 346,600 tons by 2030 [7]. - The majority of WuXi AppTec's emissions come from indirect sources, necessitating a systemic transformation of its energy structure to meet its reduction targets [8].

Core Viewpoint - The stock of WuXi AppTec experienced a decline of 4.41% on October 17, with a trading volume of 3.887 billion yuan and a market capitalization of 288.231 billion yuan [1] Group 1: Company Overview - WuXi AppTec is a leading international open-access capability and technology platform providing comprehensive and integrated new drug research and production services for the global biopharmaceutical industry [2] - The company is a domestic leader in the pharmaceutical outsourcing industry and one of the earliest integrated CRO and CMO companies in China, with a management team holding over 200 authorized and pending patents [2] - The main business involves the discovery, research, and production of small molecule chemical drugs, offering a full-spectrum integrated platform service to global pharmaceutical companies [2][7] Group 2: Financial Performance - For the first half of 2025, WuXi AppTec achieved operating revenue of 20.799 billion yuan, representing a year-on-year growth of 20.64%, and a net profit attributable to shareholders of 8.561 billion yuan, which is a 101.92% increase year-on-year [7] - The company’s revenue composition includes 78.37% from chemical business, 12.93% from testing services, 6.02% from biological services, and 1.90% from other supplementary services [7] Group 3: Market Dynamics - The company benefits from a high overseas revenue ratio of 78.67%, which is positively impacted by the depreciation of the Chinese yuan [3] - The stock has seen a net outflow of 2.92 million yuan from major funds today, with a continuous reduction in major fund holdings over the past two days [4][5] Group 4: Technical Analysis - The average trading cost of the stock is 94.96 yuan, with recent rapid outflows of shares suggesting a recommendation for portfolio adjustment [6] - The current stock price is approaching a resistance level of 97.20 yuan, indicating a potential for a pullback unless this resistance is broken [6]

Core Viewpoint - WuXi AppTec (药明康德) is actively reducing its stake in WuXi AppTec Holdings (药明合联) through multiple transactions, raising significant cash for strategic investments while experiencing a decline in R&D expenses and workforce [2][3][6]. Group 1: Share Reduction and Financial Impact - WuXi AppTec has sold 30.3 million shares of WuXi AppTec Holdings, representing 2.47% of its total share capital, for approximately HKD 23.46 billion [3]. - Over the past year, the company has cumulatively reduced its holdings in WuXi AppTec Holdings, generating HKD 69.5 billion (approximately RMB 63.72 billion) [6]. - The sale of shares is expected to impact the company's net profit for 2025 by approximately RMB 16.79 billion, which is over 10% of the latest audited net profit attributable to shareholders [4]. Group 2: R&D Expenses and Workforce Changes - WuXi AppTec's R&D expenses have been declining for two and a half years, totaling RMB 31.94 billion, which is only 3.18% of the total revenue of RMB 1003.81 billion during the same period [11]. - The company has seen a significant reduction in its workforce, with a total decrease of 6,529 employees, or 14.72%, from the end of 2022 to mid-2025 [12]. - Despite the workforce reduction, executive compensation remains high, with the CEO receiving a total of RMB 126 million over three years [13]. Group 3: Revenue Performance and Global Strategy - In 2022, WuXi AppTec reported revenue of RMB 393.55 billion, with a year-on-year growth of 71.84%, and net profit of RMB 88.14 billion, also up 72.91% [7]. - The company anticipates a return to double-digit revenue growth in 2025, adjusting its revenue forecast to between RMB 425 billion and RMB 435 billion [11]. - As of mid-2025, the company has a backlog of orders worth RMB 566.9 billion, reflecting a year-on-year increase of 37.2%, with significant contributions from U.S. and European clients [12].

Core Viewpoint - WuXi AppTec is continuously reducing its stake in WuXi AppTec Holdings, having sold 30.3 million shares recently for approximately HKD 23.46 billion, which represents 2.47% of the total share capital of WuXi AppTec Holdings [2][4] Share Reduction and Financial Impact - Over the past year, WuXi AppTec has cumulatively reduced its holdings in WuXi AppTec Holdings, realizing approximately HKD 69.5 billion, equivalent to RMB 63.72 billion [2][7] - The recent sale is part of a strategy to accelerate global capacity and capability building, aiming to attract and retain talent while enhancing its integrated CRDMO business model [4][17] - The net investment gain from the recent sale is expected to impact the company's net profit for 2025 by approximately RMB 16.79 billion, accounting for over 10% of the latest audited net profit attributable to shareholders [4][5] R&D Expenditure Trends - WuXi AppTec's R&D expenses have been declining for two and a half years, totaling RMB 31.94 billion, which is only 3.18% of the total revenue of RMB 1003.81 billion during the same period [10][12] - R&D expenses for 2023 and 2024 were RMB 14.41 billion and RMB 12.39 billion, respectively, showing a decline of over 10% each year [10][12] - The company reported a significant drop in R&D expenses in the first half of 2025, amounting to RMB 5.14 billion, which is a 19.15% decrease year-on-year [12] Employee Reduction - WuXi AppTec has reduced its workforce by 6,529 employees over two and a half years, representing a 14.72% decrease [13][14] - Employee numbers decreased from 44,361 at the end of 2022 to 37,832 by mid-2025 [13][14] Executive Compensation - Despite workforce reductions, executive compensation remains high, with the chairman and CEO receiving a total of RMB 126 million over three years [15][16] Business Performance and Global Strategy - WuXi AppTec's revenue for the first half of 2025 reached RMB 207.99 billion, a year-on-year increase of 20.64%, with net profit growing by 101.92% [11] - The company is focusing on global expansion, with a backlog of orders amounting to RMB 566.9 billion, a 37.2% increase year-on-year [17]

Core Viewpoint - Company signed a technical service contract with WuXi AppTec to enhance drug development capabilities and reduce clinical trial time and costs [1] Group 1 - Sichuan Luzhou Buchang Pharmaceutical Co., Ltd. (subsidiary of Buchang Pharmaceutical) entered into a contract with WuXi AppTec for pharmacokinetics and toxicology testing [1] - The collaboration is expected to expand the company's drug research and development capacity and scope [1] - The agreement aims to ensure the smooth progress of projects while saving time and costs associated with clinical trials [1]

Core Viewpoint - Company announced a collaboration with WuXi AppTec to enhance its drug development capabilities and reduce clinical trial time and costs [1] Group 1 - Company’s subsidiary, Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd., signed a technical service contract with WuXi AppTec [1] - The collaboration is expected to expand the company's drug research and development capacity [1] - The agreement aims to ensure the smooth progress of projects by saving time and costs associated with clinical trials [1]

本次泸州步长与第三方签订《技术服务合同》，有利于扩大公司药品研发能力和范围，一定程度上节约 了公司药品临床试验的时间和成本，保障项目的顺利进行。 格隆汇10月16日丨步长制药(603858.SH)公布，公司控股子公司四川泸州步长生物制药有限公司（称"泸 州步长"）与苏州药明康德新药开发有限公司（称"药明康德"）签订《技术服务合同》，委托药明康德 进行药代动力学和毒理学试验项目。合同总金额为1080万元，含6%税费，甲方将依合同约定分期支付 相关费用。 ...

Group 1 - Morgan Stanley's long position in WuXi AppTec's H-shares decreased from 6.02% to 5.59% [1]

Core Viewpoint - WuXi AppTec's stock price has experienced significant fluctuations, with a year-to-date increase of 83.13% but a recent decline of 7.17% over the past five trading days [1] Company Overview - WuXi AppTec, established on December 1, 2000, and listed on May 8, 2018, operates in the pharmaceutical industry, providing comprehensive services in drug discovery, development, and manufacturing [1] - The company's revenue composition includes: 78.37% from chemical business, 12.93% from testing services, 6.02% from biological services, 1.90% from other supplementary services, and 0.79% from miscellaneous [1] Financial Performance - For the first half of 2025, WuXi AppTec reported revenue of 20.799 billion yuan, a year-on-year increase of 20.64%, and a net profit attributable to shareholders of 8.561 billion yuan, reflecting a substantial growth of 101.92% [2] - The company has distributed a total of 14.06 billion yuan in dividends since its A-share listing, with 10.406 billion yuan distributed over the past three years [3] Shareholder Information - As of June 30, 2025, WuXi AppTec had 235,500 shareholders, with the Hong Kong Central Clearing Limited being the second-largest shareholder, holding 302 million shares, an increase of 5.603 million shares from the previous period [2][3] - Other notable shareholders include Huaxia SSE 50 ETF and China Europe Medical Health Mixed A, with varying changes in their holdings [3]