Summary of Wuxi Apptec Conference Call Company Overview - **Company**: Wuxi Apptec - **Industry**: Pharmaceutical Services - **Market Position**: Largest pharmaceutical R&D services platform in Asia by total revenue [38][39] Key Takeaways Resilient Performance and Customer Retention - Wuxi Apptec is on track to meet its full-year guidance despite macroeconomic uncertainties and industry challenges, demonstrating the resilience of its Contract Research, Development, and Manufacturing Organization (CRDMO) model [3] - Customer retention is exceptionally high, with over 99% of clients continuing from discovery through to manufacturing, providing strong revenue visibility [3][6] Strategic Capacity Expansion - The company is expanding its capacity for small molecules and peptides, particularly for GLP-1 assets, with plans to increase SPS capacity from 48,000 liters to 100,000 liters by year-end [4][30] - Wuxi maintains a molecule-agnostic approach, focusing on infrastructure readiness and flexibility to meet diverse customer needs [4] Margin Improvement and Geographic Diversification - Margin improvements are anticipated through a richer late-stage project mix and yield optimization, supported by disciplined capital allocation [5] - The company is exploring capacity expansion in Switzerland and Singapore to mitigate geopolitical and tariff risks, despite higher operational costs (up to 3 times compared to China) [5][35] Market Dynamics and Pipeline Positioning - The pipeline is aligned with market trends, but early-stage projects have faced funding constraints, particularly in the U.S. [6] - Pricing pressures in China persist, and demand outside China has not fully recovered [6] Financial Projections - Revenue projections for FY 2024A to FY 2027E are as follows: - FY 2024A: 39,241.4 million - FY 2025E: 44,471.6 million - FY 2026E: 52,182.5 million - FY 2027E: 60,282.0 million - EBITDA and net profit are also projected to grow significantly during this period [7] Investment Thesis - Wuxi Apptec is rated as a "Buy" due to: - Over 33% growth in non-COVID backlog - Strong growth in TIDES business (approximately 60% growth expected in 2025) driven by robust demand for peptides [10][20] Risks and Catalysts - Risks include potential decreases in demand, competition, and project failures [40][41] - Catalysts for growth include new CRO/CMO contracts, strong GLP-1 backlog growth, and advancements in clinical pipelines [28] Sustainability Initiatives - The company has set targets for reducing carbon emissions, energy consumption, and water usage by 2030 compared to a 2020 baseline [29] Conclusion Wuxi Apptec is well-positioned to capitalize on growth opportunities in the pharmaceutical services industry, supported by strong customer retention, strategic capacity expansions, and a robust pipeline. However, it must navigate ongoing market challenges and geopolitical risks to maintain its competitive edge.

Core Viewpoint - WuXi AppTec (603259.SH) has completed a block trade selling shares of its associate WuXi AppTec (2268.HK) for approximately HKD 2.346 billion, marking the fourth sale of its shares this year, which has contributed a total of RMB 4.351 billion to the company's net profit [1][2]. Group 1 - On October 8, WuXi AppTec sold 30.3 million shares of WuXi AppTec, representing 2.47% of the latter's total share capital [2]. - The net investment gain from this sale is expected to impact the company's after-tax net profit for the fiscal year 2025 by approximately RMB 1.679 billion, accounting for over 10% of the latest audited net profit attributable to shareholders for the fiscal year 2024 [2]. - This divestment aligns with a previously authorized strategy from a shareholder meeting on September 23, allowing the investment department to dispose of listed domestic and foreign stocks when market conditions are favorable, with a total limit of 15% of net assets attributable to shareholders [2][3]. Group 2 - WuXi AppTec has strategically timed its stock sales, having previously sold a total of 137 million shares of WuXi AppTec this year, generating approximately HKD 4.604 billion, bringing the total cash realized to nearly HKD 7 billion, significantly boosting the company's profit performance [2]. - The proceeds from this sale will be reinvested into global capacity expansion and capability building, enhancing its integrated CRDMO business model, and attracting top-tier research talent to support long-term growth [3]. - As of October 10, WuXi AppTec's stock closed at RMB 104.72 per share, reflecting a year-to-date increase of 95.02%, while WuXi AppTec's stock closed at HKD 71.85 per share, with a year-to-date increase of 134.42% [3].

Core Viewpoint - The report outlines the changes in shareholding and voting rights of WuXi AppTec Co., Ltd. due to the expiration of the concerted action agreement among certain shareholders, which does not affect the actual control of the company [46][48][49]. Group 1: Shareholding Changes - As of the report signing date, the total shareholding of the information disclosure obligors was 598,454,017 shares, accounting for 20.16% of the total share capital [52]. - Following the termination of the concerted action agreement, the combined voting rights of the information disclosure obligors decreased from 20.01% to 18.46% due to the exclusion of 1.55% held by the original concerted action parties [23][53]. - The total share capital of the company changed from 2,968,549,263 shares to 2,965,692,554 shares during the reporting period, affecting the shareholding percentages [54][58]. Group 2: Concerted Action Agreement - The original concerted action agreement was signed on March 23, 2016, and was terminated on October 9, 2025, allowing the parties to act independently [48][49]. - The original concerted action parties have committed to not reducing their shareholdings in WuXi AppTec for six months following the announcement of the termination [46][50]. - The termination of the concerted action agreement simplifies the shareholder voting mechanism and enhances decision-making efficiency [49][51]. Group 3: Future Plans - As of the report signing date, there are no explicit plans for the information disclosure obligors to increase or decrease their shareholdings in WuXi AppTec within the next 12 months [20].

【深圳商报讯】（记者 陈燕青）港股药明合联再次遭到股东药明康德的减持。药明康德10月9日晚称已 减持药明合联3030万股，套现逾23亿港元。截至10日收盘，药明康德和药明合联均下跌逾7%。 药明康德公告，公司于10月8日通过大宗交易方式，出售了其间接控股子公司所持有的药明合联3030万 股，约占其总股本的2.47%。此次交易成交金额达到约23.46亿港元（不含交易费用）。 本次减持对药明康德的财报将产生立竿见影的效果。公司称，出售的药明合联股票在账面上列为"长期 股权投资"。经公司财务部门初步测算，本次出售药明合联的投资净收益对公司2025年度税后净利润的 影响约为16.79亿元，占公司2024年归属净利润的比例超过10%。 记者注意到，最近一年药明康德已多次减持药明合联。2024年11月、2025年1月药明康德分别减持药明 合联3600万股和5000万股，累计成交金额约24.26亿港元；2025年4月，公司继续减持药明合联5080万 股，成交金额约21.78亿港元。如果加上本次减持，最近一年药明康德累计减持药明合联69.5亿港元。 ...

Core Viewpoint - WuXi AppTec's major shareholder, WuXi PharmaTech, has reduced its stake in WuXi AppTec again, selling 30.3 million shares for over HKD 2.3 billion, leading to significant stock price declines for both companies [2][4]. Group 1: Shareholder Actions - WuXi PharmaTech has conducted its fourth large-scale reduction of WuXi AppTec shares in the past year, totaling approximately HKD 69.5 billion in cash from these sales [4]. - The recent sale represents 2.47% of WuXi AppTec's total shares, with the stock price dropping by 7.29% following the announcement [2][4]. Group 2: Financial Impact - The sale of WuXi AppTec shares is classified as a "long-term equity investment," and the estimated net profit impact for WuXi PharmaTech in 2025 is approximately HKD 1.679 billion, accounting for over 10% of the company's net profit for 2024 [4]. - WuXi PharmaTech's revenue and net profit declined in 2024, with revenues of approximately CNY 39.241 billion, down 2.73%, and net profit of CNY 9.45 billion, down 1.63% [4]. Group 3: Business Performance - In 2025, WuXi PharmaTech's performance improved, with a revenue of CNY 20.8 billion in the first half, a 20.6% increase year-on-year, and a net profit of CNY 8.56 billion, more than doubling compared to the previous year [5]. - The company has a strong order backlog of CNY 56.69 billion, reflecting a 37.2% year-on-year growth, indicating sustainable performance recovery [5]. Group 4: Market Concerns - Concerns exist regarding the high proportion of overseas revenue, which accounted for over 80% of total revenue in the first half of the year, with significant contributions from U.S. clients [5]. - Geopolitical uncertainties and intensified competition in the CXO sector pose risks to long-term orders and profitability for WuXi PharmaTech [5][6]. Group 5: Strategic Moves - The continuous reduction in shareholding is seen as a strategic move to fund future global expansion, with planned expenditures of approximately CNY 7-8 billion for capacity expansion in various countries [8]. - The cash generated from the sale of WuXi AppTec shares will be used to enhance the company's integrated CRDMO business model to meet the growing demands of global clients [8].

Market Overview - A-shares and Hong Kong stocks experienced synchronized fluctuations, with the Shanghai Composite Index falling below 3900 points and the ChiNext Index dropping by 4.55% [1] - The AH pharmaceutical sector declined across the board, with major players like WuXi AppTec leading the drop at 7.2% [1] - The largest medical ETF (512170) saw a decrease of 2.03%, halting its three-day upward trend, with a total trading volume of 640 million yuan [1] Pharmaceutical Sector Performance - The A-share pharmaceutical sector showed relative resilience, primarily due to traditional Chinese medicine stocks performing well, with companies like China Resources Sanjiu and Jilin Aodong rising over 2.5% [3] - Innovative drug stocks faced more declines than gains, with BeiGene (BGNE) leading the drop at 6.2% [3] - The only drug ETF in the market (562050) fell by 1.07%, indicating increased buying interest as evidenced by 2.23 million yuan of funds entering on dips [3] Innovation Drug Sector Insights - The innovative drug sector, previously a strong performer, has entered a phase of adjustment since September, but investor interest remains high [5] - The Hong Kong Innovation Drug ETF (520880) has attracted over 675 million yuan in the last 20 days, indicating strong buying momentum despite recent declines [5] - Analysts suggest that the short-term adjustment is due to profit-taking after significant gains and a lack of catalysts, but the long-term outlook remains positive [7] Future Catalysts and Strategies - Upcoming academic conferences, such as ESMO and ASH, are expected to reignite interest in the innovative drug sector [8] - The fourth quarter will see the implementation of various policies, including adjustments to medical insurance directories, which may accelerate support for domestic innovations [8] - Investment strategies focus on identifying companies with strong Q3 performance and exploring opportunities in the innovative drug sector for potential rebounds [8] ETF Performance and Characteristics - The Hong Kong Innovation Drug ETF (520880) is fully invested in innovative drug development companies, while the drug ETF (562050) balances innovative and traditional Chinese medicine stocks [9] - The medical ETF (512170) includes medical devices and services, with a significant portion allocated to CXO [9] - As of September 30, 2025, the medical ETF has a scale of 26.4 billion yuan, making it the largest in the pharmaceutical category [10]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因依賴該等內容而引致之任何損失承擔任何責任。 WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2359） 海外監管公告 本海外監管公告乃由本公司根據香港聯合交易所有限公司證券上市規則第 13.10B條作出。 茲載列本公司在上海證券交易所網站刊登的以下資料中文全文，僅供參閱。 承董事會命 無錫藥明康德新藥開發股份有限公司 董事長 李革博士 香港，2025年10月10日 截至本公告日期，本公司董事會包括執行董事李革博士、陳民章博士、楊青博士及張朝暉先生； 非執行董事童小幪先生及吳亦兵博士；以及獨立非執行董事盧韶華女士、俞衛博士、張新博士、 詹智玲女士及冷雪松先生。 * 僅供識別 无锡药明康德新药开发股份有限公司 简式权益变动报告书 上市公司名称：无锡药明康德新药开发股份有限公司 股票上市地点：上海证券交易所、香港联合交易所有限公司 股票简称：药明康德 股票代码：6 ...

WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因依賴該等內容而引致之任何損失承擔任何責任。 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2359） 海外監管公告 本海外監管公告乃由本公司根據香港聯合交易所有限公司證券上市規則第 13.10B條作出。 茲載列本公司在上海證券交易所網站刊登的以下資料中文全文，僅供參閱。 承董事會命 無錫藥明康德新藥開發股份有限公司 董事長 李革博士 香港，2025年10月10日 截至本公告日期，本公司董事會包括執行董事李革博士、陳民章博士、楊青博士及張朝暉先生； 非執行董事童小幪先生及吳亦兵博士；以及獨立非執行董事盧韶華女士、俞衛博士、張新博士、 詹智玲女士及冷雪松先生。 * 僅供識別 证券代码：603259 证券简称：药明康德 公告编号：临 2025-067 无锡药明康德新药开发股份有限公司 关于股东到期解除一致行动关系暨权益变动的提示性公告 本公司董事会及全体董事及相 ...

无锡药明康德新药开发股份有限公司 简式权益变动报告书 上市公司名称：无锡药明康德新药开发股份有限公司 股票上市地点：上海证券交易所、香港联合交易所有限公司 股票简称：药明康德 股票代码：603259.SH、02359.HK | 信息披露义务人 | | 住所 | 通讯地址 | | --- | --- | --- | --- | | G&C IV | Hong Kong | Unit 826, 8/F, Ocean | | | Limited | | Centre, Harbour City, 5 | | | | | Canton Road, Tst, | 中国上海外高 | | | | Kowloon, Hong Kong | 桥 富 特 中 路 | | G&C V | Limited | PO Box 309, Ugland | 号 | | G&C VI | Limited | House, Grand Cayman, | 288 | | | | KY1-1104, Cayman | | | G&C VII | Limited | Islands | | | 嘉兴厚锦投资合伙 | | 浙江省嘉兴市南湖区 883 ...

南财智讯10月10日电，药明康德公告，公司原一致行动人与实际控制人之一GeLi（李革）签署《一致 行动关系解除协议》，导致信息披露义务人合计可支配表决权比例从20.16%下降至18.46%，触及5%的 整数倍刻度。此外，自2023年8月30日至2025年10月9日期间，因回购和注销A股及H股、A股期权激励 计划项下行权、增发H股、H股可转换债券转股等原因，公司总股本发生变动，信息披露义务人持股比 例被动变化。变动后，公司实际控制人GeLi（李革）、张朝晖、刘晓钟合计控制公司18.46%的表决 权。信息披露义务人尚无在未来12个月内增加或减少药明康德股份的明确计划。 ...