Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on five key areas: AI + Bio-Manufacturing, Green Chemistry and New Materials, Future Food, and Future Agriculture. The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by institutions such as Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Bioengineering Co., Ltd. It is supported by various associations and alliances in the field of synthetic biology [2]. Expert Guests - Notable experts, including Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University of Technology, will serve as advisory experts for the conference. Zhang has significant credentials, including being a Fellow of the American Institute for Medical and Biological Engineering and the Royal Society of Chemistry [6][7][8]. Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemistry, AI in bio-manufacturing, and future food and agriculture. The first day features a macro forum on the bio-manufacturing industry, while subsequent days will host specialized forums and networking events [41]. Key Topics of Discussion - The conference will cover various innovative topics, including the construction of efficient cell factories for producing aromatic compounds, the biomanufacturing of polyamide materials, and advancements in enzyme engineering for low-carbon bio-manufacturing [13][15][32][34]. Networking and Collaboration - The event aims to facilitate technology transfer, product scaling, and talent acquisition within the bio-manufacturing industry, promoting collaboration among enterprises, research institutions, and government bodies [1]. Registration and Participation - Interested participants can register for the conference, which promises to be a significant event for stakeholders in the synthetic biology and bio-manufacturing sectors [42][44].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Organizers and Support Units - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [2]. Expert Guests - Notable experts such as Zhang Xian'en, a prominent figure in synthetic biology, will participate as advisory experts for the conference [4][5]. Conference Agenda - The event will feature a series of forums and discussions, including a high-level roundtable on biomanufacturing, thematic forums on green chemicals and new materials, and AI-enabled biomanufacturing innovations [36][37]. Key Topics of Discussion - The conference will cover topics such as the construction of efficient cell factories for producing aromatic compounds, biomanufacturing of polyamide materials, and the development of non-grain bulk alcohols and organic acids [8][11][12][30].

Core Viewpoint - Isomaltulose is a new type of natural sweetener with low calories (4 kcal/g), high stability, and no adverse health effects, widely used in pharmaceuticals and food industries [1]. Market Overview - The global isomaltulose market reached $16.2 million in 2023 and is expected to grow to $48.9 million by 2030, with a compound annual growth rate (CAGR) of 17.19% from 2024 to 2030 [2]. Production Technology - The enzymatic preparation of isomaltulose has high conversion rates and meets green environmental requirements. Sucrose isomerase (SI) is an effective enzyme for catalyzing isomaltulose production. Immobilizing SI can improve its stability, reduce inactivation, and enhance recyclability in industrial applications [3]. Research and Development - Professor Liu Fufeng's team at Tianjin University of Science and Technology developed a directed immobilized enzyme that significantly improves heat resistance and reusability while maintaining high activity after multiple cycles. This work lays a solid foundation for the green manufacturing of isomaltulose and provides innovative ideas for the development of new directed immobilized enzyme technologies [4]. Conference Information - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials. The "Youth Forum on Biological Manufacturing" will highlight scientific issues, solutions, results, scalability, and future directions in the research field [8][11].

Core Viewpoint - The article discusses the production and market potential of bio-based 1,4-butanediol (BDO), highlighting the shift towards sustainable chemical production methods in response to environmental concerns and regulatory pressures. Group 1: Bio-based BDO Production - Cargill and HELM AG's joint venture Qore has officially launched the production of bio-based BDO using locally grown dent corn, with a total investment of $300 million, aiming for an annual production capacity of 66,000 tons [3] - BDO is a crucial organic chemical and fine chemical raw material with extensive downstream applications across various industries, including textiles, pharmaceuticals, and biodegradable plastics [4] - The production of bio-based BDO is primarily achieved through fermentation processes, with Qore utilizing a proprietary one-step fermentation technology developed by Genomatica [8] Group 2: Industry Developments and Collaborations - LYCRA plans to use QIRA to enhance the sustainability of its fibers, potentially reducing its carbon footprint by up to 44% [5] - BASF has entered a long-term supply agreement with Qore to incorporate QIRA into its product portfolio, aiming for sustainable chemical production [5] - Several companies are investing in bio-based BDO production, including the Korean company Xinying Group, which plans to build a $1 billion facility in Vietnam, and Jinfa Technology, which has launched a 10,000-ton bio-based BDO project in Liaoning [9][10] Group 3: Market Trends and Future Outlook - The traditional BDO production methods face challenges due to high carbon emissions, necessitating the development of greener, low-carbon production processes [7] - Despite the current higher costs of bio-based BDO compared to petroleum-based BDO, its competitive advantage is expected to grow as oil prices remain high and production technologies improve [12] - The upcoming SynBioCon 2025 conference will focus on the development and industrial collaboration of key products that can replace petrochemical raw materials, indicating a strong industry shift towards sustainable practices [13]

Core Viewpoint - All-trans retinoic acid (ATRA) is a key active derivative of vitamin A with extensive clinical application value, but mainstream manufacturers like BASF and DSM still rely on traditional chemical synthesis methods, which pose environmental challenges and do not meet green chemistry requirements [1][3]. Group 1: Research Breakthroughs - The team from the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, achieved a breakthrough by engineering Saccharomyces cerevisiae to produce ATRA at a fermentation yield of 1.84 g/L, providing a green solution for constructing a self-controlled vitamin industry chain [3][8]. - The research utilized a multi-faceted metabolic engineering strategy, optimizing chassis construction, module selection, cellular factory upgrades, and fermentation processes to achieve this yield [8]. Group 2: Metabolic Engineering Strategy - The initial focus was on creating a high-yield chassis for β-carotene, the precursor for ATRA, by screening genes from Xanthophyllomyces dendrorhous, leading to the construction of the Car09 strain with a β-carotene yield of 129.4 mg/L [5][6]. - The best combination for ATRA synthesis was identified as a β-carotene dioxygenase from marine bacteria and mouse retinaldehyde dehydrogenase, achieving 98.1 mg/L ATRA, although significant residual β-carotene indicated limitations in synthesis [6][7]. Group 3: Industrial Adaptation and Optimization - Four-dimensional collaborative modifications were implemented to address efficiency bottlenecks, including overexpressing transcription factors to enhance endoplasmic reticulum activity, balancing NADPH/NAD⁺ levels, and improving substrate supply, resulting in a 49.2% increase in ATRA yield [7][8]. - The development of a two-phase extraction fermentation process, combining glucose growth with ethanol and galactose induction, led to the successful production of ATRA at 1.84 g/L in a 5L fermenter [8]. Group 4: Industry Conference - The SynBioCon 2025 conference, scheduled for August 20-22 in Ningbo, will focus on the intersection of AI and biological manufacturing, exploring trends in green chemistry, new materials, future food, agriculture, and cosmetic ingredients [10][12].

Group 1 - The article introduces the "Green Bio-Manufacturing" National Key Laboratory, established by Beijing University of Chemical Technology, Tsinghua University, and Dabeinong Group, focusing on producing liquid fuels and important chemicals from non-food biomass resources to support the reduction of fossil resources and CO2 emissions [1][3]. - The laboratory is led by Professor Tan Tianwei, an academician of the Chinese Academy of Engineering, who has a distinguished background in education and research, having trained over 100 graduate students [1][5]. - The research team includes a diverse group of experts, such as 1 academician, 6 distinguished young scholars, and 30 professors, with established verification bases and industrial connections [5]. Group 2 - The laboratory is recruiting several postdoctoral researchers to work on synthetic biology, enzyme catalysis, fermentation engineering, and chemical simulation, with responsibilities including laboratory management [6]. - Candidates should have a PhD in relevant fields, with a maximum of 3 years since obtaining their degree, and must demonstrate independent research capabilities and teamwork spirit [6][7]. - The compensation for postdoctoral positions follows the university's standards, with salaries ranging from 180,000 to 250,000 CNY per year, and additional benefits such as housing support for certain scholars [6]. Group 3 - The Syn BioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on opportunities in bio-manufacturing for the bio-chemical and new materials industries [9]. - The conference will cover five key areas: AI + bio-manufacturing, green chemistry and new materials, future food, future agriculture, and beauty raw materials, aiming to explore trends and innovations in the bio-manufacturing industry [9][12]. - Participants from various sectors, including industry leaders, experts, and government representatives, are invited to discuss the future of bio-manufacturing and promote the scaling and transfer of technological achievements [9].

Core Viewpoint - The article emphasizes the importance of green biosynthesis of aromatic compounds for sustainable development, addressing the limitations of traditional production methods that are resource-intensive and environmentally harmful [1]. Group 1: Green Biosynthesis of Aromatic Compounds - Aromatic compounds are crucial in various industries such as materials, food, pharmaceuticals, and cosmetics, but traditional production methods face sustainability and pollution issues [1]. - The development of efficient cell factories is identified as a key factor in overcoming challenges such as low yield, poor cell tolerance, and low production intensity in the biosynthesis of aromatic chemicals [1]. Group 2: Research and Development Achievements - Professor Yuan Qipeng's team at Beijing University of Chemical Technology has constructed advanced cell factories for synthesizing over twenty important aromatic compounds, surpassing natural theoretical yields [1]. - Strategies to enhance the synthesis capabilities of compounds like arbutin and ferulic acid have been proposed, significantly improving their production efficiency [1]. - The establishment of industrial production lines for compounds such as arbutin and 5-hydroxytryptophan demonstrates the potential of synthetic biology in green biosynthesis [1]. Group 3: Upcoming Conference - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, focusing on the future of food and agriculture, where Professor Yuan will present on the construction of efficient cell factories for aromatic compound production [2][4]. - The conference aims to explore trends in biomanufacturing, innovative technologies, and products that can sustain the industry's vitality, involving various stakeholders including industry leaders and experts [4].

Core Viewpoint - The article discusses the advancements in green bio-manufacturing, particularly focusing on the synthesis of aliphatic short-chain diamines and diols from renewable resources, highlighting the importance of reducing reliance on fossil resources and addressing environmental concerns [3][4][5]. Group 1: Importance of Green Bio-Manufacturing - The chemical industry is a significant part of the national economy, with over 100,000 types of fine chemical products globally. Traditional production methods heavily rely on fossil resources, leading to resource depletion and CO2 emissions [4]. - Transitioning to renewable resources for bio-manufacturing is crucial for achieving a clean, low-carbon, and sustainable environment. China has set goals to replace traditional chemical raw materials with bio-based materials [4][5]. Group 2: Advances in Bio-Synthesis - Significant progress has been made in the bio-synthesis of 1,3-propanediamine, 1,4-butanediamine, and their corresponding diols, with commercial applications already realized by companies like DuPont and Genomatica, achieving cost reductions of 37% and energy savings of 30% compared to petrochemical processes [5][6]. - Companies such as Ningxia Yipin Biotechnology and Shanghai Kaisi Bio-Industry have successfully scaled up the production of 1,5-pentanediamine using whole-cell catalysis, claiming a 30% cost reduction compared to traditional methods [5][6]. Group 3: Challenges in Bio-Synthesis - Despite advancements, challenges remain in the bio-synthesis of most diamines and diols, including high production costs and the lack of natural biosynthetic pathways for certain compounds [6][7]. - Research is focused on developing bio-synthesis routes using non-food biomass and one-carbon feedstocks to reduce fossil resource dependence and CO2 emissions [6][7]. Group 4: Metabolic Pathways and Carbon Cycling - The article outlines the carbon cycling and metabolic pathways involved in utilizing renewable resources for bio-manufacturing, emphasizing the role of biomass derived from agriculture, forestry, and waste [8][9]. - Various metabolic pathways for sugars derived from lignocellulosic biomass have been identified, which can be utilized for synthesizing short-chain diamines and diols [11][13]. Group 5: Synthesis Routes for Specific Compounds - Detailed synthesis routes for 1,3-propanediamine and 1,3-propanediol are discussed, highlighting the use of key amino acid precursors and various microbial pathways [20][21]. - The synthesis of 1,4-butanediamine and 1,4-butanediol involves multiple pathways, including those utilizing ornithine and arginine, with significant advancements in microbial engineering to enhance yields [23][24]. - The article also covers the synthesis routes for 1,5-pentanediamine and 1,5-pentanediol, focusing on the use of lysine as a precursor and the challenges in achieving high yields [25][26].

Core Viewpoint - The article highlights the upcoming "Youth Forum on Biomanufacturing" scheduled for August 20 in Ningbo, Zhejiang, as part of the SynBioCon 2025 event, aimed at promoting innovation and collaboration in the field of synthetic biology and biomanufacturing [2][3]. Group 1: Event Details - The "Youth Forum on Biomanufacturing" will focus on addressing scientific issues, solutions, achievements, scalability, and future directions in the research field [3]. - The event will take place on August 20, 2025, with limited seating available (only 30 seats) [6]. - Participants can choose to register for either the Youth Forum or the Technology Achievement Showcase [6]. Group 2: Participation and Contributions - The event encourages universities and research institutions to apply for sharing their innovative achievements [4]. - SynBioCon 2025 will also feature a "Technology Achievement Showcase" to publicly collect 100 innovative achievements and projects in the field of synthetic biology and biomanufacturing for on-site display and networking [6]. Group 3: Organizers and Previous Events - The event is organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [11]. - Previous editions of the SynBioCon were successfully held in 2022, 2023, and 2024 in Ningbo, showcasing the growing interest and development in the field [13].

SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （现场展示科技成果推介墙）， 公开征集100个从0—1—100的合成生物和生物制造领域创新成果 和项目 ，于现场展示、对接。 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30 ...