关键 词 | SynBio团队 |王丹 教授| 中链脂肪酸生物制造 中链脂肪酸（ MCFAs，C6–C12）因其吸收快、能量密度高、抗菌性强等特性，在营养品、医药及绿色能源领域具有重要价值。然而，其生 物制造面临碳链长度控制难、底物成本高等挑战。传统方法依赖粮食基碳源，难以实现规模化与可持续生产。 【SynBioCon】 获 悉，近日， 重庆大学化学化工学院王丹教授团队 在中链脂肪酸的生物合成上取得重要突破 。 研究团队在大肠杆菌中构 建了高效合成途径，利用离子液体预处理的竹废料酶解液与 CO₂为共底物，在5 L发酵罐中实现MCFAs产量达9.05 g/L 。相关成果以 "Efficient production of medium-chain fatty acids in engineered Escherichia coli strains from ionic liquids pretreated bamboo enzymatic hydrolysate with carbon dioxide fixation"为题，发表在 Bioresource Technology 上。 图片说明：大肠杆菌利用竹废 ...

Core Viewpoint - Weihe Biotechnology has completed a seed round of financing, led by QuanHua Life, focusing on life sciences investment [1] Group 1: Financing Details - The funds raised will primarily be used for the development of a research platform, building a research team, and pilot production of core products [1] - The financing aims to accelerate the biomanufacturing of high-value food new materials, providing more sustainable solutions for the health industry [1] Group 2: Company Focus and Goals - Weihe Biotechnology officially established its presence in the Beijing Agricultural Zhongguancun Science Park in October 2025 [1] - The company is focused on constructing and optimizing efficient cell factories, aiming to promote green biomanufacturing of functional proteins and small molecular active substances [1]

Core Viewpoint - The article discusses the advancements in glycosyltransferase engineering for the efficient glycosylation of flavonoids, highlighting the potential applications in health and wellness products, as well as in the fields of agriculture and biomedicine [5][11]. Summary by Sections Glycosylation of Flavonoids - Flavonoids are important plant secondary metabolites with significant biological activities used in disease prevention and treatment [3]. - The glycosylation of flavonoids is catalyzed by plant UDP-glycosyltransferases (UGTs), which is a green and economical method compared to traditional chemical synthesis [3][4]. Research Findings - The study identified a rare glycosyltransferase, UGT75AJ2, capable of catalyzing the glycosylation at C-3' and C-7 hydroxyl positions of flavonoids, leading to the directed synthesis of bioactive flavonoid glycosides [5][6]. - The research demonstrated that glycosylation at these positions enhances antioxidant and blood sugar-lowering activities [4]. Engineering Strategies - A custom FRISM strategy was developed for the rational design of UGTs, resulting in a quadruple mutant (Mut4-1) of UGT75AJ2 with 128 times the catalytic activity of the wild type [7]. - The strategy was also successfully applied to other glycosyltransferases, validating its effectiveness and versatility [7][8]. Implications and Applications - The study provides a new paradigm for enhancing the activity, donor promiscuity, and regioselectivity of plant glycosyltransferases, which is crucial for the biosynthesis of high-value flavonoid glycosides [11]. - This research integrates multiple disciplines, including food science, synthetic biology, artificial intelligence, and pharmacology, contributing to the development of health products with medicinal value [11].

Core Insights - The article discusses the significance of green biomanufacturing in achieving carbon neutrality and sustainable development, highlighting the recognition of key scientists in the field [2][4][5]. Group 1: Green Biomanufacturing Potential - Biomanufacturing is projected to cover 70% of chemical manufacturing products by the end of this century, with an expected economic value of $30 trillion by 2050, although the current industry scale is less than $8 trillion [4][5]. - The concept of third-generation biomanufacturing, which utilizes carbon dioxide as a raw material, is emphasized as a crucial advancement for addressing carbon neutrality [4][5]. Group 2: Challenges and Innovations - Major scientific challenges include efficiently capturing and activating inert carbon dioxide molecules, requiring the design of new enzyme catalysts and light-enzyme coupling systems [5][6]. - Engineering challenges involve scaling up efficient but fragile biological systems to create stable, continuous, and low-cost reactors, transitioning from laboratory to industrial applications [5][6]. Group 3: Interdisciplinary Collaboration - Effective interdisciplinary collaboration is essential, necessitating the establishment of project communities, shared platforms, and talent communities to foster innovation across biology, chemistry, materials, and information fields [6][7]. - Educational reforms are needed to cultivate talent capable of leading the next industrial revolution, focusing on interdisciplinary courses and encouraging exploratory research [6][7]. Group 4: Global Position and Cooperation - China is transitioning from a "follower" to a "leader" in the global green technology race, with advantages in applied research, industrialization, and market scale [7]. - The proposed international cooperation model emphasizes open collaboration in basic research, innovation alliances in key technologies, and self-reliance in core competitive areas [7].

Core Viewpoint - The article emphasizes the significance of green bio-manufacturing as a sustainable development frontier, predicting that by the end of this century, bio-manufactured products could cover 70% of chemical manufacturing products, with bio-manufacturing potentially accounting for one-third of global manufacturing by 2050, creating an economic value of $30 trillion [4][5]. Group 1: Green Bio-Manufacturing Potential - The current scale of the bio-manufacturing industry is less than $8 trillion, indicating substantial growth potential in the future [4]. - The third generation of bio-manufacturing, which utilizes carbon dioxide as a raw material, is expected to significantly contribute to carbon neutrality efforts [5]. Group 2: Key Challenges and Innovations - Major scientific challenges include efficiently capturing and activating inert carbon dioxide molecules, requiring the design of new enzyme catalysts and light-enzyme coupling systems [5]. - Engineering challenges involve scaling up efficient but fragile biological systems to create stable, continuous, and low-cost reactors, transitioning from laboratory to industrial scale [5]. Group 3: Interdisciplinary Collaboration - Achieving deep integration across disciplines such as biology, chemistry, materials science, and information technology requires the establishment of project communities, shared platforms, and talent communities [6]. - Educational reforms are necessary to cultivate interdisciplinary talent capable of leading the next industrial revolution, including curriculum changes and new evaluation methods [6]. Group 4: China's Position in Global Green Technology - China is transitioning from a "follower" to a "leader" in the global green technology race, with advantages in applied research, industrialization, and market scale [7]. - The proposed international cooperation model emphasizes open collaboration in basic research, innovation alliances in key technology areas, and self-reliance in core competitive fields [7].

Group 1 - The core point of the article is that Hangzhou Jingou Biotechnology Co., Ltd. has completed a multi-million A round financing led by Jinding Capital, with participation from several other investment institutions [1] - The financing will primarily be used for research and development investments and the construction of production capacity, aiming to accelerate the large-scale production of high-value-added nutritional health and feed additive products [1] - Jingou Biotechnology, established in 2023, focuses on synthetic biology technology applications in essential areas such as human nutrition and feed additives, with the goal of creating a leading domestic and internationally competitive green biotechnology manufacturing platform [1] Group 2 - The actual controller of Jingou Biotechnology is Wang Zhimin, who holds a total of 55.24% of the shares and serves as the chairman and general manager of the company [3]

Group 1 - The technology and manufacturing sectors remain the primary focus of investment, with artificial intelligence and aerospace being particularly attractive to capital [1][3] - Hubei Chipking Technology Co., Ltd. completed a Series B financing round exceeding 1 billion RMB, while Dream Sky Technology (Suzhou) Co., Ltd. announced over 100 million RMB in cumulative Pre-A++ and strategic financing [1][23][44] - In the healthcare sector, Yingshi Biotechnology (Nanjing) Co., Ltd. secured over 34 million USD in Series C financing, led by Rehabilitation Capital [1][12] Group 2 - A total of 34 financing events occurred in the domestic primary market from August 18 to August 24, with 27 disclosing amounts totaling approximately 4.486 billion RMB [1][2] - The chip sector saw 4 financing rounds totaling 1.24 billion RMB, while the artificial intelligence sector had 3 rounds with disclosed amounts exceeding 59 million RMB [3][4] - Jiangsu Province, Beijing, and Shanghai were the most active regions, completing 12, 6, and 5 financing rounds respectively [5][6] Group 3 - Qiming Venture Partners and Yunze Capital were notably active, each completing 2 financing rounds primarily in the healthcare and technology sectors [6][7] - Beijing Huimei Cloud Technology Co., Ltd. raised nearly 200 million RMB, with funding from Shanghai Science and Technology Innovation Fund and Zhongding Capital [7][8] - Other companies like Zhitong Technology and Kegong Biotechnology also completed significant financing rounds, focusing on innovative medical and technological solutions [8][9][10]

Core Viewpoint - The amino acid market in China is experiencing growth driven by downstream sectors such as feed, food processing, pharmaceuticals, and health products, with a projected demand of 575.08 million tons in 2023, but expected to decline to 561.52 million tons in 2024 due to macroeconomic factors [1][19]. Overview - Amino acids are essential components of proteins and are widely used in various industries, including feed, food, and pharmaceuticals [2][6]. - The classification of amino acids includes essential, semi-essential, and non-essential types, with specific applications based on their properties [3][4]. Market Demand and Trends - The demand for amino acids is projected to decrease in 2024, with the market size expected to drop to 60.862 billion yuan, where glutamic acid accounts for 33.35%, lysine for 32.79%, threonine for 10.11%, methionine for 13.73%, and tryptophan for 2.15% [1][19]. - There is a growing consumer preference for natural and healthy products, which is expected to boost the demand for green and environmentally friendly amino acids and derivatives [1][19]. Industry Development - The amino acid industry in China has evolved from extraction methods to microbial fermentation, significantly reducing production costs and increasing efficiency [6][7]. - The industry is witnessing consolidation, with larger companies acquiring smaller ones to enhance market share and competitiveness [7][8]. Market Policies - Recent policies in China support technological innovation and industrial upgrades in the amino acid sector, promoting the use of amino acids in feed to ensure supply safety [10][12]. Industry Chain - The upstream of the amino acid industry includes suppliers of raw materials like corn, soybeans, and wheat, while the downstream encompasses applications in feed, food processing, pharmaceuticals, and health products [13][15]. - The feed sector is the largest market for amino acids, accounting for over 60% of demand, with significant growth in industrial feed production [17][19]. Competitive Landscape - The amino acid market in China is concentrated among leading companies such as Meihua Biological Technology Group, Fujian Fufeng Group, and Zhejiang New Hope Liuhe, which dominate the market [21][25]. - Meihua Biological is the largest producer of lysine, while Fufeng Group leads in MSG production, indicating a competitive environment with significant market players [21][27]. Future Trends - There is an increasing demand for high-purity amino acids in pharmaceuticals and cosmetics, supported by national policies favoring green production methods [29][30].

Core Insights - The announcement from the National Center for Food Safety Risk Assessment indicates that the application for Steviol Glycosides (enzyme conversion method) Reb M2 as a new food additive has successfully completed the public consultation phase, paving the way for its gradual entry into the domestic food and beverage market [1] - The global sugar reduction movement is reshaping the food industry, driven by WHO recommendations to limit free sugar intake to below 10% of total energy and China's "Healthy China Action (2019-2030)" initiative, which emphasizes sugar reduction as a key aspect of national health management [1] - The introduction of Reb M2 signifies a technological turning point in the sweetener industry, overcoming the taste limitations of traditional plant-extracted sweeteners and filling the market gap for "high sweetness and natural flavor balance" [1] Industry Analysis - Natural steviol glycosides primarily consist of Stevioside, RebA, and RebC, with Stevioside and RebA accounting for over 80% of the total, both of which exhibit significant aftertaste issues that limit their application in high-end food products [2] - Reb M2 offers a unique advantage, being 150-200 times sweeter than sucrose while having zero calories and high safety, with a sweetness release curve characterized by "front sweetness soft, middle sweetness full, and back sweetness short," effectively addressing the delayed sweetness issue of traditional plant-extracted steviol glycosides [2] - The vast market potential of Reb M2 is attributed to its broad applicability, allowing it to be blended with low-sweetness sweeteners like allulose and erythritol to optimize cost and taste, or with high-sweetness sweeteners like sucralose to mask metallic aftertaste and reduce usage [2] - Reb M2 has completed empirical research across over 20 food categories, covering core sectors such as dairy products, beverages, baking, and condiments, indicating its versatility and market readiness [2] - The launch of Reb M2 is set to reconstruct the sweetness logic in the food industry through technological innovation, facilitating the transition of the steviol glycoside industry from traditional extraction processes to green biomanufacturing, and opening new avenues for companies like Rhein Biotech in the health food and beverage market [2]

Group 1 - The core viewpoint of the article highlights the financial performance of Huafeng Chemical for the first half of 2025, indicating a decline in revenue and net profit due to various external economic challenges [2][3] - The company reported a revenue of approximately 12.137 billion yuan, a year-on-year decrease of 11.70%, and a net profit of 983 million yuan, down 35.23% compared to the previous year [3] - The chemical fiber segment generated revenue of about 4.215 billion yuan, reflecting a decline of 9.43%, while the gross profit margin increased by 3.68% to 18.65% [2] Group 2 - The global economic environment is described as complex and uncertain, influenced by factors such as U.S. tariffs and geopolitical issues, which have weakened growth momentum [2] - The domestic economy remains stable, but external changes have posed significant challenges to domestic demand, impacting product prices and profits across the industry [2] - The report indicates that the industry is experiencing a cyclical downturn, leading to an oversupply situation and a decrease in product prices compared to the previous year [2]