Core Viewpoint - Tianjin Pharmaceutical Industry Co., Ltd. has responded to the Shanghai Stock Exchange's inquiry regarding its 2024 annual report, particularly focusing on the prepayment of research and development (R&D) funds and the collaboration with its controlling shareholders' affiliated enterprises [1][2]. Summary by Sections R&D Project Payments - The company reported a total prepayment of approximately 20 million yuan for R&D projects in 2024, with repayments from major shareholders and their affiliates totaling about 70 million yuan, leaving a balance of approximately 160 million yuan at the end of the period [1]. - The company emphasized the necessity of collaborating with its controlling shareholders' affiliates for R&D, citing advantages such as resource integration, risk control, and enhanced R&D efficiency [1]. R&D Project Details - The company has engaged in various R&D projects, including high-end hormone and amino acid APIs, sterile lyophilized preparations, nasal sprays, eye drops, and inhalation preparations. The total prepayment for these projects in 2024 was 18.30 million yuan, with repayments amounting to 68.31 million yuan [1]. - Specific details of R&D projects were provided, including project codes, budget totals, prepayment amounts, and repayment reasons, indicating a structured approach to managing R&D expenditures [1]. Financial Management and Compliance - The company has established a milestone payment mechanism to reduce upfront financial pressure, ensuring that any excess R&D costs beyond the contract amount are borne by the R&D institutions [1]. - The annual audit confirmed that the prepayment of R&D funds is part of the company's normal business operations and does not constitute non-operating fund occupation by related parties [1][8]. Project Status and Challenges - The company is actively managing its R&D projects, which are in various stages of development. Some projects have faced challenges due to technical difficulties and regulatory changes, leading to costs exceeding initial estimates [1][8]. - The company maintains close communication with its R&D partners to address any issues and ensure the smooth progress of projects, with a focus on achieving the necessary regulatory approvals [1][8].

Group 1: Collaboration and Product Development - The company has maintained a nearly ten-year partnership with Daiichi Sankyo, expanding from a single product in 2015 to six products, including Olmesartan Medoxomil tablets and others, with a focus on cardiovascular treatments [2][3] - The company plans to continue expanding collaborations with Japanese firms, particularly in the cardiovascular treatment sector [2] Group 2: Market Performance and Sales - After the centralized procurement of Injection Multivitamins (12), prices decreased, but sales volume increased, with a 40% growth in sales volume and over 1.1 billion CNY in revenue in 2024 [3] - The company holds over 80% market share in the Injection Multivitamins (12) market, with three manufacturers currently competing [3] - Sales of the product "Dipeptide Injection" have shown a stable growth of nearly 10% in 2024 [4] Group 3: Product Portfolio and Future Prospects - Core products from the subsidiary Pude Pharmaceutical include Ginkgo Biloba Injection and others, which have maintained strong market positions [3] - The product "Anbrain Pills" achieved a revenue of 182 million CNY in 2024, an increase of over 80% year-on-year, with significant growth potential due to its unique market position [7] - The company has over 20 projects under research, focusing on differentiated products in areas like cardiovascular and orthopedic treatments [9] Group 4: Financial Performance and Challenges - The company's revenue for 2024 was 2.441 billion CNY, a decrease of 7.06% year-on-year, primarily due to strategic decisions affecting product procurement [9] - Total assets have declined due to measures taken to repay bank loans and dispose of idle assets [9] - The company reported a goodwill of 369 million CNY as of the end of 2024, with no signs of impairment [9] Group 5: Management Structure - The company's board consists of six members, with Shen Zhenyu as the chairperson and Guo Lei Feng as the general manager [10] - The management model adheres to legal regulations, with daily operations managed by the core management team [10]

Core Insights - The company reported a revenue of 3.63 billion yuan in 2024, a decrease of 4.44% year-on-year [4] - The net profit attributable to shareholders was 230.76 million yuan, down 27.98% compared to the previous year [4] - The company is actively reducing low-margin wholesale and retail drug businesses, which, along with increased R&D investment and rising raw material costs, has pressured profit margins [2] Financial Performance - Revenue for 2024 was 36.30 billion yuan, a decline of 4.44% year-on-year [4] - Net profit attributable to shareholders was 2.31 billion yuan, a decrease of 27.98% [4] - The net profit after deducting non-recurring items was 2.19 billion yuan, down 27.92% [4] - Basic earnings per share were 0.55 yuan [4] Asset and Cash Flow - Cash and cash equivalents decreased from 1.998 billion yuan to 1.344 billion yuan, primarily due to increased long-term deposits [3] - Short-term borrowings decreased by 79% to 12 million yuan, with long-term borrowings eliminated [3] - Net assets at the end of the period reached 2.462 billion yuan, a year-on-year increase of 3.04% [3] Business Segmentation - Revenue from drug production was 1.002 billion yuan, an increase of 4.2% year-on-year [3] - Revenue from traditional Chinese medicine slices decreased by 16.55% to 56 million yuan [3] - Revenue from drug wholesale and retail was 149 million yuan, down 12.39% [3] - Notable product performance included a 32% decline in entertainment products, a 13.3% increase in sanitary napkins, and a 30% increase in other products [3] R&D Investment - R&D expenditure for 2024 was 235 million yuan, accounting for 6.46% of revenue [3] - The company is advancing several products, including the registration of classic formulas and submissions for generic drugs [3]

Core Viewpoint - Tianjin Pharmaceutical Industry is recognized as a leading domestic manufacturer of steroid hormone drugs and a global leader in amino acid raw materials, showcasing its advanced position and demonstration effect in the industry for the year 2024 [1] Product Matrix - The company has a diverse product matrix with over 70 types of raw materials, including dexamethasone series, prednisone series, methylprednisolone series, betamethasone series, and amino acids, as well as more than 10 dosage forms such as injections, ointments, and tablets, catering to various patient treatment needs [2] R&D Innovation - In recent years, the company has significantly enhanced its product R&D and scientific research system, focusing on steroid hormones and amino acids, and implementing a "raw materials + formulations" full industry chain layout, with R&D investment reaching 248 million yuan in 2024, accounting for 7.7% of revenue, reflecting its strong R&D capabilities [3] Dual-Track Strategy - The company employs a dual-track strategy of "innovation line" and "generic line" to accelerate the new drug approval process, with 11 specifications of 10 products recently receiving approval, including the first domestic approval for a specific injection by its subsidiary [4] Market Performance - Among its products, the injection of isopropyl methochloride has shown strong market performance, with sales increasing from 756 million yuan in 2022 to 821 million yuan in 2023, and is expected to expand further due to its inclusion in the national medical insurance [5] - The inhalation solution of acetylcysteine is also a national medical insurance drug, with significant market potential in treating respiratory diseases, indicating a stable growth outlook as the patient population expands [5] Future Outlook - The company plans to continue its commitment to innovation, increasing investment in technology R&D, and focusing on new product development and consistency evaluation to provide high-quality, efficient drugs for patients and deliver substantial value returns to shareholders [6]

Core Viewpoint - Company Haisco (002653) has received a Notice of Acceptance from the National Medical Products Administration for its drug HSK45030 dispersible tablets, aimed at treating muscular dystrophy [1] Group 1: Product Development - HSK45030 is a self-developed oral, selective small molecule inhibitor [1] - Preclinical studies indicate that HSK45030 significantly reduces muscle damage caused by excessive muscle contraction [1] - The drug has shown excellent efficacy in preventing muscle atrophy in animal models [1]