Core Viewpoint - The article highlights the significant advancements in mass spectrometry technology in the first half of 2025, showcasing a series of groundbreaking new products that cater to diverse needs from basic analysis to high-end research [1][2]. Product Overview - A variety of new mass spectrometry products were launched in the first half of 2025, with notable entries from major companies such as Thermo Fisher, Bruker, Waters, and SCIEX, reflecting the ongoing innovation in the field [5][6]. - Key products include: - Thermo Scientific IM Orbitrap IM Zoom and Orbitrap Excedion Pro, which enhance sensitivity and throughput for complex biological molecule analysis [6][7]. - Bruker's timsOmni, timsUltra AIP, and timsMetabo, which focus on protein and metabolomics with advanced ion mobility techniques [6][8]. - SCIEX's ZenoTOF 8600, which integrates advanced detection technologies for research and precision medicine applications [7][8]. - Waters' Xevo TQ Absolute XR, designed for ultra-sensitive detection in PFAS and drug quantification [7][8]. Trends in Innovation - The new products emphasize higher sensitivity and throughput, smarter data acquisition and analysis, stronger multi-omics integration capabilities, and broader application coverage [9]. - Domestic mass spectrometry companies have achieved a near "50-50" balance with imported products in terms of new product launches, indicating significant progress in local technology and innovation [11][12]. Domestic Product Highlights - Domestic companies like Anhui Wanyi Technology and Shandong Yingsheng Biotech have introduced several new products, including the TQ9200 series and fully automated systems, showcasing advancements in automation and miniaturization [12][13]. - The GBI LINE-MS2600 from BGI highlights improvements in hardware design and intelligence, while Zhengzhou Antu Bio has launched multiple liquid chromatography tandem mass spectrometry systems [14][15]. Regulatory Progress - In the first half of 2025, three domestic medical mass spectrometry products received registration certificates, with a 55% year-on-year increase in approved mass spectrometry reagent kits and standards, indicating a growing trend in the medical application of mass spectrometry [16][17]. Market Dynamics - The article concludes that both imported and domestic manufacturers are focusing on integrating mass spectrometry technology into clinical diagnostics, drug analysis, and environmental monitoring, reshaping the landscape of the scientific instrument industry [18].

Core Viewpoint - The article discusses a groundbreaking study that presents a mouse brain stereotaxic topographic atlas with isotropic 1 μm resolution, which is expected to enhance multi-omics research at the single-cell level in neuroscience [3][6][8]. Group 1 - The research team, including academicians from Hainan University, Huazhong University of Science and Technology, and UCLA, published their findings in the journal Nature, detailing a 3D brain atlas for mice [3]. - The atlas, named STAM, provides a comprehensive dataset of 916 brain structures and allows for the generation of high-resolution images at any angle [6][8]. - The study utilizes continuous micro-optical sectioning imaging technology to create a dataset based on Nissl staining, achieving isotropic 1 μm resolution [6]. Group 2 - The STAM atlas is designed to support large-scale brain mapping projects by providing data analysis and visualization capabilities [8]. - It includes an informatics platform for visualizing and sharing atlas images, facilitating tasks such as brain slice registration and neuron circuit mapping [6]. - The atlas is compatible with widely used stereotaxic atlases, enabling cross-atlas navigation in both 2D and 3D spaces [6].

Core Viewpoint - The article highlights the launch of the ZenoTOF 8600 system by SCIEX, which sets a new benchmark in high-resolution mass spectrometry, enhancing both qualitative and quantitative capabilities for complex sample analysis [3][4]. Group 1: Product Features - The ZenoTOF 8600 system significantly improves ion generation and transmission efficiency, achieving a tenfold increase in sensitivity compared to previous models [4]. - It incorporates advanced technologies such as the OptiFlow Pro ion source, DJet ion introduction, and dual-frequency QJet ion guide [4]. - The ZT Scan DIA 2.0 mode enhances data-independent acquisition capabilities, allowing for faster scanning and broader mass range, facilitating precise identification and quantification in multi-omics research [7][9]. Group 2: Data Processing and Software - The new SCIEX OS 4.0 software improves operational efficiency through automated processes and accelerated computations, setting new standards for analysis accuracy and precision [10]. - Collaboration with the open-source mass spectrometry data analysis platform MS-DIAL enhances small molecule identification and quantification capabilities, optimizing data analysis for ZT Scan DIA [11]. - The latest PEAKS 13 software supports various data types and improves processing workflows, enhancing protein identification and post-translational modification analysis [11]. Group 3: Industry Impact - The advancements introduced by the ZenoTOF 8600 system are expected to have a profound impact on the multi-omics field, with positive feedback from customers indicating that new data and insights will drive significant research outcomes [13].