春节假日期间人员流动与聚集、境内游、出境游将会明显增多，中国疾控中心也提示，假期期间需做好 防寒保暖，关注流行性感冒等其他急性呼吸道传染病、诺如病毒胃肠炎、食源性疾病等。 冬春季节是我国急性呼吸道传染病高发季节，春节期间人群聚集增多，增加了传播风险。近期监测显 示，引起急性呼吸道感染的病原主要有流感病毒、呼吸道合胞病毒等。当前，我国呼吸道传染病总体呈 下降趋势，仍处于流行季节。中国疾控中心建议，保持良好的卫生习惯，咳嗽或打喷嚏时，用纸巾、毛 巾等遮住口鼻；勤洗手，尽量避免用手触摸眼、鼻或口；均衡饮食，适量运动，充足休息等。尽量避免 接触流感样症状患者，若需接触需保持1米以上距离并佩戴口罩。 有发热、咳嗽、咽痛等呼吸道症状 时，尽量避免前往人员密集场所，就医途中、旅行期间（如乘火车、飞机等）要全程佩戴口罩。 疫苗 春节将至，走亲访友、觥筹交错的假期生活即将开启，规律生活可能被打破。专家提醒，往年每逢春节 后，前往医院就诊的带状疱疹患者数量显著增加，这与春节期间季节交替、过度劳累和生活不规律导致 免疫力下降等因素密切相关。特别是中老年人群，可能面临"三高一疹"的局面，更应警惕疾病叠加。 此外，春节期间人员流动与聚 ...

春节假期即将来临。多位医生表示，往年每逢春节后，前往医院就诊的带状疱疹患者数量显著增加，这 与春节期间季节交替、过度劳累和生活不规律导致免疫力下降等因素密切相关。 以糖尿病为例，北京大学第一医院内分泌科主任医师郭晓蕙表示，糖尿病患者发生带状疱疹的风险比普 通人群增加60%。这两种疾病之间存在危险的"多重影响"。一方面，高血糖状态为水痘-带状疱疹病毒 激活创造了条件；另一方面，糖尿病患者罹患带状疱疹后，可能影响血糖控制，造成糖尿病管理难度增 加。患带状疱疹后的剧烈疼痛会引起血糖升高，研究显示：24%的糖尿病患者患带状疱疹后血糖控制恶 化。这样形成"血糖不稳-更易感染，感染后血糖更难控"的恶性循环，严重降低患者生活质量。 目前，带状疱疹的治疗仍以抗病毒、止痛、营养神经为主。虽然抗病毒药物治疗可以一定程度上缩短皮 疹的持续时间，但是通常患者很难在发疹后的72小时内及时开始治疗，而患者超过72小时就诊发生带状 疱疹后神经痛的概率高达41.38%。 同济大学附属杨浦医院疼痛科主任夏明教授表示，目前带状疱疹的治疗方法有限，主要以抗病毒药物和 对症止痛为主，且最佳治疗窗口期短，因此，主动预防远比发病后治疗更重要。接种疫苗是 ...

春节即将到来，大家各有各的快乐"忙法"：50岁-60岁的中老年人是家中的"顶梁柱"，忙前忙后地打扫 卫生、收拾屋子、准备丰盛的大餐；年轻人忙着聚餐、熬夜打游戏或追剧。专家11日在此间接受记者采 访时提醒，过度劳累、免疫力下降人群容易被带状疱疹"盯上"。 据悉，带状疱疹俗称"蛇缠腰""缠腰龙"，是一种由水痘-带状疱疹病毒引起的感染性皮肤病。50岁以上 为易发人群，年龄越大者越容易患病，病情也更严重。 "尤其对于50岁及以上人群，不论是否曾患过水痘或带状疱疹，都应积极接种带状疱疹疫苗。"同济大学 附属杨浦医院疼痛科主任夏明教授对记者表示，目前带状疱疹的治疗方法有限，主要以抗病毒药物和对 症止痛为主，且最佳治疗窗口期短，因此，主动预防远比发病后治疗更重要。接种疫苗是预防带状疱疹 的有效方式。 这位专家表示，接种疫苗前可就疫苗的保护效果、保护时长、接种禁忌、安全性等信息咨询专业医生， 进行科学接种。此外，预防带状疱疹的方法还包括：提高基础抵抗力，清淡饮食，适度锻炼。 据悉，带状疱疹不是"小病"，其疼痛与后遗神经痛可能长期困扰患者。对于50岁以上，患有糖尿病、高 血压等慢性病，免疫力较低的人群而言，做好主动预防，是远离 ...

Core Insights - Shingles is a significant health concern, particularly for the elderly, as it can cause severe pain and suffering due to a weakened immune system [1][2] Understanding Shingles - Shingles is an acute infectious skin disease caused by the varicella-zoster virus, which remains dormant in the body after an initial chickenpox infection and can reactivate when the immune system is compromised [2] Seasonal Increase in Cases - Winter is a peak season for shingles due to several factors: - Immune system decline due to temperature drops and increased illness [3] - Weakened skin barrier from dry air, making it easier for the virus to infect [3] - Lifestyle changes such as reduced sunlight exposure and poor dietary habits that lower immunity [3] Prevention Measures - Vaccination is the most effective preventive measure, especially recommended for adults aged 50 and above, those with weakened immune systems, and individuals who have not had chickenpox [4] - Enhancing immunity through balanced nutrition, regular exercise, and proper sleep is crucial [5] - Protecting the skin by maintaining moisture and avoiding injuries can help prevent infection [6] - Reducing cold exposure and avoiding crowded places can minimize the risk of triggering shingles [7] - Early detection of symptoms such as localized pain or burning sensations is vital for timely medical intervention [9] High-Risk Groups - Elderly individuals, chronic disease patients, immunocompromised individuals, and pregnant women are at higher risk for shingles and should take extra precautions [10]

Core Viewpoint - The approval of the recombinant zoster vaccine (RZV) for adults aged 18 and above with increased risk of herpes zoster marks a significant expansion of its market potential in China, providing new growth momentum for GSK's vaccine sales [1][2][4]. Group 1: Vaccine Approval and Market Expansion - GSK's RZV has been approved by the National Medical Products Administration (NMPA) for use in adults aged 18 and above who are at increased risk of herpes zoster due to known diseases or treatments that cause immune deficiency [1][2]. - This approval expands the vaccine's protective range, which was initially limited to individuals aged 50 and above since its launch in June 2020 [1][3]. - The vaccine is the first and only one approved in China for this specific high-risk group, addressing a significant clinical gap in prevention [2][4]. Group 2: Disease Burden and Risk Factors - Herpes zoster, commonly known as "shingles," is a significant health burden in China, particularly among individuals aged 50 and above, with approximately 1.56 million new cases reported annually in this age group [2][3]. - The risk of developing herpes zoster increases with age, and certain conditions such as HIV infection and malignancies further elevate this risk, with affected individuals being 2.3 to 4.0 times more likely to contract the disease [3][6]. Group 3: Market Potential and Growth - The domestic herpes zoster vaccine market is projected to grow significantly, with a market size of 3.73 billion yuan in 2022 expected to reach 5.63 billion yuan by 2025, reflecting a compound annual growth rate (CAGR) of 16.4% [5]. - GSK's vaccine targets a population of 340 million people aged 50 and above in China, and with an estimated peak penetration rate of 10%, the market potential could reach approximately 65 billion yuan [5][6]. - The newly approved indication for high-risk adults represents an untapped market segment with substantial growth potential, driven by a large population base and a strong demand for preventive measures [5][6]. Group 4: Competitive Landscape - Currently, there are two approved herpes zoster vaccines in China: GSK's RZV and Baike Biological's "Ganwei," which utilize different technological approaches [8]. - GSK's RZV, as a recombinant vaccine, has established itself as a core growth engine for the company's vaccine business, demonstrating strong revenue stability and market competitiveness [8][9]. - Continuous investment in research and development is crucial for maintaining the competitive edge of RZV, with ongoing studies aimed at assessing its efficacy and safety in high-risk populations [9].

Group 1 - The article highlights the seasonal increase in crab consumption among the elderly, which may lead to health risks due to high-fat diets and other factors such as lack of sleep and emotional stress [1] - It discusses the heightened risk of cardiovascular diseases and the reactivation of the varicella-zoster virus (shingles) in older adults, particularly those with pre-existing heart conditions [1] - Research indicates that patients with cardiovascular diseases have a higher risk of developing shingles, and the presence of hypertension can further increase the likelihood of postherpetic neuralgia [1] Group 2 - A three-step proactive defense strategy is proposed to combat the dual threat of cardiovascular diseases and shingles, which includes vaccination, maintaining healthy blood pressure and lipid levels, and early identification of symptoms [2] - In Guangdong, initiatives are being implemented to enhance vaccination accessibility, such as the "30-minute vaccination circle" and weekend vaccination services, with specific examples from Shenzhen [2] - The inclusion of shingles vaccine costs in health insurance is also mentioned as a measure to encourage vaccination among the population [2]

Core Insights - Recent initiatives in various cities have launched promotional activities for shingles vaccines, offering significant discounts comparable to major sales events [1] - There is a growing concern among the public regarding the necessity of vaccinating older parents against shingles, especially considering the potential for reinfection after a previous episode [1][15] Group 1: Shingles Vaccine Promotion - Many cities have initiated shingles vaccine promotional activities, with prices slashed by half, making it more accessible to the public [1] - The promotional efforts are likened to major shopping events, indicating a strong push to increase vaccination rates [1] Group 2: Shingles Infection and Risks - Approximately one-third of individuals will experience shingles at least once in their lifetime, particularly those who had chickenpox in childhood [3] - The risk of developing shingles increases with age, especially for individuals over 50, due to declining immune function [10][13] - Chronic disease patients, such as those with diabetes or cardiovascular issues, face a significantly higher risk of severe shingles symptoms [8][10] Group 3: Vaccine Efficacy and Safety - The shingles vaccine is reported to provide at least 10 years of protection, with efficacy rates of 79-79% for adults over 50 during the 6th to 11th year post-vaccination [20] - Common side effects of the vaccine include localized redness and swelling, with most reactions being mild and self-resolving [17][18] - There are two types of shingles vaccines available in China, with different age recommendations and dosing schedules [24]

Core Viewpoint - The increasing prevalence of skin health issues among the elderly in China is evolving from a cosmetic concern to a significant public health crisis, particularly highlighted by the rising incidence of shingles [1][2]. Group 1: Skin Health Challenges - There are over 2,000 named skin diseases, making dermatology one of the most complex medical fields [2]. - The incidence of skin diseases in China is alarmingly high, with a prevalence rate of 40%-70%, leading to significant health-related quality of life losses [2]. - Shingles, a disease that significantly increases in incidence with age, affects about one-third of individuals in their lifetime, with approximately 600,000 new cases annually in China, of which 1.56 million are in individuals over 50 [2]. Group 2: Chronic Diseases and Shingles - Patients with chronic diseases such as diabetes and cardiovascular conditions have a 26%-41% higher risk of developing shingles compared to the general population [2][3]. - The presence of shingles can exacerbate existing chronic conditions and increase the risk of severe pain, leading to a higher likelihood of depression and anxiety among affected individuals [3]. Group 3: Awareness and Prevention - There is a significant gap in awareness and preventive measures regarding shingles among the elderly, with over 60% believing they are not at risk [4]. - A study indicates that 30% of patients delay treatment due to the misconception that they can endure the pain [4]. - Effective public health education is essential to shift the mindset from "enduring pain" to "proactive prevention," emphasizing the importance of vaccination and early intervention [4][5]. Group 4: Community Health Initiatives - Community health service centers are crucial in addressing these health trends, particularly in managing chronic diseases and their complications [3][5]. - New models of integrated medical and preventive care are being explored, such as the introduction of public health physician prescriptions to enhance preventive measures [5]. - Trust in healthcare providers, particularly family doctors, is vital for encouraging residents to engage in preventive health actions, including vaccinations [5].