Core Insights - The article highlights the inspiring journey of Cai Lei, a former executive at JD.com, who transformed from a successful business leader to a dedicated advocate for ALS (Amyotrophic Lateral Sclerosis) research after being diagnosed with the disease in 2019 [1][3][7] - Cai Lei's efforts have led to significant advancements in ALS research and patient support, including the establishment of a large data platform for ALS patients and a charity fund to support research and treatment [3][6][8] Group 1: Career and Achievements - Cai Lei was recognized as a pioneer in the implementation of electronic invoices in China, earning the title of "the first person of electronic invoices" [1][2] - He joined JD.com during its rapid growth phase and successfully led the development of China's first electronic invoice within 45 days, revolutionizing the e-commerce industry [2][3] - His dedication to work was evident as he often worked over 12 hours a day, contributing significantly to JD.com's growth and earning accolades for his contributions to reform [2][3] Group 2: Personal Struggles and Advocacy - After his ALS diagnosis, Cai Lei decided to leave his position at JD.com to focus on combating the disease, investing his savings to create a global ALS patient data platform [3][6] - His wife, Duan Rui, played a crucial role in supporting him, transforming their personal challenges into a broader advocacy effort for ALS research and patient care [5][6] - Together, they established a charity fund and a trust to ensure the continuity of their research efforts, demonstrating a commitment to improving the lives of future ALS patients [6][8] Group 3: Impact and Legacy - As of the end of 2024, Cai Lei and Duan Rui have created a charity fund worth nearly 40 million yuan, contributing millions to ALS research and support for patients [6][8] - Cai Lei's story serves as a beacon of hope for ALS patients, emphasizing the importance of perseverance and the potential for positive change even in the face of dire circumstances [8]