中信建投证券研报指出，诺诚健华Q1-Q3亏损减少至0.72亿元，同比缩窄74.8%。业绩加速增长，全年 有望实现盈亏平衡。2025年公司进一步发展，里程碑事件有望进一步兑现：奥布替尼SLE适应症2b期数 据2025年底读出；ICP-723儿童适应症预计2025年底前提交NDA；首款ADC药物ICP-B794预计2025年底 取得临床PoC。未来展望：广泛布局新适应症，保障收入持续增长。市场销售方面，奥布替尼是目前中 国针对MZL 适应症唯一获批上市且进入医保的BTK 抑制剂，竞争小，市场空间广，占整个销售额很大 一部分，奥布替尼销售高速增长，预计2025年全年销售收入同比增长达到40%以上。2026年坦昔妥单抗 完成首个完整销售年度，预期收入超1亿元。考虑到公司自研新药开发的持续深入、临床开发和商业化 等方面更多的重磅里程碑的落地，维持"买入"评级。 ...

Market Overview - A and H shares continued to be negatively impacted by the Federal Reserve's lower-than-expected interest rate cuts, with significant declines in sectors such as non-ferrous metals and chemicals [1] - The A-share market saw the Shanghai Composite Index down 3.90%, Shenzhen Component Index down 5.13%, and ChiNext Index down 6.15% [3] - Defensive sectors like banking, media, food and beverage, and defense showed relative resilience, while sectors like power equipment, basic chemicals, and steel experienced significant declines [1][3] Industry Dynamics - The pharmaceutical industry index fell 6.88%, with sub-sectors like chemical pharmaceuticals and bioproducts declining by 7.02% and 7.46% respectively [5] - Eli Lilly became the first global healthcare company to reach a market capitalization of $1 trillion, driven by its GLP-1 weight loss drug contributing 55% of its revenue [7] - Moderna announced the termination of three mRNA projects and secured a $15 billion loan, focusing future efforts on oncology and rare diseases [7] - Innovative drug companies like BeiGene and Innovent Biologics reported significant revenue growth, with BeiGene's global revenue reaching $1 billion, up 51% year-on-year [8] Technology Sector - The technology sector faced significant adjustments, with the Hang Seng Technology Index dropping 7.18% [10] - Nvidia reported Q3 revenue of $57 billion, exceeding expectations, with data center revenue of $51.2 billion, up 66% year-on-year [17] - Google launched the Gemini 3 model, achieving breakthroughs in multi-modal understanding and reasoning capabilities, surpassing competitors [12] - Alibaba's AI application "Qianwen" quickly rose to the fourth position in the App Store rankings, aiming to become a personal AI assistant [13] Investment Strategies - Investment strategies are focusing on technological transformation and de-globalization, with an emphasis on AI and innovative pharmaceuticals [3] - The market is expected to enter a bottoming phase after two weeks of significant adjustments, with a long-term view of a structural bull market [1][3] - The focus is on identifying undervalued technology players within the overseas supply chain [2]

机构：申万宏源研究 研究员：周文远/胡梦婷 诺诚健华2025 年前三季度收入同比增长60%，达到11.2 亿元，净亏损为0.64 亿元（同比收窄77%），其 中第三季度收入同比增长38%，达到3.84 亿元，净亏损为0.34 亿元，符合我们的预期。2025 年前三季 度，公司核心产品奥布替尼销售额同比增长46%至10.1 亿元，其中第三季度销售额达到3.73 亿元（同比 增长35%，环比增长14%）。前三季度，研发费用为6.76 亿元（同比增长10%），其中第三季度销售研 发费用为2.26 亿元（同比增长17%）。前三季度，销售费用为3.86 亿元（同比增长41%），销售费用率 同比下降4.7 个百分点至35%。截至2025 年9 月底，公司在手现金约为77.6 亿元。 奥布替尼销售加速放量，血液瘤管线布局丰富。随着1L CLL/SLL 适应症获批上市，以及MZL 销售贡献 提升，2025 年第三季度奥布替尼的销售收入达到3.73 亿元（同比增长35%、环比增长14%）。考虑到奥 布替尼在前三季度的强劲销售表现，公司将2025 年销售目标从同比增长35%+提升至40%以上。此外， 坦昔妥单抗（CD19）已于2 ...

瑞银发表研究报告指，诺诚健华第三季业绩大致符合预期，收入按年增长38%至3.84亿元，与市场及该 行预测的3.83亿及3.87亿元相若。期内净亏损达3400万元，略逊于市场预期的蚀2700万元。核心产品奥 布替尼第三季销售额按年增约34%至3.69亿元，增长维持强劲，公司维持2025年奥布替尼销售按年增长 35%以上的指引，意味第四季销售将达到约3.41亿元。瑞银指，随着与Zenas合作的首付款入账，诺诚健 华预计今年可实现盈亏平衡，计及与Zenas合作的首付款影响，将今年每股盈利预测上调至0.05元，明 年每股盈利预测下调93%至0.06元，目标价由25.8港元下调至23.6港元，维持"买入"评级。 ...

瑞银指，随着与Zenas合作的首付款入账，诺诚健华预计今年可实现盈亏平衡，计及与Zenas合作的首付 款影响，将今年每股盈利预测上调至0.05元，明年每股盈利预测下调93%至0.06元，目标价由25.8港元 下调至23.6港元，维持"买入"评级。 瑞银发表研究报告指，诺诚健华第三季业绩大致符合预期，收入按年增长38%至3.84亿元，与市场及该 行预测的3.83亿及3.87亿元相若。期内净亏损达3400万元，略逊于市场预期的蚀2700万元。核心产品奥 布替尼第三季销售额按年增约34%至3.69亿元，增长维持强劲，公司维持2025年奥布替尼销售按年增长 35%以上的指引，意味第四季销售将达到约3.41亿元。 ...

未来，诺诚健华的面貌会焕然一新，其价值锚点不仅仅在于"奥布替尼的故事"，更在于其扎实的商业化 基础、精明的全球化策略以及厚实的后续研发管线。 提前两年扭亏 又一家中国创新药企抵达扭亏临界点。 11月13日，诺诚健华（688428.SH/09969.HK）向市场抛出重磅信号：凭借强劲的商业化表现和策略性的 对外授权交易，2025年全年将实现盈亏平衡，比原计划整整提前两年。 对任何一家Biotech而言，由投入依赖转向自主造血扭亏都是企业跨越式发展的关键临界点。在中国创 新药行业走过第一个十年之际，"盈亏平衡"是比"管线故事"更稀缺、更有力的价值证明。 拥有健康的经营现金流不仅意味着生存，更意味着掌握了将资金投入高价值研发管线的自主权。诺诚健 华目前拥有超10条研发管线，多条管线处于三期临床，自主造血形成的强劲现金流将助推在研分子更快 走向商业化节点。 诺诚健华2025年三季报显示，前三季度总收入达到11.2亿元，同比增长59.8%。 其核心造血机器——BTK抑制剂奥布替尼的增长尤为强劲。前三季度收入同比上涨45.8%，达到10.1亿 元，这一数字已突破去年全年收入。这主要归功于奥布替尼独家适应症边缘区淋巴瘤（M ...

Investment Rating - The report maintains a "Buy" rating for InnoCare Pharma [8][16] Core Insights - InnoCare Pharma's revenue for the first three quarters of 2025 increased by 60% year-on-year, reaching RMB 1.12 billion, with a net loss of RMB 64 million, which is a 77% year-on-year reduction [5][12] - The company has raised its sales target for its key product, orelabrutinib, from over 35% year-on-year growth to over 40% for 2025, following strong sales performance [6][13] - The company has a robust pipeline for both liquid tumors and autoimmune diseases, with several products in various stages of development [7][14][15] Financial Performance - For the first three quarters of 2025, orelabrutinib sales reached RMB 1.01 billion, a 46% increase year-on-year, with third-quarter sales of RMB 373 million, reflecting a 35% year-on-year and 14% quarter-on-quarter growth [5][12] - Research and development expenses for the first three quarters of 2025 were RMB 676 million, a 10% increase year-on-year, while selling expenses rose by 41% to RMB 386 million [5][12] - As of September 2025, the company had approximately RMB 7.76 billion in cash on hand [5][12] Future Outlook - The company plans to submit a New Drug Application (NDA) for orelabrutinib for the treatment of ITP in the first half of 2026 and expects to read out phase IIb data for SLE by the end of 2025 [7][14] - InnoCare Pharma anticipates submitting 5-7 IND applications targeting malignant tumors and autoimmune diseases in 2026 [15]

Investment Rating - The report maintains a "Buy" rating for the company [1][7][15] Core Insights - The company has raised its 2025 sales target from a year-on-year growth of over 35% to over 40% due to strong sales performance of its key product, orelabrutinib, which saw a 46% year-on-year increase in sales to RMB 1.01 billion in the first three quarters of 2025 [4][5][12] - The company reported a revenue of RMB 1.12 billion for the first nine months of 2025, reflecting a 60% year-on-year growth, with a net loss of RMB 64 million, which is a 77% reduction compared to the previous year [4][11] - The company has a robust pipeline in both oncology and autoimmune diseases, with several products in various stages of development, including orelabrutinib and ICP-332 [5][6][13][14] Financial Performance - For the first three quarters of 2025, the company recorded a revenue of RMB 1.12 billion, with a net loss of RMB 64 million, and a third-quarter revenue of RMB 384 million, marking a 38% year-on-year increase [4][11] - Research and development expenses for the first three quarters were RMB 676 million, a 10% increase year-on-year, while selling expenses rose by 41% to RMB 386 million [4][11] - The company had approximately RMB 7.76 billion in cash as of September 2025, providing a solid financial foundation for ongoing and future projects [4][11] Sales and Product Development - Orelabrutinib's sales reached RMB 373 million in the third quarter of 2025, with a year-on-year growth of 35% and a quarter-on-quarter growth of 14% [5][12] - The company is advancing its autoimmune pipeline, with plans to submit a new drug application for orelabrutinib for ITP in the first half of 2026 and to read out phase IIb data for SLE by the end of 2025 [6][13] - The company expects to submit 5-7 IND applications targeting malignant tumors and autoimmune diseases in 2026, indicating a strong early-stage pipeline [14]

Investment Rating - The report does not explicitly state an investment rating for the industry [2][19]. Core Views - The pharmaceutical and biotechnology sector saw a weekly increase of 3.29%, outperforming the Wind All A index (-0.47%) and the CSI 300 index (-1.08%) during the week of November 10-14, 2025 [3][8]. - Local governments are actively implementing policies to support innovative drug development, with Chongqing aiming to approve 1-3 new drugs annually by 2027 [3][13]. - Flu activity is on the rise, with the percentage of flu-like illness cases reported in southern provinces reaching 5.5%, higher than the previous week and the same period in 2022 and 2024 [3][13]. Market Weekly Review - The pharmaceutical and biotechnology sector increased by 3.29%, with all sub-sectors recovering. The leading sub-sectors included pharmaceutical distribution (5.92%), in vitro diagnostics (5.91%), and raw materials (5.09%) [3][8]. - Notable stock performances included Jindike (61.6%), Renmin Tongtai (61.1%), and Chengda Pharmaceutical (58.3%) with significant gains, while *ST Changyao (-33.6%) and Zhend Medical (-11.3%) faced substantial declines [3][11]. Industry News and Key Company Announcements - On November 14, Chongqing's government announced comprehensive support measures for innovative drug development, including funding for research and expedited ethical review processes [3][13]. - Merck announced a $9.2 billion acquisition of Cidara Therapeutics, expected to close in Q1 2026 [3][13]. - Adicon acquired Crown Bioscience for $204 million, aiming to enhance its integrated service platform [3][13]. - Laika Pharmaceuticals entered an exclusive licensing agreement with Qilu Pharmaceutical for LAE002, with potential payments totaling RMB 25.75 billion [3][14]. - Lyell Immunopharma announced a global licensing agreement for LYL273, with significant milestone payments and royalties [3][15]. - MeiraGTx Holdings entered a strategic collaboration with Eli Lilly for gene therapy projects, with upfront and milestone payments exceeding $400 million [3][15].

Summary of the Conference Call for 诺诚健华 Company Overview - **Company**: 诺诚健华 (Nocera Biopharma) - **Industry**: Biotechnology and Pharmaceuticals Key Financial Highlights - Total revenue for the first three quarters reached **¥11.2 billion**, a **59.8%** year-on-year increase [2][3][8] - Core product **奥布替尼 (Aubutin)** contributed **¥10.1 billion**, growing **45.8%** year-on-year [2][3][8] - The company expects full-year revenue to exceed **¥20 billion**, with a cash reserve of approximately **¥78 billion** (around **$10 billion**) [3][8] Product Development and Approvals - **奥布替尼** received approval for first-line treatment of chronic lymphocytic leukemia in China, expanding its commercial potential [5][11] - **Tansitumab** for diffuse large B-cell lymphoma has been approved and is now prescribed in over **20 provinces** in China [4][10][14] - New drug application for **Zula Tract Nap Nap** has been accepted and prioritized for review [2][5] - Ongoing clinical research includes **9 Phase III trials**, with plans for multiple new molecules to enter clinical stages annually [4][7][40] Strategic Partnerships - A global collaboration agreement with **Xenios BioPharma** was established, granting rights for **奥布替尼** outside Greater China and Southeast Asia, with a total deal value exceeding **$2 billion** [2][6][12][13] - Previous collaboration with **Prelude** for CD3/CD20 bispecific antibodies in autoimmune diseases [6] Market Performance and Future Outlook - The company anticipates achieving **break-even** by **2026** and sustainable profitability post-2027 through new drug promotions [4][7][38] - **奥布替尼** is expected to maintain its leading position in the marginal zone lymphoma market, with further growth anticipated from new indications [9][30] - The company is focused on expanding its hospital coverage and enhancing patient education to boost product awareness [30][31] Clinical Research and Innovations - **奥布替尼** is advancing in autoimmune disease research, with a Phase III NDA submission for **ITP** expected in the first half of **2026** [11][26] - The development of **Mesothelin**, a new BCL-2 inhibitor, shows promising results in various cancers, with a total market potential exceeding **$20 billion** [15][16] - **泰喜多单抗** is noted for its superior efficacy in DOR and OS compared to other mechanism drugs, enhancing its market position [14] Financial Projections and Cost Management - R&D expenses for **2025** are projected to be under **¥1 billion**, with sales expenses expected to account for **40%** of commercial product sales [36] - The company aims to maintain a commercial expense ratio of **35% to 40%** in **2026**, while increasing efficiency [37] Strategic Goals - The future strategy includes continuous innovation pipeline development, enhancing commercialization capabilities, and expanding market coverage [39] - The company plans to submit **5 to 7 new molecules** for clinical trials in the coming year, which will be crucial for its growth trajectory [40] This summary encapsulates the key points from the conference call, highlighting the company's financial performance, product developments, strategic partnerships, and future outlook in the biotechnology industry.