香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 InnoCare Pharma Limited 諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） （股份代號：9969） 海外監管公告 本公告乃諾誠健華醫藥有限公司（「本公司」）根據香港聯合交易所有限公司證 券上市規則第13.10B條作出。 茲載列本公司於上海證券交易所網站刊登之《2025年半年度報告》、《2025年半 年度報告摘要》、《2025年半年度募集資金存放與實際使用情況的專項報告》、 《關於部分募投項目延期及使用募集資金向全資子公司增資以實施募投項目的 公告》、《關於使用自有資金支付募投項目所需資金並以募集資金等額置換的 公告》、《關於收購控股子公司剩餘股權的公告》、《關於修訂及制定部分公司 治理制度的公告》、《2025年度"提質增效重回報"行動方案的半年度評估報告》、 《中國國際金融股份有限公司關於諾誠健華醫藥有限公司部分募投項目延期及 使用募集資金向全資 ...

Financial Performance - The company achieved total revenue of 381 million RMB in Q1 2025, a 129.92% year-over-year increase[9] - Sales revenue from Orelabrutinib reached 311 million RMB, an 89.22% year-over-year increase[9] - The company reported a net profit of 14 million RMB in Q1 2025[9] - Gross profit margin reached 90.5%, a 5.1 percentage point increase compared to the same period last year[9] - The company holds a strong cash reserve of 7800 million RMB[9] Orelabrutinib (BTK Inhibitor) - Orelabrutinib was approved in China for 1L CLL/SLL[9] - NDA submissions for multiple indications of Orelabrutinib are underway overseas[9] - Orelabrutinib is recommended in the 2025 CSCO lymphoma guidelines for CLL/SLL, MZL and MCL[20, 21] Pipeline Progress - Tafasitamab BLA for r/r DLBCL was accepted and granted priority review in mainland China[9] - Zurletrectinib NDA was submitted at the end of March 2025 and granted priority review[9] - A Phase III registrational clinical trial of Mesutoclax in combination with Orelabrutinib for 1L CLL/SLL is ongoing[9] Strategic Collaborations - Prolium Bioscience will gain rights to develop, register, produce, and commercialize ICP-B02 globally in non-oncology fields and in oncology fields outside of Asia[15] Autoimmune Disease - Phase III registrational clinical trials for Orelabrutinib in PPMS and SPMS are expected to enroll the first patient in the second half of 2025[9] - A Phase III registrational clinical trial for Orelabrutinib in ITP is expected to submit an NDA in the first half of 2026[9] - A Phase IIb trial for Orelabrutinib in SLE has completed patient enrollment, with data readout expected in Q4 2025[9]

Group 1: Investor Protection and Engagement - The Beijing Listed Companies Association (北上协) is actively promoting investor protection to enhance communication and cooperation between listed companies and investors, which is essential for the healthy development of the capital market [1][2] - The "Shareholders Come" series of activities, held from April 10 to June 24, involved over 400 industry analysts and institutional investors visiting seven listed companies, primarily focusing on private enterprises [1][2] Group 2: Company Highlights and Innovations - Beijing Yubang Electric Technology Co., Ltd. (煜邦电力) showcased its strong growth, achieving a revenue of 940 million yuan with a year-on-year increase of 67.35% and a net profit of 111 million yuan, reflecting a significant growth of 195.77% [3] - Innovent Biologics, Inc. (诺诚健华) is set to launch innovative treatments in the blood cancer field, with its new drug, Tanshizhuo Monoclonal Antibody, expected to be approved in May 2025 [3][4] - Sanwei Xinan Technology Co., Ltd. (三未信安) demonstrated its advancements in cryptography, showcasing a self-developed XS100 cryptographic chip and a series of quantum-resistant products [4] Group 3: Strategic Alignment and Future Prospects - Companies are aligning their strategies with national development goals, such as Beijing Zhongke Jincai Technology Co., Ltd. (中科金财), which is focusing on AI technology applications and data value extraction [6] - Beijing Jiexun Feihong Electric Co., Ltd. (佳讯飞鸿) is innovating in the ICT field, particularly in smart transportation and defense information systems [7] - Tianzhihang Medical Technology Co., Ltd. (天智航) introduced its orthopedic surgical robot, which is the first of its kind to cover major orthopedic procedures, showcasing its advanced capabilities [8] Group 4: Market Environment and Future Directions - The "14th Five-Year Plan" emphasizes the importance of investor protection, particularly for small and medium investors, as part of broader capital market reforms [9] - The North Association aims to enhance transparency and communication between listed companies and investors, fostering a more stable investment environment [10] - The initiative seeks to help investors understand the core competitiveness and industry prospects of companies, encouraging a long-term investment perspective [10]

Group 1: Innovation and Technology in Beijing - The "Vibrant China Research Tour" in Beijing focuses on exploring the city's technological innovation and its role in driving new productive forces [1] - The Zhongguancun Exhibition Center showcases over 490 technologies and products from more than 350 research institutions and companies in fields like AI, commercial aerospace, and high-end medical devices [1] - The permanent exhibition area has been upgraded to 10,000 square meters, emphasizing themes such as high-quality technological supply and the cultivation of emerging industries [1] Group 2: AI and Robotics Applications - Beijing DynaLab Technology Co., Ltd. has developed an automatic weighing robot that utilizes AI and robotics to achieve high precision in weighing viscous liquids, reducing human error [2] - The robot is part of a comprehensive solution that integrates machine learning, smart robotics, and automated control, enabling fully automated laboratory operations [2] Group 3: Pharmaceutical Industry Growth - The pharmaceutical and health industry in Beijing reached a scale of 1.06 trillion yuan in 2024, marking an 8.7% year-on-year growth, positioning Beijing as a global leader in this sector [3] - Innovative drugs like Obutinib and Tanshizhuo monoclonal antibody have been developed by Beijing Novartis, contributing to significant revenue growth of 36.68% last year and 129.9% in the first quarter of this year [3] Group 4: AI in Creative Industries - Kuaishou Technology has introduced Kling AI, a next-generation AI creative production platform that enhances video and image generation and editing capabilities [4] - The advancements in video generation technology are expected to blur the lines between consumers and producers, fostering content supply and ecological prosperity on internet platforms [5]

Group 1 - Heng Rui Medicine has set the final price for its H-share issuance at HKD 44.05 per share, with expected listing on May 23, 2025 [1] - Vanke A has signed a borrowing contract with Shenzhen Metro Group for RMB 4.2 billion, using up to RMB 6 billion of Wanwu Cloud stock as collateral [2] - Longqi Technology plans to issue H-shares and list on the Hong Kong Stock Exchange to enhance capital strength and international competitiveness [3] Group 2 - Shanghai Laishi's controlling shareholder, Haiyingkang, plans to increase its stake in the company by investing between RMB 250 million and RMB 500 million [4] - Wangzi New Materials' controlling shareholder sold 1.11 million shares, accounting for 0.29% of the total share capital, amid the "controlled nuclear fusion" concept [5] - Huashi Technology's actual controller, Ye Jianbiao, has had his detention extended by three months, but the company's operations remain normal [6] Group 3 - Sichuan Gold's major shareholders plan to reduce their stakes by 2.5% and 3% respectively, citing personal funding needs [7] - Naxinwei has set the inquiry transfer price at RMB 163.15 per share, with full subscription from institutional investors [8] - Zhejiang Rongtai plans to invest RMB 20 million to establish a wholly-owned subsidiary focused on robotics [9] Group 4 - Kingood Co. has received a notification from a global leading automaker for a wheel product project in the U.S., with an estimated sales amount of approximately USD 158 million over five years [10] - Shanghai Xiba plans to purchase patents for hydrogen-electric hybrid power systems and solid-state lithium-ion battery technology, investing a total of RMB 25 million [11] - Nocare Biopharma's application for the market approval of Tafasitamab for treating relapsed/refractory DLBCL has been approved, marking a significant milestone in the market [12]

Core Insights - Nuo Cheng Jian Hua reported a revenue of 381 million yuan for Q1 2025, representing a year-on-year growth of 129.92%, with a net profit of 14 million yuan, up 109.94% year-on-year [2] - The company's gross margin improved by 5.1 percentage points to 90.5% compared to the same period last year [2] - The main driver of revenue growth is the commercialization of the drug Acalabrutinib, which generated 310 million yuan in revenue during the reporting period, an increase of 89.2% [2] Product Development - Acalabrutinib was approved for first-line treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) in China on April 25, 2023, expanding its market potential [2][6] - The drug has already been included in the national medical insurance for multiple indications, which is expected to further boost sales [2] - The company is also advancing its pipeline with Tafasitamab, a CD19 monoclonal antibody, which has been approved for the treatment of Diffuse Large B-Cell Lymphoma (DLBCL) [3][9] Market Potential - CLL accounts for approximately 3% of adult leukemia cases in China, with about 7,500 new patients diagnosed annually [5] - The approval of Acalabrutinib for first-line treatment is anticipated to significantly enhance treatment options for patients and drive company growth [6] - The market for Tafasitamab is projected to exceed 1.5 billion yuan in peak sales under optimistic scenarios [10] Competitive Landscape - Acalabrutinib is positioned as a potential best-in-class BTK inhibitor, with superior selectivity and safety profile compared to existing competitors [7][8] - The company faces competition from other approved therapies targeting similar indications, particularly in the relapsed or refractory settings [6] Financial Health - Nuo Cheng Jian Hua reported a strong cash position of approximately 7.78 billion yuan as of the end of Q1 2025, which will support ongoing clinical trials and research investments [8]

Group 1 - Huiyu Pharmaceutical's subsidiary received drug registration certificate for Carboxymethyl Sodium Injection, which is used for treating bleeding diseases in various medical fields [1] - Baihe Co., Ltd. announced a plan for a director to reduce holdings by up to 424,000 shares, representing 0.6625% of the total share capital [1] - Kingood Co., Ltd. received a notification from a global leading automaker for a wheel project, expected to start mass production in 2026 with a lifecycle of 10 years [1][2] Group 2 - Wanhua Chemical plans to repurchase shares worth between 300 million and 500 million yuan, with a maximum repurchase price of 99.36 yuan per share [2] - Warner Pharmaceutical's subsidiary received approval for Acetylcysteine raw material drug, primarily used for treating respiratory diseases [3] - ST Mingcheng plans to publicly transfer 45% equity of its subsidiary, aiming to optimize asset structure [4] Group 3 - Qixia Construction announced a plan to reduce up to 31.5 million shares, accounting for 3% of total share capital [5][6] - Zhejiang Rongtai intends to invest 20 million yuan to establish a wholly-owned subsidiary focused on intelligent robotics [7] - Yuandong Biological received drug registration for Chloral Hydrate Enema, used for sedation and seizure control in children [9] Group 4 - Jiemai Technology's subsidiary signed a strategic cooperation agreement with a solid-state battery company to produce high-safety composite conductive materials [10] - Xianju Pharmaceutical received drug registration for Progesterone Soft Capsules, used for treating functional disorders due to luteal deficiency [11] - Lanhua Kecai's subsidiary reported a temporary production halt, with the resumption date yet to be determined [13] Group 5 - Sinopharm Modern's subsidiary received drug registration for Tocilizumab Tablets, used for treating rheumatoid arthritis and other conditions [15] - Shanghai Bank announced the resignation of its vice president due to organizational adjustments [17] - Shanghai Pharmaceutical's Ephedrine Injection passed the consistency evaluation for generic drugs [19] Group 6 - Rundu Co., Ltd. received drug registration for Amlodipine and Olmesartan Tablets, aimed at treating hypertension [21] - Zhong'an Technology announced that 61 million shares held by its controlling shareholder will be auctioned [23] - Shanghai Washba plans to purchase patent assets and establish two subsidiaries focused on hydrogen energy and solid-state battery technologies [25] Group 7 - Nuo Cheng Jianhua's new drug Tafasitamab received approval for treating relapsed/refractory diffuse large B-cell lymphoma [26] - Benli Technology plans to use up to 200 million yuan of idle funds for cash management and financial investments [28] - Taiji Co., Ltd. intends to use 60 million yuan of idle funds to purchase financial products [29] Group 8 - Haishi Co. announced that its innovative drug Anreke Fen Injection received drug registration for treating postoperative pain [32] - Yulong Co. will have its stock delisted on May 27, 2025, following a decision by the Shanghai Stock Exchange [36] - Weifu High-Tech plans to establish a joint venture with Shanghai Baolong Automotive Technology [38] Group 9 - Xichang Electric Power expects a net profit reduction of approximately 5.4 million yuan due to adjustments in the time-of-use electricity pricing mechanism [39] - Alter signed a contract worth 6.8 billion yen for the development and procurement of large truck EV kits [41] - Zhonglian Heavy Industry plans to acquire controlling stakes in its financing leasing subsidiary through public bidding [42] Group 10 - Sanyou Medical's executive plans to reduce holdings by up to 1.44% of the company's shares [43] - Hangyang Co. plans to establish a subsidiary for large modular cryogenic equipment manufacturing with an estimated investment of 557 million yuan [44] - FAW Fuwi received a notification for a dashboard project from a well-known new energy brand, with total sales expected to reach 1.06 billion yuan [45]

Group 1: Financial Data Overview - In April 2025, new social financing amounted to approximately 1.16 trillion, an increase of 1.22 trillion year-on-year, with stock social financing growing by 8.7% year-on-year, and a month-on-month increase of 0.3 percentage points [11][13][14] - New credit in April was 280 billion, a decrease of 450 billion year-on-year, reflecting a weak demand in the corporate sector and a low retail demand under pressure [11][13][17] - M1 grew by 1.5% year-on-year, while M2 increased by 8.0%, with a month-on-month rise of 1 percentage point [11][13][17] Group 2: Robotics Industry Insights - The core of embodied intelligence lies in algorithms, which are divided into upper-level "brain" for task planning and decision-making, and lower-level "cerebellum" for real-time motion planning and joint control [12][10] - Data quality and diversity are crucial for algorithm performance, with real data being the primary source, supplemented by synthetic data generated through simulation platforms [12][10] - The control system serves as the foundation for embodied intelligence, with the brain executing complex algorithms and the cerebellum controlling robot movements, primarily using SoC chips [12][10] Group 3: Company Performance Highlights - Nocera's revenue in Q1 2025 increased by 130% year-on-year, reaching 381 million, with a net profit of 18 million, compared to a net loss of 142 million in the same period last year [16][19] - The sales of the core product, Acalabrutinib, grew by 89% to 311 million in Q1 2025, leading to an upward revision of the annual sales target from over 30% to over 35% growth [16][19] - The company is actively expanding its pipeline for autoimmune diseases and has submitted an IND application for its first ADC product [19][16]

Investment Rating - The report maintains an optimistic outlook on the pharmaceutical industry, suggesting a potential for growth in 2025 due to favorable macroeconomic factors and the recovery of public fund allocations to the sector [11]. Core Insights - The pharmaceutical sector is currently undervalued, with public fund allocations at a low point, but is expected to recover, driven by large-scale products and innovations [11]. - The report highlights a shift in the innovative drug sector from quantity to quality, emphasizing the importance of differentiated products and international pipelines [11]. - In the medical device sector, there is a notable recovery in bidding volumes, particularly for imaging equipment, and a push for home medical devices supported by government subsidies [11]. - The report identifies a significant growth opportunity in the CXO and life sciences services sectors, with expectations of a rebound in domestic financing and a trend towards consolidation [11]. - The traditional Chinese medicine sector is expected to see growth driven by unique essential medicines and state-owned enterprise reforms [11]. Summary by Sections Market Review - The medical device index increased by 0.98%, underperforming the CSI 300 index by 1.03 percentage points, ranking 26th among 30 sectors [8]. - The top ten stocks by growth included JinHao Medical and ChangShan Pharmaceutical, while the bottom ten included ST HuLuWa and YongAn Pharmaceutical [8]. Medical Device Updates - The report notes a significant increase in medical device bidding volumes, with a year-on-year growth of 67.49% in Q1 2025, indicating a strong recovery [20]. - Imaging devices, particularly ultrasound, CT, and DR, are highlighted as the most sought-after categories in procurement [25]. - The report anticipates a surge in procurement activities in county-level medical communities, driven by government support policies [29]. Innovative Drugs - The report emphasizes the growth potential in the innovative drug sector, particularly for companies like BeiGene and Innovent Biologics, which are expected to benefit from their differentiated product pipelines [11]. - The focus on autoimmune diseases is noted as a new growth curve for companies like Nuo Cheng Jian Hua, with significant market potential [37]. Medical Services - The report suggests that the medical service sector will benefit from anti-corruption measures and the expansion of commercial insurance, enhancing the competitiveness of private medical institutions [11]. Blood Products - The blood products sector is expected to grow due to relaxed approval processes for plasma stations and increased demand post-pandemic, with companies like TianTan Biological and BoYa Biological highlighted as key players [11].

Market Review - The CITIC Pharmaceutical Index increased by 0.98%, underperforming the CSI 300 Index by 1.03 percentage points, ranking 26th among 30 CITIC first-level industry indices [5] - The top ten stocks by increase this week include JinHao Medical, Changshan Pharmaceutical, and HaiChuang Pharmaceutical-U, while the top ten stocks by decrease include ST HuLuWa, YongAn Pharmaceutical, and ST SuHao [4][5] Overall View and Investment Themes - The current valuation of the pharmaceutical sector is low, with public funds (excluding pharmaceutical funds) having low allocation to the sector. The company remains optimistic about the growth of the pharmaceutical industry by 2025, driven by macroeconomic factors and the performance of major products [8] - In the innovative drug sector, the focus is shifting from quantity to quality, emphasizing differentiated and internationalized pipelines. Companies such as BeiGene, Innovent, and Hengrui are recommended for investment [8] - In the medical device sector, there is a notable recovery in bidding volumes for imaging equipment, with companies like Mindray and United Imaging being highlighted. The home medical device market is also expected to benefit from subsidy policies [8] - The innovation chain (CXO + life science services) is expected to see a rebound in investment, with a positive outlook for the CXO sector as orders are anticipated to translate into revenue growth by 2025 [8] - The pharmaceutical industry is expected to enter a new growth cycle, with a focus on specialty APIs and the gradual realization of profits from formulation expansions. Companies like Tonghua Dongbao and Huahai Pharmaceutical are recommended [8] Medical Device Update - The approval of medical device update projects peaked in Q2 2024, with a new wave of approvals expected in Q1 2025. The focus remains on imaging devices such as ultrasound, CT, and DR [10][14] - The bidding scale for medical devices in China saw a year-on-year growth of 67.49% in Q1 2025, indicating a significant recovery in the market [16] - The procurement demand for imaging devices remains the highest, with a notable increase in bidding activities for radiotherapy equipment as well [21] Investment Opportunities in Traditional Chinese Medicine and Medical Services - The market for essential medicines is expected to see growth, particularly for unique essential medicines. Companies like Kunming Pharmaceutical and Kangyuan Pharmaceutical are recommended [12] - The medical service sector is anticipated to benefit from anti-corruption measures and the expansion of commercial insurance, with companies like Aier Eye Hospital and Huashan Hospital being highlighted [12] Summary of Medical Device Procurement Trends - The procurement scale of tertiary hospitals is leading the growth, with a year-on-year increase of 81.45% in Q1 2025. The demand for radiotherapy and imaging devices is particularly strong [26] - By March 2025, Jiangsu Province led in medical device procurement with a total budget of 160.3 billion yuan, followed by Guangdong and Hubei [30]