Group 1 - The core viewpoint of the report is that Everbright Securities has raised its net profit forecast for Gilead Pharmaceuticals for the first half of 2025 due to increased clinical research investment in metabolic disease treatment and lower-than-expected R&D expenses in the first half of the year, while maintaining a "buy" rating [1] Group 2 - Gilead Pharmaceuticals' ASC30 is positioned as a potential leading GLP-1 small molecule weight loss drug, with Phase Ib clinical data showing a 6.5% average weight reduction over 28 days in obese patients compared to baseline, excluding placebo effects [2] - The subcutaneous injection of ASC30 has a half-life of 36 days in obese patients, supporting low-frequency dosing, and the company is advancing both oral and subcutaneous Phase IIa clinical trials, expecting top-line data in Q4 2025 and Q1 2026 [2] - In contrast, Eli Lilly's oral GLP-1 small molecule weight loss drug Orforglipron showed lower-than-expected weight loss data over 72 weeks, enhancing the overseas business collaboration value and expectations for ASC30 [2] - Another drug, ASC47, combined with GLP-1 peptide drugs, shows potential for weight loss without muscle loss, with Phase Ib trials indicating a 1.7% weight reduction after a single 90mg subcutaneous injection on day 50, with no muscle loss observed [2] - Preclinical animal studies suggest that ASC47 combined with semaglutide has superior weight loss effects compared to monotherapy, maintaining muscle mass similar to healthy mice, and the company is conducting U.S. clinical trials for ASC47 combined with semaglutide, expecting top-line data in 2025 [2]

Core Viewpoint - The company is undergoing a full transformation towards innovative drug research and development, with significant financial resources to support its activities until 2029 [3]. Group 1: Financial Performance - The company reported a revenue of 0.01 billion RMB and a net profit attributable to shareholders of -0.88 billion RMB for the first half of 2025 [3]. - The company has approximately 18.28 billion RMB in cash and cash equivalents, which is expected to sustain its R&D and operations until 2029 [3]. Group 2: Product Development - ASC30 has shown promising results in its Phase Ib clinical trial, with an average weight loss of 6.5% in obese patients after 28 days of oral administration, positioning it as a potential best-in-class oral GLP-1 small molecule weight loss drug [4]. - The company is advancing ASC30 into Phase IIa clinical trials in the U.S., with topline data expected in Q4 2025 and Q1 2026 for oral and subcutaneous administration, respectively [4]. - ASC47, a fat-targeting drug, demonstrated a long half-life and potential for weight loss without muscle loss in its Phase Ib trial, with a peak weight loss of 1.7% observed [5]. - The company is conducting clinical trials for ASC47 in combination with semaglutide, with topline data anticipated later this year [5].

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Insights - The company focuses on innovative drug development, particularly in metabolic products, and has a strong cash position to support its R&D activities until 2029 [1] - ASC30, a potential best-in-class GLP-1 small molecule weight loss drug, shows promising clinical data with an average weight reduction of 6.5% after 28 days of oral administration [2] - ASC47, another drug in development, demonstrates the potential for fat loss without muscle loss when used in combination with GLP-1 peptides, with ongoing clinical trials expected to yield data this year [3] Financial Performance and Forecast - The company reported a revenue of 0.01 billion RMB and a net profit of -0.88 billion RMB for the first half of 2025 [1] - The revenue forecast for 2025 is expected to remain at 0.01 billion RMB, with a projected net profit of -4.21 billion RMB, an improvement from previous estimates [4][9] - The estimated earnings per share (EPS) for 2025 is projected at -0.43 RMB [4][9]