编辑丨王多鱼 排版丨水成文 在 合成生物学 领域， DNA 合成 技术一直被视为制约行业发展的关键瓶颈。传统高通量 DNA 合成技术， 是在单一芯片表面合成数百万条 DNA 短片段，虽能一次合成大量片段，但每条片段的产量极低，且容易出 现片段间交叉污染，严重影响后续长片段组装的成功率。因其无法同时满足"高通量"、"长片段"、"低成 本"的需求，直接限制了复杂代谢途径研究、染色体工程、大规模突变库构建等前沿研究的深入推进。 与传统技术不同， mMPS 技术采用了一种创新的合成路径：将一张芯片分为一个个独立的、毫米级的微芯 片，在每个微芯片上仅合成一条短链 DNA，且芯片表面均带有专属识别码，可对 DNA 片段进行身份识别 与分选，全程追踪 该 片段的合成过程。此外，通过 "识别-分选-合成-回收"的循环机制，使芯片具备可重 复使用的能力，为可持续、低成本的 DNA 合成奠定了坚实基础。 mMPS技术原理示意 简单来说， 这些微芯片就像一个个带着专属 工号 的 " 工人 " 。合成工厂的智能扫描仪识别出它的工号之 后，能够快速判断它应该去合成哪条 特定的短链 DNA ，便通过传送带将不同的工人精准送往对应的工作 ...

Core Viewpoint - The Chinese beauty industry is undergoing a deep upgrade driven by technology and consumer demand, with pharmaceutical companies emerging as key players due to their strong R&D capabilities and quality systems [3][4]. Industry Overview - Over 400 pharmaceutical companies in China are venturing into the cosmetics sector, aiming to transform pharmaceutical technology into effective skincare and health aesthetic products [3]. - The market for cosmetics in China reached approximately 1,073.82 billion yuan in 2024, continuing to exceed the trillion yuan mark for two consecutive years [8]. Company Profile: Zhejiang Haizheng Pharmaceutical Co., Ltd. - Established in 1956, Haizheng Pharmaceutical has a long history in chemical and pharmaceutical production, with a diversified business matrix focusing on various therapeutic areas [5][6]. - The company reported a revenue of 9.787 billion yuan and a net profit of 600 million yuan in 2024, with R&D investment reaching 420 million yuan [6]. Strategic Moves - Haizheng Pharmaceutical is actively engaging in the "pharmaceutical + aesthetics" trend, leveraging its industrial strength and R&D foundation to innovate in synthetic biology and health aesthetic products [4][9]. - The establishment of Haizheng Weilan and Luan Sheng Synthetic Biology marks the company's strategic entry into health aesthetics and synthetic biology, respectively [9][13]. Product Development and Innovation - Luan Sheng Synthetic Biology has developed over 30 raw material varieties, focusing on high-tech and high-value products to avoid low-level price competition [13][14]. - The company plans to create a product pyramid structure, including "road lamp products" for quick commercialization and "lighthouse products" for mid-term development [14]. Market Strategy - Haizheng Weilan aims to build a comprehensive health aesthetic platform, integrating pharmaceutical e-commerce and innovative business models [15][16]. - The company is focusing on nutrition, functional skincare, and medical beauty, utilizing its raw material advantages to develop products that address joint health and liver protection [18]. Future Outlook - The ultimate goal for Haizheng Pharmaceutical is to establish a complete value chain from synthetic biology raw material innovation to health aesthetic brand products, ensuring each link maintains pharmaceutical-grade quality [21][22]. - The company emphasizes a long-term approach to development, prioritizing solid R&D and reliable quality over quick market gains [22].

Group 1: Industry Overview - The chemical sector's overall performance ranked 17th this week (2025/09/22-2025/09/26) with a decline of 0.95%, underperforming the Shanghai Composite Index by 1.16 percentage points and the ChiNext Index by 2.91 percentage points [2][3] - The chemical industry is expected to continue its trend of divergence in 2025, with a focus on synthetic biology, pesticides, chromatography media, sweeteners, vitamins, light hydrocarbon chemicals, COC polymers, and MDI [2] Group 2: Key Industry Trends - Synthetic biology is at a pivotal moment, with low-energy products likely to gain a longer growth window due to the shift in energy structure. Traditional chemical companies will need to focus on energy consumption and carbon tax costs [2] - The introduction of quota policies for third-generation refrigerants is anticipated to lead to a high-growth cycle, with supply constraints and stable demand growth from markets like heat pumps and cold chains [3] - The electronic specialty gases market is characterized by high technical barriers and value, with domestic production opportunities arising from the rapid upgrade of downstream industries [4] Group 3: Specific Chemical Segments - The trend towards light hydrocarbon chemicals is becoming global, with a shift from heavy naphtha to lighter feedstocks like ethane and propane, which are more cost-effective and environmentally friendly [5] - The industrialization of COC/COP (cyclic olefin copolymer) is accelerating in China, driven by domestic production capabilities and the need for supply chain security [6] - MDI (methylene diphenyl diisocyanate) is experiencing a favorable supply landscape due to its high technical barriers and the concentration of production among a few global players [9] Group 4: Price Tracking and Supply Chain - Weekly price tracking shows significant increases in liquid chlorine (252.38%) and paraquat (42%), while PX and bisphenol A saw declines of -5.56% and -4.27% respectively [10] - The supply side of the chemical industry is affected, with 155 companies reporting changes in production capacity, including 4 new shutdowns and 12 restarts this week [11]

Investment Rating - Industry investment rating: Overweight [1] Core Views - The chemical sector's overall performance ranked 17th this week, with a decline of 0.95%, underperforming the Shanghai Composite Index by 1.16 percentage points and the ChiNext Index by 2.91 percentage points [4][22] - The chemical industry is expected to continue its trend of differentiated growth in 2025, with recommendations to focus on synthetic biology, pesticides, chromatography media, sweeteners, vitamins, light hydrocarbon chemicals, COC polymers, and MDI [4] Summary by Sections Industry Performance - The chemical sector's performance this week was -0.95%, ranking it 17th among all sectors, while the top three performing sectors were power equipment, non-ferrous metals, and electronics [22][23] - The top three individual stocks in the chemical sector this week were Bluefeng Biochemical (61.16%), Shangwei New Materials (44.81%), and Huarsoft Technology (31.83%) [28] Key Industry Dynamics - A new plan for stable growth in the petrochemical industry was released by seven departments, aiming for an average annual growth of over 5% in value added from 2025 to 2026 [34] - The plan emphasizes the importance of technological innovation, digital empowerment, and environmental sustainability in the petrochemical sector [34] Investment Opportunities - Synthetic biology is highlighted as a key area for growth, with companies like Kasei Biotech and Huaheng Biological being recommended for investment [4][8] - The third-generation refrigerants are expected to enter a high prosperity cycle due to upcoming quota policies and stable demand growth from the air conditioning and cold chain markets [5] - The electronic specialty gases market presents significant domestic substitution opportunities, driven by rapid upgrades in the semiconductor and photovoltaic industries [6][8] - Light hydrocarbon chemicals are identified as a global trend, with a shift towards lighter raw materials expected to enhance the value of leading companies in this sector [8] - The COC polymer industry is accelerating its domestic industrialization process, with companies like AkzoNobel being recommended for attention [9] - Potash fertilizer prices are anticipated to rebound as supply tightens and demand increases due to rising agricultural planting intentions [10] - The MDI market is expected to improve due to oligopolistic supply dynamics and stable demand from polyurethane applications [12]

Core Insights - The discussion at the 2025 Pujiang Innovation Forum highlighted the core challenges and breakthrough strategies in the field of synthetic biology, which is seen as a disruptive field with a broad future [2][3] Challenges and Breakthroughs - The main challenge in synthetic biology is the complexity and uncertainty of biological systems, which requires an engineering approach to design life [3] - Key issues include stability during scaling processes, energy consumption of cell factories, and the lack of predictive design tools [3] - Current advancements in biological development processes, such as using engineered yeast in traditional industrial platforms, face fundamental challenges in strain engineering and construction models [3] - The need to address stability issues during strain expansion immediately rather than waiting until scaling is crucial for successful engineering [3] Perspectives on Scaling - The perception that scaling challenges in synthetic biology are exaggerated is noted, with emphasis on the high costs associated with scaling processes [4] - Solutions should focus on optimizing laboratory conditions to ensure that microbial performance in lab settings translates to scaled production [4] - The comparison of costs between synthetic biology and chemical products should be made on a fair basis, considering sustainability and environmental benefits [4] Global Collaboration and Market Entry - Collaboration between global synthetic biology technologies and Chinese factories is essential for achieving scalable progress [5] - China's stable policy environment, reliable competition, and the technical background of policymakers contribute to a favorable landscape for synthetic biology projects [5] - Scientists must have a long-term vision when commercializing disruptive technologies, considering distribution and sales alongside product development [6] Future Outlook - Synthetic biology is expected to make specialty chemicals more accessible and competitively priced, with localized production becoming more feasible [6][7] - The potential of synthetic biology in regenerative medicine is significant, offering solutions for chronic diseases and promoting healthier lifestyles through preventive measures [7]

Core Insights - The article discusses significant advancements made by Professor Deng Yu's research team at Jiangnan University in the design and strength regulation of Escherichia coli core promoters, published in Nucleic Acids Research [1][5] - The research addresses the challenges in accurately predicting and rationally designing bacterial core promoters, which are crucial for transcription initiation [1][2] Research Progress - The team developed a comprehensive platform that integrates rational library construction, predictive modeling, and generative design to achieve programmable regulation of E. coli core promoters [2][3] - They introduced the Mutation-Barcoding-Reverse Sequencing (MBRS) strategy, creating a high-quality dataset of 112,955 promoters, covering a 16,226-fold expression range [2][3] Model Performance - A Transformer model trained on this dataset achieved high prediction accuracy with a correlation coefficient of R = 0.87, revealing attention patterns consistent with classical motifs and contextual dependencies [3] - The platform can generate novel promoters with precise target strengths, achieving a correlation coefficient of R = 0.95, and demonstrated good generalization across different genetic backgrounds (R = 0.93) [3] Application and Impact - The designed promoters exhibited stable modular "plug-and-play" regulatory effects in both constitutive and inducible systems, contributing to the optimization of microbial cell factories [3][6] - The research has been supported by various funding sources, including the National Key Research and Development Program and the National Natural Science Foundation [5]

9月15日，中国科学院深圳先进技术研究院定量合成生物学全国重点实验室金帆团队联合中国科学 院成都文献情报中心杨帅团队，在国际期刊《自然·物理学》发表最新研究成果，首次破解了细菌频率 调制（FM）信号处理的物理密码。 研究发现，在三基因调控系统中，频率调制可比传统振幅调制提升约2个比特的信息熵，从而实现 对多基因系统的精确协调控制。 这是定量合成生物学全国重点实验室继今年3月揭示细菌信号"编码"规律后，在"解码"机制研究方 面取得的又一重要突破。研究在提升人工生命系统的理性设计能力的同时，也为合成生物学开辟了全新 的设计维度。 打破传统策略 工程化破解频率解码机制 当前，合成生物学面临一项核心挑战：如何仿效自然界实现多个基因的精确协调控制？现有调控方 法大多基于"振幅调制"，即调节信号强度来操控基因表达。 "这就像是为细菌安装了一个可编程的'信号接收器'。"杨帅介绍，"我们可以精确控制输入什么样的 频率信号，并观察细菌是如何'理解'和'响应'这些信号的。" 通过严格的时间尺度分析，研究团队发现FDCC系统天然呈现三个功能明确的模块："波形转换 器"负责将周期性光刺激转化为cAMP的锯齿波浓度变化；"阈值滤波器" ...

Industry Overview - The chemical sector's overall performance ranked 12th this week (2025/09/08-2025/09/12) with a change of 2.36%, outperforming the Shanghai Composite Index by 0.83 percentage points and the ChiNext Index by 0.25 percentage points [2][3] - The chemical industry is expected to continue its differentiated trend in 2025, with recommendations to focus on synthetic biology, pesticides, chromatography media, sugar substitutes, vitamins, light hydrocarbon chemicals, COC polymers, and MDI [2][3] Synthetic Biology - The arrival of a pivotal moment in synthetic biology is anticipated, driven by energy structure adjustments that may disrupt fossil-based materials, favoring low-energy products [2] - Traditional chemical companies are expected to compete on energy consumption and carbon tax costs, with successful firms leveraging green energy alternatives and integrated advantages to reduce costs [2] - Companies like Kasei Bio and Huaheng Bio are highlighted as leaders in the synthetic biology sector [2] Refrigerants - The implementation of quota policies is expected to lead to a high-growth cycle for third-generation refrigerants, with supply entering a "quota + continuous reduction" phase starting in 2024 [3] - The demand for refrigerants is projected to grow due to the development of heat pumps, cold chain markets, and the expansion of the air conditioning market in Southeast Asia [3] - Companies such as Juhua Co., Sanmei Co., Haohua Technology, and Yonghe Co. are positioned to benefit from this trend [3] Electronic Specialty Gases - Electronic specialty gases are critical to the electronics industry, characterized by high technical barriers and added value [4] - The domestic market faces a contradiction between rapid upgrades in wafer manufacturing and insufficient high-end electronic specialty gas capacity [4] - Companies like Jinhong Gas, Huate Gas, and China Shipbuilding Gas are expected to capitalize on the growing demand driven by semiconductors, displays, and photovoltaics [4] Light Hydrocarbon Chemicals - The trend towards lighter raw materials in the global olefin industry is noted, with a shift from heavy naphtha to lighter alkanes like ethane and propane [5] - Light hydrocarbon chemicals are recognized for their low carbon emissions, low energy consumption, and low water usage, aligning with global carbon neutrality goals [5] - Satellite Chemical is recommended as a key player in the light hydrocarbon chemical sector [5] COC Polymers - The industrialization of COC/COP (cyclic olefin copolymer) is accelerating in China, driven by domestic companies achieving breakthroughs and the shift of downstream industries to China [6] - COC/COP materials are increasingly used in high-end applications, with domestic firms expected to overcome supply-side bottlenecks [6] - Akolai is identified as a company to watch in the COC polymer production segment [6] MDI Market - The MDI market is characterized by oligopoly, with demand steadily increasing due to the expansion of polyurethane applications [9] - The market is currently experiencing price stabilization at low levels, but profitability remains strong [9] - Wanhu Chemical is highlighted as a key player in the polyurethane sector, benefiting from the anticipated improvement in the MDI supply landscape [9] Potash Fertilizer - Potash fertilizer prices are expected to rebound as the industry enters a destocking phase, with supply constraints due to Canpotex withdrawing new quotes and Nutrien announcing production cuts [7][8] - The demand for potash is projected to rise as farmers increase planting intentions, influenced by rising grain prices [8] - Companies such as Yara International, Salt Lake Potash, and Cangge Mining are noted as leading firms in the potash sector [8] Weekly Price Tracking - The top five price increases this week included liquid chlorine (21.69%), acrylic acid (5.66%), and trichloroethylene (4.44%) [10] - The top five price decreases included butyl rubber (-11.25%), NYMEX natural gas futures (-4.33%), and DMF (-3.68%) [10] Supply-Side Tracking - A total of 162 chemical enterprises had their production capacities affected this week, with 7 new repairs and 11 restarts reported [11]

Industry Overview - The chemical sector's overall performance ranked 11th this week (2025/08/25-2025/08/29) with a fluctuation of 1.11%, positioned in the upper-middle of the market. The Shanghai Composite Index fluctuated by 0.84%, while the ChiNext Index saw a fluctuation of 7.74%. The Shenwan Chemical sector outperformed the Shanghai Composite by 0.27 percentage points but underperformed the ChiNext by 6.63 percentage points [1][2]. Key Industry Insights - The chemical industry is expected to continue its differentiated trend in 2025, with recommendations to focus on synthetic biology, pesticides, chromatography media, sweeteners, vitamins, light hydrocarbon chemicals, COC polymers, and MDI [2]. Synthetic Biology - A pivotal moment for synthetic biology is anticipated, driven by energy structure adjustments. Traditional chemical companies will face competition based on energy consumption and carbon tax costs. Companies that utilize green energy alternatives and scale advantages are likely to reduce energy costs and expand into larger overseas markets. The demand for bio-based materials is expected to surge, leading to potential profitability and valuation increases. Key companies to watch include Kasei Bio and Huaheng Bio [2]. Refrigerants - The implementation of quota policies is expected to usher in a high-growth cycle for third-generation refrigerants. Starting in 2024, the supply of these refrigerants will enter a "quota + continuous reduction" phase, while second-generation refrigerants will see accelerated reductions. The demand for refrigerants is projected to grow steadily due to the development of heat pumps, cold chain markets, and the expansion of the air conditioning market in Southeast Asia. Companies with a high quota share in refrigerants are likely to benefit from the ongoing supply-demand gap. Relevant companies include Juhua Co., Sanmei Co., Haohua Technology, and Yonghe Co. [3][4]. Electronic Specialty Gases - Electronic specialty gases are critical to the electronics industry and represent a core aspect of domestic industrial chain localization. The domestic market is experiencing rapid upgrades in wafer manufacturing, leading to a mismatch between the demand for high-end electronic specialty gases and the insufficient domestic production capacity. Companies that can establish high-end production capacity and possess substantial technical reserves are expected to gain a competitive edge. Key players include Jinhong Gas, Huate Gas, and China Shipbuilding Gas [4][5]. Light Hydrocarbon Chemicals - The trend towards light raw materials in the global olefin industry has been significant over the past decade, with a shift from heavy naphtha to lighter low-carbon alkanes like ethane and propane. This transition is characterized by shorter processes, higher yields, and lower costs. Light hydrocarbon chemicals are also aligned with global low-carbon and energy-saving initiatives. The leading companies in this sector are expected to see their valuations reassessed positively [5]. COC Polymers - The industrialization process of COC/COP (cyclic olefin copolymer) is accelerating in China, driven by domestic companies achieving breakthroughs after years of research. The shift of downstream industries, such as consumer electronics and new energy vehicles, to domestic production has heightened the urgency for local alternatives. The market for COC/COP remains constrained by supply-side bottlenecks, but domestic companies are poised to break through and expand market opportunities. Notable companies include Akerley [6]. MDI Market Dynamics - The MDI market is characterized by oligopolistic supply dynamics, with demand remaining stable due to the expansion of polyurethane applications. The global MDI production capacity is concentrated among eight manufacturers, with five major companies accounting for 90.85% of total capacity. Despite current price pressures, MDI is expected to maintain profitability, and the supply landscape is likely to improve as demand recovers. Key companies to monitor include Wanhua Chemical [9]. Price Tracking - The top five price increases this week included NYMEX natural gas (11.08%), bisphenol A (2.99%), PX (2.86%), refrigerant R32 (2.56%), and butadiene (2.08%). Conversely, the largest price declines were seen in liquid chlorine (-25.86%), urea (-3.45%), TDI (-3.33%), toluene (-3.18%), and pure benzene (-2.70%) [10]. Supply Side Tracking - This week, 153 chemical companies reported changes in production capacity, with six new maintenance activities and four restarts noted [11].

晁然(中)与研发团队成员 衍进科技的研发实验室 商报记者骆伊莎 科技之眼 柔性又智能的"达尔文"系统 据了解，作为一套由人工智能驱动的自动化平台，"达尔文"系统目前已经实现了全自动高通量DNA组 装、工业菌种筛选等研发流程。研究人员只需利用生物CAD(Computer-Aided Design，即计算机辅助设 计)平台将自己的工程改造思路表达出来，系统就可自主完成后续实验。 "通量高、速度快、误差小是'达尔文'的核心优势。"晁然介绍，这一方面得益于该系统采用的柔性化设 计。"我们发现，在生物制造领域，把实验室的流程串起来，需要一条接近智慧工厂的流水线。但当我 们进一步分析工作流程时又发现，它的步骤其实比很多制造业还要复杂，同时它操作的方式方法又比较 多变，存在很多不确定性，比如某一步的实验是否成功，产生不同的结果后下一步要走向哪里。"他表 示，这就要求生产线具备足够的柔性。"'达尔文'拥有的柔性特性，可以支持它更好地适应合成生物学 冗长、复杂且多变的研发流程，同时能通过对流程模块的封装，完成每一个实验操作步骤的标准化，使 得生物系统的构建与数据产出具有足够的确定性。" 在此基础上，"达尔文"所接入的AI算法， ...