Core Viewpoint - Shanghai Mengke Pharmaceutical Co., Ltd. has received approval for a patent term compensation for its core product, extending the patent protection period for its antibacterial drug, Kantizolam Tablets, until August 6, 2033, which enhances its market exclusivity and competitive edge [1][2]. Summary by Sections Patent Information - The patent number is ZL200880020610.0, and it pertains to an antibacterial compound used for treating bacterial infections, specifically Kantizolam Tablets. The patent was applied for on August 6, 2008, and is owned by Shanghai Mengke Pharmaceutical Co., Ltd. [1]. Patent Term Compensation Decision - The National Intellectual Property Administration has granted a patent term compensation of 1,826 days, extending the original patent expiration date from August 6, 2028, to August 6, 2033. The compensation is applicable only to the new drug approved by the State Council's drug regulatory authority and its related indications [1]. Impact on the Company - The approval of the patent term compensation for Kantizolam Tablets provides an additional five years of market protection, significantly enhancing the product's exclusive sales window in the domestic market and improving the company's core competitiveness. However, this approval is not expected to have a significant short-term impact on the company's performance [2].

证券日报网讯 1月8日，富祥药业在互动平台回答投资者提问时表示，锂电池电解液添加剂VC、FEC产 品价格回升，会对公司业绩产生积极影响。公司将积极把握锂电池电解液添加剂产品价格上涨的市场机 遇，同时依托医药制造业务的成本改善、微生物蛋白业务的战略推进，努力提升整体盈利能力。目前， 公司具有8000吨/年VC产品产能，计划通过技改等措施将VC产品产能增加至10000吨/年，预计2026年二 季度改造完成。 （文章来源：证券日报） ...

Core Viewpoint - The global largest caffeine supplier, Shiyao Innovation Pharmaceutical Co., Ltd., is preparing for an IPO on the Hong Kong Stock Exchange, marking a significant transition as the company shifts from its traditional caffeine business to innovative pharmaceuticals amid a leadership change within its parent company, Shiyao Group [2][9]. Group 1: Company Background and Business Transition - Shiyao Innovation, formerly known as Sinoway, has been a long-term supplier of caffeine to major brands like Coca-Cola and Red Bull, and is recognized as the world's largest producer of synthetic caffeine [3][4]. - The company has been diversifying its business since 2016, entering the health food sector and acquiring 100% of Shiyao Shengxue, becoming a leading producer of acarbose raw materials [3][6]. - Despite its historical revenue from functional raw materials and health foods, which constituted over 90% of total revenue, there has been a decline from 2.57 billion yuan in 2022 to 1.84 billion yuan in 2024 [6][8]. Group 2: Financial Performance and Challenges - The financial performance of Shiyao Innovation has been declining, with revenues dropping from 2.84 billion yuan in 2022 to 1.98 billion yuan in 2024, and a net profit decrease from 294 million yuan in 2022 to a loss of 304 million yuan in 2024 [8][6]. - The acquisition of Shiyao Shengxue has introduced a new biopharmaceutical platform, but the revenue contribution from biopharmaceutical products remains below 10%, with the acquired entity still operating at a significant loss [8][6]. Group 3: Leadership Transition - A notable leadership transition occurred as Cai Lei, the son of the founder Cai Dongchen, took over as CEO of Shiyao Group, indicating a shift to a second-generation leadership [9][12]. - Cai Lei's background in international research and sales is expected to enhance the company's global strategy, focusing on overseas collaborations and clinical advancements [11][12]. - The leadership change coincides with the company's IPO plans, adding a layer of family legacy to the transition [9][12].

广生堂（300436.SZ）1月8日在投资者互动平台表示，我司GST-HG141的III期临床试验正在顺利推进， 目前入组人数已过半，整体进展符合预期，且日前GST-HG141相关研究已被纳入新发突发与重大传染 病防控国家科技重大专项，有望依托国家重大专项的资源与政策支持，加快研发进展，力争早日获批上 市，惠及广大患者。后续进展公司将依法依规及时披露，敬请持续关注。 每经AI快讯，有投资者在投资者互动平台提问：您好董秘，请问公司141产品三期临床进展怎么样了？ （记者 张明双） ...

每经AI快讯，1月8日，东诚药业(002675.SZ)公告称，公司近日取得招商银行烟台分行出具的《贷款承 诺函》，承诺为公司本次回购股份专项贷款融资提供支持，贷款金额不超过人民币17,000万元（且贷款 金额不得超过实际回购金额的90%），期限不超过36个月，承诺函有效期自出具之日起至2027年1月5日 止。该事项不构成关联交易，不会对公司经营及业绩产生重大影响。 ...

东诚药业公告称，2025年12月31日公司通过以集中竞价方式回购股份方案，回购价不超18元/股，资金1 亿 - 2亿元，期限不超12个月。近日，公司获招商银行烟台分行《贷款承诺函》，贷款不超1.7亿元（不 超实际回购金额90%），期限不超36个月，承诺函至2027年1月5日有效。本次贷款不构成关联交易，不 影响公司经营及业绩，公司将依规实施回购并披露信息。 ...

Group 1 - The chemical pharmaceutical sector increased by 0.24% on January 8, with Bibete leading the gains [1] - The Shanghai Composite Index closed at 4082.98, down 0.07%, while the Shenzhen Component Index closed at 13959.48, down 0.51% [1] - Notable gainers in the chemical pharmaceutical sector included Bibete, which rose by 20.00% to a closing price of 49.68, and Qijingt, which increased by 10.00% to 28.27 [1] Group 2 - The chemical pharmaceutical sector experienced a net outflow of 191 million yuan from institutional investors, while retail investors saw a net inflow of approximately 84.42 million yuan [2] - The trading volume for Bibete was 140,500 shares, with a transaction value of 682 million yuan, indicating strong market interest [1] - The sector's overall trading activity showed a mix of inflows and outflows, with specific stocks like Hainan Haiyao and Xinyu Pharmaceutical seeing significant institutional interest [3]

Group 1 - East Asia Pharmaceutical's stock price increased by 5.75% on January 8, reaching 19.69 CNY per share, with a trading volume of 28.52 million CNY and a turnover rate of 1.33%, resulting in a total market capitalization of 2.259 billion CNY [1] - The stock has risen for three consecutive days, with a cumulative increase of 4.61% during this period [1] - The company, established on February 6, 1998, and listed on November 25, 2020, specializes in the research, production, and sales of chemical raw materials and pharmaceutical intermediates [1] Group 2 - The main revenue composition of East Asia Pharmaceutical includes: β-lactam antibiotics (44.84%), anticholinergic and synthetic antispasmodic drugs (23.92%), quinolone antibiotics (12.86%), antifungal drugs for skin use (8.87%), and other products (5.05%) [1] - Notably, the fund "Nuoan Multi-Strategy Mixed A" (320016) has entered the top ten circulating shareholders of East Asia Pharmaceutical, holding 811,700 shares, which is 0.72% of the circulating shares [2] - The fund has generated a floating profit of approximately 868,600 CNY today, with a floating profit of 665,600 CNY during the three-day increase [2]

Core Viewpoint - The stock price of Zhejiang Hai Zheng Pharmaceutical Co., Ltd. has shown a positive trend, with a year-to-date increase of 7.38% and a recent uptick in trading activity, indicating potential investor interest and market confidence in the company's performance [2]. Group 1: Stock Performance - As of January 8, the stock price increased by 2.02%, reaching 10.62 CNY per share, with a trading volume of 1.11 billion CNY and a turnover rate of 0.88%, resulting in a total market capitalization of 12.732 billion CNY [1]. - The stock has experienced a 7.49% increase over the last five trading days and a 2.02% increase over the last 20 days [2]. Group 2: Financial Performance - For the period from January to September 2025, the company reported a revenue of 7.923 billion CNY, reflecting a year-on-year growth of 0.61%, while the net profit attributable to shareholders decreased by 10.55% to 461 million CNY [2]. - Cumulative cash dividends since the company's A-share listing amount to 1.726 billion CNY, with 445 million CNY distributed over the past three years [3]. Group 3: Shareholder Information - As of September 30, 2025, the number of shareholders increased to 54,400, a rise of 5.04%, with an average of 22,041 circulating shares per shareholder, which is a decrease of 4.79% [2]. - Among the top ten circulating shareholders, Hong Kong Central Clearing Limited holds 28.6504 million shares, an increase of 6.1171 million shares compared to the previous period [3].

Group 1 - In the fourth quarter of last year, notable fund managers such as Ge Lan and Tang Xiaobin reduced their holdings in Kelun Pharmaceutical, while Zhao Bei increased her stake [2][3] - Ge Lan's fund, the China Europe Medical Health Mixed Fund, held 38.1954 million shares of Kelun Pharmaceutical as of December 31, 2025, having reduced its holdings by 1.867 million shares compared to the end of the third quarter [4] - Tang Xiaobin's fund, the GF Multi-Factor Mixed Fund, exited the top ten shareholders of Kelun Pharmaceutical by the end of 2025, having reduced its holdings from 24.2335 million shares to an estimated 1.394 million shares [6] Group 2 - Zhao Bei's fund, the ICBC Credit Suisse Frontier Medical Equity Fund, increased its holdings in Kelun Pharmaceutical to 22 million shares by December 31, 2025, up by 2 million shares from the end of the third quarter [6] - The National Social Security Fund's 416 portfolio became the tenth largest shareholder of Kelun Pharmaceutical with 13.9445 million shares by the end of 2025 [6] Group 3 - Liu Yanchun and Hu Xinwei reduced their holdings in Proya Cosmetics, with Liu's fund holding 2.6 million shares as of December 30, 2025, down from 3.332 million shares at the end of the third quarter [8] - Hu Xinwei's fund exited the top ten shareholders of Proya Cosmetics by the end of 2025 [8] Group 4 - Zhou Yun's fund, the Dongfanghong New Energy Mixed Fund, and the National Social Security Fund's 404 portfolio entered the top ten shareholders of Jiazhe New Energy by the end of 2025 [10] - The National Social Security Fund's 114 portfolio increased its holdings in Nanshan Aluminum by 4.3432 million shares in the fourth quarter of 2025, with five ETF products included in the top ten shareholders of Nanshan Aluminum by the end of 2025 [10] Group 5 - A surge in institutional research activities has been noted, with over 10,000 research sessions conducted in the past month, focusing on sectors such as semiconductors, general equipment, automotive, and artificial intelligence [12] - Fund managers from various firms, including Chang'an Fund and Nord Fund, have actively participated in company research activities, indicating a strong interest in the market outlook for 2026 [13]