Core Viewpoint - The article emphasizes the rapid advancements in biological microscopy technologies and their significant applications in molecular mechanism research, disease diagnosis, and drug discovery. It announces the upcoming "6th Biological Microscopy Technology and Application" online seminar scheduled for September 23-25, 2025, aimed at enhancing communication and learning among professionals in the life sciences field [2]. Summary by Sections Conference Highlights - The conference will focus on core areas of biological microscopy technology, structured around "cutting-edge technology - 3D imaging - single-molecule imaging - biomedical applications," covering the entire chain from technology development to medical application [3]. - The quality of reports will combine innovation and practical value, featuring various imaging techniques such as label-free imaging, SIM super-resolution, light-sheet microscopy, two-photon microscopy, and single-molecule imaging, along with applications in metabolic research and tissue imaging [3]. - The expert lineup includes professionals from universities, research institutes, and companies, ensuring a diverse and authoritative representation. Notable institutions like Peking University and Tsinghua University will participate, facilitating in-depth dialogue between academic research and industry applications [3]. Conference Schedule - The conference is set for September 23-25, 2025, organized by Instrument Information Network [5]. - The agenda includes various sessions on advanced microscopy techniques, with specific topics such as "Label-free super-resolution live-cell imaging and applications" and "Fluorescence lifetime imaging in metabolic research" [6][8][9]. Expert Participants - The conference will feature experts from leading institutions and companies, including Peking University, Tsinghua University, and various optical microscopy firms, contributing to a rich exchange of knowledge and experience in the field [10][11][12].

Core Viewpoint - The article outlines the 2025 project application guidelines for the National Key R&D Program on Disruptive Technology Innovation, emphasizing the need for strategic breakthroughs in various fields to foster new industries and production capabilities [1][2]. Group 1: Overall Goals - The initiative aims to address major national needs and health issues while exploring global technological frontiers, focusing on selecting and nurturing disruptive technologies with significant strategic value [2]. Group 2: Project Requirements and Layout - The program is exploratory and nurturing in nature, without specific project or topic guidelines, allowing for open discovery and systematic layout of key technologies [3]. Subgroup: Brain-Computer Interface - The brain-computer system is a key focus area, aiming to develop disruptive technologies for brain analysis, protection, and development, thereby establishing a leading global technology cluster [3][4]. Subgroup: Cell and Gene Therapy - The cell and gene therapy sector is targeted for key technological advancements, focusing on creating a new technology lineage and industry chain to promote precision medicine and regenerative medicine [5][6]. Subgroup: AI-Driven Scientific Research - The AI-driven scientific research area aims to combine artificial intelligence with theoretical deduction and scientific experimentation to create disruptive technologies that can transform research paradigms [8][9]. Subgroup: Clean and Efficient Use of Coal - The clean and efficient utilization of coal is another focus, targeting key technologies for safe production and high-value utilization, contributing to carbon management strategies [10][11].

Core Viewpoint - Jiangsu is accelerating the independent research and development of domestic scientific research instruments and their verification applications to gain control over technological innovation in the face of increasing competition in the technology sector [2][4]. Group 1: Domestic Instrument Development - The Suzhou Institute of Biomedical Engineering and Technology has successfully developed the world's first 8mm large-field dual-photon microscope, enabling real-time observation of neuronal activity in mouse brains [2][3]. - Jiangsu has been approved as one of the first pilot provinces for the National Major Scientific Instrument and Equipment Development Project, achieving breakthroughs in the independent research and development of high-end scientific research instruments [2][4]. Group 2: Industry Collaboration and Application - Jiangsu is supporting universities like China Pharmaceutical University and Nanjing University of Science and Technology to establish domestic scientific instrument application demonstration centers, validating 13 sets of domestic instruments against imported counterparts [3][4]. - Over 20 key enterprises have collaborated with these demonstration centers to enhance the performance and application of domestic instruments such as transmission electron microscopes and nuclear magnetic resonance instruments [3][4]. Group 3: Market Position and Financial Support - Jiangsu's scientific instrument industry leads the nation, with market shares in optical instruments, specialized instrument components, and medical devices ranking first in the country [4]. - The Jiangsu government has introduced financial products like "Instrument Loans" to support enterprises engaged in the research and use of domestic scientific instruments [4].

Group 1: Breakthroughs in Life Sciences - The exhibition at the Zhongguancun Forum showcased significant advancements in life sciences, including high-speed heavy ion bombardment for tumor treatment and the artificial cultivation of neuron cells from stem cells [1] - A self-developed two-photon microscope, weighing only 2.2 grams, allows real-time imaging of brain cells in running mice, contributing to groundbreaking research in autism and neural resilience [2] - The development of a 3D brain organoid culture system enables the simulation of human brain growth and development, which is crucial for understanding diseases like autism [3] Group 2: Medical Equipment Advancements - The domestically developed heavy ion accelerator has been utilized for tumor treatment, significantly reducing treatment costs compared to imported systems [4] - Robotic-assisted surgeries have improved precision and reduced incision sizes, allowing younger doctors to perform complex procedures with greater ease [5] - The integration of internet technology with robotic surgery enables remote operations, bringing quality medical resources closer to the public [5]