Core Viewpoint - The article emphasizes the rapid advancements in biological microscopy technologies and their significant applications in molecular mechanism research, disease diagnosis, and drug discovery. It announces the upcoming "6th Biological Microscopy Technology and Application" online seminar scheduled for September 23-25, 2025, aimed at enhancing communication and learning among professionals in the life sciences field [2]. Summary by Sections Conference Highlights - The conference will focus on core areas of biological microscopy technology, structured around "cutting-edge technology - 3D imaging - single-molecule imaging - biomedical applications," covering the entire chain from technology development to medical application [3]. - The quality of reports will combine innovation and practical value, featuring various imaging techniques such as label-free imaging, SIM super-resolution, light-sheet microscopy, two-photon microscopy, and single-molecule imaging, along with applications in metabolic research and tissue imaging [3]. - The expert lineup includes professionals from universities, research institutes, and companies, ensuring a diverse and authoritative representation. Notable institutions like Peking University and Tsinghua University will participate, facilitating in-depth dialogue between academic research and industry applications [3]. Conference Schedule - The conference is set for September 23-25, 2025, organized by Instrument Information Network [5]. - The agenda includes various sessions on advanced microscopy techniques, with specific topics such as "Label-free super-resolution live-cell imaging and applications" and "Fluorescence lifetime imaging in metabolic research" [6][8][9]. Expert Participants - The conference will feature experts from leading institutions and companies, including Peking University, Tsinghua University, and various optical microscopy firms, contributing to a rich exchange of knowledge and experience in the field [10][11][12].

Core Viewpoint - The article outlines the 2025 project application guidelines for the National Key R&D Program on Disruptive Technology Innovation, emphasizing the need for strategic breakthroughs in various fields to foster new industries and production capabilities [1][2]. Group 1: Overall Goals - The initiative aims to address major national needs and health issues while exploring global technological frontiers, focusing on selecting and nurturing disruptive technologies with significant strategic value [2]. Group 2: Project Requirements and Layout - The program is exploratory and nurturing in nature, without specific project or topic guidelines, allowing for open discovery and systematic layout of key technologies [3]. Subgroup: Brain-Computer Interface - The brain-computer system is a key focus area, aiming to develop disruptive technologies for brain analysis, protection, and development, thereby establishing a leading global technology cluster [3][4]. Subgroup: Cell and Gene Therapy - The cell and gene therapy sector is targeted for key technological advancements, focusing on creating a new technology lineage and industry chain to promote precision medicine and regenerative medicine [5][6]. Subgroup: AI-Driven Scientific Research - The AI-driven scientific research area aims to combine artificial intelligence with theoretical deduction and scientific experimentation to create disruptive technologies that can transform research paradigms [8][9]. Subgroup: Clean and Efficient Use of Coal - The clean and efficient utilization of coal is another focus, targeting key technologies for safe production and high-value utilization, contributing to carbon management strategies [10][11].

Core Viewpoint - Jiangsu is accelerating the independent research and development of domestic scientific research instruments and their verification applications to gain control over technological innovation in the face of increasing competition in the technology sector [2][4]. Group 1: Domestic Instrument Development - The Suzhou Institute of Biomedical Engineering and Technology has successfully developed the world's first 8mm large-field dual-photon microscope, enabling real-time observation of neuronal activity in mouse brains [2][3]. - Jiangsu has been approved as one of the first pilot provinces for the National Major Scientific Instrument and Equipment Development Project, achieving breakthroughs in the independent research and development of high-end scientific research instruments [2][4]. Group 2: Industry Collaboration and Application - Jiangsu is supporting universities like China Pharmaceutical University and Nanjing University of Science and Technology to establish domestic scientific instrument application demonstration centers, validating 13 sets of domestic instruments against imported counterparts [3][4]. - Over 20 key enterprises have collaborated with these demonstration centers to enhance the performance and application of domestic instruments such as transmission electron microscopes and nuclear magnetic resonance instruments [3][4]. Group 3: Market Position and Financial Support - Jiangsu's scientific instrument industry leads the nation, with market shares in optical instruments, specialized instrument components, and medical devices ranking first in the country [4]. - The Jiangsu government has introduced financial products like "Instrument Loans" to support enterprises engaged in the research and use of domestic scientific instruments [4].

速度达到光速70%的重离子轰击，已经治疗了数千名肿瘤患者；只有米粒大小的神经元细胞，从干 细胞分化出来，已经实现了人工培养；国产高载量核酸合成仪一次能合成30多克高质量核酸，这对于以 纳克为单位的核酸生产已是"极大量级"…… 最快、最小、最高产，在今年中关村论坛期间推出的展览上，除了有机器人的炫技，还有生命科学 领域突破极限的各类"最"新成果集中亮相。 开拓"最终疆域"取得原创成果 以脑科学为例，它被认为是科学研究的"最终疆域"，是生命科学最难以攻克的领域之一。在中关村 论坛中，脑科学领域的重重"禁地"正在"解除封印"。 "研究生命必须要有新的分析工具、观测工具。如果靠购买尖端设备开展研究，那么用的将是别人 早就用过多年的设备，科学家也很难取得原创性科学成果。"在3月29日举办的医学AI创新与发展论坛 上，中国科学院院士、北京大学国家生物医学成像科学中心主任程和平带来了自主研发的仅有2.2克、 能跟着小鼠奔跑的双光子显微镜的研究进展和应用成果。他表示，双光子显微镜能够在动物奔跑时实时 对脑细胞进行成像，已经装机上百台，助力中国团队在孤独症研究、神经韧性研究等方面取得了开创性 成果。 这一脑科学研究的"利器"所 ...