Core Viewpoint - SiPeng Technology has successfully completed a multi-million Pre-A+ round of financing, which will be used to accelerate the commercialization of bio-based materials and the construction of a third-generation carbon source bio-manufacturing platform [1][2]. Group 1: Company Overview - SiPeng Technology, established in 2022, focuses on material synthesis and bio-manufacturing, with a founding team that has over 20 years of industry experience [1]. - The company has achieved significant breakthroughs in "bottleneck" technologies and has successfully scaled up multiple bio-manufacturing products [1][2]. - SiPeng Technology is recognized as a representative enterprise for the transformation of scientific achievements from Shanghai Jiao Tong University [1]. Group 2: Financing and Investment - The recent Pre-A+ round was led by Shanghai Guotou Futeng Capital, with XiQiao Capital serving as the exclusive financial advisor [1]. - In October 2024, SiPeng Technology completed a nearly 100 million Pre-A round, which was led by Guotou Chuanghe and followed by Rugao Kechuang Investment [1]. Group 3: Technological Advancements - SiPeng Technology has developed a smart bio-manufacturing platform and a high-performance material application development platform, aiming to produce globally competitive bio-based products [1][2]. - The company has broken the overseas technology monopoly and has completed mass production verification of various bio-based polyols/acids, achieving international leadership in fermentation concentration and cost [1][2]. Group 4: Carbon Source Utilization - SiPeng Technology is collaborating with the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences to promote the industrialization of bio-based material monomers using methanol as a raw material [2]. - The company is focusing on the industrialization of first and second-generation carbon source products while planning to utilize methanol and carbon dioxide as raw materials for third-generation carbon sources, significantly reducing the reliance on food carbon sources and lowering bio-manufacturing costs [2]. Group 5: Market Outlook - Shanghai Guotou Futeng Capital emphasizes that the synthetic biology field requires both product development and scalable sales for long-term success, aligning with the goals of carbon neutrality and sustainability [4]. - SiPeng Technology aims to establish a long-term market advantage through strain iteration, carbon source replacement, and continuous optimization of production processes [4].

在"双碳"目标与生物制造产业升级的双重驱动下，碳源迭代——即以粮食作物、淀粉为原料的第一代碳源逐渐过渡到以非粮生物质为原料的第二代碳 源，进而转向以二氧化碳、甲醇等一碳化合物为原料的第三代碳源，成为合成生物学领域的核心命题之一。 【SynBioCon】 获 悉， 4 月 21 日，上海肆芃科技有限公司（以下简称"肆芃科技"）宣布和中国科学院天津工业生物技术研究所（以下简称"天津工 生所"）达成合作，双方 将以甲醇为原料开发大宗生物基材料单体产品 ，突破传统生物制造对粮食碳源的依赖，并推动" 一碳生物制造 "的工业化落 地。 这场产学联姻将如何突破技术壁垒？甲醇路线能否推动生物基材料技术与产业发展？ 肆芃科技的创始人兼董事长 陶飞 ，以及天津工生所的 王钰研究员 ，就此次合作的目标、未来发展规划等方面进行了深入交流。 在实际应用过程中，如何提高其转化率和流向产物的代谢通量仍是核心挑战。"天津工生所在甲醇利用微生物底盘上的积累，尤其是对 高温甲醇利用底 盘 的改造技术，为我们提供了从 0 到 1 的技术突破的希望。"陶飞表示。 "我们团队最初尝试改造现有工业菌种（如大肠杆菌）以高效利用甲醇，但甲醇利用能力与自然界 ...