Core Viewpoint - The hypertension medication market in China is experiencing significant changes due to national centralized procurement, leading to a decline in overall sales and a shift in market dynamics [1][2][18]. Market Overview - The sales scale of hypertension medications in the hospital terminal market has decreased from over 60 billion yuan in 2019 to 47.726 billion yuan in 2024, reflecting a year-on-year decline of 4.16% [2][18]. - Prior to 2018, the market growth rate was consistently above 10%, peaking at 60.932 billion yuan in 2019 [2]. Drug Categories - Drugs acting on the renin-angiotensin system (RAS) hold the largest market share at 41.22%, followed by calcium channel blockers at 37.57% [4]. - Oral medications dominate the market, accounting for over 90% of sales, while intravenous injections represent 8.42% [4]. Top 10 Drugs - The top 10 hypertension medications in 2024 include: 1. Sacubitril/Valsartan 2. Nifedipine Controlled Release 3. Amlodipine Besylate 4. Metoprolol Succinate 5. Lercanidipine 6. Irbesartan/Hydrochlorothiazide 7. Valsartan/Amlodipine 8. Felodipine Controlled Release 9. Valsartan/Hydrochlorothiazide 10. Aliskiren [6][8]. Sales Performance - Among the top 10 drugs, only two achieved positive growth in 2024: Sacubitril/Valsartan with a 30.96% increase and Aliskiren with a 20.89% increase [9]. - Nifedipine Controlled Release, once the market leader, has seen its sales drop significantly, nearing a halving since the implementation of centralized procurement [10][18]. Competitive Landscape - The market is characterized by intense competition, with 27 manufacturers producing Nifedipine Controlled Release, leading to a drastic reduction in its market share [10][12]. - In 2024, foreign companies like Novartis and Bayer continue to dominate the top positions in the hypertension medication market, while six domestic companies have also made it to the top 10 [15][18]. Conclusion - The implementation of centralized procurement has reshaped the hypertension medication market, resulting in a significant decline in sales and a rise of innovative drugs like Sacubitril/Valsartan, which combines blood pressure reduction with heart protection [18].

Company Overview - Shanghai Ailis Pharmaceutical Technology Co., Ltd. focuses on innovative drugs for cancer treatment, with key products including Aifuritini (third-generation EGFR-TKI) and Alisartan [1] - The company has developed a rich R&D pipeline in the field of small molecule targeted drugs for non-small cell lung cancer [1] - Ailis has successfully developed and transferred its independently researched product, Alisartan tablets, which is part of a major national project for new drug creation [1] Financial Performance - As of the latest Q3 2024 report, the company achieved a revenue of 2.533 billion yuan, representing a year-on-year increase of 87.97% [1] - The net profit for the same period was 1.063 billion yuan, showing a significant year-on-year growth of 158.99% [1] - The sales gross margin stood at 95.80% [1] Market Position - Ailis's current closing price is 85.63 yuan, with a PE ratio of 27.06, which is lower than the industry average of 47.09 [2] - The total market capitalization of the company is 38.533 billion yuan [2] - Among 147 institutions holding Ailis shares, the total number of shares held is 24.0823 million, with a market value of 1.443 billion yuan [1]