Core Viewpoint - The Hu Run Research Institute released the "2025 Hu Run Women Entrepreneurs List," highlighting that Zhong Huijuan and her daughter Sun Yuan topped the list as China's richest women with a wealth of 141 billion yuan, marking an increase of 64 billion yuan or 83% from the previous year. This is the first time a woman from the life and health sector has achieved this status [1][3]. Company Overview - Zhong Huijuan, 64, is from Lianyungang, Jiangsu, and is married to Sun Piaoyang, the founder of Heng Rui Medicine. Together, they are known as "China's most powerful pharmaceutical couple," each leading companies with market values exceeding 100 billion yuan [3]. - Over the past year, Hansoh Pharmaceutical's market value doubled, driven by the launch of innovative drugs and international collaborations. Since 2025, the company's stock price has increased by over 115%, reaching 35.78 HKD per share, with a market capitalization of 216.65 billion HKD [3][4]. Business Transformation - Hansoh Pharmaceutical transitioned from a generic drug manufacturer to a leader in innovative drugs, reflecting the evolution of China's pharmaceutical industry over the past three decades. As of the first half of 2025, innovative drug revenue accounted for 82.7% of total revenue, with frequent overseas licensing deals [3][7]. - The company faced significant challenges due to the implementation of centralized drug procurement policies, which drastically reduced profits from generic drugs. In response, the company shifted its focus to innovative drug development, increasing R&D investments and establishing multiple research centers [7][10]. Financial Performance - In 2024, Hansoh Pharmaceutical reported total revenue of 12.261 billion yuan, a year-on-year increase of 21.3%, with a net profit of 4.372 billion yuan, up 33.4%. Innovative drug and collaboration product sales reached 9.477 billion yuan, a 38.1% increase, making up 77.3% of total revenue [8][10]. - For the first half of 2025, the company achieved revenue of 7.434 billion yuan, a 14.3% increase, and a net profit of 3.135 billion yuan, up 15%. Innovative drug sales further increased to 6.145 billion yuan, representing 82.7% of total revenue [8][10]. R&D Investment - Hansoh Pharmaceutical's commitment to R&D is evident, with R&D expenditures of approximately 2.702 billion yuan in 2024, a 28.8% increase, accounting for over 20% of total revenue. In the first half of 2025, R&D spending was about 1.441 billion yuan, up 20.4% [10]. - The company has over 1,800 R&D professionals and is advancing more than 70 innovative drug clinical trials across various therapeutic areas, including oncology and autoimmune diseases [10][11]. Licensing and Collaborations - International pharmaceutical giants have increasingly sought partnerships with Hansoh Pharmaceutical, leading to significant licensing agreements. Notable deals include a $1.85 billion upfront payment from GSK for ADC drug HS-20093 and a $1.12 billion upfront payment from Merck for GLP-1 receptor agonist HS-10535 [11]. - The company has established a "R&D-licensing-reinvestment" cycle, ensuring stable revenue growth while funding further research initiatives [11][12]. Market Position - The wealth increase of Zhong Huijuan and her daughter is largely attributed to the rise in Hansoh Pharmaceutical's stock price, which has surged over 115% since 2025. However, compared to other major domestic pharmaceutical companies, Hansoh remains relatively under the radar, focusing on R&D rather than media attention [12].

Core Insights - Hansoh Pharmaceutical has secured a significant business development (BD) deal worth up to $1.53 billion with Roche for the global rights (excluding Greater China) to its investigational CDH17-targeted antibody-drug conjugate (ADC) HS-20110 [1][2] - The deal includes an upfront payment of $80 million, potential milestone payments of up to $1.45 billion, and a share of future sales [1][2] - This transaction highlights Hansoh's strategic shift from generics to innovative drugs, with innovative drug revenue projected to account for over 80% of total revenue by mid-2025 [1][7] Business Development Strategy - Hansoh has successfully executed multiple BD transactions in the ADC field, totaling approximately $4.8 billion across three major deals, including recent agreements with GSK for other ADCs [3][4] - The company employs a dual strategy of license-in and license-out to expand its product pipeline, having completed over 20 BD transactions since 2019 [5][6] - Recent license-in agreements include collaborations with three companies to develop new drugs, with ongoing clinical trials for several candidates [6] Financial Performance - In the first half of 2025, Hansoh reported revenues of 7.434 billion yuan, a year-on-year increase of 14.27%, with net profit attributable to shareholders reaching 3.135 billion yuan, up 15.02% [7] - Sales from innovative drugs and collaborative products accounted for 82.17% of total revenue during the same period [7] Company Background - Hansoh Pharmaceutical was founded in 1995 by Sun Piaoyang and his wife Zhong Huijuan, who have played pivotal roles in the company's growth and transition from generics to innovative pharmaceuticals [8][9] - The company has a history of launching significant generic products and has now established a strong presence in the innovative drug market, with several products already on the market [5][6] Market Position - The recent BD deal with Roche and previous agreements reflect the growing trend of Chinese ADCs entering global markets, showcasing the country's R&D capabilities in this area [3][4] - Hansoh's stock has seen significant appreciation, with a 115.3% increase since the beginning of 2025, indicating strong market confidence in the company's future prospects [10]

Core Viewpoint - The company, Hansoh Pharmaceutical, reported strong revenue and profit growth in the first half of 2025, driven by its innovative drug sales and business development (BD) initiatives, with expectations for continued performance improvement in the coming years [1][4]. Group 1: Financial Performance - In the first half of 2025, the company achieved revenue of 7.434 billion yuan, a year-on-year increase of 14.3%, and a net profit of 3.135 billion yuan, up 15.0% [1]. - The company's cooperative revenue reached 1.657 billion yuan in the first half of 2025, reflecting an 18.1% year-on-year growth, with expectations for total cooperative revenue to exceed 2 billion yuan for the year [1]. Group 2: Product Development and Sales - Sales revenue from innovative drugs and cooperative products amounted to 6.145 billion yuan, marking a 22.1% year-on-year increase and accounting for 82.7% of total revenue [1]. - The oncology sector generated revenue of 4.531 billion yuan, while the anti-infection sector brought in 735 million yuan, the central nervous system sector 768 million yuan, and the metabolic and other diseases sector 1.4 billion yuan [2]. - The company’s key product, Amivantamab (Amivantinib), received approval for two new indications in China and was the first Chinese original EGFR TKI approved for sale in the UK [2]. Group 3: Research and Development - R&D expenditure reached 1.441 billion yuan in the first half of 2025, a 20.4% increase year-on-year, representing 19.4% of total revenue [3]. - The company has over 40 candidate innovative drugs in its pipeline and is conducting more than 70 clinical trials [3]. - Eight innovative drugs entered clinical stages for the first time in the first half of 2025, providing fresh momentum for future performance growth [3]. Group 4: Future Outlook - The company is expected to achieve revenues of 14.685 billion yuan, 15.801 billion yuan, and 18.471 billion yuan for the years 2025 to 2027, with corresponding net profits of 5.237 billion yuan, 5.434 billion yuan, and 6.417 billion yuan [4].

Investment Rating - The report maintains a "Recommended" rating for the company [4] Core Insights - The company achieved a revenue of 7.434 billion RMB in the first half of 2025, representing a year-on-year growth of 14.3%, and a net profit of 3.135 billion RMB, up 15.0% year-on-year [1] - The company's collaboration revenue reached 1.657 billion RMB in the first half of 2025, with an expected total collaboration revenue exceeding 2 billion RMB for the year [1][4] - Sales of innovative drugs and collaboration products amounted to 6.145 billion RMB, a year-on-year increase of 22.1%, accounting for 82.7% of total revenue [2] - The company has over 40 candidate innovative drugs in its pipeline and is conducting more than 70 clinical trials, with significant advancements in various therapeutic areas [3] Summary by Sections Revenue and Profit Growth - The company reported a revenue of 7.434 billion RMB for the first half of 2025, a 14.3% increase year-on-year, and a net profit of 3.135 billion RMB, reflecting a 15.0% growth [1] Collaboration and Licensing - The collaboration revenue for the first half of 2025 was 1.657 billion RMB, an 18.1% increase year-on-year, with expectations of exceeding 2 billion RMB for the full year [1] - Key collaborations include a 112 million USD upfront payment from MSD and an 80 million USD upfront payment from Regeneron [1] Innovative Drug Sales - Sales from innovative drugs and collaboration products reached 6.145 billion RMB, with a 22.1% year-on-year growth, driven by new indications for existing products [2] - The oncology segment generated 4.531 billion RMB, while other therapeutic areas also contributed significantly to revenue [2] Research and Development - R&D expenses for the first half of 2025 were 1.441 billion RMB, a 20.4% increase year-on-year, constituting 19.4% of total revenue [3] - The company has over 40 innovative drug candidates and is advancing multiple drugs into late-stage clinical trials [3] Financial Forecast - The company is projected to achieve revenues of 14.685 billion RMB, 15.801 billion RMB, and 18.471 billion RMB for 2025, 2026, and 2027 respectively, with corresponding net profits of 5.237 billion RMB, 5.434 billion RMB, and 6.417 billion RMB [5]