男性雄激素性脱发（AGA）治疗在停滞30多年后，迎来了首个真正意义上的机制突破。 12月3日，Cosmo宣布Clascoterone 5%外用溶液用于AGA的两项3期临床取得积极结果：与安慰剂相比目 标区域毛发数量相对改善高达539%，治疗中出现的TRAE与安慰剂一致，消息公布后Cosmo股价上涨 20%。 脱发作为一项世界性难题，市场苦防脱发新药久矣。除了米诺地尔、非那雄胺、JAK抑制剂，获批的药 物并不多。而Cascoterone 5%的突破在于实现了雄激素脱发的"局部精准治疗"，治疗无需全身暴露、仅 在毛囊局部阻断DHT受体也能实现可测量的毛发再生。 值得注意的是，Cascoterone 5%与已上市药物Winlevi活性成分相同，后者为浓度为1%的Cascoterone，是 美国销量最高的外用痤疮治疗药物。 这款从痤疮治疗药物跨界而来的 "新选手"，通过改造药物递送方式及优化浓度的"非结构创新"，为千 亿脱发市场的创新浪潮按下了加速键。 01 重新定义AGA治疗？ Cosmo的脱发药数据引爆其股价，再一次佐证了市场对脱发药物需求旺盛。 这并不令人感到意外。毕竟脱发是一项世界难题，最新报告显示，男性雄激 ...

Core Insights - The article emphasizes the importance of prostate health across different age groups, highlighting common misconceptions and the need for awareness and regular check-ups [1][5][9] Group 1: Prostate Health in Young Men (20+) - Prostatitis is often misunderstood as a sexually transmitted disease, but it is primarily linked to poor lifestyle habits [2] - Prolonged sitting, consumption of spicy food and alcohol, high stress levels, and infrequent urination can lead to prostatitis [3] - Symptoms of prostatitis include not only urinary issues but also pelvic pain and emotional disturbances, necessitating medical consultation for proper diagnosis and treatment [4] Group 2: Prostate Cancer Awareness (40+) - Prostate cancer is referred to as a "silent killer" due to its asymptomatic early stages, making PSA testing crucial for early detection [6] - Men with a family history of prostate cancer should start annual PSA tests and digital rectal exams at age 45, while average-risk men should begin at age 50 [7][8] Group 3: Prostate Enlargement in Older Men (70+) - Prostate enlargement is a natural part of aging, driven by hormonal changes, leading to urinary difficulties [9] - Management strategies for mild to moderate symptoms include lifestyle adjustments and medications, while severe cases may require minimally invasive surgical procedures [10]

Core Viewpoint - The article discusses the importance of prostate health across different age groups, emphasizing the need for awareness, early detection, and appropriate treatment methods for prostate-related issues in men. Group 1: Prostate Health in Young Men (20+) - Prostatitis is often misunderstood as a result of poor lifestyle choices rather than a sexually transmitted disease, with bad habits being the primary cause [2] - Prolonged sitting can compress the prostate, leading to poor blood circulation and inflammation; it is recommended to take breaks every hour [3] - Consumption of spicy foods and alcohol can cause blood vessel dilation in the pelvic area, exacerbating discomfort [4] - Stress and anxiety can lead to muscle spasms affecting the prostate, resulting in frequent urination despite low fluid intake [5] - Insufficient water intake and holding urine can lead to concentrated urine irritating the prostate; symptoms may include pain in the perineum and lower back [6] Group 2: Prostate Health in Middle-Aged Men (40+) - Prostate cancer is often referred to as a "silent killer" due to its asymptomatic early stages; regular PSA testing is crucial for early detection [7][9] - PSA tests and B-scan ultrasounds serve different purposes; PSA levels indicate internal prostate health, while B-scan assesses external changes [8] - Men with a family history of prostate cancer should start annual PSA testing and digital rectal exams at age 45, while others should begin at 50 [9] Group 3: Prostate Health in Older Men (70+) - Benign prostatic hyperplasia (BPH) is a common condition in older men, resulting from hormonal changes that cause prostate enlargement [10] - Mild symptoms can often be managed through lifestyle adjustments, such as reducing fluid intake before bed and avoiding diuretics [11] - Moderate symptoms may require medication like alpha-blockers to relax prostate muscles, while severe cases may necessitate minimally invasive surgical procedures [12]

Core Viewpoint - The "Chronic Disease Prevention and Treatment in China" academic conference held on May 18 highlighted the significant advancements in the treatment of prostate diseases, particularly through the innovative use of Xia Li Qi capsules, which have shown promising results in alleviating lower urinary tract symptoms (LUTS) associated with prostate conditions [1][3][4] Group 1: Prostate Disease Prevalence and Impact - Prostate diseases, such as benign prostatic hyperplasia (BPH), have a high incidence rate that severely affects male health, with approximately 20% of men aged 51-60, 50% of those aged 61-70, and 83% of men aged 81-90 being affected [3] - LUTS are common among BPH patients, with 90% of men aged 45-80 experiencing these symptoms, which include urinary frequency, urgency, incontinence, and nocturia [3] Group 2: Treatment Approaches and Innovations - For patients without surgical indications, the primary treatment for LUTS is medication; however, current conventional Western medications have limitations in safety and efficacy, necessitating better treatment options [3] - Xia Li Qi capsules, guided by the theory of "Luo Disease," combine "promoting, supplementing, and transforming" principles, offering advantages over traditional heat-clearing and dampness-dispelling methods [3][4] Group 3: Clinical Research and Efficacy - Research indicates that Xia Li Qi capsules significantly improve LUTS, delay disease progression, and enhance patients' quality of life, demonstrating good safety profiles [4] - Clinical studies confirm that Xia Li Qi capsules can reduce the International Prostate Symptom Score (IPSS) and improve urinary flow rates, with additional benefits when combined with medications like Tamsulosin and Finasteride [4] - Xia Li Qi capsules are classified as a Category B drug under medical insurance and are recommended in various clinical guidelines, providing new treatment options for prostate disease patients [4]