Group 1: Macro Strategy and Policy Analysis - The "Beautiful America Act" emphasizes tax cuts for residents and businesses while neglecting social welfare and healthcare sectors [3][21] - The rising U.S. fiscal deficit is attributed to the shift from "balanced finance" to "functional finance," driven by slowing economic output and increasing government spending [3][21] - Support for the new act is divided among social groups, with small business owners and manufacturers in favor, while healthcare and clean energy sectors express dissatisfaction [3][22] - The market's reaction to the fiscal deficit has become "dull," indicating that the narrative around the impact of the deficit on broad national credit has lessened [3][24] Group 2: Industry Insights and Company Analysis - Zhejiang Shibao is a leading player in the automotive steering system industry, focusing on electric power steering systems and line control steering technology [9][32] - The company has seen a recovery in gross margin and net profit due to increased production capacity and the introduction of high-margin products [9][34] - Forecasts for Zhejiang Shibao's revenue from 2025 to 2027 are projected at 35.1 billion, 43.7 billion, and 52.0 billion CNY, with net profits expected to grow significantly [9][36] - Zhonggu Logistics is experiencing high demand in the container shipping market, with domestic shipping rates expected to rise due to capacity shortages [16][39] - The company is projected to maintain high dividend payouts, with a forecasted dividend ratio of 90% in 2025, resulting in a dividend yield of around 10% [16][40] Group 3: Pharmaceutical Developments - BeiGene's CDK4 inhibitor BGB-43395 is on track to become the second CDK4 inhibitor to enter the registration clinical phase, showing promising early efficacy signals [11][41] - The drug demonstrates higher selectivity compared to existing CDK4/6 inhibitors and has shown strong pharmacokinetic data [11][42] - Revenue forecasts for BeiGene from 2025 to 2027 are estimated at 375.17 billion, 450.24 billion, and 540.34 billion CNY, with significant growth in net profit anticipated [11][43]

公司报告 | 公司专题研究 百济神州（688235） 证券研究报告 CDK4 抑制剂展现出优异早期疗效信号，后续将进入 注册临床研究阶段 CDK4 抑制剂 BGB-43395 具有更优抑制效力。目前 CDK4i 领域 FIC 的药物是 进入 III 期临床的辉瑞的 PF-07220060，在 MCF-7 增殖实验中，BGB-43395 的抑制细胞增殖效力IC₅₀为126 nM，比PF-07220060 更强（后者为544 nM）， 活性提升 4.3 倍，展现出卓越疗效。 后续随访时间延长，整体响应率有望大幅提升 从辉瑞披露的数据可以看到，CDK4 抑制剂 Atirmociclib 的中位起效时间是 3.6M。所以对同靶点药物，百济神州的 CDK4i 来说，3 个月的中位随访时 间还未到中位起效时间。过往数据提示 CDK4/6i 的应答率随时间延长逐 步提升，在 9 个月时达到最高应答概率。BGB-43395 在 3 个月的评估时间 看到 240mg、400mg、600mg BID 联用组 SD+PR 为 67%(8/12)，83%（5/6）， 75%（6/8），趋势较好。 盈利预测与投资评级 我们预计 202 ...

百济神州 20250608 摘要 百济神州目前市场关注的核心点包括：第一，公司指引今年（2025 年）在 GAAP 口径下实现经营利润转正，市场关心其盈利是否可持续及未来 3-5 年的 释放节奏。预期公司净利润率可达 10%以上。第二，泽布替尼作为公司核心销 售产品，其后续销售方案及分值变化备受关注。从获批上市以来，其预期从 20 亿美金逐步提升至 30 亿美金，再到 2023 年 1 月全线适应症获批后的 26 亿美 金。今年预计整体销售将达到 37 亿美金，同比增长 50%。第三，从竞争格局 看，Pirtobrutinib 对泽布替尼影响有限，新患者占比已超过 50%，预期未来 分值可达 75 亿美金。 泽布替尼未来发展前景如何？ 泽布替尼作为百济神州核心产品，其销售爬坡非常明确，今年（2025 年）预 计达到 37 亿美金，并保持 50%的增长率。从竞争格局看，新患占比已超过 50%，且随着 BTK 抑制剂大适应症 CLL/SLL 一线试用证在今年 Q1 入组完毕 并提交上市申请，我们相信其未来 3-5 年的销售放量前景良好。此外，公司还 计划启动两项三期临床试验，包括与礼来的非共价 BTK 抑制剂 P ...