Group 1 - The article discusses the recruitment of 7 postdoctoral researchers for projects related to "Basic and Interdisciplinary Breakthroughs (Synthetic Multi-cell Genomes)" and "National Major Instrument Development Projects (High-Precision Synthesis Systems for Long Fragments of DNA)" [3] - Candidates with backgrounds in epigenomics, strain construction, and enzyme catalysis are particularly encouraged to apply, especially those who have recently completed or are about to complete their PhD [3] - The age limit for applicants is generally set at 35 years, and candidates should possess strong academic qualifications and research capabilities [3] Group 2 - The hiring package includes competitive salary and performance rewards, support for applying to national postdoctoral programs, and benefits such as children's education and social insurance [4] - The institution offers assistance in applying for various research projects, including the National Natural Science Foundation and postdoctoral programs [4] - A good research platform and opportunities for international collaboration and exchange are provided [4] Group 3 - Application materials must be combined into a single PDF and sent to the specified email address, with a clear subject line indicating the position and applicant's name [5] - Required documents include a personal resume, a personal statement outlining research interests and development plans, and contact information for three referees along with recommendation letters [5] - The recruitment is ongoing until positions are filled, and self-recommendations are welcomed [5]

【SynBioCon】 获 悉，近日， 华东理工大学 生物工程学院 生物催化与合成生物团队郁惠蕾课题组 在 Nature Communications 上 发表题为 "Designing an oxidase toolbox for site-directed oxidation of taxanes" 的研 究论文（doi.org/10.1038/s41467-025-67544-4）。该研究 成功开发出一种 紫杉烷非天然氧化酶工具箱，能够实现紫杉烷骨架 C-4、C-6、C-10、C-11、C-12 和 C-13 位点的区域和立体选择性氧化 。该 工具箱不仅实现了11个紫杉烷新结构的高效合成，更为人工重构紫杉醇及其类似物的高效合成路线奠定了坚实基础。 关键 词 | SynBio团队 | 郁惠蕾 教授|紫杉醇合成 华东理工许建和/郁惠蕾团队：ω-氨基脂肪酸和α,ω-二胺的高效可持续生产 首次在蓝藻中实现紫杉醇前体生物合成 世界难题突破！Science: 破解紫杉醇生物合成关键缺失酶 ▌ 参考信息 ： 本 文部分 素 材 来 自华恒生物 。由 作 者 重新 编写，系作者个人观点，本平台发布仅为了传达一种不同观点 ...

Core Viewpoint - The article discusses the upcoming 2026 Bio-based Conference and Exhibition in Shanghai, focusing on the collaboration between Huaheng Biological and academic institutions to advance amino acid applications in animal nutrition, emphasizing the importance of non-essential amino acids in sustainable livestock production [2][4][8]. Group 1: Event Overview - The 2026 Bio-based Conference will take place from May 20-22 in Shanghai, featuring 11 thematic forums, 7 concurrent activities, over 1000 new product displays, and an industry award ceremony [2][11]. - The conference aims to create an efficient platform for upstream and downstream industry connections, promoting low-carbon and green transformation in the sector [2]. Group 2: Collaboration and Research - Huaheng Biological has signed a strategic cooperation agreement with academician Yin Yulong and his team to focus on innovative research and industrial application of amino acids in animal nutrition [4][5]. - The collaboration aims to convert research outcomes into efficient and environmentally friendly feed additives, enhancing animal health and production performance [4]. Group 3: Importance of Non-Essential Amino Acids - Non-essential amino acids (NEAAs) play a crucial role in enhancing gut immunity, maintaining gut health, and improving animal growth performance while reducing antibiotic use and heavy metal emissions [4][6]. - The demand for NEAAs increases significantly during immune stress conditions, with specific amino acids like glutamine and arginine showing a 2-3 times higher requirement during peak immune responses [6][7]. Group 4: Advances in Amino Acid Production - Synthetic biology is revolutionizing the production of amino acids, with Huaheng Biological collaborating with academician Zheng Yuguo's team to establish a 3000-ton/year bio-based L-methionine production line [8][10]. - The team has developed key technologies for the efficient synthesis of L-methionine precursors, achieving the highest domestic and international production rates [10].

Core Viewpoint - The 11th Bio-based Industry Conference & Exhibition (Bio-based 2026) will take place from May 20-22, 2026, in Shanghai, China, focusing on the latest advancements in the bio-based sector and fostering connections between supply and demand sides of the industry [2][20]. Group 1: Event Overview - The event will feature 11 thematic forums, 7 concurrent activities, 1000 new product displays, and an innovation award ceremony, creating a platform for showcasing bio-based technology innovations and applications [3][11]. - Over 50 sponsors have already confirmed their participation, including leading companies in the bio-based materials and chemicals sector [2][3]. Group 2: Focus Areas - The exhibition will emphasize bio-based innovative materials and products in packaging, footwear, 3D printing, and structural components, as well as bio-based monomers and non-food biomass raw materials [5][8]. - The event aims to connect upstream and downstream industries and international resources, promoting new opportunities for industry collaboration [5]. Group 3: Thematic Forums and Activities - The 11 thematic forums will cover key topics such as critical chemicals and materials, international cooperation, and applications in various sectors including packaging, textiles, automotive, and 3D printing [20][22]. - Seven concurrent activities will include brand demand matching sessions, standard review meetings, and new product technology release events [21][22]. Group 4: Innovation and Awards - The 4th DT New Leaf Award will be held concurrently, recognizing innovations in materials, applications, and industry solutions [21][22]. - The event aims to explore the cost-effectiveness and feasibility of bio-based products, enhancing product innovation through strategic discussions with leading brands [8].

Core Viewpoint - The article highlights the participation of Jiangsu Huacheng Biotechnology Co., Ltd. in the 2026 DT New Leaf Award, focusing on its innovative bio-based blue pigment and green dyeing solutions aimed at promoting sustainable practices in the textile industry [2][13]. Group 1: Company Overview - Jiangsu Huacheng Biotechnology Co., Ltd. was established in 2024, focusing on synthetic biology research and product commercialization, particularly in bio-based materials and biochemicals for pharmaceuticals, cosmetics, food, and health products [3]. - The company aims to drive industrial upgrades through technological innovation, emphasizing large-scale bio-manufacturing of food colorants, chemical dyes, and functional food ingredients [3]. Group 2: Bio-based Blue Pigment - The bio-based blue pigment is produced using synthetic biology techniques, utilizing engineered microorganisms as "cell factories" for efficient fermentation [4]. - Compared to chemical dyes, bio-based dyes are natural, non-toxic, and exhibit excellent antibacterial and anti-yellowing properties, with lower damage to high-end fabrics like silk and wool [4][10]. - The production process avoids traditional petroleum-based methods, reducing harmful substance generation and wastewater treatment costs, while achieving USDA bio-based product certification [8][10]. Group 3: Green Dyeing Solutions - Traditional chemical dyes pose significant health and environmental risks, leading to complex pollution issues in the textile industry [9]. - Huacheng's approach involves replacing chemical dyes with bio-based alternatives, providing scalable clean dyeing solutions that align with national environmental goals [9]. - The innovative process utilizes renewable carbon sources and mild fermentation conditions, significantly lowering wastewater chemical oxygen demand and overall energy consumption [9]. Group 4: Awards and Recognition - The DT New Leaf Award features four categories: Innovation Material Award, Innovation Application Award, Most Commercially Valuable Award, and Innovative Industry Solution Award, with the first round of applications closing on February 10, 2026 [5][13]. - Huacheng's participation in the award reflects its commitment to sustainable practices and innovation in the bio-based industry [2][13].

Core Viewpoint - The article discusses the successful development of a high-throughput screening system based on Surface-Enhanced Raman Spectroscopy (SERS) by Professor Wang Dan's team at Chongqing University, which allows for real-time, label-free analysis of bacterial metabolites within microdroplets, providing an efficient and sustainable technology for green biomanufacturing [2][4]. Group 1: High-Throughput Screening Platform - The RH-RMSS platform utilizes SERS technology to directly detect metabolite concentrations without the need for cell staining or labeling, processing 180 microdroplets per second, significantly faster than traditional methods [4]. - The platform successfully screened high-yield strains for various organic acids, achieving yields of 1.61 times, 1.52 times, and 1.81 times that of the original strains for succinic acid (SA), D-lactic acid (D-PLA), and acrylic acid (AA), respectively [4]. - The system reveals key enzyme mutation mechanisms and implements multi-level metabolic optimization, achieving a maximum succinic acid yield of 138.92 g/L using optimized strains [4]. Group 2: System Validation and Performance - The RH-RMSS system demonstrated high accuracy (>98%) and efficiency in screening, effectively enriching high-yield strains from a large pool of mutants [10]. - The system's ability to accurately quantify organic acids within individual microdroplets was validated, establishing its reliability as a high-throughput screening tool [8]. - The research successfully transitioned from microdroplet screening to large-scale fermentation verification, showcasing the engineered strains' capability to utilize non-food biomass as a carbon source for succinic acid production [15]. Group 3: Mechanistic Insights and Optimization Strategies - The D210G mutation was shown to enhance the catalytic efficiency of the phosphoenolpyruvate carboxylase (PEPC) enzyme, which is crucial for achieving high succinic acid yields [11]. - The study highlights the synergistic effects of neutralizing agent optimization, RBS sequence optimization, and adaptive evolution on improving succinic acid production [14]. - The RH-RMSS platform is presented as a versatile tool adaptable for screening high-yield strains for various organic acids and other metabolites with characteristic Raman signals [18].

Core Viewpoint - The "2026 DT New Leaf Award" is a global and comprehensive award focused on innovation in the bio-based sector, aimed at discovering, showcasing, and recognizing outstanding products and companies in the bio-based industry [2]. Group 1: Award Overview - The award symbolizes vitality and sustainable innovation, with the goal of uncovering pioneering forces in the bio-based industry that utilize renewable biomass and green technologies to drive low-carbon development [2]. - Over 30 representative companies from the bio-based industry are participating in the "2026 DT New Leaf Award" evaluation, with the first batch of participating companies announced [2]. Group 2: Participating Companies and Products - Wanhua Chemical Group Co., Ltd. is recognized as a leading global chemical new materials enterprise, participating with its low-carbon PCDL product, which is a versatile polyol used for high-end polyurethane materials [3]. - Leaf Bio, a global leader in bio-based aromatic materials, focuses on the development and production of furan-based materials, with core products FDCA and PEF being recognized as potential bio-based platform compounds [4]. - Henan Qiye Technology Development Co., Ltd. is the world's first company to produce non-food cellulose crystalline glucose in bulk, showcasing its innovative production techniques [5]. - Suzhou Polywin Biotechnology Co., Ltd. specializes in straw-based bio-manufacturing, presenting products such as bio-based 1,4-butanediamine and fully bio-based packaging materials [8]. - Ningbo Huafu New Materials Technology Co., Ltd. has developed a novel air oxidation route for producing FDCA, significantly reducing production costs and enhancing competitiveness [11][12]. - Henan Haosen Biological Materials Co., Ltd. has pioneered a continuous production process for bio-based 1,5-pentanediol using non-food biomass, achieving large-scale and efficient green production [15]. Group 3: Award Categories and Timeline - The award features four main categories: Innovation Material Award, Innovation Application Award, Most Commercially Valuable Award, and Innovative Industry Solution Award, likened to the "Oscars" of the bio-based industry [19]. - The first round of applications is open until February 10, 2026, with subsequent voting and evaluation phases scheduled for March 2026, culminating in an award ceremony on May 21, 2026 [27].

对于生物制造行业发展而言，在国家新质生产力东风之下，提升关键技术壁垒，跨越原料成本鸿沟，拓展核心价值或差异化替代产品，或许会是重点发展 趋势。 从产业案例来看，值得关注的是 微元合成 。 微元合成的融资速度足够证明了其丰富的核心技术储备和投资价值。更值得关注的是，在全面率先布局阿洛酮糖的同时，公司步履不止于此，跨越"非 粮"鸿沟，加速甲醇生物制造大宗生物基产品。（ 3亿元融资！微元合成加速推进甲醇生物制造大宗生物基产品 ） 另一方 面值得关注的信号是， 金威达 的及时止损， 变更阿洛酮糖和肌醇募投项目，转战核心赛道的油脂和营养保健品。 基本信息： 关键词 | 未来食品&农业 |金威达 短短几 年，随着我国全面应用许可，「六边形代糖顶流」的阿洛酮糖产品在生物制 造产业逐渐在"失宠"。 近期，金达威公司发布关于变更部分 募集资金投资项目的公告，表示将"年产30,0 00 吨阿洛酮糖、年产5,000吨肌醇建设项目"变更为" 内蒙古金达威药 业有限公司万吨油脂项目"、"营养保健品智慧工厂建设项目" 。 变更后，本次向不特定对象发行可转换公司债券的募投项目及募集资金使用计划如下： | 序号 | 项目 | 计划投资总额 ...

Bio-based 2026！ 生物基行业标杆盛会 合肥利夫生物科 技有限公司 （ PEF & FDCA 全球领军企业 ） 山东京博中聚新材料有限公司 （ 生物基衣康酸酯橡胶创新企业 ） —— # 第11届生物基大会暨展览 将于5月20-22日在中国·上海举行！ 展会将展示生物基"供给侧"的最新成果 更将释放出应用端"需求侧"的声音 活动官宣半月已确认50+赞助商 ... " 澎湃新生机， 50 +赞助商已加盟 Bio-based 2026 第11届生物基展览 ，以行业趋势和 客户需 求出发 ，以 "跨越新周期，澎湃新生机"为主题，更 以" 11 场主题论坛 + 7大同期活动 + 1000 个新品展 示 + 1 场创新评选颁奖 "为核心载体，打造生物基技术革新与应用展示交流平台。截 止目前， 已加盟赞助商 包括： 赢创特种化学（上海）有限公司 (全球领先特种化学品公司) A vantium Chemicals B.V. , NL （全球知名FDCA及生物基聚酯企业 ） 上 海苏尔寿工程机械制造有限公司 （ 全球流体工程领域头部企业 ） 中科国生（杭州）科技有限公司 （ HMF-FDCA-PEF全产业链代表性企 ...

关键 词 | 底层技术&AI |幻 量科技 "more than Yellow and Orange"到"DeepVerse Blue"，共同拓展材料创新的光谱 【SynBioCon】 获悉，近日，幻量科技（上海）有限公司宣布获得 A 股上市公司 七彩化学（ 300758 ） 战略入股。本次合作是产业资本对材料 信息学与 AI4Science 产业化路径的进一步认可，也为双方在化工与新材料领域探索 "AI 驱动研发 " 提供了更稳健的协同基础 。 幻量科技始终坚持 " 把研发变成可复用的工程系统 " ，让 AI 从概念走向研发一线，真正能在工业场景中持续交付，从一次性项目走向平台化能力 01 产业资本入场，释放材料信息学"从概念到交付"的信号 本次战略投资事件中，七彩化学作为 A 股上市公司产业资本参与方，为材料信息学的产业化落地注入了更强的产业协同势能。对我们而言，这不仅 是一次投资事件，更是一个 AI4Science 正在从 " 被讨论 " 走向 " 被采用 " 的时刻 —— 资本市场与产业链开始更关注 " 可交付的研发效率提升 " ，而非停留在概念叙事 。 回顾融资历程，幻量科技自成立以来持续获得多方关 ...