非粮生物质预处理是破解其抗降解屏障的有效途径，是制备糖平台的关键技术，关系生物基材料和能源化学品高效制备。传统浓酸和强碱预处理方法存在化 学品消耗大、能耗高、环境污染严重、设备腐蚀及抑制物生成多等问题。 因此，发展 "清洁、高效"的预处理技术与装备，是实现生物质精炼产业可持续发展的核心技术瓶颈 。 围绕我国在生物质绿色炼制的重大需求， 华南理工大学先进造纸与纸基材料全国重点实验室任俊莉教授团队 研究了不同化学环境中非粮生物质半纤维素或 木质素的溶出动力学以及分子响应行为，发展了半纤维素和木质素高效拆解的关键技术， 开发了适合秸秆和木材关键组分高选择性拆解转化的工艺技术 ， 实现预处理的低能耗、清洁化、高效化的目标。该研究为糖平台、平台化学品、生物能源及其他生物质产业的可持续发展提供可工业化的关键技术。 华南理工大学任俊莉教授 于 202 5 年 1 1 月 27-29 日 在 浙江 ·杭州 举办 " 202 5 （第 五 届）非粮生物质高值化利用论坛 （ NFUCon 2025 ） "，于 【专场一 | 非粮生物基化学品和材料】分享以 《非粮生物质清洁高效预处理技术》 为题的报告。欢迎行业参与交流合作！ 点击 ...

非粮N生F物U基Co科n技2成02果5发布 第五届非粮生物质高值化利用论坛 11月27-29日 浙江 · 杭州 DT新材料致力于科技成果转移转化。大会 聚焦非粮生物基领域创新科研成果和商业化可行性 ，至今已 完成1500+次技术和项目对接。 本届大会 将 持续同期举办 特色活动「科技成果展示与对接」 ， 论坛 公开征集与筛选 50 个生物质利用领域具备商业化基础的创新成果和项目 ，并于现场展示和精准对 接，以促进行业产学研用对接交流。 本文公布创新成果如下： 成果名称 新型防晒剂：浅色油茶果壳木质素 所在单位 华南理工大学轻工科学与工程学院 成果简介 木质素因绿色安全、优越的抗紫外性能，且与化学防晒剂之间具有良好的协同作用，向化学防晒霜中 添加木质素可显著提高其防晒指数（SPF），可替代防晒霜中相当含量的化学防晒剂，近年来被广泛 认为是一种具有潜力的、安全的新型天然防晒剂。然而，大多数木质素都为深色，面临在防晒霜中应 用受限的困境。 成果1 ：我们从油茶果壳中高效分离出浅色的纳米木质素，最佳白度可达70.90。进一步地分别向 SPF20和SPF30的化学防晒霜中添加1%的浅色油茶果壳木质素，可使防晒霜的性能分 ...

/生物制造产业社群/ 让上下游聚在一起, 未来食农、绿色化工、大健康、美妆个护 等产业同行❤️↓ 全球政策进展 | 湖北省 【SynBioCon】 获 悉，近日，全国中小企业股转系统最新公告显示，东晓生物科技股份有限公司 拟挂牌新三板上市。 东晓生物 以合成生物制造和发酵技术为核心，以 多元化玉米精深加工 为主业，主要生产动物营养 类产品、固体饮料类产品、食品添加剂、有机酸、健康甜味剂等系列产品。 年玉米深加工能力达160万吨，具体产品包括 L-赖氨酸盐酸盐、L-赖氨酸硫酸盐、植脂末、赤藓糖 醇、麦芽糊精、麦芽糖浆、山梨糖醇、食用葡萄糖 等。 我国正从农业大国向科技大国转型，东晓作为玉米深加工领域的领军企业，将传统农业原料通过生物 制造技术转化为高附加值产品。在推动农业产业链向科技化、高端化升级中，进行了新的科技创新。 在原料端， 东晓生物 在全国范围内收储玉米，解决了中国8亿农民的常规种植作物——玉米的销售 问题；生产端，公司依托可再生原料'玉米'，使用风能、光伏等绿色能源，运用合成生物和发酵技 术，实现了产品向食品、药品、保健品、婴幼品、日化品等产品的绿色可持续转化；销售端，公司的 产品在生物制造技术的赋 ...

Core Insights - The article discusses the first batch of bio-manufacturing landmark products announced by Hubei Province's Economic and Information Technology Department on October 9, highlighting significant advancements in the bio-manufacturing sector [2]. Group 1: Landmark Products - The first batch of landmark bio-manufacturing products includes: - Dongyang Sunshine: Thiocyanate Erythromycin - Tianji Bioenergy: Ultra-clean biodiesel - Bafeng Pharmaceutical: Amino acid raw materials - Xinhua Yang: Feed enzyme preparations - Guangji Pharmaceutical: High-quality riboflavin - China National Pharmaceutical Group: Inactivated vaccine for Porcine Circovirus Type 2 - Aibotai Bio: Research antibodies - Huisheng Biotechnology: Tylosin tartrate - Hite Bio-pharmaceutical: Injectable Epinephrine - Fuxing Biotechnology: Arachidonic acid (ARA) powder [2][3]. Group 2: Product Categories - The products are categorized into different types: - Scale Replacement Type: Thiocyanate Erythromycin, Ultra-clean biodiesel, Research antibodies, Tylosin tartrate - Key Improvement Type: Amino acid raw materials, Feed enzyme preparations, High-quality riboflavin, Arachidonic acid powder - Major Innovation Type: Inactivated vaccine for Porcine Circovirus Type 2, Injectable Epinephrine [3].

Core Viewpoint - The article discusses the advancements in non-grain biomass utilization, highlighting innovative research outcomes and their commercial viability in the bio-based sector, particularly focusing on the development of bio-based dicarboxylic acids [2][3]. Summary by Sections Event Overview - The fifth Non-Grain Biomass High-Value Utilization Forum will be held from November 27-29 in Hangzhou, Zhejiang, focusing on innovative research results and commercial feasibility in the non-grain bio-based field, with over 1500 technology and project connections completed to date [2]. Innovation Achievements - The article presents the innovative development of bio-based medium-chain dicarboxylic acids (C5-C8), which include glutaric acid, adipic acid, heptanedioic acid, and octanedioic acid, with a global market size exceeding 20 billion and continuing to expand [5]. Technical Advantages - The project utilizes biomass-derived platform compounds (such as glycerol, furfural, and 5-hydroxymethylfurfural) to create a renewable supply chain for producing bio-based dicarboxylic acids, significantly reducing reliance on petroleum and lowering carbon emissions compared to petrochemical routes [7][8]. Production Process - The innovative one-step dicarbonylation synthesis technology achieves product selectivity of ≥85% and catalyst recovery rate of ≥99.99%, shortening production cycles and reducing overall costs, addressing high energy consumption and cost challenges [7][8]. Market Compliance - Bio-based products are certified for carbon footprint, overcoming international green barriers and filling the gap in high-end applications for domestic bio-based C5-C8 dicarboxylic acids, creating a competitive advantage through "cost reduction - green compliance - market adaptation" [8]. Intellectual Property and Collaboration - The project has published five domestic patents and is open to collaborative development, result transformation, or intellectual property transfer [9].

Core Viewpoint - The research team at the Tianjin Institute of Industrial Biotechnology has made significant advancements in the bioconversion of lignin into microbial oils and proteins, addressing the challenges of lignin degradation and high-value utilization [5][7]. Summary by Sections Research Breakthroughs - The team successfully developed a genetically engineered strain, Curvularia clavata M6, which efficiently degrades lignin and simultaneously synthesizes oils and proteins. This was achieved by combining genome editing technology with high-throughput screening methods [5][6]. - The engineered strain M6 exhibited a 75% increase in laccase activity, reaching 228.58 U/L, and achieved an oil accumulation of 49% of the cell dry weight while maintaining a stable protein content of 33% [6]. Industrial Application Potential - In a 5-liter fermentation scale-up, the laccase activity further increased to 240.43 U/L, with oil content rising to 51%, indicating strong stability and potential for industrial applications [6][7]. - The research highlights the effective conversion of lignin into valuable microbial oils and proteins, providing a feasible pathway for high-value utilization of lignin resources [7][9]. Future Directions - The research is supported by national strategic technology initiatives, and the team has filed for two patents related to their findings. They will present their latest research at the upcoming NFUCon 2025 forum, focusing on biomass utilization strategies [8][9].

Core Insights - The article discusses the development of an AI-driven digital cloning selection platform (Digital Colony Picker, DCP) for high-throughput single-cell screening, which addresses the challenges in microbial strain selection and industrial application [2][4]. Group 1: Technology Development - The DCP system utilizes three major technological innovations: micro-chamber separation culture, AI-assisted image recognition, and non-contact laser single-clone picking, enabling precise high-throughput screening of microbial multi-dimensional phenotypes [4][5]. - The DCP platform can independently culture individual microbial cells using a microfluidic chip with thousands of micro-chambers, allowing real-time monitoring of cell growth dynamics, metabolic activity, and morphological characteristics [5][6]. Group 2: Application and Results - In application validation, researchers successfully isolated a "super strain" of Zymomonas mobilis, which showed a 19.6% increase in lactic acid production and a 75.9% improvement in growth rate under 30 g/L lactic acid stress conditions [5]. - The superior phenotype of the isolated strain is linked to mutations and overexpression of the outer membrane transporter gene ZMOp39x027, enhancing lactic acid transmembrane transport capacity [5]. Group 3: Future Prospects - The DCP platform is expected to significantly accelerate the discovery of superior strains, providing strong technical support for metabolic engineering, environmental microbial resource exploration, and industrial strain optimization [5]. - The DCP platform works synergistically with the FlowRACS system, which excels in instantaneous snapshot/sorting capabilities, creating a comprehensive solution for functional strain discovery [6].

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Event Overview - The NFUCon 2025 will be held from November 27 to 29, 2025, in Hangzhou, Zhejiang, under the theme "Top-notch Intelligence, Industrial Symbiosis" [2]. - The forum will invite representatives from government, enterprises, and experts to discuss key strategic directions such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy [2]. Group 2: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and the National Key Laboratory of Biomass Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 3: Guest Speakers - Notable speakers include Zhu Jin, who has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other biomass materials [4]. - Li Zhenglong focuses on the conversion and utilization of low-carbon resources, particularly in renewable aviation fuel and biomass high-value utilization [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 4: Forum Agenda - The forum will feature various activities, including a youth forum on non-grain biomass, a sustainable aviation fuel industry exchange, and thematic discussions on biomass chemicals and energy [15][16]. - A technology achievement display area will be set up to showcase 50 innovative results and projects with commercial potential in biomass utilization [17]. Group 5: Laboratory Focus - The National Key Laboratory of Biomass Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel technology, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

Core Viewpoint - The article discusses the recent policy developments in the petrochemical industry in China, emphasizing the shift towards high-end and green transformation, particularly focusing on non-grain biomass utilization and bio-based materials as new growth areas [2][5][6]. Group 1: Policy Developments - On September 25, 2023, seven Chinese government departments released a work plan aimed at stabilizing and optimizing the petrochemical industry from 2025 to 2026, addressing challenges such as intensified competition in organic raw materials and slowing domestic demand [2]. - The work plan encourages the development of emerging fields like bio-based chemicals and non-grain biomass utilization, providing new momentum for the industry's green transformation [2][4]. Group 2: Focus on Bio-based Materials - The policy has shifted from "technology transformation" to "supply and demand quality improvement," indicating a maturation of industry technology and a focus on enhancing the quality of bio-based materials [5][6]. - The emphasis on non-grain bio-based materials has evolved from "industrial demonstration" to "typical case collection and promotion," suggesting that some bio-based materials can achieve a replicable business model [6]. Group 3: Growth in Bio-chemicals - The new work plan introduces a focus on "bio-chemicals," highlighting the rapid growth of synthetic biology in the chemical sector due to its green and efficient characteristics [7]. - Multiple government departments have issued documents supporting the development of bio-based and bio-manufacturing sectors throughout 2023, indicating a strong governmental push towards these industries [8][10].

Core Insights - The article discusses the establishment of a Synthetic Biology Innovation and Entrepreneurship Center in Jiang'an District, Hubei Province, in collaboration with Hubei University, aimed at fostering the synthetic biology industry and linking local industrial needs with academic research resources [2][4]. Group 1: Establishment of the Center - Jiang'an District signed an agreement with Hubei University to co-establish a Synthetic Biology Innovation and Entrepreneurship Center, which will serve as a crucial link between local industry demands and university research capabilities [2][4]. - The center will accelerate the gathering of synthetic biology industries in Jiang'an, leveraging Hubei University's strengths in this field [4]. Group 2: High-Tech Enterprises Involvement - Several high-tech companies, including Wuhan Xingquan Gene and Health Technology Co., Ltd. and Wuhan Ruidu Biotechnology Co., Ltd., have moved into the collaborative innovation building, showcasing the effectiveness of the university-industry cooperation platform [5]. - Xingquan Gene focuses on early cancer screening technologies based on canine olfactory capabilities, while Ruidu Biotechnology specializes in unique DNA synthesis and assembly technologies derived from academic research [5]. Group 3: Supportive Infrastructure - The collaborative building offers a "zero-cost entrepreneurship space," providing two years of rent-free and three years of reduced rent for university entrepreneurs, promoting the growth of the synthetic biology innovation center and related industries [5]. - The initiative aims to create a comprehensive support system that includes industry funds, intellectual property, and professional services to enhance innovation and entrepreneurship [5]. Group 4: Future Plans and Policies - Jiang'an District plans to launch the "Bian Plan" in 2024, introducing nine key policies to support technological innovation in various sectors, including environmental protection and artificial intelligence [6]. - The district has also implemented a plan to promote zero-cost entrepreneurship, fostering a conducive ecosystem for innovation and job creation [6].