Core Viewpoint - The article discusses South Korea's initiative to promote Sustainable Aviation Fuel (SAF) through a mandatory blending system, aiming for carbon neutrality in aviation and the establishment of a SAF alliance [3][4]. Group 1: SAF Blending Mandate - South Korea plans to implement a mandatory SAF blending ratio starting from 2027 at 1%, increasing to 3-5% by 2030, and 7-10% by 2035, with specific targets to be confirmed in 2026 and 2029 respectively [4]. - The government will support the development and investment in bio-based SAF through tax incentives, with facility investment support up to 25% and R&D support up to 40% [4]. Group 2: Global SAF Initiatives - Various countries have set their own SAF targets, including Japan aiming for a 10% replacement rate by 2030, Singapore targeting a 3-5% blending ratio by 2030, the UK planning to increase from 2% in 2025 to 22% by 2040, and the EU requiring a 2% blending ratio this year with a goal of 70% by 2050 [5]. Group 3: SAF Production Pathways - The article highlights the potential of non-grain alcohol-based SAF production pathways, particularly the Alcohol-to-Jet (AtJ) process, which is currently in the commercial pilot stage [6]. - Research focuses on efficiently constructing long carbon chain products from non-grain biomass, with significant advancements made by a team at Zhejiang University in developing a one-step ethanol to C3+ olefins technology, which reduces operational complexity and costs while achieving high yields [7].

Core Insights - The article discusses significant advancements made by Professor Deng Yu's research team at Jiangnan University in the design and strength regulation of Escherichia coli core promoters, published in Nucleic Acids Research [1][5] - The research addresses the challenges in accurately predicting and rationally designing bacterial core promoters, which are crucial for transcription initiation [1][2] Research Progress - The team developed a comprehensive platform that integrates rational library construction, predictive modeling, and generative design to achieve programmable regulation of E. coli core promoters [2][3] - They introduced the Mutation-Barcoding-Reverse Sequencing (MBRS) strategy, creating a high-quality dataset of 112,955 promoters, covering a 16,226-fold expression range [2][3] Model Performance - A Transformer model trained on this dataset achieved high prediction accuracy with a correlation coefficient of R = 0.87, revealing attention patterns consistent with classical motifs and contextual dependencies [3] - The platform can generate novel promoters with precise target strengths, achieving a correlation coefficient of R = 0.95, and demonstrated good generalization across different genetic backgrounds (R = 0.93) [3] Application and Impact - The designed promoters exhibited stable modular "plug-and-play" regulatory effects in both constitutive and inducible systems, contributing to the optimization of microbial cell factories [3][6] - The research has been supported by various funding sources, including the National Key Research and Development Program and the National Natural Science Foundation [5]

Core Viewpoint - The bio-manufacturing industry is entering a new phase of accelerated development characterized by clear policies, specific support, and close integration with the real economy [7]. Policy Developments - The National Development and Reform Commission (NDRC) has emphasized the importance of bio-manufacturing as a key part of light industry upgrades, particularly in sectors such as plastic products, textiles, food and beverages, household chemicals, cosmetics, leather, and paper industries [6]. - The recent announcement from the Ministry of Industry and Information Technology highlights support for bio-based, biodegradable materials, and bio-manufacturing industries as part of the "Light Industry Growth Stabilization Work Plan (2025-2026)" [6]. Industry Transformation - Bio-technology is driving a systematic transformation of the light industry from a "resource-consuming" and "cost-competitive" model to a new paradigm focused on green, intelligent, and high-end development through raw material revolution, process innovation, functional upgrades, and supply chain security [6]. Economic Integration - The government is guiding localities to develop new growth engines such as artificial intelligence and bio-manufacturing, focusing on the integration of these technologies into traditional industries to enhance productivity and innovation [4].

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths, technological challenges, and opportunities in the biomass industry [2]. Group 1: Forum Overview - The NFUCon 2025 forum will be held from November 27-29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as biomass green pretreatment, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][4]. Group 2: Forum Agenda - The forum will feature a series of specialized sessions, including: - Session 1: Biomass Green Pretreatment focusing on steam explosion technology and efficient pretreatment methods [6]. - Session 2: Non-grain sugars and their industrial applications [7]. - Session 3: Bio-based chemicals and their production processes [8]. - Session 4: Non-grain bio-based materials and their commercialization [8]. - The second theme of the forum will address biomass energy, including sessions on biomass methanol, fuel ethanol, biogas, and sustainable aviation fuel (SAF) [9]. Group 3: Supporting Activities - The forum will include a special activity for showcasing and connecting technological achievements, aiming to promote innovation and commercialization in the biomass sector [10]. - A total of 50 innovative projects in biomass utilization will be selected for display and networking opportunities during the forum [10]. Group 4: Industry Participation - The forum will attract various stakeholders, including: - Production companies involved in biomass energy and chemicals, cellulose materials, and green composite materials [14]. - Academic and research institutions focusing on biomass chemistry, advanced catalysis, and resource utilization [14]. - Equipment and solution providers for biomass processing and analysis [14].

Core Viewpoint - The article emphasizes the significant policy support for the bio-manufacturing industry in China, highlighting the government's initiatives to promote green, intelligent, and high-end transformations in the light industry sector, particularly focusing on bio-based and biodegradable materials [2][3]. Policy Developments - On September 18, the Ministry of Industry and Information Technology, along with other departments, released the "Light Industry Stabilization Growth Work Plan (2025-2026)", which aims to enhance the quality and efficiency of traditional light industries while supporting emerging fields like bio-manufacturing [2]. - The plan outlines strategies to stabilize growth through consumption, investment, and exports, addressing structural contradictions in supply and demand [2]. Key Initiatives - The plan sets a target to promote 300 upgraded and innovative products and cultivate 10 specialty industrial zones with a scale exceeding 100 billion yuan by 2026 [3]. - It emphasizes optimizing supply, expanding consumption, and enhancing industrial ecology, with specific measures to accelerate technological breakthroughs in bio-manufacturing [3]. Green Development Focus - The plan promotes the establishment of a strict green standard system covering energy consumption, water usage, and pollutant emissions, encouraging the development of green factories in the light industry [4]. - It aims to drive innovation in bio-based materials and biodegradable products, supporting the transition to a circular economy in packaging and other sectors [4]. Recent Government Actions - The Ministry of Industry and Information Technology has issued multiple documents this year to support bio-based and bio-manufacturing initiatives, including the announcement of a list of 36 bio-manufacturing landmark products [5][6]. - The government is also fostering the establishment of pilot platforms for bio-manufacturing to facilitate industrial scale-up by 2027 [6][7]. Industry Events - The article mentions the upcoming "Non-grain Biomass High-Value Utilization Forum" scheduled for November 27-29 in Hangzhou, focusing on non-grain bio-based chemicals and materials [10].

Core Viewpoint - The article discusses the comprehensive utilization of crop straw in Henan Province, emphasizing the establishment of a robust network for straw collection, storage, transportation, and utilization, aiming for a stable comprehensive utilization rate of over 93% by 2027 [2][3]. Summary by Sections Action Plan Overview - The Henan Provincial Government has issued an action plan for the comprehensive utilization of crop straw from 2025 to 2027, focusing on enhancing the resource value of straw [2]. Key Tasks - **Task 1**: Establish high-standard farmland areas for straw return, focusing on improving soil fertility in major grain-producing regions [3]. - **Task 2**: Develop a straw feed utilization industry, particularly in major cattle-raising cities like Luoyang and Nanyang [3]. - **Task 3**: Build a comprehensive network for straw collection, storage, transportation, and utilization, ensuring land use for storage facilities [3]. Industry Alliance and Innovation - **Task 4**: Form a straw comprehensive utilization industry alliance, collaborating with universities and research institutions to create an information platform for straw utilization [4]. - **Task 5**: Explore new pathways for high-value transformation of straw, including the production of edible fungi substrates and green methanol, while enhancing agricultural machinery for straw utilization [4]. Policy Support - **Task 6**: Increase policy support for straw utilization projects, encouraging financial institutions to innovate credit products and reduce guarantee fees for small enterprises [4].

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths, technological challenges, and opportunities in the industry [2]. Group 1: Forum Overview - The NFUCon 2025 will be held from November 27-29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as green pretreatment of biomass, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][3]. Group 2: Forum Agenda - The forum will feature two main thematic discussions: - The first theme focuses on non-grain bio-based chemicals and materials, including sessions on biomass green pretreatment, non-grain sugars, and bio-based chemicals [6][9]. - The second theme addresses non-grain biomass energy, covering topics like biomass methanol, fuel ethanol, biogas, and sustainable aviation fuel (SAF) [9][10]. Group 3: Special Activities - A special activity titled "Technology Achievement Display and Docking" will be held to promote the development and large-scale application of non-grain biomass industries, showcasing 50 innovative projects with commercial potential [9][10]. Group 4: Participating Entities - The forum will attract a diverse range of participants, including biomass energy and chemical development companies, academic institutions, and solution providers in biomass processing technologies [14].

Core Viewpoint - The article emphasizes the significance of green bio-manufacturing as a sustainable development frontier, predicting that by the end of this century, bio-manufactured products could cover 70% of chemical manufacturing products, with bio-manufacturing potentially accounting for one-third of global manufacturing by 2050, creating an economic value of $30 trillion [4][5]. Group 1: Green Bio-Manufacturing Potential - The current scale of the bio-manufacturing industry is less than $8 trillion, indicating substantial growth potential in the future [4]. - The third generation of bio-manufacturing, which utilizes carbon dioxide as a raw material, is expected to significantly contribute to carbon neutrality efforts [5]. Group 2: Key Challenges and Innovations - Major scientific challenges include efficiently capturing and activating inert carbon dioxide molecules, requiring the design of new enzyme catalysts and light-enzyme coupling systems [5]. - Engineering challenges involve scaling up efficient but fragile biological systems to create stable, continuous, and low-cost reactors, transitioning from laboratory to industrial scale [5]. Group 3: Interdisciplinary Collaboration - Achieving deep integration across disciplines such as biology, chemistry, materials science, and information technology requires the establishment of project communities, shared platforms, and talent communities [6]. - Educational reforms are necessary to cultivate interdisciplinary talent capable of leading the next industrial revolution, including curriculum changes and new evaluation methods [6]. Group 4: China's Position in Global Green Technology - China is transitioning from a "follower" to a "leader" in the global green technology race, with advantages in applied research, industrialization, and market scale [7]. - The proposed international cooperation model emphasizes open collaboration in basic research, innovation alliances in key technology areas, and self-reliance in core competitive fields [7].

Core Points - The "2025 (5th) Non-Grain Biomass High-Value Utilization Forum (NFUCon 2025)" will be held from November 27-29, 2025, in Hangzhou, Zhejiang, focusing on the theme "Top-notch Intelligence, Industrial Symbiosis" [1][8] - The forum aims to gather representatives from various industries to discuss key areas such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy, contributing to the achievement of carbon neutrality goals [8] Group 1: Event Details - NFUCon 2025 is co-hosted by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuel Technology [1][9] - The forum will feature a series of specialized sessions on topics including biomass green pretreatment, non-grain sugars, and sustainable aviation fuel (SAF) [10] Group 2: Key Personnel - Li Zhenglong, a distinguished professor at Zhejiang University and a national-level high-level talent, serves as one of the conference chairs [5][9] - The National Key Laboratory of Bio-based Transportation Fuel Technology, established in April 2023, focuses on the development of bio-liquid energy applications and the comprehensive utilization of biomass materials [6][9] Group 3: Laboratory Overview - The laboratory has 158 fixed members and aims to become a significant international innovation hub in the field of bio-based transportation fuels [6] - Key tasks include advancing fiber ethanol technology and promoting the industrialization of fiber ethanol, as well as enhancing the quality of by-product utilization [6]

Core Viewpoint - The article discusses the advancements in the production of 1,3-propanediol (1,3-PDO) using engineered strains of Klebsiella pneumoniae, highlighting significant improvements in yield and efficiency through metabolic engineering and strain evolution [2][20][23]. Summary by Sections 1. Production Methodology - 1,3-PDO is a high-value fine chemical used in cosmetics, pharmaceuticals, and plastics, traditionally produced through chemical synthesis, which involves toxic substances and high pressure. Microbial fermentation has emerged as a more economical and environmentally friendly production method [2]. - The research team led by Professor Liu Liming achieved a production yield of 138.6 g/L of 1,3-PDO using the engineered strain FMME-51, with a conversion rate of 0.52 g/g, without the need for additional VB12 [2][20]. 2. Strain Optimization - Initial strain FMME-01 produced 67.2 g/L of 1,3-PDO but generated multiple by-products that reduced yield. Subsequent modifications led to strain FMME-14, which showed improved production performance [6]. - Further optimization of the cell membrane composition in strain FMME-38 resulted in a 62.5% increase in tolerance to high 1,3-PDO concentrations and a 41.2% reduction in cell death [9][10]. 3. Enhancements in Co-Factor Synthesis - The production process relies on VB12 and NADH. The integration of genes responsible for VB12 synthesis into the genome of strain FMME-48 resulted in a VB12 concentration of 50.8 μg/L and a 1,3-PDO yield of 118.3 g/L [14]. - The dynamic regulation of NADH levels was achieved through the construction of a biosensor-based system, enhancing the NADH/NAD⁺ ratio by 31.3% in strain FMME-51, leading to a 12.3% increase in 1,3-PDO yield [18][14]. 4. Process Optimization - The optimization of glycerol feeding rates and pH levels significantly improved the production performance of strain FMME-51, achieving a 1,3-PDO yield of 135.9 g/L at a pH of 6.8 [19]. - The final optimized strain FMME-51 demonstrated a production capacity of 122.7 g/L of 1,3-PDO using low-cost crude glycerol as a substrate, showcasing its industrial potential [20][23]. 5. Industrial Implications - The research indicates a significant advancement in the bioproduction of 1,3-PDO, achieving unprecedented yields and efficiencies while eliminating the need for expensive co-factors, thus reducing production costs [20][23]. - The ability of engineered strain FMME-51 to efficiently utilize crude glycerol highlights its potential for large-scale industrial applications in the production of high-value chemicals [23].