Core Viewpoint - Zhejiang Haizheng Pharmaceutical Co., Ltd. has signed a project agreement with Zhejiang University for the development and industrialization of bio-synthesized anticoagulant heparin, with a total project amount of 120 million yuan, aiming to provide green innovative solutions for the global anticoagulant drug market [1][3]. Group 1: Market Context - The domestic heparin market has nearly reached 30 billion yuan, while the global market has surpassed 10 billion USD [3]. - The demand for heparin drugs is increasing due to factors such as an aging population, rising surgical procedures, and increasing chronic disease prevalence [3]. Group 2: Challenges in Traditional Production - Traditional heparin production relies on pig intestinal mucosa, leading to supply instability, quality fluctuations, and environmental pressures [3]. - The bio-synthesis method using microbial fermentation technology offers a sustainable supply of raw materials and significantly improves quality control [3]. Group 3: Company Expertise and Strategy - Haizheng Pharmaceutical has 69 years of experience in the pharmaceutical field and over 55 years of expertise in microbial technology [3]. - The collaboration will enhance Haizheng's product matrix in the anticoagulant drug sector, optimize existing industrial resources, and improve competitiveness in the high-end biopharmaceutical market [3][4]. Group 4: Project Significance - The bio-engineered heparin project is a core initiative of the research institute, marking a significant transition from laboratory research to industrial application [4]. - The partnership aims to disrupt traditional animal extraction methods for heparin production, facilitating a comprehensive process from laboratory research to mass production [4]. Group 5: Future Aspirations - The collaboration seeks to establish a globally leading research and production platform for anticoagulant drugs, filling the clinical application gap for bio-engineered heparin and providing safer and more effective treatment options for patients worldwide [5].

Core Viewpoint - The New Leaf Award, organized by DT New Materials, is a prestigious global award focused on innovation in the bio-based industry, aimed at recognizing and showcasing outstanding products and companies in this sector. The fourth edition of the award is set to begin its registration process for 2026, culminating in an award ceremony at the Bio-based 2026 conference on May 21, 2026 [2][22]. Group 1: Award Categories - The New Leaf Award features four main categories: Innovation Materials Award, Innovation Application Award, Innovation Industry Solutions Award, and Most Commercially Valuable Award [4][22]. Group 2: Registration Timeline and Process - Registration for the 2026 New Leaf Award starts on December 1, 2025, and ends on March 13, 2026. The initial online voting phase will take place from March 16 to March 22, 2026, followed by an online competition and expert review from March 23 to March 27, 2026, with the award ceremony scheduled for May 21, 2026 [6][9]. Group 3: Evaluation Criteria - The evaluation criteria for the awards include: - Innovation in Technology (30% for Innovation Materials Award, 10% for Innovation Application Award) - Innovation in Application (10% for Innovation Materials Award, 30% for Innovation Application Award) - Functionality (25% for Innovation Materials Award, 25% for Innovation Application Award) - Commercial Value (20% for Innovation Materials Award, 30% for Innovation Industry Solutions Award) - Sustainability (15% across all categories) [10]. Group 4: Benefits of Participation - Participating companies will receive free publicity, leveraging DT New Materials' extensive network of over 100,000 industry followers and 100+ communication groups, enhancing brand visibility through a professional selection process and media support [11]. - Award-winning companies will also have the opportunity to attend the award ceremony for free, receiving a high-end trophy and certificate in front of a large audience, celebrating their achievements with industry peers [12].

本届大赛赛题设计仍为"技术赛"与"案例赛"相结合的形式，围绕"安全治理"和"创新发展"两大方向设置赛题，吸引了全 国顶尖团队和技术精英参与。酶赛生物报送的案例《人工智能赋能新型酶催化非天然手性氨基化合物合成》从一众高水平 项目中脱颖而出，取得佳绩。 第六届中国人工智能大赛由国家互联网信息办公室、公安部指导，厦门市人民政府主办，旨在进一步推动人工智能技术创 新发展，促进人工智能与实体经济深度融合，加快构建以大模型为代表的人工智能技术应用落地。 【SynBioCon】 获 悉， 12 月 12 日，第六届中国人工智能大赛颁奖典礼在厦门圆满收官。酶赛生物携 AI 驱动的合成 生物制造创新方案 ，从全国强队中突围，斩获人工智能赋能合成生物制造创新案例赛 A 级荣誉，同时获奖的还有中科院 天工所孙周通团队等，再次验证我们在人工智能与产业融合赛道的硬核实力。 Bio-based 2026 第十一届生物基大会暨展览 The 11th Bio-based Industry Conference & Exhibition 跨越新周期 澎湃新生机 7 场行业评选 新叶奖(第四届) 11 场论坛+7 大同期活动 关键词 | 底层技 ...

关键词 | 底层技术&AI |华为|万华化学 【SynBioCon】 获 悉， 近日，由广州生物岛实验室联合 华为云 、 万华化学 、 华龙讯达等共同研发的"生鸿"工业操作系统发布 ， 这是 鸿蒙化工业 系统首次引入生物制造领域 。 生物制造 作为全球科技竞争的战略制高点，正深刻重塑医药、材料、能源等关键产业，是我国发展新质生产力的重要方向。其技术的自主可控，直接关 乎国家产业安全与核心竞争力。然而，长期以来，底层控制系统的依赖与数据孤岛问题，制约着行业的智能化升级。在此背景下， 构建自主可控的数字 技术底座，推进"鸿蒙化"转型 ，成为关乎未来的必然选择。 "生鸿"工业操作系统由生物岛实验室牵头，联合华为云、华龙讯达、万华化学等行业领军力量共同研发 。其命名寓意"生命如鸿，自主翱翔"，基于开 源鸿蒙（OpenHarmony）打造，具有完全的自主知识产权，核心目标直指实现底层控制自主可控、设备智能互联与工艺数据安全闭环，旨在为未来数 字化、智能化的生物工厂奠定坚实的技术 底座。 02 从理念到实践 "生鸿"系统已取得阶段性应用成果 由生物岛实验室和万华化学等单位的协同推进下， "生鸿"系统已经在生物制造领域的多 ...

【SynBioCon】 获 悉， 近日， 山东大学微生物改造技术全国重点实验室祁庆生团队 在《 Metabolic Engineering 》上发表题为" Engineered Non-Canonical Reductive TCA Pathway Drives High-Yield Succinic Acid Biosynthesis in Yarrowia lipolytica "的研究论文。博士研究生 陶慧琳为论文第一作者，祁庆生教授和崔志勇副研究员为通讯作者。山东大学微生物改造技术全国重点实验室为第一完成单位和通讯作者单位。 C4-二羧酸是一类具有应用价值的化合物，广泛应用于医药、化工、食品等领域。其中，丁二酸作为多种高价值化学品的平台化合物，可以合成1,4 - 丁二醇、四氢呋喃、聚丁二酸丁二醇酯等产品，在化工以及塑料降解领域具有重要价值。解酯耶氏酵母凭借优异的耐酸性以及对低成本原料的兼容性， 成为丁二酸生物合成的潜力宿主。还原TCA（rTCA）途径由于合成路径短、理论转化率高是目前C4-二羧酸合成的主要途径。但酵母不存在天然的 rTCA途径，异源引入后胞质内NADH不足以满足rTCA途径合成丁二酸所 ...

Core Viewpoint - The New Leaf Award, organized by DT New Materials, is a prestigious global award focused on innovation in the bio-based industry, aimed at recognizing and showcasing outstanding products and companies in this sector. The fourth edition of the award is set to begin its registration process for 2026, culminating in an award ceremony at the Bio-based 2026 conference on May 21, 2026 [2][22]. Group 1: Award Categories - The New Leaf Award features four main categories: Innovation Materials Award, Innovation Application Award, Innovation Industry Solutions Award, and Most Commercially Valuable Award [4][22]. Group 2: Registration Timeline and Process - Registration for the 2026 New Leaf Award starts on December 1, 2025, and ends on March 13, 2026. The initial online voting phase will take place from March 16 to March 22, 2026, followed by an online competition and expert review from March 23 to March 27, 2026, with the award ceremony scheduled for May 21, 2026 [6][9]. Group 3: Evaluation Criteria - The evaluation criteria for the awards include: - Innovation in Technology (30% for Innovation Materials Award, 10% for Innovation Application Award) - Innovation in Application (10% for Innovation Materials Award, 30% for Innovation Application Award) - Functionality (25% for Innovation Materials Award, 25% for Innovation Application Award) - Commercial Value (20% for Innovation Materials Award, 30% for Innovation Industry Solutions Award) - Sustainability (15% across all categories) [10]. Group 4: Benefits of Participation - Participating companies will receive free publicity, leveraging DT New Materials' extensive network of over 100,000 industry followers and 100+ communication groups, enhancing brand visibility through a professional selection process and media support [11]. - Award-winning companies will also have the opportunity to attend the award ceremony for free, receiving a high-end trophy and certificate in front of a large audience, celebrating their achievements with industry peers [12].

Core Insights - The article discusses the announcement by the Ministry of Industry and Information Technology and the Ministry of Agriculture and Rural Affairs regarding the selection of typical cases for the innovation and development of non-grain bio-based materials, highlighting 25 key technological innovations, 8 application scenarios, and 2 characteristic gathering areas [2]. Group 1: Key Technological Innovations - A total of 25 enterprises have been recognized for their key technological innovations in non-grain bio-based materials, including companies like Shandong Elpai Powder, Wuhan Ruijia Kang Biological, and Guangdong Boxing New Materials [3]. - Shandong Elpai Powder has developed a technology for preparing silicon-carbon anode materials using agricultural straw and organic waste, addressing issues like volume expansion and conductivity [4]. - Wuhan Ruijia Kang Biological has created high-yield industrial strains and efficient genome editing technologies to produce high-purity lactic acid from non-grain biomass [5]. - Guangdong Boxing New Materials has developed high-performance light-cured resin technology from plant oils, enhancing material strength and curing speed [6]. - Heilongjiang Boneng Green Energy has implemented a circular model for processing agricultural waste into biogas, methanol, and organic fertilizers [7]. Group 2: Application Scenario Expansions - Eight enterprises have been recognized for their innovative applications of non-grain bio-based materials, including Shanghai Kaisa Biotechnology and Weifang Xinlong Biological [29]. - Shanghai Kaisa has developed high-strength, lightweight non-grain bio-based polyamide composite materials for cold chain logistics, achieving a weight reduction of 20% compared to traditional materials [30]. - Weifang Xinlong has successfully scaled up the production of inorganic flame-retardant fibers, addressing safety concerns associated with traditional flame-retardant materials [32]. - Suzhou Juwei Yuan Chuang has created green packaging solutions from brewing by-products, significantly reducing carbon emissions [33]. - Anhui Fengyuan has focused on the application of polylactic acid (PLA) in mineral water bottles, promoting environmental benefits [34]. Group 3: Characteristic Gathering Areas - The Anhui Guzhen Economic Development Zone has been recognized for its focus on the comprehensive utilization of biomass, developing a robust industrial chain from straw to polylactic acid [40]. - The Nanle County Advanced Manufacturing Development Zone has established innovation platforms for low-carbon utilization of biomass, creating a collaborative innovation environment for cellulose, hemicellulose, and lignin [42].

Core Insights - Levinthal Biotech, a leading company in AI-driven protein design, has successfully completed a multi-million RMB Pre-A round financing, led by Jinyumaowu and with participation from JunKedanmu, aiming to accelerate the development of its Pallatom platform and expand its product pipeline [2][3] Group 1: Company Overview - Levinthal Biotech was founded in September 2021, focusing on AI algorithms for protein design, named after Cyrus Levinthal, who proposed the "Levinthal Paradox" regarding protein folding [3] - The company is led by Dr. Wang Haobo, who has a strong background in AI protein design research and has assembled a team of experts from prestigious institutions [3] Group 2: Technology Platforms - Pallatom is a high-performance, all-atom protein design platform that has been recognized alongside models like AlphaFold 3 and ESM3, showcasing its advanced capabilities in precise protein structure design [4][9] - The platform has achieved significant breakthroughs, including solving the design challenges of mixed chirality cyclic peptides, opening new avenues for next-generation cyclic peptide drug development [10] Group 3: Commercial Applications - Pallatom has demonstrated commercial value by overcoming technical barriers in antibody purification, successfully designing a Protein A alternative that surpasses imported products, thus enhancing supply chain autonomy for Chinese biopharmaceutical companies [10] - The Lésign platform integrates evolutionary information and physical potential into AI co-evolution analysis, achieving scalable applications in industrial enzymes and functional proteins [11] Group 4: Business Strategy - Levinthal Biotech has established a comprehensive value chain from molecular design to process development, successfully launching multiple product lines across various sectors, including synthetic biology, new pharmaceuticals, and health foods [13] - The company's innovative approach has significantly reduced the research and development cycle from years to months, drastically lowering experimental validation scales and costs, thereby providing unprecedented momentum for biomedicine and industrial manufacturing [13]

Core Viewpoint - The article highlights the transformation of agricultural waste into a thriving bio-based materials industry in Nanle County, Henan Province, showcasing a complete industrial ecosystem that effectively addresses the challenges of technology, supply chain, and cost control [1][4][56]. Group 1: Industry Development - Nanle County has developed the first closed-loop bio-based materials industry chain in China, turning agricultural waste like straw and corn cobs into valuable products over 20 years [1][6]. - The county's wood sugar production capacity reaches 40,000 tons per year, making it the largest wood sugar production base globally [9]. - The county has established a global first non-grain crystalline glucose production line, certified by ISCC, enabling stable and large-scale conversion of non-grain raw materials into high-purity glucose [10]. Group 2: Technological Breakthroughs - Key technological advancements support each stage of the production process, with 34 proprietary intellectual property rights held by local bio-based material companies [19]. - The production of L-lactic acid has positioned Nanle County as the largest high-purity polymer-grade L-lactic acid production base globally [12]. - The county has developed a high-end polylactic acid (PLA) production technology with an annual capacity of 120,000 tons [14]. Group 3: Cost Control Measures - Nanle County has implemented five major guarantees to systematically reduce operational costs for enterprises, including raw material, land, steam, water, and electricity guarantees [21][38]. - The establishment of a steam public network provides three types of steam supply, keeping prices below 200 yuan per ton [30]. - Industrial water costs have been reduced by 60% through a circular system for industrial water, reclaimed water, and wastewater treatment [33]. Group 4: Investment Opportunities - Three key investment areas are recommended: fine chemicals and derivatives, polylactic acid and PEF fibers, and biomass energy, based on the county's industrial foundation and market demand [46]. - The fine chemicals sector has a strong market demand, particularly for bio-based fine chemicals, which are rapidly expanding under carbon reduction goals [47]. - The county's established partnerships with 128 textile and apparel enterprises create a favorable environment for businesses involved in polylactic acid fibers [48]. Group 5: Lessons from Nanle County - The success of Nanle County illustrates the importance of building a competitive industrial cluster through a comprehensive ecosystem rather than relying solely on investment attraction and policy subsidies [54]. - Key factors for success include technological breakthroughs, a closed industrial loop, cost control through public infrastructure, and strong support from technology and finance [56]. - The county's agricultural waste management, resource advantages, and supportive policies position it as a model for other regions aiming to develop similar bio-based industries [55].

Core Viewpoint - The article discusses a novel multi-enzyme cascade-electrochemical coupling system developed by Professor Wang Dan's team at Chongqing University, which efficiently synthesizes L-lactic acid from ethanol and CO₂, presenting a new strategy for CO₂ resource utilization and green chemical synthesis [2][20]. Summary by Sections Multi-Enzyme Cascade System - A multi-enzyme cascade system was constructed that does not rely on external NADH, utilizing ADH, PDC, and LDH to convert ethanol to acetaldehyde and CO₂ to pyruvate, ultimately producing L-lactic acid [4]. - PDC was identified as the rate-limiting enzyme, with a high-activity mutant Ptdqy developed through random mutation, resulting in a Kcat/Km value 2.92 times higher than the wild type, leading to a 2.94-fold increase in L-lactic acid production [4][10]. Electrochemical Platform - An electrochemical platform was established to regenerate NADH efficiently at -1.5 V and 0.2 mM NAD⁺, achieving an 18% increase in yield compared to pure enzyme systems, thus addressing the coenzyme regeneration challenge [4][16]. Ionic Liquids - The ionic liquid [CH][His] was selected as a solvent, demonstrating a CO₂ adsorption capacity of 0.57 mol/mol, which enhanced L-lactic acid production by 1.89 times compared to Tris buffer systems, making it the optimal solvent choice [4][19]. Scale-Up Production - The system successfully scaled up to synthesize 22.5 mM (2.03 g/L) of L-lactic acid using 50 mM ethanol as a substrate, with production costs 10% lower than traditional microbial fermentation routes and an atomic utilization rate of 100% [4][22]. Industrial Application Potential - This system not only achieves green production with 100% atomic utilization but also reduces L-lactic acid synthesis costs through scale-up validation and cost control, making it a potential alternative to traditional fermentation routes in food, chemical, and biodegradable materials industries [22]. Future Optimization Directions - Future efforts will focus on reducing the cost of NAD⁺, which currently constitutes a significant portion of production costs, and exploring the application of this coupling platform for synthesizing other high-value chemicals from CO₂ [23]. Concept Learning - L-lactic acid is a key raw material in food, chemical, and material sectors, and this research provides a new pathway for its green production by utilizing CO₂ and ethanol, thus avoiding competition with food resources [24]. - Multi-enzyme cascade reactions allow for high substrate flexibility and efficiency, with the rate-limiting enzyme's activity directly influencing overall reaction rates and yields [25]. - The electrochemical coupling method for NADH regeneration offers a low-cost solution for continuous coenzyme supply, enhancing production efficiency [26]. - Ionic liquids enhance CO₂ solubility and enzyme stability, contributing significantly to the increased yield of L-lactic acid [27].