第三代生物炼制技术旨在利用一碳分子和可再生能源，实现燃料与化学品的"负碳"生产，以应对日益严峻的气候变化和粮 食短缺问题。由合成气发酵制得的乙酸，作为一种可行的非粮碳源，近来在大宗化学品的生物合成中地位日益凸显。 3-羟基丙酸（3-HP）是一种可再生的大宗化学品，可通过氧化还原反应衍生出丙烯腈、1,3-丙二醇、丙烯酰胺、丙二酸和 丙烯酸等多种高值产品。据预测，其市场规模将突破360万吨/年，产值超过100亿美元/年。 SynBio团队 | 吴辉 【SynBioCon】 获 悉 ， 华东理工大学生物工程学院上海生物制造技术协同创新中心生物反应器工程国家重点实验室 的吴辉老 师团队 通过丙二酰 -CoA 途径，在大肠杆菌中成功构建了以乙酸为原料合成 3- 羟基丙酸（ 3-HP ）的工程菌 株。最终，工程菌株 ZWR18(M DA) 的 3-HP 产量达到 5.53 g/L ，得率为 0.732 g/g ，占理论得率的 97.60% 。在全 细胞催化条件下，该菌株可产 23.89 g/L 3-HP ，得率为 0.734 g/g ，达到理论得率的 97.87% 。以合成气来源的乙酸 为底物进行全细胞催化时， ZWR1 ...

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology sector since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The SynbioCon 2025 conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference will have the opportunity to receive a free copy of the industry map, valued at 499 yuan, and companies that qualify can apply to be listed on the global bio-based and biomanufacturing industry service platform [6][10].

Core Viewpoint - The article discusses the "Qingdao Synthetic Biology Innovation Development Action Plan (2025-2027)", aiming to enhance the synthetic biology industry in Qingdao through innovation, technology breakthroughs, and the establishment of key projects and platforms [1]. Overall Requirements - The plan emphasizes innovation-driven development, focusing on key technologies and products to empower various industries such as healthcare, environmental protection, agriculture, and energy [2]. - By 2027, the goals include achieving at least 30 key technology breakthroughs, 5 internationally advanced innovation results, and the establishment of over 10 landmark industrial projects [2]. Key Tasks Bottom-Level Technology Innovation - The plan outlines actions for advancing foundational technologies in synthetic biology, including artificial life design, gene editing, and microbial genome databases [3]. - A target is set to establish a global marine metagenomic microbial database with over 100,000 entries by 2027 [3]. Platform-Level Tool Innovation - The initiative aims to develop high-throughput and high-precision synthesis platforms using automation and machine learning, with a goal of creating a microbial strain repository of over 40,000 strains by 2027 [4]. Empowering Biopharmaceutical Industry - Focus on mRNA vaccines, gene therapy, and the development of new drug clinical approvals, with a target of obtaining over 5 new drug clinical approvals by 2027 [5]. Empowering Food and Health Industry - The plan includes the development of marine functional sugars and high-value natural products, aiming to establish a library of over 800 marine carbohydrate compounds by 2027 [6]. Empowering Materials and Energy Industry - The initiative targets breakthroughs in biodegradable materials and biofuels, with a goal of developing over 5 landmark synthetic biology products by 2027 [7]. Empowering Agriculture and Environmental Protection - The plan emphasizes precision molecular breeding and the development of new pesticides, aiming to create a special microbial resource library for organic waste degradation by 2027 [8]. Policy Measures Support for Technological Innovation - The plan includes funding support for key technology research and development projects in synthetic biology [10]. Support for Industrial Innovation Platforms - Encouragement for the establishment of key laboratories and innovation centers, with funding for those evaluated as excellent [11]. Accelerating Local Innovation Results - The establishment of a market for technology transfer and the training of specialized technology brokers to facilitate the commercialization of synthetic biology innovations [12]. Financial Empowerment for Industry Development - A financial support system is proposed to cover the entire synthetic biology industry chain, including government-led industry funds [13]. Promotion of Innovative Product Applications - Support for the application of innovative products and the establishment of market application laboratories [14]. Development of Specialized Industrial Parks - The plan includes the construction of specialized synthetic biology parks to incubate projects and support infrastructure development [15]. Guarantee Measures - The article outlines measures for coordination, funding assurance, and industry services to support the implementation of the action plan [18].

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology industry since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference can receive a free copy of the industry map valued at 499 yuan, and eligible biomanufacturing companies can apply to be listed on the map [6][10].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will be held from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Supporters - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Key Speakers and Experts - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes [4][5][7][8][11][15][19][21][27][30]. - The conference will feature discussions on innovative biomanufacturing technologies and applications, including the development of bio-based products and processes [9][12][24][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will include a high-level roundtable, youth forums, and specialized sessions focusing on various aspects of biomanufacturing [36][37].

Core Viewpoint - Isomaltulose is a new type of natural sweetener with low calories (4 kcal/g), high stability, and no adverse health effects, widely used in pharmaceuticals and food industries [1]. Market Overview - The global isomaltulose market reached $16.2 million in 2023 and is expected to grow to $48.9 million by 2030, with a compound annual growth rate (CAGR) of 17.19% from 2024 to 2030 [2]. Production Technology - The enzymatic preparation of isomaltulose has high conversion rates and meets green environmental requirements. Sucrose isomerase (SI) is an effective enzyme for catalyzing isomaltulose production. Immobilizing SI can improve its stability, reduce inactivation, and enhance recyclability in industrial applications [3]. Research and Development - Professor Liu Fufeng's team at Tianjin University of Science and Technology developed a directed immobilized enzyme that significantly improves heat resistance and reusability while maintaining high activity after multiple cycles. This work lays a solid foundation for the green manufacturing of isomaltulose and provides innovative ideas for the development of new directed immobilized enzyme technologies [4]. Conference Information - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials. The "Youth Forum on Biological Manufacturing" will highlight scientific issues, solutions, results, scalability, and future directions in the research field [8][11].

Project Overview - The project is named "Biopharmaceutical Raw Materials and Bio-based Materials Production Line Construction Project" [2] - It is a new construction project located in the Weinan Economic and Technological Development Zone [2] - The total investment for the project is 92.871 million yuan, with an environmental investment of 6.737 million yuan, accounting for 7.25% of the total investment [2] - The project aims to establish 9 production lines with an annual output of 200 tons of biopharmaceutical raw materials and bio-based materials, along with various supporting facilities [2] Company Profile - Shaanxi Huasen Shengbang Technology Co., Ltd. is located in the Pucheng Provincial High-tech Industrial Development Zone in Shaanxi Province [4] - The company focuses on high-end biopharmaceutical technology research and development, product manufacturing, and sales [4] - It produces biopharmaceutical intermediates and raw materials, as well as health food raw materials, and collaborates with several universities and research institutes [4] - The company has established research centers in Xi'an and Pucheng, aiming to overcome technical bottlenecks in the biopharmaceutical field through innovative microbial synthesis methods [4] Product Information - The main products currently promoted by the company include ergotioneine, rhodiola rosea glycosides, resveratrol, and tetrahydropyridine [3] Industry Event - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang [6] - The conference focuses on five key areas: AI + biological manufacturing, green chemistry and new materials, future food, future agriculture, and beauty raw materials [7] - It aims to explore the development trends of the biomanufacturing industry and promote the scaling of products and the transfer of scientific achievements [7]

Core Viewpoint - Nanjing Membrane Materials is a key player in the development and supply of specialized membrane materials and equipment, focusing on the biomanufacturing industry and participating in the upcoming SynBioCon 2025 conference [1][16]. Group 1: Company Overview - Nanjing Membrane Materials Industry Technology Research Institute is a collaborative innovation entity established with the support of Nanjing University of Technology, focusing on high-performance membrane material research and production, as well as the manufacturing of complete membrane separation equipment [7]. - The company provides integrated technology and equipment for fermentation, enzyme catalysis, separation, and purification processes in bioproducts, with a strong emphasis on engineering applications in the fields of biobased products such as succinic acid, long-chain dicarboxylic acids, and amino acids [7]. Group 2: Product Introduction - High-precision ceramic membranes are designed for the separation and purification of fermentation and enzyme reaction liquids, featuring small and narrowly distributed pore sizes, high flux, and excellent anti-pollution performance [9][10]. - Special nanofiltration membranes are resistant to acids, bases, and solvents, with molecular weight cut-offs of 200, 400, and 600 Da, enabling specific separation needs such as desalting, concentration, and decolorization [11][12]. - The multi-component concentration detection instrument, SENSAP, allows for rapid detection of various substances, including glucose and lactic acid, with a detection time of less than 1 minute and high precision [13][15]. Group 3: Industry Events - The SynBioCon 2025 conference will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and biomanufacturing, as well as four key application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [16]. - The conference will feature a special session, "Biomanufacturing Youth Forum," aimed at providing insights into scientific issues, solutions, results, scalability, and future directions in the research field [16].

【SynBioCon】 获 悉， 7月16日，中国光谷2025"瞪羚精选"企业榜单发布， 武汉睿嘉康 从全区5800余家高新技术企业中脱颖而出， 成功入选光 谷首批100家"瞪羚精选"企业， 且为其中7家生物制造企业之一 。 "瞪羚精选"企业作为光谷高新技术企业的"尖子生"，呈现鲜明的"5678"特征：平均研发人员占比超50%，近三年平均每家获得股权融资超6000万 元，70%处于赛道第一梯队，80%集中在集成电路、智能机器人、 生物制造 等前沿领域。 | 序号 | 企业名称 | 舞道 | 成立时间 | | --- | --- | --- | --- | | 41 | 武汉国创科光电装备有限公司 | 新型显示 | 2020 | | 42 | 武汉伯远科技集团有限公司 | 生物制造 | 2022 | | 43 | 武汉合生科技有限公司 | 牛物制造 | 2021 | | 44 | 武汉睿嘉康生物科技有限公司 | 生物制造 | 2021 | | ਕਟ | 武汉格瑞农生物科技有限公司 | 生物制造 | 2019 | | 46 | 武汉艾迪晶生物科技有限公司 | 生物制造 | 2019 | | 47 | 武汉维恩生物 ...

Core Viewpoint - The article emphasizes the significance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, particularly in China, as part of its manufacturing strength initiatives. The upcoming SynBioCon 2025 conference aims to explore the development trends in biomanufacturing and foster collaboration among industry leaders, experts, and investors [1]. Group 1: Conference Overview - The SynBioCon 2025 will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing, along with four application areas: green chemicals and new materials, future food, future agriculture, and beauty ingredients [1]. - The conference will gather international leading companies, industry experts, government representatives, and capital to discuss the trends and innovations in the biomanufacturing sector during the "14th Five-Year Plan" period [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by institutions such as Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Sai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - Key highlights include forums and closed-door discussions on biomanufacturing development trends, sharing of innovative technologies and values, and over 100 financing project roadshows to discover new cooperation opportunities [5]. - The event will feature a high-level closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [9]. Group 4: Agenda and Special Sessions - The first day will include a high-level closed-door seminar and a youth innovation technology forum aimed at discovering potential teams and technologies in biomanufacturing [12]. - The second and third days will feature a macro forum on biomanufacturing, specialized sessions on green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty ingredients [13][15][18]. Group 5: Topics of Discussion - Discussions will cover various topics such as the development of bio-based materials, new carbon source biomanufacturing, and the application of AI in enzyme discovery and industrial fermentation processes [16][17]. - The conference will also explore the biomanufacturing of high-value food ingredients, natural flavors, and the application of biotechnology in cosmetics [20].