新京报贝壳财经讯 2月22日，四环医药在港交所公告称，根据恒生指数有限公司于2026年2月13日公布 的截至2025年12月31日止期间恒生指数系列季度检讨结果，集团旗下非全资附属公司轩竹生物科技股份 有限公司（"轩竹生物"，股份代号：2575）被纳入恒生综合指数成份股，该调整将于2026年3月9日正式 生效。 ...

Core Viewpoint - Four Seasons Pharmaceutical (00460.HK) announced that its non-wholly owned subsidiary, Xuan Zhu Biotechnology Co., Ltd. ("Xuan Zhu Bio"), will be included in the Hang Seng Composite Index, effective March 9, 2026, following the quarterly review results published by Hang Seng Indexes Company on February 13, 2026 [1] Group 1 - Xuan Zhu Bio is set to be listed on the Hong Kong Stock Exchange under stock code 2575 on October 15, 2025 [1] - The Hang Seng Composite Index covers the top 95% of listed companies on the Hong Kong Stock Exchange by market capitalization [1] - Inclusion in the Hang Seng Composite Index is expected to meet the eligibility criteria for the Stock Connect programs, which facilitate trading between Hong Kong and mainland Chinese investors [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 四 環 醫 藥 控 股 集 團 有 限 公 司（「本公司」或「四環醫藥」，連 同 其 附 屬 公 司，統 稱 為「本集團」）董 事 會（「董事會」）欣 然 宣 佈，根 據 恒 生 指 數 有 限 公 司 於2026年2月 13日公佈的截至2025年12月31日 止 期 間 之 恒 生 指 數 系 列 季 度 檢 討 結 果，本 集 團 旗 下 非 全 資 附 屬 公 司 軒 竹 生 物 科 技 股 份 有 限 公 司（「軒竹生物」，於 二 零 二 五 年 十 月 十 五 日 在 香 港 聯 合 交 易 所 有 限 公 司（「香港聯交所」）主 板 上 市，股 份 代 號： 2575）被 納 入 恒 生 綜 合 指 數 之 成 分 股，該 調 ...

Core Viewpoint - The company anticipates a revenue of no less than RMB 2.5 billion for the year, representing a growth rate of over 30% compared to the same period last year, along with a net profit of no less than RMB 150 million [1] Group 1: Business Performance - The aesthetic medicine segment is expected to achieve revenue exceeding RMB 1.4 billion and a segment profit of over RMB 700 million, with both revenue and profit growth rates exceeding 90% year-on-year, becoming the largest revenue and profit contributor for the company [1] - The innovative drug business is entering a harvest phase, with combined revenue from XuanZhu Bio and HuiSheng Bio significantly increasing compared to the previous year, and the commercialization of new products progressing smoothly, indicating a transition from investment to profitability for this segment [1] Group 2: Financial Health - The company maintains a robust financial position with ample cash reserves, having implemented multiple rounds of share buybacks and successfully completed the spin-off listing of XuanZhu Bio, which has led to significant equity appreciation and alleviated R&D funding pressures, thereby optimizing the company's financial structure and driving profit breakthroughs [1]

Summary of the Conference Call for Sihuan Pharmaceutical Company Overview - **Company**: Sihuan Pharmaceutical - **Industry**: Pharmaceutical and Aesthetic Medicine Key Points Financial Performance and Projections - Sihuan Pharmaceutical is expected to turn profitable in 2025, with projected earnings between 150 million to 250 million RMB, reversing previous losses due to R&D investments in innovative drugs and the impact of generic drug procurement [2][5] - The company anticipates entering a product expansion and distribution phase in 2026 and 2027, which is expected to further enhance performance [2][4] - The aesthetic medicine segment is projected to generate nearly 1.4 billion RMB in revenue by 2025, driven by strong sales of the botulinum toxin product, Letibotulinum, expected to reach around 1 billion RMB, and the Sephora Youth Needle, estimated at 200 million RMB [2][6] Product Pipeline and Market Position - Sihuan Pharmaceutical has a robust pipeline in the aesthetic medicine sector with nearly 60 products, showcasing strong R&D capabilities and significant channel advantages [2][4] - Letibotulinum is rapidly penetrating approximately 8,000 aesthetic institutions, with new products like the Youth Needle and Composite Water Light Needle also performing well [2][4] - For 2026, Letibotulinum is expected to maintain a growth rate of over 20%, while new products are projected to achieve sales of 400-500 million RMB [2][6] Innovative Drug Business - The innovative drug segment is expected to significantly reduce losses in 2026, with anticipated annual revenue exceeding 500 million RMB, and a potential break-even point in 2027 [2][7] - Core products such as CDK 4/6 are entering a commercialization acceleration phase, supported by the listing of the subsidiary, Xuanzhu [2][7] Market Valuation and Investment Potential - Current market capitalization of Sihuan Pharmaceutical is 14.1 billion RMB, with earnings forecasts of 710 million and 930 million RMB for 2026 and 2027, respectively, leading to P/E ratios of 19.8 and 15.2 [3][7] - The valuation is considered low relative to growth potential, with a reasonable valuation estimated at 22-25 times P/E, suggesting a target market cap of 21 billion RMB, indicating a potential upside of approximately 50% [3][7] Market Conditions and Strategic Outlook - Recent surveys indicate a stabilization in demand within the aesthetic medicine industry, with some institutions experiencing a shift from declining to positive growth [4] - Improved market liquidity compared to the previous year and increased attention from core institutional investors are expected to bolster the company's market position [5] Additional Insights - The aesthetic medicine segment's revenue for 2025 is expected to be around 1.4 billion RMB, with the generic and innovative drug segments contributing an estimated 1-1.1 billion RMB [6] - The company is poised for significant growth, with a focus on leveraging its product pipeline and market conditions to enhance shareholder value [5][6]

Core Viewpoint - The company, Sihuan Pharmaceutical (00460), has announced a positive earnings forecast, expecting revenue of at least 2.5 billion RMB for the year ending December 31, 2025, representing a growth rate of over 30% compared to the previous year [1][5]. Group 1: Financial Performance - The company anticipates a net profit of no less than 150 million RMB for the same period [1][5]. - The growth in performance is primarily driven by the rapid expansion of the medical aesthetics business, which is expected to generate over 1.4 billion RMB in revenue and over 700 million RMB in segment profit, with both metrics showing an annual growth rate exceeding 90% [1][5]. Group 2: Business Segments - The medical aesthetics segment has become the largest contributor to both revenue and profit for the company, significantly boosting overall performance [1][5]. - The innovative drug business is entering a harvest phase, which is expected to improve the company's profit structure [1][5]. Group 3: Financial Health - The company maintains a robust financial position with ample cash reserves, having conducted multiple rounds of share buybacks and completed the spin-off of Xuan Bamboo Biotechnology, which has optimized the financial structure and driven profit breakthroughs [1][5].

四环医药重点推荐3-医美行业需求企稳有拐点，预期带动四环新老产品增长 #医美25年获批3大新品全年业绩转正+26年医美加速创新药大幅减亏业绩3倍增长 行业需求： 1）大趋势有企稳迹象：近期调研华东多地反馈经过22-24年客流、零售价格双重承压下，12-1月客流呈现有好转 的态势，美莱、所调研精品机构均实现双位数客流增长。 2）零售价格鉴于人力、营销成本老品逐渐稳定；3）另外老客户 四环医药重点推荐3-医美行业需求企稳有拐点，预期带动四环新老产品增长 4）肉毒是第二大注射品类，目前行业出货量高单位数-低双位数增长，预计未来多年都有增长动能。 四环现有医美核心产品：1）肉毒素乐提葆；2）斯弗妍童颜针倾妍少女针；3）复合动能素冷妍；4）铂安润玻尿 酸；5）黑曜双波黄金微针。 行业需求： 1）大趋势有企稳迹象：近期调研华东多地反馈经过22-24年客流、零售价格双重承压下，12-1月客流呈现有好转 的态势，美莱、所调研精品机构均实现双位数客流增长。 2）零售价格鉴于人力、营销成本老品逐渐稳定；3）另外老客户消费有升级趋势，客单走高。 品类细分： 1）注射填充类玻尿酸有压力，但童颜针2025年因为更多定位中档的厂家获批出 ...

消息面上，四环医药公告，集团预期截至2025年12月31日止年度录得收入不低于25亿元人民币，相较于 去年同期增速逾30%，及不低于1.5亿元人民币的净利润。 四环医药(00460)盈喜后涨超6%，截至发稿，涨2.99%，报1.72港元，成交额5114.13万港元。 业绩增长主要由于集团医美业务实现高速增长，于该年度内实现收入逾14亿元及实现分部利润逾7亿 元，相较于去年收入及分部利润年度增速均超过90%，成为集团第一大收入与利润支柱，带动整体业绩 大幅提升；创新药业务进入收获期，显著改善集团盈利结构；公司财务状况稳健，账面现金充裕，实施 多轮股份回购并完成轩竹生物分拆上市，优化了集团财务结构，推动利润端实现突破。 ...

Core Viewpoint - Four Seasons Pharmaceutical (00460) anticipates significant revenue growth, projecting at least 2.5 billion RMB in revenue and 150 million RMB in net profit for the fiscal year ending December 31, 2025, driven primarily by its aesthetic medicine business and innovative drug segment [1] Group 1: Financial Performance - The company expects revenue growth of over 30% compared to the same period last year, with a minimum revenue target of 2.5 billion RMB [1] - Net profit is projected to be no less than 150 million RMB for the same period [1] Group 2: Business Segments - The aesthetic medicine segment is expected to generate over 1.4 billion RMB in revenue and over 700 million RMB in segment profit, with both metrics showing an annual growth rate exceeding 90% [1] - The innovative drug business is entering a harvest phase, significantly improving the company's profit structure [1] Group 3: Financial Health - The company maintains a robust financial position with ample cash reserves [1] - Multiple rounds of share buybacks have been implemented, and the successful spin-off of Xuan Bamboo Biotechnology has optimized the company's financial structure, contributing to profit breakthroughs [1]

Major Events - Xian Dao Intelligent (00470) received a subscription rate of 79.54 times for its public offering in Hong Kong, with a final issue price of HKD 45.8 per share [1] - Shishi Pharmaceutical Group (02005) is expected to win bids for 45 products in the national centralized procurement [1] - Gilead Sciences-B (01672) has selected the oral amylin receptor agonist peptide ASC36 for clinical development [1] - China Railway Construction (01186) recently won major projects totaling CNY 451.42 billion [1] - Shoucheng Holdings (00697) invested in Qimiao Labi through its subsidiary fund, focusing on expanding its product matrix around core intellectual property [1] - Minshi Group (00425) plans to establish a joint venture to produce aluminum body frame components [1] - Fubo Group (03738) has reached a strategic cooperation with Xinglu Technology [1] - Jin Xun Resources (03636) plans to increase capital by a total of USD 44 million for its overseas subsidiaries [1] - Changfei Optical Fiber and Cable (06869) experienced abnormal fluctuations in A-share trading, clarifying that it does not engage in CPO-related businesses [1] Operating Performance - SMIC (00981) reported Q4 revenue of USD 2.489 billion, a quarter-on-quarter increase of 4.5%, with a gross margin of 19.2% [1] - PCCW (00008) reported a loss attributable to shareholders of HKD 253 million for the fiscal year 2025, narrowing by 16% year-on-year [1] - WuXi Biologics (02269) issued a positive profit alert, expecting a year-on-year profit increase of approximately 46.3% to CNY 4.908 billion for the fiscal year 2025 [1] - Dongyue Group (00189) issued a positive profit alert, anticipating over 100% year-on-year growth in profit attributable to owners for 2025 [1] - Elephant Future Group (02309) issued a positive profit alert, expecting a mid-term profit attributable to owners of approximately HKD 178 million, reversing from a loss [1] - Sihuan Pharmaceutical (00460) issued a positive profit alert, expecting revenue of no less than CNY 2.5 billion for 2025, with a growth rate exceeding 30% compared to the previous year [1] - Beijing Automotive (01958) expects a net profit attributable to the parent company of approximately CNY 110 million to CNY 130 million for 2025, a year-on-year decrease of about 86.4% to 88.5% [1] - COFCO Joycome (01610) issued a profit warning, expecting a loss attributable to shareholders of approximately CNY 230 million to CNY 350 million, reversing from profit year-on-year [1] - New Town Development (01030) achieved a contract sales amount of approximately CNY 714 million in January, a year-on-year decrease of 29.79% [1] - Yue Yuen Industrial (00551) reported a net operating income of approximately USD 705 million in January, a year-on-year decrease of 12.5% [1] - Baoshan International (03813) reported a cumulative net operating income of CNY 1.748 billion in January, a year-on-year decline of 32.5% [1]