Group 1 - The company expects to achieve revenue of no less than RMB 1.1 billion and net profit of no less than RMB 50 million for the six months ending June 30, 2025 [1] - Key factors influencing the financial performance include a high growth rate in the medical aesthetics business, with an expected increase of 50%-60% compared to the same period last year [1] - The innovative drug business is entering a harvest phase, with reduced R&D expenses and a steady stream of new product approvals contributing to revenue growth [1] - The decline in the generic drug business is narrowing year by year, indicating improved performance in this segment [1] - The company's financial position is robust, with ample cash reserves [1] Group 2 - From January 2024 to July 2025, the company has 41 new medical aesthetics and pharmaceutical products approved for launch, including nine medical aesthetics products and 32 pharmaceutical products [2] - Notable products include self-developed medical devices and innovative drugs, which are expected to drive significant future revenue and profit growth [2] - The company is confident about its future development prospects due to the simultaneous launch of multiple heavyweight new products [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 （於百慕達註冊成立的有限公司） （股份代號：0460） 正面盈利預告 – 1 – (1) 醫 美 業 務 高 增 長，相 較 於 去 年 同 期 增 速 在50%–60%之 間； (2) 創 新 藥 業 務 進 入 收 穫 期，包 括 創 新 藥 研 發 開 支 逐 步 減 少，獲 批 新 產 品 持 續 湧 現，新 產 品 的 商 業 化 進 展 順 利，該 板 塊 的 分 部 收 入 持 續 增 長； (3) 仿 製 藥 業 務 的 下 跌 幅 度 逐 年 收 窄；及 (4) 本 公 司 財 務 狀 況 穩 健，賬 面 現 金 充 裕。 自 二 零 二 四 年 一 月 至 二 零 二 五 年 七 月 底，本 集 團 共 有41個醫美及醫 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 四環醫藥控股集團有限公司 呈交日期: 2025年8月1日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 00460 | 說明 | 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,000,000,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,000,000, ...

港股创新药概念股盘初冲高，石药集团(01093.HK)涨超5%，亚盛医药(06855.HK)涨超4%，四环医药 (00460.HK)、丽珠医药(01513.HK)等跟涨。 ...

Performance Summary - Ningde Times (03750.HK) reported a revenue of 178.886 billion yuan for the first half of the year, an increase of 7.27% year-on-year, with a net profit of 30.512 billion yuan, up 33.02% year-on-year [2] - Hisense Home Appliances (00921.HK) achieved a total operating revenue of 49.34 billion yuan, a year-on-year increase of 1.44%, and a net profit of 2.077 billion yuan, up 3.01% year-on-year [2] - New Oriental-S (09901.HK) recorded a net revenue of 4.9 billion USD for the fiscal year 2025, a year-on-year increase of 13.6%, with a net profit of 372 million USD, up 20.1% year-on-year [2] - Weisheng Holdings (03393.HK) reported an operating income of 1.368 billion yuan, a year-on-year increase of 11.88%, and a net profit of 305 million yuan, up 12.24% year-on-year [2] - Yingda Real Estate (00432.HK) had a total revenue of 736 million HKD, a year-on-year growth of 35%, but reported a net loss of approximately 249 million HKD, an increase of 62.75% year-on-year [2] - Saint Bella (02508.HK) announced a profit alert, expecting a net profit of over 320 million yuan, turning from loss to profit year-on-year [2] - Aoneng Construction (01183.HK) issued a profit alert, expecting a net profit increase of over 125% to no less than 18 million MOP year-on-year [2] - Da Cheng Corn Group (03889.HK) issued a profit warning, expecting a net loss of approximately 65 to 85 million HKD, turning from profit to loss year-on-year [2] Company News - Sinopec Oilfield Services (01033.HK) announced that its subsidiary won a natural gas pipeline engineering project with a bid amount of 3.597 billion yuan, accounting for 4.44% of the 2024 revenue [2] - CSPC Pharmaceutical Group (01093.HK) signed an exclusive licensing agreement with MADRIGAL for SYH2086, with potential total payments of up to 2.075 billion USD [2] - China Biopharmaceutical (01177.HK) reported successful external licensing cooperation for LM-299, with a milestone payment of 300 million USD expected to be received soon [2] - Chunquan Industrial Trust (01426.HK) reported an average rental rate of approximately 86% for Huamao Property in the second quarter [2] - Sihuan Pharmaceutical (00460.HK) completed the first patient enrollment in a Phase III clinical trial for the new indication of the innovative drug Annelazole Sodium for gastroesophageal reflux disease [2] - Zhaoke Ophthalmology-B (06622.HK) received orphan drug designation from the FDA for Mephalan for the treatment of retinoblastoma in children [2] - Yunnan Construction Investment Concrete (01847.HK) continues to sign concrete supply contracts for the expansion project of Kunming Changshui International Airport, with a contract amount of approximately 283 million yuan [2] Buyback and Increase Dynamics - Vitasoy International (00345.HK) repurchased 2.122 million shares for approximately 19.6 million HKD at a price range of 9.2 to 9.26 HKD [2] - China Eastern Airlines (00670.HK) spent approximately 7.2536 million HKD to repurchase 2.5 million shares at a price range of 2.89 to 2.92 HKD [2]

Group 1 - The core announcement is that the Phase III clinical study for Annelazole Sodium Enteric-Coated Tablets (brand name: Anjiuwei) for the treatment of gastroesophageal reflux disease has completed its first patient enrollment, marking the second indication expansion for this drug [1] - The study is a multicenter, randomized, double-blind, positive drug-controlled trial led by Shanghai Changzheng Hospital, with participation from 32 authoritative digestive departments, aiming to evaluate the efficacy and long-term safety of Annelazole Sodium for gastroesophageal reflux disease [1] - The study is crucial for providing key data support for the approval of this indication [1] Group 2 - Annelazole Sodium Enteric-Coated Tablets is a new generation proton pump inhibitor (PPI) developed by Xuan Bamboo Biotechnology, holding global intellectual property rights and being the first and only PPI fully developed in China [2] - It is currently the only innovative PPI in China with no approved generics, featuring advantages such as multi-enzyme and non-enzyme metabolism, as well as dual-channel excretion through the intestine and kidneys, resulting in a low risk of drug interactions [2] - A publication in June 2025 indicated that elderly patients and those with renal impairment may benefit more from Annelazole Sodium treatment for gastroesophageal reflux disease [2]

Group 1 - The core point of the news is that Sihuan Pharmaceutical's subsidiary, Xuan Zhu Bio-Tech, has completed the first patient enrollment in a Phase III clinical trial for its innovative drug, Annelazole Sodium Enteric-Coated Tablets, aimed at treating gastroesophageal reflux disease (GERD) [1] - The Phase III clinical trial is a multicenter, randomized, double-blind, positive drug-controlled study led by Shanghai Changzheng Hospital, involving 32 authoritative digestive departments from various hospitals [1] - The trial aims to comprehensively evaluate the efficacy and long-term safety of Annelazole Sodium Enteric-Coated Tablets for GERD, providing critical data support for the approval of this indication [1] Group 2 - Annelazole Sodium Enteric-Coated Tablets is a new generation proton pump inhibitor (PPI) developed by Xuan Zhu Bio-Tech, holding global intellectual property rights and being the first and only PPI fully developed in China [2] - It is currently the only innovative PPI in China with no approved generics, featuring advantages such as multi-enzyme and non-enzyme metabolism, as well as dual-channel excretion through the intestine and kidneys [2] - A publication in June 2025 indicates that elderly patients and those with renal impairment may benefit more from Annelazole Sodium treatment for GERD [2]

Core Viewpoint - The announcement highlights the completion of the first subject enrollment in the Phase III clinical study of Annelazole Sodium Enteric-Coated Tablets for the treatment of gastroesophageal reflux disease (GERD), marking a significant milestone for the company and the industry [1] Group 1: Company Developments - The Phase III clinical study aims to comprehensively evaluate the efficacy and long-term safety of Annelazole Sodium Enteric-Coated Tablets for GERD, providing critical data support for regulatory approval of this indication [1] - Annelazole Sodium Enteric-Coated Tablets is the first and only PPI (Proton Pump Inhibitor) fully developed in China, representing a significant innovation in the domestic pharmaceutical market [1] Group 2: Industry Insights - According to ZhiShi Consulting data, the number of individuals suffering from GERD in China is approximately 38.3 million in 2024, with projections to increase to 42.4 million by 2032, indicating a growing market potential for GERD treatments [1]

自願公告 創新藥安奈拉唑鈉用於反流性食管炎的新適應症 III期臨床完成首例受試者入組 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 （於百慕達註冊成立的有限公司） （股份代號：0460） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 關於軒竹生物 軒 竹 生 物 是 四 環 醫 藥 旗 下 的 創 新 藥 子 公 司，是 一 家 根 植 於 中 國、具 有 全 球 化 視 野 的 創 新 型 制 藥 企 業，聚 焦 於 消 化、腫 瘤 及 非 酒 精 性 脂 肪 性 肝 炎 等 重 大 疾 病 領 域，致 力 於 研 發、生 產 及 商 業 化 具 有 核 心 自 主 知 識 產 權 的1類 新 藥。公 司 擁 有 一 流 的 研 發 團 隊，核 心 人 員 均 具 有 多 年 新 藥 研 發 經 驗。公 司 同 時 具 備 小 ...

Investment Rating - The industry investment rating is "Positive" (maintained) [1] Core Viewpoints - The report highlights a moderate recovery in the beauty and cosmetics sector, with a notable performance in hair care and color cosmetics, indicating a stable growth trajectory [7][35] - The medical aesthetics sector is expected to gain momentum from the introduction of innovative products, particularly in the field of collagen and hair loss treatments [30][46] Summary by Sections Market Review - In June, the beauty and personal care index fell by 3.61%, ranking 31st among all primary industries, underperforming the market [14] - The medical aesthetics sector saw significant stock price increases for companies like Meili Tianyuan Medical Health (+64.4%), Yonghe Medical (+50.0%), and Sihuan Pharmaceutical (+13.3%) [20][26] - For the first half of 2025, the medical aesthetics sector recorded substantial gains, with Jinbo Biological (+124.6%), Yonghe Medical (+83.3%), and Meili Tianyuan Medical Health (+69.9%) leading the way [20][26] Medical Aesthetics - Jinbo Biological launched the world's first recombinant type III humanized collagen gel, HiveCOL, which is expected to revolutionize tissue regeneration [30] - Sihuan Pharmaceutical introduced new products targeting skin quality improvement and contour shaping, while Kedi's external finasteride spray received approval, marking a significant advancement in hair loss treatment [31][32] Cosmetics - The retail sales of cosmetics in the first half of 2025 reached 229.1 billion yuan, reflecting a year-on-year growth of 2.9% [35] - Online sales of cosmetics amounted to 267.83 billion yuan, growing by 11.1%, while offline sales decreased by 4.1% to 228.44 billion yuan [36] - The report emphasizes the strong performance of domestic brands in the online market, particularly on platforms like Douyin and Tmall [40][43] Investment Recommendations - The report recommends focusing on leading domestic beauty brands that are expected to gain market share, particularly in high-growth segments [46][47] - Key recommendations include companies like Shangmei Co., Ltd., Maogeping, and Pulaia, which are well-positioned to benefit from the ongoing trends in the beauty market [50]