Core Viewpoint - Heng Rui Medicine (01276.HK) announced that its subsidiary, Suzhou Shengdiya Biopharmaceutical Co., Ltd., has received approval from the National Medical Products Administration for the clinical trial of injection Rituximab, which will commence soon [1] Group 1: Product Development - The injection Rituximab is set to be launched in China by May 2025 [1] - It is indicated for the treatment of adult patients with unresectable locally advanced or metastatic non-small cell lung cancer (NSCLC) who have HER2 (ERBB2) activating mutations and have previously received at least one systemic therapy [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 中國上海 2025年10月23日 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 一、药品的基本情况 药品名称：注射用瑞康曲妥珠单抗 剂 型：注射剂 证 ...

| 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 | 否 | | | | 證券代號 (如上市) | 600276 | 說明 | A股（於上海證券交易所上市） | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | 佔有關事件前的現有已發 行股份（不包括庫存股 份）數目百分比 (註3) | | 庫存股份數目 | 每股發行/出售價 (註4) | | 已發行股份總數 | | 於下列日期開始時的結存(註1) | 2025年10月20日 | | 6,364,288,664 | | 14,713,610 | | | 6,379,002,274 | | 1). 購回股份 (股份被持作庫存股份) | | | -97,500 | 0.0015 % | 97 ...

Core Insights - The article highlights the current AH premium rates of various stocks, with Northeast Electric (00042), Sinopec Oilfield Service (01033), and Andeli Juice (02218) leading the premium rankings at 864.29%, 271.60%, and 243.99% respectively [1][2] - Conversely, CATL (03750), Hengrui Medicine (01276), and China Merchants Bank (03968) have the lowest AH premium rates, with values of -15.84%, 1.21%, and 1.28% respectively [1][2] AH Premium Rate Rankings - The top three stocks with the highest AH premium rates are: - Northeast Electric (00042): H-share at 0.280 HKD, A-share at 2.25 CNY, premium rate of 864.29%, deviation value of 45.78% [1] - Sinopec Oilfield Service (01033): H-share at 0.810 HKD, A-share at 2.51 CNY, premium rate of 271.60%, deviation value of 47.60% [1] - Andeli Juice (02218): H-share at 16.050 HKD, A-share at 46.09 CNY, premium rate of 243.99%, deviation value of 14.60% [1] - The bottom three stocks with the lowest AH premium rates are: - CATL (03750): H-share at 535.000 HKD, A-share at 375.88 CNY, premium rate of -15.84%, deviation value of -0.86% [1] - Hengrui Medicine (01276): H-share at 76.300 HKD, A-share at 64.47 CNY, premium rate of 1.21%, deviation value of 4.33% [1] - China Merchants Bank (03968): H-share at 49.960 HKD, A-share at 42.24 CNY, premium rate of 1.28%, deviation value of -2.95% [1] Deviation Value Rankings - The stocks with the highest deviation values are: - Sinopec Oilfield Service (01033): premium rate of 271.60%, deviation value of 47.60% [1] - Northeast Electric (00042): premium rate of 864.29%, deviation value of 45.78% [1] - Shandong Molong (00568): premium rate of 122.86%, deviation value of 44.45% [1] - The stocks with the lowest deviation values are: - Tianjin Chuangye Environmental Protection (01065): premium rate of 60.04%, deviation value of -27.29% [2] - Shanghai Electric (02727): premium rate of 141.91%, deviation value of -21.13% [2] - China National Foreign Trade Transportation Group (00598): premium rate of 38.03%, deviation value of -17.35% [2]

Core Viewpoint - Heng Rui Pharmaceutical (01276.HK) announced a share buyback plan, indicating confidence in its stock value and commitment to returning capital to shareholders [1] Group 1 - The company plans to repurchase 10,000 A-shares at a total cost of RMB 650,000 [1] - The buyback price is set at RMB 65 per share [1] - The transaction is scheduled for October 22, 2025 [1]

Core Viewpoint - Heng Rui Medicine (01276) announced a share buyback plan, indicating confidence in its stock value and future prospects [1] Summary by Categories Company Actions - The company plans to repurchase 10,000 A-shares at a total cost of 650,000 yuan, with a buyback price of 65 yuan per share [1]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 江蘇恒瑞醫藥股份有限公司 呈交日期： 2025年10月22日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | A | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | 600276 | 說明 | A股（於上海證券交易所上市） | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | 事件 | | 已發行股份（不包括庫存股份）變動 | 庫存股份變動 | 每股發行/出售價 (註4) | 已發行股份總數 | | | | 已發 ...

Core Insights - The article highlights the top and bottom AH premium rates for various stocks as of October 22, with Northeast Electric, Hongye Futures, and Andeli Juice leading in premium rates, while CATL, Heng Rui Medicine, and China Merchants Bank lag behind [1][2]. AH Premium Rate Rankings - The top three stocks by AH premium rate are: - Northeast Electric (00042) with a premium rate of 847.37% - Hongye Futures (03678) with a premium rate of 248.83% - Andeli Juice (02218) with a premium rate of 248.39% [2] - The bottom three stocks by AH premium rate are: - CATL (03750) with a premium rate of -18.20% - Heng Rui Medicine (01276) with a premium rate of 0.15% - China Merchants Bank (03968) with a premium rate of 1.60% [2] Deviation Values - The top three stocks by deviation value are: - Guanghe Tong (00638) with a deviation value of 81.35% - Shandong Molong (00568) with a deviation value of 38.55% - Changfei Optical Fiber (06869) with a deviation value of 35.75% [1][2] - The bottom three stocks by deviation value are: - Shanghai Electric (02727) with a deviation value of -23.77% - Chalco International (02068) with a deviation value of -22.62% - China National Foreign Trade (00598) with a deviation value of -17.07% [1][3]

Core Insights - The article highlights the current premium rates of AH shares, with Northeast Electric (00042) leading at a premium rate of 881.82% [1] - The bottom three in terms of premium rates are Ningde Times (03750) at -17.23%, China Merchants Bank (03968) at 1.09%, and Hengrui Medicine (01276) at 1.64% [1] - The article also discusses the deviation values of these stocks, indicating significant discrepancies between their A-shares and H-shares [1] Premium Rate Rankings - The top three AH shares by premium rate are: 1. Northeast Electric (00042) with a premium rate of 881.82% and a deviation value of 68.11% [1] 2. Hongye Futures (03678) with a premium rate of 248.18% and a deviation value of 18.60% [2] 3. Zhejiang Shibao (01057) with a premium rate of 247.12% and a deviation value of 23.76% [1] - The bottom three AH shares by premium rate are: 1. Ningde Times (03750) with a premium rate of -17.23% and a deviation value of -2.71% [1] 2. China Merchants Bank (03968) with a premium rate of 1.09% and a deviation value of -3.46% [1] 3. Hengrui Medicine (01276) with a premium rate of 1.64% and a deviation value of 4.78% [1] Deviation Value Rankings - The top three AH shares by deviation value are: 1. Northeast Electric (00042) with a deviation value of 68.11% [1] 2. Shandong Molong (00568) with a deviation value of 29.50% [1] 3. Changfei Optical Fiber (06869) with a deviation value of 28.06% [1] - The bottom three AH shares by deviation value are: 1. Shanghai Electric (02727) with a deviation value of -27.72% [2] 2. China Foreign Transport (00598) with a deviation value of -17.01% [2] 3. COSCO Shipping Energy (01138) with a deviation value of -15.18% [2]

Core Insights - The article highlights the top and bottom AH share premium rates, with Northeast Electric (00042) leading at 918.87% and Ningde Times (03750) at -17.09% [1][2] Summary by Category Top AH Share Premium Rates - Northeast Electric (00042) has a premium rate of 918.87% with a deviation value of 109.61% [2] - Hongye Futures (03678) follows with a premium rate of 246.28% and a deviation value of 16.95% [2] - Zhejiang Shibao (01057) ranks third with a premium rate of 241.04% and a deviation value of 19.03% [2] Bottom AH Share Premium Rates - Ningde Times (03750) has the lowest premium rate at -17.09% with a deviation value of -2.80% [2] - Heng Rui Pharmaceutical (01276) has a premium rate of -1.38% and a deviation value of 1.69% [2] - China Merchants Bank (03968) has a premium rate of 0.51% with a deviation value of -4.32% [2] Top AH Share Deviation Values - Northeast Electric (00042) leads with a deviation value of 109.61% [2] - Changfei Optical Fiber (06869) has a deviation value of 31.51% [2] - Shandong Molong (00568) follows with a deviation value of 26.68% [2] Bottom AH Share Deviation Values - Shanghai Electric (02727) has the lowest deviation value at -25.42% [3] - China National Foreign Trade Transportation Group (00598) has a deviation value of -16.00% [3] - COSCO Shipping Energy Transportation (01138) has a deviation value of -14.18% [3]