Core Viewpoint - The announcement highlights a non-exclusive licensing agreement between Nona Bio, a wholly-owned subsidiary of HAPO (02142), and Pfizer to advance preclinical antibody discovery for various potential disease indications [1] Group 1: Agreement Details - Pfizer will gain global rights to utilize Nona Bio's proprietary HCAb platform for the development of fully human only heavy chain antibodies [1] - Nona Bio will receive an upfront payment and is entitled to regulatory, clinical, and commercial milestone payments [1] - The collaboration allows Nona Bio to leverage its HCAb platform, advanced B cell screening technology, and comprehensive services for antibody discovery, development, and engineering [1]

Core Viewpoint - The company, Heptagon Pharmaceuticals-B (02142.HK), has entered into a non-exclusive licensing agreement with Pfizer to advance preclinical antibody discovery for various potential disease indications [1] Group 1: Agreement Details - Heptagon's wholly-owned subsidiary, Nona Biotech (Suzhou) Co., Ltd., will provide Pfizer with global access to its proprietary HCAb platform for the development of fully human only heavy chain antibodies [1] - Nona Biotech will receive an upfront payment and is entitled to receive regulatory, clinical, and commercial milestone payments [1] - The collaboration allows Nona Biotech to utilize its HCAb platform, advanced B cell screening technology, and comprehensive services for antibody discovery, development, and engineering [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） 根據協議條款，輝瑞將獲得諾納生物專有HCAb平台的全球使用權，以開發全人 源僅重鏈抗體。諾納生物將獲得首付款，並有權獲得監管、臨床及商業里程碑付 款。此外，諾納生物可與輝瑞合作，利用諾納生物的HCAb平台、先進的B細胞篩 選技術及綜合服務開展抗體發現、開發及工程。 警示聲明 我們無法保證我們或合作夥伴將能成功開發或最終銷售本公告所提述的任何候選 產品。本公司股東及潛在投資者於買賣本公司股份時務請審慎行事。 承董事會命 和鉑醫藥控股有限公司 主席兼執行董事 王勁松博士 （股份代號：02142） 自願公告 與輝瑞訂立非獨家授權協議 本公告由和鉑醫藥控股有限公司（「本公司」，連同其附屬公司統稱「本集團」）自願 作出，以告知本公司股東及潛在投資者有關本集團的最新業務更新。 本公司董事會（「董事會」）欣然宣佈，本公司 ...

Core Viewpoint - The company, HeBo Pharmaceutical-B (02142.HK), announced a share buyback on November 18, 2023, spending HKD 1.368 million to repurchase 100,000 shares [1]. Group 1 - The total expenditure for the share buyback was HKD 1.368 million [1]. - The number of shares repurchased in this transaction was 100,000 [1].

Core Viewpoint - The company, Heptagon Pharmaceuticals-B (02142), announced a share buyback plan, intending to repurchase 100,000 shares at a cost of HKD 1.368 million [1] Group 1 - The total amount allocated for the share buyback is HKD 1.368 million [1] - The company plans to repurchase a total of 100,000 shares [1] - The buyback is scheduled to take place on November 18, 2025 [1]

智通财经APP讯，和铂医药-B(02142)发布公告，于2025年11月18日斥资136.8万港元回购10万股。 ...

FF305 表格類別： 股票 狀態： 新提交 公司名稱： 和鉑醫藥控股有限公司 呈交日期： 2025年11月18日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 02142 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | | 已發行股份（不包括庫存股份）數 目 | 佔有關事件前的現有已發 行股份（不包括庫存股 份）數目百分比 (註3) ...

Summary of Conference Call Notes Company and Industry Overview - **Company**: 和铂医药 (HaploMed) and its subsidiary 诺纳生物 (Nona Bio) - **Industry**: Biopharmaceuticals, focusing on innovative drug development and clinical research Key Points and Arguments Nona Bio's Strategic Positioning - Nona Bio aims to provide integrated delivery services, differentiating itself from traditional CROs by offering comprehensive solutions rather than fragmented services [2][5] - The company has four key technology platforms: 1. HMI humanized transgenic mouse platform 2. ADC/RDC/AOC delivery systems 3. Novel in vivo CAR systems 4. AI research platform [2][6] Future Expansion Plans - Nona Bio plans to expand from the Discovery phase to CMC and clinical concept validation stages over the next three years [3][8] - Collaborations with top GLP and CDMO companies are intended to enhance capabilities in GLP and high-end formulation development [3][8] AI Integration in Drug Development - AI is a crucial part of Nona Bio's strategy, with plans to establish an AI innovation center in Shanghai to enhance drug discovery efficiency [7][10] - The company aims to utilize accumulated high-quality data to improve antibody discovery processes [7][10] Clinical Development of 4,003 Project - The 4,003 project, a Treg cell-clearing therapy, has shown significant efficacy in preclinical studies, demonstrating a potency 100 times greater than the control group [2][21] - In clinical trials for MSS colorectal cancer, the objective response rate (ORR) was 34.8%, with a 12-month overall survival (OS) rate of 84% [3][22] Market Potential and Unmet Needs - Colorectal cancer (CRC) represents a significant market opportunity, with approximately 1.9 million new cases globally each year, and 95% of patients being MSS CRC [33][34] - The 4,003 project addresses unmet needs in MSS CRC, where current treatments are limited [22][34] Safety and Efficacy of 4,003 - The safety profile of 4,003 is comparable to existing checkpoint inhibitors, with manageable adverse events primarily at grade 1 or 2 [23][24] - The project is positioned to explore further indications beyond colorectal cancer, maximizing its therapeutic potential [25][26] Competitive Landscape - Nona Bio's 4,003 project is distinct from traditional CTLA-4 therapies, focusing on Treg cell clearance rather than blocking CTLA-4 function [27][28] - The company is actively seeking partnerships to enhance the development and commercialization of HBM 403, retaining rights in key markets like China [29] Financial Projections - Nona Bio aims to achieve normalized revenue of 1 billion RMB by 2028, with projected growth rates of 50%-80% in 2026-2027 [12][19] Workforce Expansion - The company plans to double its workforce by 2026 and again by 2028 to support business growth [16] Additional Important Insights - Nona Bio's unique advantage lies in its ability to generate high-quality data through its proprietary platforms, enhancing AI model training and drug discovery efficiency [14][15] - The company does not currently have plans for a separate IPO and focuses on its core competencies in preclinical stages [35][36]

Summary of Key Points Core Viewpoint - A total of 30 companies conducted share buybacks on November 17, 2025, with China Feihe (06186) leading in both the number of shares repurchased and the total amount spent on buybacks [1]. Group 1: Buyback Details - China Feihe (06186) repurchased 10.81 million shares for a total of 47.19 million yuan, representing 1.532% of its total share capital [2]. - COSCO Shipping Holdings (01919) repurchased 3 million shares for 41.62 million yuan, accounting for 1.083% of its total share capital [2]. - Sinopec Limited (00386) repurchased 3.79 million shares for 16.73 million yuan, which is 0.120% of its total share capital [2]. Group 2: Other Notable Buybacks - Lianlian Digital (02598) repurchased 1.71 million shares for 13.67 million yuan, representing 2.608% of its total share capital [2]. - Linklogis Technology (09959) repurchased 2.65 million shares for 7.40 million yuan, accounting for 4.885% of its total share capital [2]. - Jitu Express (01519) repurchased 640,000 shares for 6.25 million yuan, which is 0.041% of its total share capital [2]. Group 3: Additional Companies - Mengniu Dairy (02319) repurchased 200,000 shares for 2.98 million yuan, representing 0.660% of its total share capital [2]. - Kangning Jereh Pharmaceutical (09966) repurchased 350,000 shares for 3.42 million yuan, accounting for 0.211% of its total share capital [3]. - Huajian Medical (01931) repurchased 593,000 shares for 3.64 million yuan, which is 0.660% of its total share capital [3].

Group 1 - The company, HAPO Pharmaceutical-B (02142), announced a share buyback plan, intending to repurchase 100,000 shares at a total cost of HKD 1.375 million [1] - The buyback price per share is set between HKD 13.68 and HKD 13.80 [1]